Robin S B Williams
Affiliation: University College London
- Pharmacogenetics in model systems: defining a common mechanism of action for mood stabilisersRobin S B Williams
Department of Biology and Wolfson Institute for Biomedical Research, University College London, Gower St, London WC1E 6BT, United Kingdom
Prog Neuropsychopharmacol Biol Psychiatry 29:1029-37. 2005..The use of pharmacogenetics in model systems will provide a powerful tool for the ongoing analysis of both the treatment and cause of psychiatric disorders...
- Lithium therapy and signal transductionR S Williams
MRC Laboratory for Molecular Cell Biology and Department of Biology, University College London, Gower St, London, UK WC1E 6BT
Trends Pharmacol Sci 21:61-4. 2000..This article describes recent experiments in cell and developmental biology that advance our understanding of how lithium works and it presents new directions for the study of both depression and Alzheimer's disease (AD)...
- Towards a molecular understanding of human diseases using Dictyostelium discoideumRobin S B Williams
Department of Biology and the Wolfson Institute for Biomedical Research, University College London, London, WC1E 6BT, UK
Trends Mol Med 12:415-24. 2006..Findings that have been made in these areas using Dictyostelium have driven research in mammalian systems and have established Dictyostelium as a powerful model for human-disease analysis...
- Pharmacogenetics: defining the genetic basis of drug action and inositol trisphosphate analysisKathryn E Adley
Department of Biology, University College London, UK
Methods Mol Biol 346:517-34. 2006..In this system, we have identified genes that confer resistance to bipolar disorder drugs. This work has implicated inositol (1,4,5) trisphosphate (InsP3) signaling as a common mechanism of action for these drugs in patients...
- Loss of the beta-catenin homologue aardvark causes ectopic stalk formation in DictyosteliumJuliet C Coates
MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, UK
Mech Dev 116:117-27. 2002..We postulate that poor synthesis of the stalk tube matrix allows diffusion of a stalk cell-inducing factor into the surrounding tissue...
- The neuroprotective agent, valproic acid, regulates the mitogen-activated protein kinase pathway through modulation of protein kinase A signalling in Dictyostelium discoideumKatrina Boeckeler
Department of Biology and the Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK
Eur J Cell Biol 85:1047-57. 2006..This work therefore suggests a conserved pathway in eukaryotes that is targeted by neuroprotective and bipolar disorder drugs and allows us to propose a model for this neuroprotective effect...
- Inhibition of long-term potentiation by valproic acid through modulation of cyclic AMPPishan Chang
UCL Institute of Neurology, University College London, London, UK
Epilepsia 51:1533-42. 2010..We, therefore, asked whether VPA modulates cyclic adenosine monophosphate (cAMP)/PKA-dependent synaptic plasticity and whether this mode of action could explain its anticonvulsant effect...
- A common mechanism of action for three mood-stabilizing drugsRobin S B Williams
Intracellular Signalling Group, MRC Laboratory for Molecular Cell Biology, University College London, Gower St, London WC1E 6BT, UK
Nature 417:292-5. 2002..Inhibitors of prolyl oligopeptidase reverse the effects of all three drugs on sensory neuron growth cone area and collapse. These results suggest a molecular basis for both bipolar affective disorder and its treatment...
- Two peptidase activities decrease in treated bipolar disorder not schizophrenic patientsGerome Breen
Section of Molecular Genetics, Division of Psychological Medicine, Institute of Psychiatry, Kings College London, London, UK
Bipolar Disord 6:156-61. 2004..However, this association is complicated by the discovery in bovine plasma of a Z-Pro-prolinal-insensitive peptidase (ZIP), a novel enzyme that cleaves the same substrate as PO...
- Loss of a prolyl oligopeptidase confers resistance to lithium by elevation of inositol (1,4,5) trisphosphateR S Williams
MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK
EMBO J 18:2734-45. 1999..Our results offer a novel mechanism that links POase activity to IP3 signalling and provides further clues for the action of Li+ in the treatment of depression...
- An inverse PCR technique to rapidly isolate the flanking DNA of dictyostelium insertion mutantsMelanie Keim
MCR Laboratory Molecular Cell Biology and Dept of Biology, University College London, Gower St, London WC1E 6BT, UK
Mol Biotechnol 26:221-4. 2004..We have established a simple and rapid polymerase chain reaction-based technique that works for all mutants and circumvents the need for Southern blot analysis and plasmid rescue...
- Attenuation of phospholipid signaling provides a novel mechanism for the action of valproic acidXuehua Xu
School of Biological Sciences, Royal Holloway University of London, Egham, United Kingdom
Eukaryot Cell 6:899-906. 2007....