Robin S B Williams

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc Pharmacogenetics in model systems: defining a common mechanism of action for mood stabilisers
    Robin S B Williams
    Department of Biology and Wolfson Institute for Biomedical Research, University College London, Gower St, London WC1E 6BT, United Kingdom
    Prog Neuropsychopharmacol Biol Psychiatry 29:1029-37. 2005
  2. ncbi request reprint Lithium therapy and signal transduction
    R S Williams
    MRC Laboratory for Molecular Cell Biology and Department of Biology, University College London, Gower St, London, UK WC1E 6BT
    Trends Pharmacol Sci 21:61-4. 2000
  3. ncbi request reprint Towards a molecular understanding of human diseases using Dictyostelium discoideum
    Robin S B Williams
    Department of Biology and the Wolfson Institute for Biomedical Research, University College London, London, WC1E 6BT, UK
    Trends Mol Med 12:415-24. 2006
  4. ncbi request reprint Pharmacogenetics: defining the genetic basis of drug action and inositol trisphosphate analysis
    Kathryn E Adley
    Department of Biology, University College London, UK
    Methods Mol Biol 346:517-34. 2006
  5. ncbi request reprint Loss of the beta-catenin homologue aardvark causes ectopic stalk formation in Dictyostelium
    Juliet C Coates
    MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, UK
    Mech Dev 116:117-27. 2002
  6. ncbi request reprint The neuroprotective agent, valproic acid, regulates the mitogen-activated protein kinase pathway through modulation of protein kinase A signalling in Dictyostelium discoideum
    Katrina Boeckeler
    Department of Biology and the Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK
    Eur J Cell Biol 85:1047-57. 2006
  7. doi request reprint Inhibition of long-term potentiation by valproic acid through modulation of cyclic AMP
    Pishan Chang
    UCL Institute of Neurology, University College London, London, UK
    Epilepsia 51:1533-42. 2010
  8. ncbi request reprint A common mechanism of action for three mood-stabilizing drugs
    Robin S B Williams
    Intracellular Signalling Group, MRC Laboratory for Molecular Cell Biology, University College London, Gower St, London WC1E 6BT, UK
    Nature 417:292-5. 2002
  9. ncbi request reprint Two peptidase activities decrease in treated bipolar disorder not schizophrenic patients
    Gerome Breen
    Section of Molecular Genetics, Division of Psychological Medicine, Institute of Psychiatry, Kings College London, London, UK
    Bipolar Disord 6:156-61. 2004
  10. pmc Loss of a prolyl oligopeptidase confers resistance to lithium by elevation of inositol (1,4,5) trisphosphate
    R S Williams
    MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK
    EMBO J 18:2734-45. 1999

Collaborators

Detail Information

Publications12

  1. pmc Pharmacogenetics in model systems: defining a common mechanism of action for mood stabilisers
    Robin S B Williams
    Department of Biology and Wolfson Institute for Biomedical Research, University College London, Gower St, London WC1E 6BT, United Kingdom
    Prog Neuropsychopharmacol Biol Psychiatry 29:1029-37. 2005
    ..The use of pharmacogenetics in model systems will provide a powerful tool for the ongoing analysis of both the treatment and cause of psychiatric disorders...
  2. ncbi request reprint Lithium therapy and signal transduction
    R S Williams
    MRC Laboratory for Molecular Cell Biology and Department of Biology, University College London, Gower St, London, UK WC1E 6BT
    Trends Pharmacol Sci 21:61-4. 2000
    ..This article describes recent experiments in cell and developmental biology that advance our understanding of how lithium works and it presents new directions for the study of both depression and Alzheimer's disease (AD)...
  3. ncbi request reprint Towards a molecular understanding of human diseases using Dictyostelium discoideum
    Robin S B Williams
    Department of Biology and the Wolfson Institute for Biomedical Research, University College London, London, WC1E 6BT, UK
    Trends Mol Med 12:415-24. 2006
    ..Findings that have been made in these areas using Dictyostelium have driven research in mammalian systems and have established Dictyostelium as a powerful model for human-disease analysis...
  4. ncbi request reprint Pharmacogenetics: defining the genetic basis of drug action and inositol trisphosphate analysis
    Kathryn E Adley
    Department of Biology, University College London, UK
    Methods Mol Biol 346:517-34. 2006
    ..In this system, we have identified genes that confer resistance to bipolar disorder drugs. This work has implicated inositol (1,4,5) trisphosphate (InsP3) signaling as a common mechanism of action for these drugs in patients...
  5. ncbi request reprint Loss of the beta-catenin homologue aardvark causes ectopic stalk formation in Dictyostelium
    Juliet C Coates
    MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, UK
    Mech Dev 116:117-27. 2002
    ..We postulate that poor synthesis of the stalk tube matrix allows diffusion of a stalk cell-inducing factor into the surrounding tissue...
  6. ncbi request reprint The neuroprotective agent, valproic acid, regulates the mitogen-activated protein kinase pathway through modulation of protein kinase A signalling in Dictyostelium discoideum
    Katrina Boeckeler
    Department of Biology and the Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK
    Eur J Cell Biol 85:1047-57. 2006
    ..This work therefore suggests a conserved pathway in eukaryotes that is targeted by neuroprotective and bipolar disorder drugs and allows us to propose a model for this neuroprotective effect...
  7. doi request reprint Inhibition of long-term potentiation by valproic acid through modulation of cyclic AMP
    Pishan Chang
    UCL Institute of Neurology, University College London, London, UK
    Epilepsia 51:1533-42. 2010
    ..We, therefore, asked whether VPA modulates cyclic adenosine monophosphate (cAMP)/PKA-dependent synaptic plasticity and whether this mode of action could explain its anticonvulsant effect...
  8. ncbi request reprint A common mechanism of action for three mood-stabilizing drugs
    Robin S B Williams
    Intracellular Signalling Group, MRC Laboratory for Molecular Cell Biology, University College London, Gower St, London WC1E 6BT, UK
    Nature 417:292-5. 2002
    ..Inhibitors of prolyl oligopeptidase reverse the effects of all three drugs on sensory neuron growth cone area and collapse. These results suggest a molecular basis for both bipolar affective disorder and its treatment...
  9. ncbi request reprint Two peptidase activities decrease in treated bipolar disorder not schizophrenic patients
    Gerome Breen
    Section of Molecular Genetics, Division of Psychological Medicine, Institute of Psychiatry, Kings College London, London, UK
    Bipolar Disord 6:156-61. 2004
    ..However, this association is complicated by the discovery in bovine plasma of a Z-Pro-prolinal-insensitive peptidase (ZIP), a novel enzyme that cleaves the same substrate as PO...
  10. pmc Loss of a prolyl oligopeptidase confers resistance to lithium by elevation of inositol (1,4,5) trisphosphate
    R S Williams
    MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK
    EMBO J 18:2734-45. 1999
    ..Our results offer a novel mechanism that links POase activity to IP3 signalling and provides further clues for the action of Li+ in the treatment of depression...
  11. ncbi request reprint An inverse PCR technique to rapidly isolate the flanking DNA of dictyostelium insertion mutants
    Melanie Keim
    MCR Laboratory Molecular Cell Biology and Dept of Biology, University College London, Gower St, London WC1E 6BT, UK
    Mol Biotechnol 26:221-4. 2004
    ..We have established a simple and rapid polymerase chain reaction-based technique that works for all mutants and circumvents the need for Southern blot analysis and plasmid rescue...
  12. pmc Attenuation of phospholipid signaling provides a novel mechanism for the action of valproic acid
    Xuehua Xu
    School of Biological Sciences, Royal Holloway University of London, Egham, United Kingdom
    Eukaryot Cell 6:899-906. 2007
    ....