R A Williamson

Summary

Affiliation: University of Kent
Country: UK

Publications

  1. ncbi request reprint Mapping the binding site for matrix metalloproteinase on the N-terminal domain of the tissue inhibitor of metalloproteinases-2 by NMR chemical shift perturbation
    R A Williamson
    Research School of Biosciences, University of Kent, Canterbury, U K
    Biochemistry 36:13882-9. 1997
  2. ncbi request reprint High resolution structure of the N-terminal domain of tissue inhibitor of metalloproteinases-2 and characterization of its interaction site with matrix metalloproteinase-3
    F W Muskett
    Department of Biosciences, University of Kent, Canterbury, Kent, CT2 7NJ, United Kingdom
    J Biol Chem 273:21736-43. 1998
  3. ncbi request reprint Solution structure of the active domain of tissue inhibitor of metalloproteinases-2. A new member of the OB fold protein family
    R A Williamson
    Research School of Biosciences, Biological Laboratory, University of Kent, Canterbury, U K
    Biochemistry 33:11745-59. 1994
  4. pmc Disulphide bond assignment in human tissue inhibitor of metalloproteinases (TIMP)
    R A Williamson
    Biological Laboratory, University of Kent, Canterbury, U K
    Biochem J 268:267-74. 1990
  5. ncbi request reprint In vivo evaluation of 111In-DTPA-N-TIMP-2 in Kaposi sarcoma associated with HIV infection
    R Kulasegaram
    Biosciences Department, University of Kent, Canterbury, UK
    Eur J Nucl Med 28:756-61. 2001

Collaborators

Detail Information

Publications5

  1. ncbi request reprint Mapping the binding site for matrix metalloproteinase on the N-terminal domain of the tissue inhibitor of metalloproteinases-2 by NMR chemical shift perturbation
    R A Williamson
    Research School of Biosciences, University of Kent, Canterbury, U K
    Biochemistry 36:13882-9. 1997
    ..Sequence conservation data and recent site-directed mutagenesis studies are discussed in relation to the MMP binding site identified in this work...
  2. ncbi request reprint High resolution structure of the N-terminal domain of tissue inhibitor of metalloproteinases-2 and characterization of its interaction site with matrix metalloproteinase-3
    F W Muskett
    Department of Biosciences, University of Kent, Canterbury, Kent, CT2 7NJ, United Kingdom
    J Biol Chem 273:21736-43. 1998
    ....
  3. ncbi request reprint Solution structure of the active domain of tissue inhibitor of metalloproteinases-2. A new member of the OB fold protein family
    R A Williamson
    Research School of Biosciences, Biological Laboratory, University of Kent, Canterbury, U K
    Biochemistry 33:11745-59. 1994
    ..Furthermore, the structure has revealed conserved surface regions of potential functional importance...
  4. pmc Disulphide bond assignment in human tissue inhibitor of metalloproteinases (TIMP)
    R A Williamson
    Biological Laboratory, University of Kent, Canterbury, U K
    Biochem J 268:267-74. 1990
    ..s. analysis permitted the assignments Cys-1-Cys-70, Cys-3-Cys-99, Cys-13-Cys-124 and Cys-127-Cys-174 from these peptides. The sixth bond Cys-132-Cys-137 was assigned by inference, as the native protein has no detectable free thiol groups...
  5. ncbi request reprint In vivo evaluation of 111In-DTPA-N-TIMP-2 in Kaposi sarcoma associated with HIV infection
    R Kulasegaram
    Biosciences Department, University of Kent, Canterbury, UK
    Eur J Nucl Med 28:756-61. 2001
    ..It is unlikely to be of use for imaging KS, but may have a role in other tumours that produce matrix metalloproteinases...