Jeffrey G Williams

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. pmc An anatomy ontology to represent biological knowledge in Dictyostelium discoideum
    Pascale Gaudet
    dictyBase, Northwestern University, Center for Genetic Medicine, 676 N, St, Clair, Chicago, IL 60611, USA
    BMC Genomics 9:130. 2008
  2. ncbi request reprint STAT signalling in cell proliferation and in development
    J G Williams
    Department of Anatomy and Physiology, University of Dundee, Wellcome Trust Building Complex, Dow Street, DD1 5EH, Dundee, UK
    Curr Opin Genet Dev 10:503-7. 2000
  3. pmc Dictyostelium finds new roles to model
    Jeffrey G Williams
    College of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    Genetics 185:717-26. 2010
  4. pmc Transcriptional regulation of Dictyostelium pattern formation
    Jeffrey G Williams
    School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    EMBO Rep 7:694-8. 2006
  5. ncbi request reprint HAPPY days for the Dictyostelium genome project
    J G Williams
    School of Biological Sciences, University of Dundee, MSI WTB complex, Dundee DD1 5EH, Scotland
    Genome Res 10:1658-9. 2000
  6. pmc A new family of transcription factors
    Yoko Yamada
    School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Development 135:3093-101. 2008
  7. ncbi request reprint Regulation of Dictyostelium prestalk-specific gene expression by a SHAQKY family MYB transcription factor
    Masashi Fukuzawa
    University of Dundee, MSI WTB complex, Dow Street, Dundee DD1 5EH, UK
    Development 133:1715-24. 2006
  8. pmc A Dictyostelium SH2 adaptor protein required for correct DIF-1 signaling and pattern formation
    Christopher Sugden
    School of Life Sciences, University of Dundee, Dow St, Dundee, DD1 5EH, UK
    Dev Biol 353:290-301. 2011
  9. doi request reprint A Dictyostelium homologue of the metazoan Cbl proteins regulates STAT signalling
    Judith Langenick
    University of Dundee, School of Life Sciences, Dow Street, Dundee DD1 5EH, UK
    J Cell Sci 121:3524-30. 2008
  10. ncbi request reprint The Dictyostelium bZIP transcription factor DimB regulates prestalk-specific gene expression
    Natasha V Zhukovskaya
    School of Life Sciences, University of Dundee, MSI WTB complex, UK
    Development 133:439-48. 2006

Collaborators

Detail Information

Publications38

  1. pmc An anatomy ontology to represent biological knowledge in Dictyostelium discoideum
    Pascale Gaudet
    dictyBase, Northwestern University, Center for Genetic Medicine, 676 N, St, Clair, Chicago, IL 60611, USA
    BMC Genomics 9:130. 2008
    ..The recent sequencing of the genome has revealed the presence of over 12,500 protein-coding genes. The model organism database dictyBase hosts the genome sequence as well as a large amount of manually curated information...
  2. ncbi request reprint STAT signalling in cell proliferation and in development
    J G Williams
    Department of Anatomy and Physiology, University of Dundee, Wellcome Trust Building Complex, Dow Street, DD1 5EH, Dundee, UK
    Curr Opin Genet Dev 10:503-7. 2000
    ..Two different ways in which STAT signalling pathways can interface with Smad signalling pathways significantly increasing combinatorial signalling possibilities, have also been described...
  3. pmc Dictyostelium finds new roles to model
    Jeffrey G Williams
    College of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    Genetics 185:717-26. 2010
    ..These cover a remarkably wide gamut, ranging from sociobiological to medical research with much else in between...
  4. pmc Transcriptional regulation of Dictyostelium pattern formation
    Jeffrey G Williams
    School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    EMBO Rep 7:694-8. 2006
    ....
  5. ncbi request reprint HAPPY days for the Dictyostelium genome project
    J G Williams
    School of Biological Sciences, University of Dundee, MSI WTB complex, Dundee DD1 5EH, Scotland
    Genome Res 10:1658-9. 2000
    ..With the HAPPY Map the YAC clones can be remapped and the original YAC skim strategy followed. In conclusion, this method has already made one community very happy and seems sure to make its mark in many other genome projects...
  6. pmc A new family of transcription factors
    Yoko Yamada
    School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Development 135:3093-101. 2008
    ..These results define a hitherto unrecognised class of transcription factors and suggest a model for the evolution of STATs and their DNA-binding sites...
  7. ncbi request reprint Regulation of Dictyostelium prestalk-specific gene expression by a SHAQKY family MYB transcription factor
    Masashi Fukuzawa
    University of Dundee, MSI WTB complex, Dow Street, Dundee DD1 5EH, UK
    Development 133:1715-24. 2006
    ..The ecmA gene is not induced by DIF-1 in a mybE-strain. Thus, MybE is necessary for DIF-1 responsiveness and for the correct differentiation of pstO cells and ALCs...
  8. pmc A Dictyostelium SH2 adaptor protein required for correct DIF-1 signaling and pattern formation
    Christopher Sugden
    School of Life Sciences, University of Dundee, Dow St, Dundee, DD1 5EH, UK
    Dev Biol 353:290-301. 2011
    ..These observations, coupled with its domain structure, suggest that LrrB is an SH2 adaptor protein active in diverse developmental signaling pathways...
  9. doi request reprint A Dictyostelium homologue of the metazoan Cbl proteins regulates STAT signalling
    Judith Langenick
    University of Dundee, School of Life Sciences, Dow Street, Dundee DD1 5EH, UK
    J Cell Sci 121:3524-30. 2008
    ..Thus Cbl proteins have an ancient origin but, whereas metazoan Cbl proteins regulate tyrosine kinases, the Dictyostelium Cbl regulates via a tyrosine phosphatase...
  10. ncbi request reprint The Dictyostelium bZIP transcription factor DimB regulates prestalk-specific gene expression
    Natasha V Zhukovskaya
    School of Life Sciences, University of Dundee, MSI WTB complex, UK
    Development 133:439-48. 2006
    ..Thus, DIF-1 regulates DimB activity to generate a gradient of ecmA expression in the prestalk zone of the slug...
  11. pmc Dictyostelium Myb transcription factors function at culmination as activators of ancillary stalk differentiation
    Masatsune Tsujioka
    University of Dundee, MSI WTB complex, Dow Street, Dundee DD1 5EH, United Kingdom
    Eukaryot Cell 6:568-70. 2007
    ..A Myb site within the mrrA promoter is necessary for expression in both cups. Thus, multiple Myb proteins are required for ancillary stalk differentiation...
  12. ncbi request reprint Dd-STATb, a Dictyostelium STAT protein with a highly aberrant SH2 domain, functions as a regulator of gene expression during growth and early development
    Natasha V Zhukovskaya
    School of Life Sciences, University of Dundee, MSI WTB complex, Dow Street, Dundee DD1 5EH, UK
    Development 131:447-58. 2004
    ..These observations suggest a non-canonical mode of activation of Dd-STATb that does not rely on orthodox SH2 domain:phosphotyrosine interactions...
  13. ncbi request reprint A STAT-regulated, stress-induced signalling pathway in Dictyostelium
    Tsuyoshi Araki
    School of Life Sciences, University of Dundee, Wellcome Trust Biocentre, Dow Street, Dundee, DD1 5EH, UK
    J Cell Sci 116:2907-15. 2003
    ..These data show that Dd-STATc functions as a transcriptional activator in a stress-response pathway and the pharmacological evidence, at least, is consistent with cGMP acting as a second messenger...
  14. pmc DIF-1 regulates Dictyostelium basal disc differentiation by inducing the nuclear accumulation of a bZIP transcription factor
    Yoko Yamada
    College of Life Sciences, Welcome Trust Building, University of Dundee, Dow St, Dundee, UK
    Dev Biol 354:77-86. 2011
    ..These results suggest that the differentiation of pstB cells is caused by a high perceived level of DIF-1 signalling, leading to nuclear localization of DimB and direct activation of cell type-specific gene expression...
  15. pmc Two novel Src homology 2 domain proteins interact to regulate dictyostelium gene expression during growth and early development
    Christopher Sugden
    School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, United Kingdom
    J Biol Chem 285:22927-35. 2010
    ..Thus, just as in metazoa, but on a vastly reduced numerical scale, an interacting network of SH2 domain proteins regulates specific Dictyostelium gene expression...
  16. pmc Evidence that DIF-1 and hyper-osmotic stress activate a Dictyostelium STAT by inhibiting a specific protein tyrosine phosphatase
    Tsuyoshi Araki
    University of Dundee, College of Life Sciences, Dow Street, Dundee DD1 5EH, UK
    Development 135:1347-53. 2008
    ....
  17. pmc Identification of the kinase that activates a nonmetazoan STAT gives insights into the evolution of phosphotyrosine-SH2 domain signaling
    Tsuyoshi Araki
    Division of Cell and Developmental Biology, Wellcome Trust Biocentre, College of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    Proc Natl Acad Sci U S A 109:E1931-7. 2012
    ..Also, as predicted, Pyk2 is constitutively active as a STATc kinase. This observation provides further evidence for this highly atypical, possibly ancestral, STAT regulation mechanism...
  18. pmc Transcriptional repression by a bZIP protein regulates Dictyostelium prespore differentiation
    Beatriz Nuñez-Corcuera
    College of Life Sciences, University of Dundee, Dundee, United Kingdom
    PLoS ONE 7:e29895. 2012
    ..These results suggest a coupled control mechanism, whereby the same DIF-DimB signaling pathway that directly activates ecmB gene expression directly represses pspA gene expression...
  19. ncbi request reprint GSK3 is a multifunctional regulator of Dictyostelium development
    Christina Schilde
    School of Life Sciences, Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, UK
    Development 131:4555-65. 2004
    ..These observations show that GskA functions throughout Dictyostelium development, to regulate several key aspects of cellular patterning...
  20. pmc Synergy between two transcription factors directs gene expression in Dictyostelium tip-organiser cells
    Hong Yu Wang
    College of Life Sciences, University of Dundee, Dow Street, Dundee, U K
    Int J Dev Biol 54:1301-7. 2010
    ....
  21. ncbi request reprint The Dictyostelium prestalk cell inducer DIF regulates nuclear accumulation of a STAT protein by controlling its rate of export from the nucleus
    Masashi Fukuzawa
    School of Life Sciences, University of Dundee, MSI WTB complex, Dow Street, Dundee DD1 5EH, UK
    Development 130:797-804. 2003
    ..These results show that the regulated nuclear accumulation of a STAT protein can be controlled at the level of nuclear export and they also provide a better understanding of the mechanism whereby DIF directs cell type divergence...
  22. pmc A new Dictyostelium prestalk cell sub-type
    Yoko Yamada
    School of Life Sciences, University of Dundee, Dow St, Dundee DD3 5EH, UK
    Dev Biol 339:390-7. 2010
    ..Thus genetic removal of MybE or DimB reveals an alternate DIF-1 activation pathway, for pstU differentiation, that functions under monolayer assay conditions but that is not essential during multicellular development...
  23. pmc Dual regulation of a Dictyostelium STAT by cGMP and Ca2+ signalling
    Tsuyoshi Araki
    University of Dundee, College of Life Sciences, Dow Street, Dundee DD1 5EH, UK
    J Cell Sci 123:837-41. 2010
    ....
  24. pmc Rapid generation of gene disruption constructs by in vitro transposition and identification of a Dictyostelium protein kinase that regulates its rate of growth and development
    Tomoaki Abe
    School of Life Sciences, University of Dundee, Wellcome Trust Biocentre, Dow Street, Dundee DD1 5EH, UK
    Nucleic Acids Res 31:e107. 2003
    ..Disruption of the qkgA gene causes a marked increase in growth rate and, during development, aggregation occurs relatively slowly to form abnormally large multicellular structures...
  25. pmc Identification of a target for CudA, the transcription factor which directs formation of the Dictyostelium tip organiser
    Hong Yu Wang
    College of Life Sciences, University of Dundee, Dundee, UK
    Int J Dev Biol 54:161-5. 2010
    ..STATa then induces expression of cudA and cudA directs the transcription of target genes such as expl7...
  26. pmc Perturbations of the actin cytoskeleton activate a Dictyostelium STAT signalling pathway
    Tsuyoshi Araki
    College of Life Sciences, Welcome Trust Biocentre, University of Dundee, Dow St, Dundee DD1 5EH, United Kingdom
    Eur J Cell Biol 91:420-5. 2012
    ..We suggest that PTP3 phosphorylation, and consequent STATc activation, are regulated by changes in F-actin polymerization status during stress and DIF-induced cytoskeletal remodelling...
  27. pmc A SET/MYND chromatin re-modelling protein regulates Dictyostelium prespore patterning
    Beatriz Nuñez-Corcuera
    College of Life Sciences, Welcome Trust Building, University of Dundee, Dundee, UK
    Int J Dev Biol 55:205-8. 2011
    ..We suggest that one or more genes regulated by SmdA acts to repress prespore re-specification...
  28. doi request reprint The Dictyostelium prestalk inducer DIF-1 directs phosphorylation of a bZIP transcription factor
    Yoko Yamada
    College of Life Sciences, Welcome Trust Biocentre, University of Dundee, UK
    Int J Dev Biol 57:375-81. 2013
    ..iii) We also present evidence that the kinase activity, which phosphorylates S590, is non-nuclear and that this signalling pathway is, in part at least, independent of the DIF-regulated STATc activation pathway. ..
  29. ncbi request reprint Manifestations of multicellularity: Dictyostelium reports in
    Jeffrey G Williams
    School of Life Sciences, University of Dundee, MSI WTB complex, Dow Street, Dundee DD1 5EH Scotland, UK
    Trends Genet 21:392-8. 2005
    ..The presence of these proteins strengthens the case for a relatively close relationship with animals and extends the range of problems that can be addressed using Dictyostelium as a model organism...
  30. ncbi request reprint Engineered gene over-expression as a method of drug target identification
    Christopher J Sugden
    School of Life Sciences, University of Dundee, Wellcome Trust Biocentre, Dow Street, Dundee DD1 5EH, UK
    Biochem Biophys Res Commun 334:555-60. 2005
    ..This confirms FDP synthase as the primary target of aBPs and suggests a general method of drug target identification based upon engineered gene over-expression...
  31. ncbi request reprint Tyrosine phosphorylation-independent nuclear translocation of a dictyostelium STAT in response to DIF signaling
    M Fukuzawa
    School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    Mol Cell 7:779-88. 2001
    ..We show instead that DIF mediates nuclear translocation via sequences located in the divergent, N-terminal half of the Dd-STATc molecule...
  32. ncbi request reprint OSBPa, a predicted oxysterol binding protein of Dictyostelium, is required for regulated entry into culmination
    Masashi Fukuzawa
    School of Life Sciences, University of Dundee, Wellcome Trust Biocentre, Dow Street, DD1 5EH, Dundee, UK
    FEBS Lett 527:37-42. 2002
    ..Thus a plasma membrane-enriched OSBP family member is essential for correct regulation of the slug-fruiting body switch...
  33. pmc Glycogen synthase kinase-3 enhances nuclear export of a Dictyostelium STAT protein
    R S Ginger
    Department of Anatomy and Physiology, MSI WTB complex, University of Dundee, Dow Street, Dundee, UK
    EMBO J 19:5483-91. 2000
    ..It also raises the possibility of an analogous regulation of STAT nuclear export in higher eukaryotes...
  34. pmc Analyses of cDNAs from growth and slug stages of Dictyostelium discoideum
    Hideko Urushihara
    Institute of Biological Sciences, University of Tsukuba, Tsukuba shi 305 8572, Japan
    Nucleic Acids Res 32:1647-53. 2004
    ..Genes encoding the enzymes of basic metabolism are mainly found in the common gene population. These results therefore suggest major differences between growing and developing Dictyostelium cells in the nature of the genes transcribed...
  35. ncbi request reprint Structure of an activated Dictyostelium STAT in its DNA-unbound form
    Montserrat Soler-Lopez
    European Molecular Biology Laboratory, Grenoble Outstation, B P 181, 38042 Grenoble Cedex 9, France
    Mol Cell 13:791-804. 2004
    ..Functional and evolutionary implications for metazoan STAT proteins are discussed...
  36. ncbi request reprint SH2 domains in plants imply new signalling scenarios
    Jeffrey G Williams
    Trends Plant Sci 9:161-3. 2004
  37. ncbi request reprint DNA-PKcs-dependent signaling of DNA damage in Dictyostelium discoideum
    Jessica J R Hudson
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
    Curr Biol 15:1880-5. 2005
    ..These data illustrate a cell cycle-dependent requirement for Dictyostelium DNA-PK in signaling and combating DNA DSBs and represent the first experimental verification of DNA-PKcs in a nonvertebrate organism...
  38. pmc Proteomic and microarray analyses of the Dictyostelium Zak1-GSK-3 signaling pathway reveal a role in early development
    Lana Strmecki
    Biochemistry Department, Oxford University, South Parks Rd, Oxford OX1 3QU, United Kingdom
    Eukaryot Cell 6:245-52. 2007
    ..Two of the targets, H5 and discoidin 1, are well-characterized markers for early development, indicating that the Zak1-GskA pathway plays a role in development earlier than previously observed...