Genomes and Genes
Saffron A G Willis-Owen
Affiliation: University of Oxford
- The genetic basis of emotional behaviour in miceSaffron A G Willis-Owen
Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Headington, Oxford, UK
Eur J Hum Genet 14:721-8. 2006..Ultimately, we describe a method of assessing gene candidacy, and show that given sufficient access to genetic diversity and recombination, progression from QTL to gene can be achieved even for low magnitude genetic effects...
- The serotonin transporter length polymorphism, neuroticism, and depression: a comprehensive assessment of associationSaffron A G Willis-Owen
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
Biol Psychiatry 58:451-6. 2005..Several explanations have been posited to account for this discrepancy, including underpowered experimental design and variation in gender ratio, age, and ethnicity...
- The Val66Met coding variant of the brain-derived neurotrophic factor (BDNF) gene does not contribute toward variation in the personality trait neuroticismSaffron A G Willis-Owen
Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, UK
Biol Psychiatry 58:738-42. 2005..The val66met variant located within the brain-derived neurotrophic factor gene (BDNF) has previously been associated with human neuroticism, a dimension of personality strongly predictive of depressive illness...
- Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in miceBinnaz Yalcin
Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
Nat Genet 36:1197-202. 2004..We then use quantitative complementation to show that Rgs2 is a quantitative trait gene. This combined genetic and functional approach should be applicable to the analysis of any quantitative trait...
- Identifying the genetic determinants of emotionality in humans; insights from rodentsSaffron A G Willis-Owen
Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Headington, Oxford, OX3 7BN, UK
Neurosci Biobehav Rev 31:115-24. 2007..In this review we discuss the potential for using cross-species QTL concordance as a tool for QTL dissection in behaviour genetics, using an affect-related locus mapped to human chromosome 1 as an example...
- Human-mouse quantitative trait locus concordance and the dissection of a human neuroticism locusJanice M Fullerton
Wellcome Trust Centre for Human Genetics, Headington, Oxford, United Kingdom
Biol Psychiatry 63:874-83. 2008..This locus is syntenic with a human region that has been consistently implicated in the genetic aetiology of neuroticism...
- No association between the BDNF Val66Met polymorphism and mood status in a non-clinical community sample of 7389 older adultsPaul G Surtees
Strangeways Research Laboratory and University of Cambridge, Department of Public Health and Primary Care, Worts Causeway, Cambridge CB1 8RN, UK
J Psychiatr Res 41:404-9. 2007..A total of 1214 (16.4%) participants reported lifetime MDD and 355 (4.8%) reported lifetime GAD. In this population based study we found no evidence to support an association between the BDNF gene Val66Met polymorphism and mood status...
- Social adversity, the serotonin transporter (5-HTTLPR) polymorphism and major depressive disorderPaul G Surtees
Strangeways Research Laboratory and University of Cambridge Department of Public Health and Primary Care, Worts Causeway, Cambridge, UK
Biol Psychiatry 59:224-9. 2006..We report an investigation designed to replicate this finding...
- The brain-derived neurotrophic factor Val66Met polymorphism is associated with sense of coherence in a non-clinical community sample of 7335 adultsPaul G Surtees
J Psychiatr Res 41:707-10. 2007
- Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthmaMiriam F Moffatt
National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
Nature 448:470-3. 2007..The results indicate that genetic variants regulating ORMDL3 expression are determinants of susceptibility to childhood asthma...