Saffron A G Willis-Owen

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint The genetic basis of emotional behaviour in mice
    Saffron A G Willis-Owen
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Headington, Oxford, UK
    Eur J Hum Genet 14:721-8. 2006
  2. ncbi request reprint The serotonin transporter length polymorphism, neuroticism, and depression: a comprehensive assessment of association
    Saffron A G Willis-Owen
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Biol Psychiatry 58:451-6. 2005
  3. ncbi request reprint The Val66Met coding variant of the brain-derived neurotrophic factor (BDNF) gene does not contribute toward variation in the personality trait neuroticism
    Saffron A G Willis-Owen
    Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, UK
    Biol Psychiatry 58:738-42. 2005
  4. ncbi request reprint Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice
    Binnaz Yalcin
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Nat Genet 36:1197-202. 2004
  5. ncbi request reprint Identifying the genetic determinants of emotionality in humans; insights from rodents
    Saffron A G Willis-Owen
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Headington, Oxford, OX3 7BN, UK
    Neurosci Biobehav Rev 31:115-24. 2007
  6. ncbi request reprint Human-mouse quantitative trait locus concordance and the dissection of a human neuroticism locus
    Janice M Fullerton
    Wellcome Trust Centre for Human Genetics, Headington, Oxford, United Kingdom
    Biol Psychiatry 63:874-83. 2008
  7. ncbi request reprint No association between the BDNF Val66Met polymorphism and mood status in a non-clinical community sample of 7389 older adults
    Paul G Surtees
    Strangeways Research Laboratory and University of Cambridge, Department of Public Health and Primary Care, Worts Causeway, Cambridge CB1 8RN, UK
    J Psychiatr Res 41:404-9. 2007
  8. ncbi request reprint Social adversity, the serotonin transporter (5-HTTLPR) polymorphism and major depressive disorder
    Paul G Surtees
    Strangeways Research Laboratory and University of Cambridge Department of Public Health and Primary Care, Worts Causeway, Cambridge, UK
    Biol Psychiatry 59:224-9. 2006
  9. ncbi request reprint The brain-derived neurotrophic factor Val66Met polymorphism is associated with sense of coherence in a non-clinical community sample of 7335 adults
    Paul G Surtees
    J Psychiatr Res 41:707-10. 2007
  10. ncbi request reprint Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma
    Miriam F Moffatt
    National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
    Nature 448:470-3. 2007

Collaborators

Detail Information

Publications10

  1. ncbi request reprint The genetic basis of emotional behaviour in mice
    Saffron A G Willis-Owen
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Headington, Oxford, UK
    Eur J Hum Genet 14:721-8. 2006
    ..Ultimately, we describe a method of assessing gene candidacy, and show that given sufficient access to genetic diversity and recombination, progression from QTL to gene can be achieved even for low magnitude genetic effects...
  2. ncbi request reprint The serotonin transporter length polymorphism, neuroticism, and depression: a comprehensive assessment of association
    Saffron A G Willis-Owen
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Biol Psychiatry 58:451-6. 2005
    ..Several explanations have been posited to account for this discrepancy, including underpowered experimental design and variation in gender ratio, age, and ethnicity...
  3. ncbi request reprint The Val66Met coding variant of the brain-derived neurotrophic factor (BDNF) gene does not contribute toward variation in the personality trait neuroticism
    Saffron A G Willis-Owen
    Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, UK
    Biol Psychiatry 58:738-42. 2005
    ..The val66met variant located within the brain-derived neurotrophic factor gene (BDNF) has previously been associated with human neuroticism, a dimension of personality strongly predictive of depressive illness...
  4. ncbi request reprint Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice
    Binnaz Yalcin
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Nat Genet 36:1197-202. 2004
    ..We then use quantitative complementation to show that Rgs2 is a quantitative trait gene. This combined genetic and functional approach should be applicable to the analysis of any quantitative trait...
  5. ncbi request reprint Identifying the genetic determinants of emotionality in humans; insights from rodents
    Saffron A G Willis-Owen
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Headington, Oxford, OX3 7BN, UK
    Neurosci Biobehav Rev 31:115-24. 2007
    ..In this review we discuss the potential for using cross-species QTL concordance as a tool for QTL dissection in behaviour genetics, using an affect-related locus mapped to human chromosome 1 as an example...
  6. ncbi request reprint Human-mouse quantitative trait locus concordance and the dissection of a human neuroticism locus
    Janice M Fullerton
    Wellcome Trust Centre for Human Genetics, Headington, Oxford, United Kingdom
    Biol Psychiatry 63:874-83. 2008
    ..This locus is syntenic with a human region that has been consistently implicated in the genetic aetiology of neuroticism...
  7. ncbi request reprint No association between the BDNF Val66Met polymorphism and mood status in a non-clinical community sample of 7389 older adults
    Paul G Surtees
    Strangeways Research Laboratory and University of Cambridge, Department of Public Health and Primary Care, Worts Causeway, Cambridge CB1 8RN, UK
    J Psychiatr Res 41:404-9. 2007
    ..A total of 1214 (16.4%) participants reported lifetime MDD and 355 (4.8%) reported lifetime GAD. In this population based study we found no evidence to support an association between the BDNF gene Val66Met polymorphism and mood status...
  8. ncbi request reprint Social adversity, the serotonin transporter (5-HTTLPR) polymorphism and major depressive disorder
    Paul G Surtees
    Strangeways Research Laboratory and University of Cambridge Department of Public Health and Primary Care, Worts Causeway, Cambridge, UK
    Biol Psychiatry 59:224-9. 2006
    ..We report an investigation designed to replicate this finding...
  9. ncbi request reprint The brain-derived neurotrophic factor Val66Met polymorphism is associated with sense of coherence in a non-clinical community sample of 7335 adults
    Paul G Surtees
    J Psychiatr Res 41:707-10. 2007
  10. ncbi request reprint Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma
    Miriam F Moffatt
    National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
    Nature 448:470-3. 2007
    ..The results indicate that genetic variants regulating ORMDL3 expression are determinants of susceptibility to childhood asthma...