Hywel Williams

Summary

Affiliation: University of Nottingham
Country: UK

Publications

  1. ncbi request reprint Prevention of atopic eczema: a dream not so far away?
    Hywel C Williams
    Department of Dermatoepidemiology, Centre of Evidence Based Dermatology, Queen s Medical Centre, Nottingham NG7 2UH, England
    Arch Dermatol 138:391-2. 2002
  2. pmc Mapping randomized controlled trials of treatments for eczema--the GREAT database (the Global Resource of EczemA Trials: a collection of key data on randomized controlled trials of treatments for eczema from 2000 to 2010)
    Helen Nankervis
    Centre of Evidence Based Dermatology, Room A103, King s Meadow Campus, University of Nottingham, Lenton Lane, Nottingham, NG7 2NR, UK
    BMC Dermatol 11:10. 2011
  3. pmc Prevention of atopic dermatitis
    Hywel C Williams
    Centre of Evidence Based Dermatology, University of Nottingham King s Meadow Campus, Lenton Lane, Nottingham, NG7 2NR, UK Nottingham University Hospitals NHS Trust, Dermatology Department Queen s Medical Centre Campus, Derby Road, Nottingham, NG7 2RB, UK
    F1000 Med Rep 4:24. 2012
  4. pmc Key considerations for the experimental training and evaluation of cancer odour detection dogs: lessons learnt from a double-blind, controlled trial of prostate cancer detection
    Kevin R Elliker
    Centre of Evidence Based Dermatology, Nottingham University Hospitals NHS Trust, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    BMC Urol 14:22. 2014
  5. pmc UK Dermatology Clinical Trials Network's STOP GAP trial (a multicentre trial of prednisolone versus ciclosporin for pyoderma gangrenosum): protocol for a randomised controlled trial
    Fiona F Craig
    University of Nottingham, Centre of Evidence Based Dermatology, Nottingham, NG7 2NR, UK
    Trials 13:51. 2012
  6. pmc What determines patient preferences for treating low risk basal cell carcinoma when comparing surgery vs imiquimod? A discrete choice experiment survey from the SINS trial
    Michela Tinelli
    Centre of Evidence Based Dermatology, University of Nottingham, A103, King s Meadow Campus, Lenton Lane, Nottingham, NG7 2NR, UK
    BMC Dermatol 12:19. 2012
  7. doi request reprint Epidemiology of human atopic dermatitis--seven areas of notable progress and seven areas of notable ignorance
    Hywel C Williams
    Centre of Evidence Based Dermatology, University of Nottingham King s Meadow Campus, Nottingham NG7 2NR, UK
    Vet Dermatol 24:3-9.e1-2. 2013
  8. pmc Why is the center of evidence-based dermatology relevant to Indian dermatology?
    Hywel Williams
    Centre of Evidence Based Dermatology, King s Meadow Campus, University of Nottingham, Lenton Lane, Nottingham NG7 2NR, UK
    Indian J Dermatol 54:118-23. 2009
  9. pmc The value of the pragmatic-explanatory continuum indicator summary wheel in an ongoing study: the bullous pemphigoid steroids and tetracyclines study
    Daniel J Bratton
    Centre of Evidence Based Dermatology, Nottingham University Hospitals NHS Trust, Nottingham, UK
    Trials 13:50. 2012
  10. doi request reprint The growth of clinical trials and systematic reviews in informing dermatological patient care
    Hywel C Williams
    Centre of Evidence Based Dermatology, Nottingham University Hospitals NHS Trust, Nottingham, UK
    J Invest Dermatol 132:1008-17. 2012

Detail Information

Publications94

  1. ncbi request reprint Prevention of atopic eczema: a dream not so far away?
    Hywel C Williams
    Department of Dermatoepidemiology, Centre of Evidence Based Dermatology, Queen s Medical Centre, Nottingham NG7 2UH, England
    Arch Dermatol 138:391-2. 2002
  2. pmc Mapping randomized controlled trials of treatments for eczema--the GREAT database (the Global Resource of EczemA Trials: a collection of key data on randomized controlled trials of treatments for eczema from 2000 to 2010)
    Helen Nankervis
    Centre of Evidence Based Dermatology, Room A103, King s Meadow Campus, University of Nottingham, Lenton Lane, Nottingham, NG7 2NR, UK
    BMC Dermatol 11:10. 2011
    ....
  3. pmc Prevention of atopic dermatitis
    Hywel C Williams
    Centre of Evidence Based Dermatology, University of Nottingham King s Meadow Campus, Lenton Lane, Nottingham, NG7 2NR, UK Nottingham University Hospitals NHS Trust, Dermatology Department Queen s Medical Centre Campus, Derby Road, Nottingham, NG7 2RB, UK
    F1000 Med Rep 4:24. 2012
    ..Large scale and long term randomized controlled trials are needed to demonstrate that these ideas result in clinical benefit...
  4. pmc Key considerations for the experimental training and evaluation of cancer odour detection dogs: lessons learnt from a double-blind, controlled trial of prostate cancer detection
    Kevin R Elliker
    Centre of Evidence Based Dermatology, Nottingham University Hospitals NHS Trust, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    BMC Urol 14:22. 2014
    ..Our study sought to determine whether dogs could be trained to discriminate the odour of urine from men with prostate cancer from controls, using rigorous testing procedures and well-defined samples from a major research hospital...
  5. pmc UK Dermatology Clinical Trials Network's STOP GAP trial (a multicentre trial of prednisolone versus ciclosporin for pyoderma gangrenosum): protocol for a randomised controlled trial
    Fiona F Craig
    University of Nottingham, Centre of Evidence Based Dermatology, Nottingham, NG7 2NR, UK
    Trials 13:51. 2012
    ..The UK Dermatology Clinical Trials Network's STOP GAP Trial has been designed to address this lack of trial evidence...
  6. pmc What determines patient preferences for treating low risk basal cell carcinoma when comparing surgery vs imiquimod? A discrete choice experiment survey from the SINS trial
    Michela Tinelli
    Centre of Evidence Based Dermatology, University of Nottingham, A103, King s Meadow Campus, Lenton Lane, Nottingham, NG7 2NR, UK
    BMC Dermatol 12:19. 2012
    ..The trial included a discrete choice experiment questionnaire to explore patient preferences of a cream versus surgery for the treatment of their skin cancer...
  7. doi request reprint Epidemiology of human atopic dermatitis--seven areas of notable progress and seven areas of notable ignorance
    Hywel C Williams
    Centre of Evidence Based Dermatology, University of Nottingham King s Meadow Campus, Nottingham NG7 2NR, UK
    Vet Dermatol 24:3-9.e1-2. 2013
    ..The review is supported by systematic reviews wherever possible, with the purpose of stimulating fresh approaches to human and veterinary research into AD...
  8. pmc Why is the center of evidence-based dermatology relevant to Indian dermatology?
    Hywel Williams
    Centre of Evidence Based Dermatology, King s Meadow Campus, University of Nottingham, Lenton Lane, Nottingham NG7 2NR, UK
    Indian J Dermatol 54:118-23. 2009
    ..Such new knowledge only has value if it is shared and used...
  9. pmc The value of the pragmatic-explanatory continuum indicator summary wheel in an ongoing study: the bullous pemphigoid steroids and tetracyclines study
    Daniel J Bratton
    Centre of Evidence Based Dermatology, Nottingham University Hospitals NHS Trust, Nottingham, UK
    Trials 13:50. 2012
    ..Our team applied this tool to an ongoing trial (BLISTER) to determine whether the initial suggestion among some team members that the trial could be described as largely pragmatic was the consensus...
  10. doi request reprint The growth of clinical trials and systematic reviews in informing dermatological patient care
    Hywel C Williams
    Centre of Evidence Based Dermatology, Nottingham University Hospitals NHS Trust, Nottingham, UK
    J Invest Dermatol 132:1008-17. 2012
    ..Future challenges include optimizing the use of research resources, adopting methodological developments in health technology assessment, and prospective registration and complete reporting of all study results...
  11. ncbi request reprint Acne vulgaris
    Hywel C Williams
    Centre of Evidence Based Dermatology, Nottingham University Hospitals NHS Trust, Nottingham, UK
    Lancet 379:361-72. 2012
    ..New research is needed into the therapeutic comparative effectiveness and safety of the many products available, and to better understand the natural history, subtypes, and triggers of acne...
  12. pmc Problems in the reporting of acne clinical trials: a spot check from the 2009 Annual Evidence Update on Acne Vulgaris
    John R Ingram
    Welsh Institute of Dermatology, University Hospital of Wales, Heath Park, Cardiff, Wales CF14 4XW, UK
    Trials 11:77. 2010
    ..Most of the reporting problems could have been avoided by use of the CONSORT guidelines and prospective trial registration on a public clinical trials database...
  13. pmc The SINS trial: a randomised controlled trial of excisional surgery versus imiquimod 5% cream for nodular and superficial basal cell carcinoma
    Mara Ozolins
    Centre of Evidence Based Dermatology, King s Meadow Campus, Lenton Lane, Nottingham, NG7 2NR, UK
    Trials 11:42. 2010
    ..2. To ascertain if certain phenotypic features and gene polymorphisms predict tumour responsiveness to treatment...
  14. pmc Introducing the National Library for Health Skin Conditions Specialist Library
    Douglas Grindlay
    National Library for Health Skin Conditions Specialist Library, Centre of Evidence Based Dermatology, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    BMC Dermatol 5:4. 2005
    ..This paper introduces the new National Library for Health Skin Conditions Specialist Library http://www.library.nhs.uk/skin...
  15. pmc Validation of epidemiological tools for eczema diagnosis in Brazilian children: the ISAAC's and UK Working Party's criteria
    Agostino Strina
    Universidade Federal da Bahia, Instituto De Saude Coletiva, Salvador, Brazil
    BMC Dermatol 10:11. 2010
    ..Our objective was to assess the validity of ISAAC and UK Working Party criteria for field diagnosis of eczema in children...
  16. ncbi request reprint Dermatological games, by J. A. Cotterill Br. J. Dermatol. 1981: 105: 311-320
    Hywel Williams
    Centre of Evidence Based Dermatology, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Clin Exp Dermatol 27:349-51. 2002
  17. ncbi request reprint How to reply to referees' comments when submitting manuscripts for publication
    Hywel C Williams
    Centre of Evidence Based Dermatology, Queen s Medical Centre, United Kingdom
    J Am Acad Dermatol 51:79-83. 2004
    ..Little guidance is available in the biomedical literature on how to deal with such comments...
  18. doi request reprint What's new in atopic eczema? An analysis of systematic reviews published in 2007 and 2008. Part 1. Definitions, causes and consequences of eczema
    H C Williams
    NHS Evidence Skin Disorders, Centre of Evidence Based Dermatology, University of Nottingham, Nottingham, UK
    Clin Exp Dermatol 35:12-5. 2010
    ..A review of four economic studies from the US found that the annual cost of AE in the States was as high as $3.8 billion when indirect costs are included...
  19. ncbi request reprint Twice-weekly topical corticosteroid therapy may reduce atopic dermatitis relapses
    Hywel C Williams
    Queen s Medical Center University Hospital NHS Trust, Nottingham, England
    Arch Dermatol 140:1151-2. 2004
  20. ncbi request reprint Conflicts of interest in dermatology
    Hywel C Williams
    Centre of Evidence Based Dermatology, Nottingham University Hospital NHS Trust, UK
    Acta Derm Venereol 86:485-97. 2006
    ..Collectively, they illustrate the many ways in which conflicts can pervade the world of dermatology publications and patient support group activities...
  21. ncbi request reprint Epidemiology of atopic dermatitis
    H C Williams
    Department of Dermatology, University Hospital, Queen s Medical Centre, Nottingham, UK
    Clin Exp Dermatol 25:522-9. 2000
    ..Future research gaps include evaluation of gene-environment interactions, better studies of the natural history of AD, and better clinical trials that answer questions that are important to physicians and their patients...
  22. ncbi request reprint What's new in atopic eczema? An analysis of systematic reviews published in 2007 and 2008. Part 2. Disease prevention and treatment
    H C Williams
    NHS Evidence Skin Disorders, Centre of Evidence Based Dermatology, University of Nottingham, Nottingham, UK
    Clin Exp Dermatol 35:223-7. 2010
    ..A review of 13 studies of probiotics for treating established eczema did not show convincing evidence of a clinically worthwhile benefit, an observation that has been substantiated in a subsequent Cochrane Review...
  23. ncbi request reprint Clinical practice. Atopic dermatitis
    Hywel C Williams
    Center of Evidence Based Dermatology, Queen s Medical Center, University of Nottingham, Nottingham, United Kingdom
    N Engl J Med 352:2314-24. 2005
  24. doi request reprint Eczema across the world: the missing piece of the jigsaw revealed
    Hywel C Williams
    Centre of Evidence Based Dermatology, University Hospitals NHS Trust, Nottingham, UK
    J Invest Dermatol 131:12-4. 2011
    ..Novel findings include the demonstration of higher eczema prevalence along the East Coast. The study correlates well with previous reports and may help point to environmental factors that contribute to the development of eczema...
  25. ncbi request reprint Applying trial evidence back to the patient
    Hywel C Williams
    Centre of Evidence Based Dermatology, University of Nottingham, Queen s Medical Centre, Nottingham, England
    Arch Dermatol 139:1195-200. 2003
  26. ncbi request reprint What's new in atopic eczema? An analysis of the clinical significance of systematic reviews on atopic eczema published in 2006 and 2007
    H C Williams
    National Library for Health Skin Disorders Specialist Library, Centre of Evidence Based Dermatology, University of Nottingham, UK
    Clin Exp Dermatol 33:685-8. 2008
    ..Future trials need to be larger, and include active comparators, patient-reported outcomes and longer-term aspects of disease control. They should be better reported, and registered on a public clinical trials register...
  27. ncbi request reprint The Cochrane Skin Group. Preparing, maintaining, and disseminating systematic reviews of clinical interventions in dermatology
    H Williams
    Dermato Epidemiology Unit, Queen s Medical Centre, Nottingham, England
    Arch Dermatol 134:1620-6. 1998
    ..The Cochrane Skin Group aims to become the best source of unbiased external evidence for summarizing the effects of dermatological care...
  28. pmc Established corticosteroid creams should be applied only once daily in patients with atopic eczema
    Hywel C Williams
    Centre of Evidence Based Dermatology, Queen s Medical Centre, University of Nottingham NG7 2UH
    BMJ 334:1272. 2007
  29. ncbi request reprint How epidemiology has challenged 3 prevailing concepts about atopic dermatitis
    Hywel Williams
    Centre of Evidence Based Dermatology, University of Nottingham King s Meadow Campus, Lenton Lane, Nottingham NG7 2NR, UK
    J Allergy Clin Immunol 118:209-13. 2006
    ..Collectively, these observations underline the importance of epidemiologic studies conducted at a population level to gain a more balanced understanding of the enigma of atopic dermatitis...
  30. pmc Cars, CONSORT 2010, and clinical practice
    Hywel C Williams
    Centre of Evidence Based Dermatology, University of Nottingham, Nottingham, UK
    Trials 11:33. 2010
    ..The CONSORT statement evolves as empirical research moves on. CONSORT 2010 is even clearer than before and includes some new items with a particular emphasis on selective reporting of outcomes. The challenge is for everyone to use it...
  31. ncbi request reprint Is eczema really on the increase worldwide?
    Hywel Williams
    Centre of Evidence Based Dermatology, University of Nottingham, Nottingham, United Kingdom
    J Allergy Clin Immunol 121:947-54.e15. 2008
    ..It is unclear whether eczema prevalence is truly increasing worldwide...
  32. pmc Prophylactic antibiotics for the prevention of cellulitis (erysipelas) of the leg: results of the UK Dermatology Clinical Trials Network's PATCH II trial
    Kim Thomas
    Centre of Evidence Based Dermatology, University of Nottingham, King s Meadow Campus, Lenton Lane, Nottingham NG7 2N, UK
    Br J Dermatol 166:169-78. 2012
    ..Cellulitis (erysipelas) of the leg is a common, painful infection of the skin and underlying tissue. Repeat episodes are frequent, cause significant morbidity and result in high health service costs...
  33. pmc Studying a disease with no home--lessons in trial recruitment from the PATCH II study
    Kim S Thomas
    Centre of Evidence Based Dermatology, University of Nottingham, King s Meadow Campus, Nottingham NG7 2NR, UK
    Trials 11:22. 2010
    ..This was the first trial to be undertaken by the UK Dermatology Clinical Trials Network. As such, it was the first to test a recruitment model that involved many busy clinicians each contributing just a few patients...
  34. doi request reprint Rapid acquisition of Raman spectral maps through minimal sampling: applications in tissue imaging
    Christopher J Rowlands
    School of Physics and Astronomy, University of Nottingham, University Park, NG7 2RD, Nottingham, UK
    J Biophotonics 5:220-9. 2012
    ..The benefits of this selective sampling method are not limited to tissue imaging however; it is expected that the method may be applied to other techniques which employ point-by-point mapping of large substrates...
  35. ncbi request reprint The use of corticosteroids and corticosteroid phobia in atopic dermatitis
    Carolyn Charman
    Department of Dermatology, Queen s Medical Centre, Nottingham, United Kingdom
    Clin Dermatol 21:193-200. 2003
  36. doi request reprint How well do questionnaires perform compared with physical examination in detecting flexural eczema? Findings from the International Study of Asthma and Allergies in Childhood (ISAAC) Phase Two
    C Flohr
    Centre for Evidence Based Dermatology, Institute of Clinical Research, University of Nottingham, Nottingham, UK
    Br J Dermatol 161:846-53. 2009
    ..Questionnaires are widely used in epidemiological studies to measure eczema symptom prevalence, but there are concerns regarding their accuracy if used as a diagnostic tool...
  37. ncbi request reprint What causes worsening of eczema? A systematic review
    S M Langan
    Centre of Evidence Based Dermatology, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Br J Dermatol 155:504-14. 2006
    ..Flares of eczema are attributed to many factors, often with minimal scientific evidence...
  38. ncbi request reprint What causes flares of eczema in children?
    S M Langan
    Centre of Evidence Based Dermatology, C Floor, South Block, Queen s Medical Centre, University of Nottingham, Nottingham, UK
    Br J Dermatol 161:640-6. 2009
    ..Although eczema affects 2-20% of children worldwide, there is little direct evidence on the role of environmental factors in disease flares...
  39. doi request reprint A systematic review of randomized controlled trials of treatments for inherited forms of epidermolysis bullosa
    S M Langan
    Centre of Evidence Based Dermatology, University of Nottingham, Nottingham, UK
    Clin Exp Dermatol 34:20-5. 2009
    ..Many interventions have been described for inherited epidermolysis bullosa (EB), but it is unclear which are beneficial...
  40. doi request reprint The use of electronic diaries in dermatology research
    S M Langan
    Centre of Evidence Based Dermatology, C f loor, South Block, Queen s Medical Centre, Nottingham NG 2UH, UK
    Dermatology 218:344-6. 2009
    ..This method has the potential to reduce recall bias. We report on our experience in the use of electronic diaries in a panel study of children with eczema...
  41. ncbi request reprint Reliability testing of the Six Area, Six Sign Atopic Dermatitis severity score
    C R Charman
    Department of Dermatology, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Br J Dermatol 146:1057-60. 2002
    ..Validity has been demonstrated in single and multicentre clinical trials, although data on the reliability of the index have not previously been published...
  42. pmc Self-regulation in hospital waiting lists
    D P Smethurst
    Centre of Evidence Based Dermatology, Queen s Medical Centre, University Hospital, Nottingham NG7 2UH, UK
    J R Soc Med 95:287-9. 2002
    ..01)--dermatology, R=0.68; ear-nose-throat R=0.78; trauma/orthopaedics (R=0.64). These were the three with the longest lists. These results help to explain why initiatives to shorten waiting lists are commonly ineffective in the long term...
  43. ncbi request reprint Interventions to reduce Staphylococcus aureus in the management of atopic eczema: an updated Cochrane review
    F J Bath-Hextall
    Centre of Evidence Based Dermatology, Faculty of Medicine and Health Science, University of Nottingham, Nottingham, UK
    Br J Dermatol 163:12-26. 2010
    ..Although few would dispute the benefit of systemic antibiotics in people with overtly clinically infected eczema, the clinical role of S. aureus in causing inflammatory flares in clinically uninfected eczema is less clear...
  44. ncbi request reprint Topical corticosteroid phobia in patients with atopic eczema
    C R Charman
    Department of Dermatology, Queen s Medical Centre, Nottingham NG7 2UH, U K
    Br J Dermatol 142:931-6. 2000
    ..This study highlights the need for provision of better information and education to patients and possibly general practitioners regarding the safety, potency and appropriate use of topical corticosteroids...
  45. ncbi request reprint An exploratory prospective observational study of environmental factors exacerbating atopic eczema in children
    S M Langan
    Department of Dermatology, South Infirmary Victoria Hospital, Old Blackrock Road, Cork, Ireland, and Trent Research and Development Support Unit, University of Nottingham Medical School, UK
    Br J Dermatol 154:979-80. 2006
    ..Possible exacerbating factors are a major concern of parents of children with atopic eczema (AE). However, there is minimal evidence for their direct role in leading to disease flares...
  46. ncbi request reprint The Nottingham Eczema Severity Score: preliminary refinement of the Rajka and Langeland grading
    R M Emerson
    Dermato Epidemiology Research Unit, University Hospital, Queen s Medical Centre, Nottingham, UK
    Br J Dermatol 142:288-97. 2000
    ..Further validation is required with respect to use in older children, administration by researchers/health professionals and development as a wholly questionnaire-based assessment...
  47. ncbi request reprint The natural history of childhood eczema: observations from the British 1958 birth cohort study
    H C Williams
    Department of Dermatology, Queen s Medical Centre, Nottingham NG7 2UH
    Br J Dermatol 139:834-9. 1998
    ..The long-term prognosis of childhood eczema may be worse than some previous studies have suggested, especially when subsequent recurrences are taken into account...
  48. ncbi request reprint A multicentre randomised controlled trial and economic evaluation of ion-exchange water softeners for the treatment of eczema in children: the Softened Water Eczema Trial (SWET)
    K S Thomas
    Centre of Evidence Based Dermatology, University of Nottingham, Nottingham, UK
    Health Technol Assess 15:v-vi, 1-156. 2011
    ..To determine whether installation of an ion-exchange water softener in the home could improve atopic eczema in children and, if so, to establish its likely cost and cost-effectiveness...
  49. pmc A multi-centre randomised controlled trial of rehabilitation aimed at improving outdoor mobility for people after stroke: study protocol for a randomised controlled trial
    Pip A Logan
    Division of Rehabilitation and Aging, University of Nottingham, Nottingham, UK
    Trials 13:86. 2012
    ..This can impede a person's quality of life. This study is testing the clinical effectiveness and cost effectiveness of a new outdoor mobility rehabilitation intervention by comparing it to usual care...
  50. doi request reprint Development of Raman microspectroscopy for automated detection and imaging of basal cell carcinoma
    Marta Larraona-Puy
    University of Nottingham, School of Physics and Astronomy, University Park, Nottingham, NG7 2RD, United Kingdom
    J Biomed Opt 14:054031. 2009
    ..The replacement of current histopathology during MMS by a "generalization" of the proposed technique may improve the feasibility and efficacy of MMS, leading to a wider use according to clinical need...
  51. ncbi request reprint What is the cost of atopic dermatitis in preschool children?
    R M Emerson
    Department of Dermatology, University Hospital, Queen s Medical Centre, Nottingham NG7 2UH, U K
    Br J Dermatol 144:514-22. 2001
    ....
  52. ncbi request reprint Identification of loci associated with schizophrenia by genome-wide association and follow-up
    Michael C O'Donovan
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Nat Genet 40:1053-5. 2008
    ..Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 x 10(-7)) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 x 10(-9))...
  53. pmc Psycho-education with problem solving (PEPS) therapy for adults with personality disorder: a pragmatic multi-site community-based randomised clinical trial
    Mary McMurran
    Institute of Mental Health, University of Nottingham, Sir Colin Campbell Building, Nottingham NG7 2TU, UK
    Trials 12:198. 2011
    ..A definitive evaluation is now being conducted to determine whether PEPS therapy is a clinically and cost-effective treatment for people with personality disorder..
  54. ncbi request reprint Measuring atopic eczema severity visually: which variables are most important to patients?
    Carolyn R Charman
    Department of Dermatology, Queen s Medical Centre, University Hospital, Nottingham NG7 2UH, England, UK
    Arch Dermatol 141:1146-51; discussion 1151. 2005
    ..There is wide variation in the objective visual variables used to measure atopic eczema severity in clinical trials, making comparison and interpretation of results difficult...
  55. ncbi request reprint Measuring atopic dermatitis severity in randomized controlled clinical trials: what exactly are we measuring?
    Carolyn Charman
    Center of Evidence Based Dermatology, Queen s Medical Center, University Hospital, Nottingham, UK
    J Invest Dermatol 120:932-41. 2003
    ..More emphasis should be placed on measuring things that are important to patients such as symptoms and quality of life...
  56. ncbi request reprint How atopic is atopic dermatitis?
    Carsten Flohr
    Centre of Evidence Based Dermatology, University of Nottingham, United Kingdom
    J Allergy Clin Immunol 114:150-8. 2004
    ..The extent to which the phenotype of atopic dermatitis (AD) is truly atopic has been the subject of much debate...
  57. ncbi request reprint A multicentre randomized controlled trial of ion-exchange water softeners for the treatment of eczema in children: protocol for the Softened Water Eczema Trial (SWET) (ISRCTN: 71423189)
    K S Thomas
    Centre of Evidence Based Dermatology, University of Nottingham, King s Meadow Campus, UK
    Br J Dermatol 159:561-6. 2008
    ..The most likely explanation is increased soap usage in hard water areas, the deposits of which can cause skin irritation in individuals with eczema...
  58. doi request reprint Dietary exclusions for improving established atopic eczema in adults and children: systematic review
    F Bath-Hextall
    Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, UK
    Allergy 64:258-64. 2009
    ..50, 95% CI 0.19-10.81) and end of treatment (MD 6.10, 95% CI 0.06-12.14). Despite their frequent use, we find little good quality evidence to support the use of exclusion diets in atopic eczema...
  59. ncbi request reprint Randomised controlled multiple treatment comparison to provide a cost-effectiveness rationale for the selection of antimicrobial therapy in acne
    M Ozolins
    Department of Dermatology, University of Nottingham, UK
    Health Technol Assess 9:iii-212. 2005
    ....
  60. ncbi request reprint The natural history of hidradenitis suppurativa
    J M von der Werth
    Department of Dermatology, Queen s Medical Centre, Nottingham, UK
    J Eur Acad Dermatol Venereol 14:389-92. 2000
    ..To investigate aspects of the natural history of hidradenitis...
  61. ncbi request reprint Acne prevalence, knowledge about acne and psychological morbidity in mid-adolescence: a community-based study
    A Smithard
    Behavioural Sciences Section, Division of Psychiatry, A Floor, Queens Medical Centre, Nottingham NG7 2UH, UK
    Br J Dermatol 145:274-9. 2001
    ..Low levels of acne knowledge and poor acne management are concerns that could be amenable to a school-based education programme...
  62. pmc Randomised controlled trial of short bursts of a potent topical corticosteroid versus prolonged use of a mild preparation for children with mild or moderate atopic eczema
    K S Thomas
    Centre of Evidence Based Dermatology, Queen s Medial Centre, Nottingham NG7 2UH
    BMJ 324:768. 2002
    ..To determine whether a three day burst of a potent corticosteroid is more effective than a mild preparation used for seven days in children with mild or moderate atopic eczema...
  63. ncbi request reprint A randomized controlled trial of nurse follow-up clinics: do they help patients and do they free up consultants' time?
    C Gradwell
    Department of Dermatology, University Hospital, Queen s Medical Centre, Nottingham NG7 2UH, U K
    Br J Dermatol 147:513-7. 2002
    ..Their impact on service delivery within dermatology may be useful in relation to chronic diseases, where education and treatment concordance are important factors in disease management...
  64. pmc Feasibility, double-blind, randomised, placebo-controlled, multi-centre trial of hand-held NB-UVB phototherapy for the treatment of vitiligo at home (HI-Light trial: Home Intervention of Light therapy)
    Viktoria Eleftheriadou
    Centre of Evidence Based Dermatology, University of Nottingham, Kings Meadow Campus, Lenton Lane, Nottingham NG7 2NR, UK
    Trials 15:51. 2014
    ..The pilot Hi-Light trial examined the feasibility of conducting a large multi-centre randomised controlled trial (RCT) on the use of such devices by exploring recruitment, adherence, acceptability, and patient education...
  65. pmc Analysis of copy number variation using quantitative interspecies competitive PCR
    Nigel M Williams
    Department of Psychological Medicine, Wales School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Nucleic Acids Res 36:e112. 2008
    ....
  66. ncbi request reprint Impact of a multimedia intervention "Skinsafe" on patients' knowledge and protective behaviors
    Cristine Glazebrook
    Behavioral Sciences Section, Division of Psychiatry, School of Community Health Sciences, Queens Medical Centre, Nottingham, NG7 2UH, UK
    Prev Med 42:449-54. 2006
    ..This study aimed to evaluate the impact of an interactive multimedia intervention "Skinsafe" on patients' knowledge about melanoma and on their skin protective behaviors...
  67. pmc Interventions for basal cell carcinoma of the skin: systematic review
    Fiona Bath-Hextall
    Centre for Evidence Based Dermatology, Queen s Medical Centre, Nottingham NG7 2UH
    BMJ 329:705. 2004
    ..To assess the effects of treatments for basal cell carcinoma...
  68. ncbi request reprint The reporting of observational research studies in dermatology journals: a literature-based study
    Sinead Langan
    Centre of Evidence Based Dermatology, C Floor, South Block, Queen s Medical Centre, Nottingham NG 2UH, England
    Arch Dermatol 146:534-41. 2010
    ..To assess the quality of reporting in observational studies in dermatology...
  69. ncbi request reprint Atopic dermatitis and the 'hygiene hypothesis': too clean to be true?
    C Flohr
    Department of Dermatology, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, U K
    Br J Dermatol 152:202-16. 2005
    ..The so-called 'hygiene hypothesis' postulates an inverse relationship between atopic dermatitis (AD) and an environment that leads to increased pathogen exposure...
  70. doi request reprint A case report and critical appraisal of the literature on the use of DermaSilk in children with atopic dermatitis
    C Vlachou
    Dermatology Department, Queen s Medical Centre, Nottingham University Hospitals NHS Trust and Centre of Evidence Based Dermatology, University of Nottingham, Nottingham, UK
    Clin Exp Dermatol 34:e901-3. 2009
    ..We report a sericin-free silk (DermaSilk), which is treated with AEGIS AEM5772/5, a product that has antibacterial properties, and evaluate its use in the treatment of AD...
  71. doi request reprint How prominent are patient-reported outcomes in clinical trials of dermatological treatments?
    A P Townshend
    Centre of Evidence Based Dermatology, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, U K
    Br J Dermatol 159:1152-9. 2008
    ..Assessment of symptoms or disease improvement by study participants is an important aspect of assessing new dermatological therapies in clinical trials, especially for chronic skin diseases that lack objective severity markers...
  72. ncbi request reprint Effectiveness and cost-effectiveness of salicylic acid and cryotherapy for cutaneous warts. An economic decision model
    K S Thomas
    University of Nottingham, UK
    Health Technol Assess 10:iii, ix-87. 2006
    ..To create an economic decision model to evaluate the cost-effectiveness of these treatments, and, as a result, assess whether a randomised controlled trial (RCT) would be feasible and cost-effective...
  73. ncbi request reprint The role of furry pets in eczema: a systematic review
    Sinead M Langan
    MRCP, Centre of Evidence Based Dermatology, Queen s Medical Centre, Nottingham NG7 2UH, England
    Arch Dermatol 143:1570-7. 2007
    ..To systematically search, summarize, and critically appraise the literature to examine whether pet exposure in early life is associated with an increased risk of eczema...
  74. ncbi request reprint Comparison of five antimicrobial regimens for treatment of mild to moderate inflammatory facial acne vulgaris in the community: randomised controlled trial
    Mara Ozolins
    Centre of Evidence Based Dermatology, Queens Medical Centre, Nottingham, UK
    Lancet 364:2188-95. 2004
    ..We investigated the efficacy and cost-effectiveness of five antimicrobial regimens for mild to moderate facial acne and whether propionibacterial antibiotic resistance affects treatment response...
  75. ncbi request reprint The patient-oriented eczema measure: development and initial validation of a new tool for measuring atopic eczema severity from the patients' perspective
    Carolyn R Charman
    Department of Dermatology, Queen s Medical Centre, Nottingham, England
    Arch Dermatol 140:1513-9. 2004
    ..To develop a simple, valid, repeatable, and readily understandable patient-oriented assessment measure for monitoring disease activity in children and adults with atopic eczema...
  76. ncbi request reprint Natural history of atopic dermatitis and its relationship to serum total immunoglobulin E in a population-based birth cohort study
    Michael R Perkin
    Department of Child Health, St George s Hospital Medical School, London, UK
    Pediatr Allergy Immunol 15:221-9. 2004
    ..A cutoff point of 78 kU/l had the highest positive predictive value for visible eczema at 5 years of age of 28.6%, with a sensitivity of 12% and specificity of 95%...
  77. pmc Efficacy and tolerability of topical pimecrolimus and tacrolimus in the treatment of atopic dermatitis: meta-analysis of randomised controlled trials
    Darren M Ashcroft
    School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester M13 9PL
    BMJ 330:516. 2005
    ..To determine the efficacy and tolerability of topical pimecrolimus and tacrolimus compared with other treatments for atopic dermatitis...
  78. ncbi request reprint Evidence-based dermatology: number needed to treat and its relation to other risk measures
    Juan Jorge Manriquez
    Unit of Dermatology, School of Medicine, Pontificia Universidad Catolica de Chile, San Joaquin, Santiago
    J Am Acad Dermatol 56:664-71. 2007
    ..In this article we describe the usefulness and limits of the NNT with particular reference to dermatology, and compare NNT with other relative measures such as the relative risk and relative risk reduction...
  79. ncbi request reprint The role of atopic sensitization in flexural eczema: findings from the International Study of Asthma and Allergies in Childhood Phase Two
    Carsten Flohr
    Centre of Evidence Based Dermatology and the Centre for Population Sciences, Institute of Clinical Research, University of Nottingham, Nottingham, United Kingdom
    J Allergy Clin Immunol 121:141-147.e4. 2008
    ..The association between allergic sensitization and eczema has been debated for years...
  80. ncbi request reprint Current management of atopic eczema
    Jane C Ravenscroft
    Centre of Evidence Based Dermatology, Queen s Medical Centre, Nottingham
    Practitioner 246:690-5. 2002
  81. ncbi request reprint What is meant by a "flare" in atopic dermatitis? A systematic review and proposal
    Sinead M Langan
    Centre of Evidence Based Dermatology, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, England
    Arch Dermatol 142:1190-6. 2006
    ..To make preliminary recommendations for defining a flare of atopic dermatitis (AD) in clinical research based on a systematic review of the literature and experience in running clinical trials...
  82. ncbi request reprint Full disclosure--nothing less will do
    Hywel C Williams
    J Invest Dermatol 127:1831-3. 2007
  83. pmc Evening primrose oil for atopic dermatitis
    Hywel C Williams
    BMJ 327:1358-9. 2003
  84. ncbi request reprint Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003
    S G O Johansson
    Department of Medicine, Unit of Clinical Immunology and Allergy, Karolinska University Hospital, L2 04, S 171 76 Stockholm, Sweden
    J Allergy Clin Immunol 113:832-6. 2004
    ..It is assumed that as knowledge about basic causes and mechanisms improves, the nomenclature will need further review...
  85. ncbi request reprint Randomised controlled study of early pulsed dye laser treatment of uncomplicated childhood haemangiomas: results of a 1-year analysis
    Kapila Batta
    Department of Dermatology, The Birmingham Children s Hospital NHS Trust, Birmingham B4 6NL, UK
    Lancet 360:521-7. 2002
    ..The role of pulsed dye lasers (PDL) in the treatment of childhood haemangiomas is controversial. Our aim was to compare treatment with PDL with a wait-and-see policy...
  86. ncbi request reprint What is the point of databases of reviews for dermatology if all they compile is "insufficient evidence"?
    Eva R Parker
    Department of Dermatology, University of Colorado School of Medicine, Denver, USA
    J Am Acad Dermatol 50:635-9. 2004
    ..The use of review databases for dermatology has been questioned because of the impression that these reviews frequently report finding insufficient evidence to guide therapeutic recommendations...
  87. ncbi request reprint Clinical evidence epistemology
    Robert P Dellavalle
    J Invest Dermatol 127:2668-9. 2007
  88. ncbi request reprint Have you ever seen an Asian/Pacific Islander?
    Hywel C Williams
    Arch Dermatol 138:673-4. 2002
  89. ncbi request reprint A scientific look at seasonality of symptom severity in atopic dermatitis
    Paul Silcocks
    Trent Research Development and Support Unit, Queen s Medical Centre, Nottingham University, Nottingham, UK
    J Invest Dermatol 124:xviii-xix. 2005
  90. pmc Educational programmes for young people with eczema
    Hywel C Williams
    BMJ 332:923-4. 2006
  91. ncbi request reprint What are the best outcome measurements for atopic eczema? A systematic review
    Jochen Schmitt
    Department of Dermatology, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany
    J Allergy Clin Immunol 120:1389-98. 2007
    ..Valid and reliable outcome measurements are a prerequisite for evidence-based practice. The comparative validity and reliability of outcome measurements for assessing atopic eczema (AE) severity is unclear...
  92. ncbi request reprint The increasing importance of systematic reviews in clinical dermatology research and publication
    Scott R Freeman
    J Invest Dermatol 126:2357-60. 2006
  93. pmc Self-regulation in hospital waiting lists
    Dominic P Smethurst
    J R Soc Med 95:220. 2002