Affiliation: University of Cambridge
- Visualizing uncertainty about the futureDavid Spiegelhalter
Centre for Mathematical Sciences, University of Cambridge, Cambridge CB3 0WB, UK
Science 333:1393-400. 2011..Nonetheless, communicating deeper uncertainties resulting from incomplete or disputed knowledge--or from essential indeterminacy about the future--remains a challenge...
- Protocol for the ADDITION-Plus study: a randomised controlled trial of an individually-tailored behaviour change intervention among people with recently diagnosed type 2 diabetes under intensive UK general practice careSimon J Griffin
MRC Epidemiology Unit, Box 285, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 0QQ, UK
BMC Public Health 11:211. 2011..The ADDITION-Plus trial was designed to address these issues among recently diagnosed patients in primary care over one year...
- The ADDITION-Cambridge trial protocol: a cluster -- randomised controlled trial of screening for type 2 diabetes and intensive treatment for screen-detected patientsJustin B Echouffo-Tcheugui
MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge, UK
BMC Public Health 9:136. 2009..Population-based screening and early treatment for type 2 diabetes could reduce this growing burden. However, the benefits of such a strategy remain uncertain...
- The ProActive trial protocol - a randomised controlled trial of the efficacy of a family-based, domiciliary intervention programme to increase physical activity among individuals at high risk of diabetes [ISRCTN61323766]Kate Williams
General Practice and Primary Care Research Unit, Department of Public Health and Primary Care, Institute of Public Health, Forvie Site, Robinson Way, Cambridge CB2 2SR, UK
BMC Public Health 4:48. 2004..While previous evaluations of interventions to increase physical activity have involved communities or individuals with established disease, less attention has been given to interventions for individuals at risk of disease...
- Do increases in physical activity encourage positive beliefs about further change in the ProActive cohort?Wendy Hardeman
Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge CB2 0SR, UK
Psychol Health 26:899-914. 2011..Future studies could test the effect of such techniques on physical activity and a wider range of cognitive, affective and physiological consequences, using more frequent measurement intervals...
- The BUGS project: Evolution, critique and future directionsDavid Lunn
Medical Research Council Biostatistics Unit, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge CB2 0SR, U K
Stat Med 28:3049-67. 2009..We also present a historical overview of the BUGS project and some future perspectives...
- Allowing for correlations between correlations in random-effects meta-analysis of correlation matricesA Toby Prevost
General Practice and Primary Care Research Unit, University of Cambridge, Institute of Public Health, Cambridge United Kingdom
Psychol Methods 12:434-50. 2007..Because of potential instability in the generalized least squares methods, they recommend a model-based approach, either the maximum marginal likelihood approach or a full Bayesian analysis...
- Efficacy of a theory-based behavioural intervention to increase physical activity in an at-risk group in primary care (ProActive UK): a randomised trialAnn Louise Kinmonth
General Practice and Primary Care Research Unit, Department of Public Health and Primary Care, University of Cambridge, UK
Lancet 371:41-8. 2008..Efforts to reverse this trend have not been successful. We aimed to assess the efficacy of a facilitated behavioural intervention to increase the physical activity of sedentary individuals at familial risk of diabetes...
- Who will increase their physical activity? Predictors of change in objectively measured physical activity over 12 months in the ProActive cohortRebecca K Simmons
MRC Epidemiology Unit, Institute of Metabolic Science, Box 285, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 0QQ, UK
BMC Public Health 10:226. 2010..The aim was to identify predictors of change in objectively measured physical activity over 12 months in the ProActive cohort to improve understanding of factors influencing change in physical activity...
- Components of variance in a multicentre functional MRI study and implications for calculation of statistical powerJohn Suckling
Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
Hum Brain Mapp 29:1111-22. 2008..Thus, theoretical models of power and empirical data indicate that between-centre variability can be small enough to encourage multicentre designs without major compensatory increases in sample size...
- More than measurement: practice team experiences of screening for type 2 diabetesJonathan Graffy
Institute of Public Health, General Practice and Primary Care Research Unit, University of Cambridge, Robinson Way, Cambridge CB2 0SR, UK
Fam Pract 27:386-94. 2010..The feasibility, cost-effectiveness and best means to implement population screening for type 2 diabetes remain to be established...
- Combining MCMC with 'sequential' PKPD modellingDavid Lunn
Medical Research Council Biostatistics Unit, Institute of Public Health, University Forvie Site, Cambridge, UK
J Pharmacokinet Pharmacodyn 36:19-38. 2009..This is in contrast to standard two-stage approaches whereby 'plug-in' point estimates for either the population or the individual-specific PK parameters are required...
- Risk-adjusted sequential probability ratio tests: applications to Bristol, Shipman and adult cardiac surgeryDavid Spiegelhalter
MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK
Int J Qual Health Care 15:7-13. 2003..To investigate the use of the risk-adjusted sequential probability ratio test in monitoring the cumulative occurrence of adverse clinical outcomes...
- The legacy of Bristol: public disclosure of individual surgeons' resultsBruce Keogh
Society of Cardiothoracic Surgeons of Great Britain and Ireland, Royal College of Surgeons of England, London WC2A 3PE
BMJ 329:450-4. 2004
- Bayesian analysis of population PK/PD models: general concepts and softwareDavid J Lunn
Department of Epidemiology and Public Health, Imperial College School of Medicine, Norfolk Place, London W2 1PG, UK
J Pharmacokinet Pharmacodyn 29:271-307. 2002....