Gary Williamson

Summary

Affiliation: University of Leeds
Country: UK

Publications

  1. ncbi Nutrients and phytochemicals: from bioavailability to bioefficacy beyond antioxidants
    Birgit Holst
    BioAnalytical Science Department, Nestle Research Center, Nestec Ltd, Vers chez les Blanc, CH 1000 Lausanne 26, Switzerland
    Curr Opin Biotechnol 19:73-82. 2008
  2. ncbi Possible effects of dietary polyphenols on sugar absorption and digestion
    Gary Williamson
    School of Food Science and Nutrition, University of Leeds, Leeds LS2 9JT, UK
    Mol Nutr Food Res 57:48-57. 2013
  3. ncbi Polyphenol content and health benefits of raisins
    Gary Williamson
    School of Food Science and Nutrition, University of Leeds, LS92JT Leeds, United Kingdom
    Nutr Res 30:511-9. 2010
  4. ncbi Colonic metabolites of berry polyphenols: the missing link to biological activity?
    Gary Williamson
    School of Food Science and Nutrition, University of Leeds, Leeds, UK
    Br J Nutr 104:S48-66. 2010
  5. ncbi Flavanols from green tea and phenolic acids from coffee: critical quantitative evaluation of the pharmacokinetic data in humans after consumption of single doses of beverages
    Gary Williamson
    School of Food Science and Nutrition, University of Leeds, Leeds, UK
    Mol Nutr Food Res 55:864-73. 2011
  6. ncbi Dietary reference intake (DRI) value for dietary polyphenols: are we heading in the right direction?
    Gary Williamson
    Chair of Functional Food, Procter Department of Food Science, University of Leeds, Leeds LS2 9JT, UK
    Br J Nutr 99:S55-8. 2008
  7. ncbi Review of the efficacy of green tea, isoflavones and aloe vera supplements based on randomised controlled trials
    Gary Williamson
    School of Food Science and Nutrition, University of Leeds, Leeds, LS2 9JT, UK
    Food Funct 2:753-9. 2011
  8. ncbi Interaction of hydroxycinnamic acids and their conjugates with organic anion transporters and ATP-binding cassette transporters
    Chi C Wong
    School of Food Science and Nutrition, University of Leeds, Leeds, UK
    Mol Nutr Food Res 55:979-88. 2011
  9. ncbi Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study
    Tracy L Farrell
    School of Food Science and Nutrition, University of Leeds, Leeds, UK
    Drug Metab Dispos 40:397-406. 2012
  10. ncbi Absorption of dimethoxycinnamic acid derivatives in vitro and pharmacokinetic profile in human plasma following coffee consumption
    Tracy L Farrell
    School of Food Science and Nutrition, University of Leeds, Leeds, UK
    Mol Nutr Food Res 56:1413-23. 2012

Collaborators

Detail Information

Publications55

  1. ncbi Nutrients and phytochemicals: from bioavailability to bioefficacy beyond antioxidants
    Birgit Holst
    BioAnalytical Science Department, Nestle Research Center, Nestec Ltd, Vers chez les Blanc, CH 1000 Lausanne 26, Switzerland
    Curr Opin Biotechnol 19:73-82. 2008
    ....
  2. ncbi Possible effects of dietary polyphenols on sugar absorption and digestion
    Gary Williamson
    School of Food Science and Nutrition, University of Leeds, Leeds LS2 9JT, UK
    Mol Nutr Food Res 57:48-57. 2013
    ....
  3. ncbi Polyphenol content and health benefits of raisins
    Gary Williamson
    School of Food Science and Nutrition, University of Leeds, LS92JT Leeds, United Kingdom
    Nutr Res 30:511-9. 2010
    ..More research is required to establish the bioavailability and health effects of the PPT component of raisins, the effects of raisins on health biomarkers in vivo in humans, and how these effects compare to grapes and wine...
  4. ncbi Colonic metabolites of berry polyphenols: the missing link to biological activity?
    Gary Williamson
    School of Food Science and Nutrition, University of Leeds, Leeds, UK
    Br J Nutr 104:S48-66. 2010
    ....
  5. ncbi Flavanols from green tea and phenolic acids from coffee: critical quantitative evaluation of the pharmacokinetic data in humans after consumption of single doses of beverages
    Gary Williamson
    School of Food Science and Nutrition, University of Leeds, Leeds, UK
    Mol Nutr Food Res 55:864-73. 2011
    ..Most studies report a very low amount of intact chlorogenic acids in plasma, with one exception. More studies on absorption of chlorogenic acids from coffee are required, including dose-response studies...
  6. ncbi Dietary reference intake (DRI) value for dietary polyphenols: are we heading in the right direction?
    Gary Williamson
    Chair of Functional Food, Procter Department of Food Science, University of Leeds, Leeds LS2 9JT, UK
    Br J Nutr 99:S55-8. 2008
    ..We are heading in the right direction towards a DRI, but bioavailability and dose-effects, including toxic levels, need to be established before DRIs can be considered...
  7. ncbi Review of the efficacy of green tea, isoflavones and aloe vera supplements based on randomised controlled trials
    Gary Williamson
    School of Food Science and Nutrition, University of Leeds, Leeds, LS2 9JT, UK
    Food Funct 2:753-9. 2011
    ....
  8. ncbi Interaction of hydroxycinnamic acids and their conjugates with organic anion transporters and ATP-binding cassette transporters
    Chi C Wong
    School of Food Science and Nutrition, University of Leeds, Leeds, UK
    Mol Nutr Food Res 55:979-88. 2011
    ..Hydroxycinnamic acids are abundant antioxidants in our diet. In humans, hydroxycinnamic acids are metabolized to form sulfates and glucuronides, with the majority recovered in urine...
  9. ncbi Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study
    Tracy L Farrell
    School of Food Science and Nutrition, University of Leeds, Leeds, UK
    Drug Metab Dispos 40:397-406. 2012
    ....
  10. ncbi Absorption of dimethoxycinnamic acid derivatives in vitro and pharmacokinetic profile in human plasma following coffee consumption
    Tracy L Farrell
    School of Food Science and Nutrition, University of Leeds, Leeds, UK
    Mol Nutr Food Res 56:1413-23. 2012
    ....
  11. ncbi Carrier-mediated transport of quercetin conjugates: involvement of organic anion transporters and organic anion transporting polypeptides
    Chi Chun Wong
    School of Food Science and Nutrition, University of Leeds, Leeds LS2 9JT, UK
    Biochem Pharmacol 84:564-70. 2012
    ..siRNA knockdown of OATP4C1 expression in HepG2 cells reduced uptake of quercetin-3'-O-sulfate by ∼40%. This study highlights a role for OATs and OATPs in the cellular uptake of biologically active flavonoid conjugates...
  12. ncbi Characterization of hydroxycinnamic acid glucuronide and sulfate conjugates by HPLC-DAD-MS(2): enhancing chromatographic quantification and application in Caco-2 cell metabolism
    Tracy Farrell
    School of Food Science and Nutrition, University of Leeds, UK
    J Pharm Biomed Anal 55:1245-54. 2011
    ..The characterization data presented here will significantly improve quantification and understanding of the bioavailability in vivo...
  13. ncbi Polyphenols and phenolic acids from strawberry and apple decrease glucose uptake and transport by human intestinal Caco-2 cells
    Susana Manzano
    School of Food Science and Nutrition, University of Leeds, Leeds, United Kingdom
    Mol Nutr Food Res 54:1773-80. 2010
    ..The results in this assay show that some PPTs inhibit glucose transport from the intestinal lumen into cells and also the GLUT2-facilitated exit on the basolateral side...
  14. ncbi In vitro and in vivo conjugation of dietary hydroxycinnamic acids by UDP-glucuronosyltransferases and sulfotransferases in humans
    Chi Chun Wong
    School of Food Science and Nutrition, University of Leeds, LS29JT Leeds, UK
    J Nutr Biochem 21:1060-8. 2010
    ..These data suggest that sulfates are the predominant hydroxycinnamic acid conjugates in humans, and that SULT mediated sulfation is a major factor determining the bioavailability of hydroxycinnamic acids in vivo...
  15. ncbi Absorption of quercetin-3-glucoside and quercetin-4'-glucoside in the rat small intestine: the role of lactase phlorizin hydrolase and the sodium-dependent glucose transporter
    Andrea J Day
    Procter Department of Food Science, University of Leeds, Leeds LS2 9JT, UK
    Biochem Pharmacol 65:1199-206. 2003
    ..Evidently the mechanism of absorption of quercetin-4'-glucoside involves both an interaction with SGLT1 and luminal hydrolysis by LPH, whereas quercetin-3-glucoside appears to be absorbed only following hydrolysis by LPH...
  16. ncbi Flavonoid conjugates interact with organic anion transporters (OATs) and attenuate cytotoxicity of adefovir mediated by organic anion transporter 1 (OAT1/SLC22A6)
    Chi Chun Wong
    School of Food Science and Nutrition, University of Leeds, Woodhouse Lane, Leeds, UK
    Biochem Pharmacol 81:942-9. 2011
    ..Interaction with OATs limits systemic availability of flavonoids and may be a mechanism of food-drug interaction via inhibition of renal uptake...
  17. ncbi Interactions affecting the bioavailability of dietary polyphenols in vivo
    Susanne Scholz
    Nestle Research Center, Vers chez les Blanc, 1000 Lausanne 26, Switzerland
    Int J Vitam Nutr Res 77:224-35. 2007
    ..Information derived from such experiments could be useful for the optimal design of future bioefficacy studies...
  18. ncbi Lycopene isomerisation takes place within enterocytes during absorption in human subjects
    Myriam Richelle
    Nestle Research Center, Nestec Ltd, Lausanne, Switzerland
    Br J Nutr 103:1800-7. 2010
    ..Although there is a huge inter-individual variability of total lycopene absorption reported both in in vitro intestinal cell lines as well as in human chylomicrons, the lycopene isomer profile is quite similar...
  19. ncbi Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies
    Gary Williamson
    Nutrient Bioavailability Group, Nestle Research Center, Lausanne, Switzerland
    Am J Clin Nutr 81:243S-255S. 2005
    ..The length of human intervention studies should be increased, to more closely reflect the long-term dietary consumption of polyphenols...
  20. ncbi Absorption and metabolism of chlorogenic acids in cultured gastric epithelial monolayers
    Tracy L Farrell
    School of Food Science and Nutrition, University of Leeds, Leeds, UK
    Drug Metab Dispos 39:2338-46. 2011
    ..We propose that the stomach is the first location for the release of hydroxycinnamic acids, which could explain their early detection after coffee consumption...
  21. ncbi Functional foods for health promotion: state-of-the-science on dietary flavonoids. Extended abstracts from the 12th Annual Conference on Functional Foods for Health Promotion, April 2009
    Gary Williamson
    University of Leeds, Leeds, UK
    Nutr Rev 67:736-43. 2009
    ..While more data are needed on the long-term health impacts of dietary flavonoids in humans, including the efficacious dose, current data indicate it may soon be possible to develop public health messages about flavonoid-rich foods...
  22. ncbi Cocoa and health: a decade of research
    Karen A Cooper
    Nestle Research Center, Vers chez les Blanc, PO Box 44, CH 1000 Lausanne 26, Switzerland
    Br J Nutr 99:1-11. 2008
    ..However, after 10 years of research, what is known about the potential health benefits of cocoa and what are the important next steps in understanding this decadent source of antioxidants?..
  23. ncbi Investigation of the metabolic fate of dihydrocaffeic acid
    Laure Poquet
    Nestle Research Centre, Vers chez les Blanc, 1000 Lausanne 26, Switzerland
    Biochem Pharmacol 75:1218-29. 2008
    ..As a conclusion, the main form of dihydrocaffeic acid circulating in plasma after its ingestion is a mixture of different primary and secondary metabolites...
  24. ncbi Measurement of caffeic and ferulic acid equivalents in plasma after coffee consumption: small intestine and colon are key sites for coffee metabolism
    Mathieu Renouf
    Nestle Research Center, Nestec Limited, Vers chez les Blanc, Lausanne, Switzerland
    Mol Nutr Food Res 54:760-6. 2010
    ..This study confirms that the small intestine is a significant site for absorption of PA, but shows for the first time that the colon/microflora play the major role in absorption and metabolism of CGAs and PA from coffee...
  25. ncbi Predictive relationship between polyphenol and nonfat cocoa solids content of chocolate
    Karen A Cooper
    Nestle Research Centre, Lausanne, Switzerland
    J Agric Food Chem 56:260-5. 2008
    ..40), but these relationships were independent of the nature of the chocolate type, indicating that they might still have some predictive capabilities...
  26. ncbi Transport and metabolism of ferulic acid through the colonic epithelium
    Laure Poquet
    Nestle Research Center, Vers chez les Blanc, Lausanne, Switzerland
    Drug Metab Dispos 36:190-7. 2008
    ..These results show that the form of ferulic acid available to the blood after passage across the colonic barrier would be mainly the free form, together with only a small percentage of conjugated and reduced ferulic acid...
  27. ncbi Review of the factors affecting bioavailability of soy isoflavones in humans
    Inge Lise Finné Nielsen
    Nutrient Bioavailability Group, Nestle Research Center, Lausanne, Switzerland
    Nutr Cancer 57:1-10. 2007
    ..In conclusion, it is important to consider the factors affecting bioavailability of isoflavones when designing intervention studies...
  28. ncbi Interaction of positional isomers of quercetin glucuronides with the transporter ABCC2 (cMOAT, MRP2)
    Gary Williamson
    Nestle Research Center, Vers chez les Blanc, 1000 Lausanne 26, Switzerland
    Drug Metab Dispos 35:1262-8. 2007
    ....
  29. ncbi A review of the health effects of green tea catechins in in vivo animal models
    Vanessa Crespy
    , Vers chez les Blanc, CH-1000 Lausanne 26, Switzerland
    J Nutr 134:3431S-3440S. 2004
    ..Further investigations on mechanisms, the nature of the active compounds, and appropriate dose levels are needed...
  30. ncbi Effect of dihydrocaffeic acid on UV irradiation of human keratinocyte HaCaT cells
    Laure Poquet
    Nestle Research Centre, Vers chez les Blanc, 1000 Lausanne 26, Switzerland School of Biomedical and Molecular Sciences, The University of Surrey, Guildford, Surrey GU2 7XH, UK
    Arch Biochem Biophys 476:196-204. 2008
    ..The data obtained suggest that dihydrocaffeic acid is a potential candidate for photo-protection by interfering with the events initiated after UV exposure in keratinocytes...
  31. ncbi An integrative metabolism approach identifies stearoyl-CoA desaturase as a target for an arachidonate-enriched diet
    David M Mutch
    , Vers-chez-les-Blanc, Lausanne, Switzerland
    FASEB J 19:599-601. 2005
    ....
  32. ncbi Rapid reversed phase ultra-performance liquid chromatography analysis of the major cocoa polyphenols and inter-relationships of their concentrations in chocolate
    Karen A Cooper
    Nestle Research Center, CH 1000 Lausanne 26, Switzerland
    J Agric Food Chem 55:2841-7. 2007
    ..Finally, the (-)-catechin content is not predictable from the epicatechin content, and it is concluded that this is the main form of polyphenol that varies according to manufacturing conditions and cocoa origin...
  33. ncbi Bioavailability and metabolism
    Wilhelm Stahl
    , , Germany
    Mol Aspects Med 23:39-100. 2002
  34. ncbi Polyphenols from alcoholic apple cider are absorbed, metabolized and excreted by humans
    M Susan DuPont
    Institute of Food Research, Norwich Research Park, Colney, Norwich, NR4 7UA United Kingdom
    J Nutr 132:172-5. 2002
    ..These data show that polyphenols are taken up from cider, that phloretin is excreted in the urine and suggest that low doses of quercetin are extensively methylated in humans...
  35. ncbi How should we assess the effects of exposure to dietary polyphenols in vitro?
    Paul A Kroon
    Nutrition Division, Institute of Food Research, Norwich, United Kingdom
    Am J Clin Nutr 80:15-21. 2004
    ..1-10 micromol/L. For correct interpretation of results, future efforts to define biological activities of polyphenols must make use of the available data concerning bioavailability and metabolism in humans...
  36. ncbi Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
    Claudine Manach
    Unité des Maladies Métaboliques et Micronutriments, INRA, Saint Genes Champanelle, France
    Am J Clin Nutr 81:230S-242S. 2005
    ..Data are still too limited for assessment of hydroxycinnamic acids and other polyphenols. These data may be useful for the design and interpretation of intervention studies investigating the health effects of polyphenols...
  37. ncbi (+)-Catechin is more bioavailable than (-)-catechin: relevance to the bioavailability of catechin from cocoa
    Jennifer L Donovan
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA
    Free Radic Res 40:1029-34. 2006
    ..Our findings provide an explanation for the poor bioavailability of catechin when consumed in chocolate or other cocoa containing products...
  38. ncbi Skin bioavailability of dietary vitamin E, carotenoids, polyphenols, vitamin C, zinc and selenium
    Myriam Richelle
    Nestle Research Center, Nestec Ltd, PO Box 44, CH 1000 Lausanne 26, Switzerland
    Br J Nutr 96:227-38. 2006
    ..Even for compounds that have been studied well in other organs, information on skin is relatively sparse. Gaps in knowledge are identified and suggestions made for future research...
  39. ncbi Divergent effects of quercetin conjugates on angiogenesis
    Sandra Donnini
    Section of Pharmacology, Department of Molecular Medicine, University of Siena, Via A. Moro 2, 53100 Siena, Italy
    Br J Nutr 95:1016-23. 2006
    ..Q3G and Q3'S are the two major conjugates in plasma, but their ratio is dependent on several factors, so that inhibition or activation of angiogenesis could be subtly shifted as a result of metabolism in vivo...
  40. ncbi Absorption/metabolism of sulforaphane and quercetin, and regulation of phase II enzymes, in human jejunum in vivo
    Niclas Petri
    Department of Pharmacy, Biopharmaceutics Research Group Uppsala University, Uppsala, Sweden
    Drug Metab Dispos 31:805-13. 2003
    ..These results show that food components have the potential to modify drug metabolism in the human enterocyte in vivo very rapidly...
  41. ncbi Chocolate intake increases urinary excretion of polyphenol-derived phenolic acids in healthy human subjects
    Laurent Y Rios
    , INRA, , France
    Am J Clin Nutr 77:912-8. 2003
    ..CONCLUSION: The antioxidant and biological effects of chocolate may be explained not solely by the established absorption of catechin monomers but also by the absorption of microbial phenolic acid metabolites...
  42. ncbi Bioavailability of phyto-oestrogens
    Ian Rowland
    Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, UK
    Br J Nutr 89:S45-58. 2003
    ..Factors influencing absorption and metabolism of phyto-oestrogens include diet and gut microflora...
  43. ncbi Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans
    Kitti Németh
    Institute of Food Research, Colney Lane, Norwich NR4 7 UA, UK
    Eur J Nutr 42:29-42. 2003
    ..Hence, first-pass metabolism (small intestine-liver) appears to involve a critical deglycosylation step for which the mechanisms are not known...
  44. ncbi Metabolism of quercetin-7- and quercetin-3-glucuronides by an in vitro hepatic model: the role of human beta-glucuronidase, sulfotransferase, catechol-O-methyltransferase and multi-resistant protein 2 (MRP2) in flavonoid metabolism
    Andrea J Day
    Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK
    Biochem Pharmacol 65:479-91. 2003
    ..These results show that HepG2 cells can absorb and turnover quercetin glucuronides and that human endogenous beta-glucuronidase activity could modulate the intracellular biological activities of dietary antioxidant flavonoids...
  45. ncbi Quercetin metabolism in the lens: role in inhibition of hydrogen peroxide induced cataract
    Kelly M Cornish
    School of Biological Sciences, University of East Anglia, Norwich, Norfolk, UK
    Free Radic Biol Med 33:63-70. 2002
    ..The results indicate dietary quercetin and metabolites are active in inhibiting oxidative damage in the lens and thus could play a role in prevention of cataract formation...
  46. ncbi Sulforaphane and quercetin modulate PhIP-DNA adduct formation in human HepG2 cells and hepatocytes
    James R Bacon
    Institute of Food Research, Norwich Research Park, Norwich NR4 7UA, UK
    Carcinogenesis 24:1903-11. 2003
    ....
  47. ncbi Regional variations in ABC transporter expression along the mouse intestinal tract
    David M Mutch
    , CH-1000 Lausanne 26, Switzerland
    Physiol Genomics 17:11-20. 2004
    ....
  48. ncbi Quercetin metabolites downregulate cyclooxygenase-2 transcription in human lymphocytes ex vivo but not in vivo
    Sonia de Pascual-Teresa
    Nutrition Division, Institute of Food Research, Norwich Research Park, Norwich NR4 7UA, UK
    J Nutr 134:552-7. 2004
    ..The results show that a single high dose of the flavonoid quercetin from onions does not change COX-2 mRNA expression in human lymphocytes in vivo even though this change occurred in vitro and ex vivo...
  49. ncbi Changes in the transcriptional profile of transporters in the intestine along the anterior-posterior and crypt-villus axes
    Pascale Anderle
    ISREC, Swiss Institute for Experimental Cancer Research, 1066 Epalinges s Lausanne, Switzerland
    BMC Genomics 6:69. 2005
    ....
  50. ncbi Flavonoid-mediated inhibition of intestinal ABC transporters may affect the oral bioavailability of drugs, food-borne toxic compounds and bioactive ingredients
    Walter Brand
    , Nestec Ltd, Vers-chez-les-Blanc, PO Box 44, 1000 Lausanne 26, Switzerland
    Biomed Pharmacother 60:508-19. 2006
    ....
  51. ncbi Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription
    Sonia de Pascual-Tereasa
    Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK
    Mutat Res 551:245-54. 2004
    ..Flavonoid modulation of COX-2 transcription may therefore be an important mechanism in anti-carcinogenesis...
  52. ncbi Properties of quercetin conjugates: modulation of LDL oxidation and binding to human serum albumin
    Kerstin M Janisch
    Technical University of Munich, WZW Department of Plant Sciences, Institute of Phytopathology, Am Hochanger 2, 85350 Freising-Weihenstephan, Germany
    Free Radic Res 38:877-84. 2004
    ..The data show that flavonoid intestinal and hepatic metabolism have profound effects on ability to inhibit LDL oxidation and a lesser but significant effect on binding to serum albumin...
  53. ncbi Glucuronidation of the green tea catechins, (-)-epigallocatechin-3-gallate and (-)-epicatechin-3-gallate, by rat hepatic and intestinal microsomes
    Vanessa Crespy
    , PO Box 44, CH-1000 Lausanne 26, Switzerland
    Free Radic Res 38:1025-31. 2004
    ..The low glucuronidation rates could partially explain why these flavanols are present in plasma as unconjugated forms...
  54. ncbi Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver
    David M Mutch
    Nutrient Bioavailability, Nestlé Research Center Vers Chez Les Blanc, Lausanne 26, Switzerland
    Am J Physiol Gastrointest Liver Physiol 291:G63-72. 2006
    ....
  55. ncbi Interactions between sulforaphane and apigenin in the induction of UGT1A1 and GSTA1 in CaCo-2 cells
    Vanda Svehlíková
    Nutrition Division, Institute of Food Research, Norwich Research Park, Norwich NR4 7UA, UK
    Carcinogenesis 25:1629-37. 2004
    ....