Christine M Williams

Summary

Affiliation: University of Reading
Country: UK

Publications

  1. ncbi Soy isoflavones increase preprandial peptide YY (PYY), but have no effect on ghrelin and body weight in healthy postmenopausal women
    Martin O Weickert
    German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    J Negat Results Biomed 5:11. 2006
  2. ncbi Dietary interventions affecting chylomicron and chylomicron remnant clearance
    C M Williams
    Department of Food Science and Technology, University of Reading, UK
    Atherosclerosis 141:S87-92. 1998
  3. ncbi Inulin and oligofructose: effects on lipid metabolism from human studies
    C M Williams
    Hugh Sinclair Unit of Human Nutrition, Department of Food Science and Technology, The University of Reading, UK
    Br J Nutr 87:S261-4. 2002
  4. ncbi The challenges for molecular nutrition research 1: linking genotype to healthy nutrition
    Christine M Williams
    Hugh Sinclair Unit of Human Nutrition, University of Reading, Reading, RG6 6AP, USA
    Genes Nutr 3:41-9. 2008
  5. ncbi Long-chain n-3 PUFA: plant v. marine sources
    Christine M Williams
    Hihj Sinclair Unit Human Nutrition, School of Food Biosciences, University of Reading, UK
    Proc Nutr Soc 65:42-50. 2006
  6. ncbi Dietary fatty acids and chylomicron synthesis and secretion
    C M Williams
    Hugh Sinclair Unit Human Nutrition, School of Food Biosciences, University of Reading, Reading RG6 6AP, UK
    Biochem Soc Trans 32:55-8. 2004
  7. ncbi Lipid metabolism in women
    Christine M Williams
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Reading RG6 6AP, UK
    Proc Nutr Soc 63:153-60. 2004
  8. ncbi Nutritional quality of organic food: shades of grey or shades of green?
    Christine M Williams
    High Sinclair Unit of Human Nutrition, School of Human Nutrition, School of Food Biosciences, University of Reading, UK
    Proc Nutr Soc 61:19-24. 2002
  9. ncbi Beneficial nutritional properties of olive oil: implications for postprandial lipoproteins and factor VII
    C M Williams
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Reading, RG6 6AP, UK
    Nutr Metab Cardiovasc Dis 11:51-6. 2001
  10. ncbi Triacylglycerol-rich lipoprotein-gene interactions in endothelial cells
    C M Williams
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Reading RG6 6AP, UK
    Biochem Soc Trans 32:994-8. 2004

Detail Information

Publications89

  1. ncbi Soy isoflavones increase preprandial peptide YY (PYY), but have no effect on ghrelin and body weight in healthy postmenopausal women
    Martin O Weickert
    German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    J Negat Results Biomed 5:11. 2006
    ..Seventeen of the subjects were classified as equol producers. Plasma concentrations of ghrelin and PYY, as well as energy intake and body weight were measured at baseline and after four and eight weeks of each intervention arm...
  2. ncbi Dietary interventions affecting chylomicron and chylomicron remnant clearance
    C M Williams
    Department of Food Science and Technology, University of Reading, UK
    Atherosclerosis 141:S87-92. 1998
    ....
  3. ncbi Inulin and oligofructose: effects on lipid metabolism from human studies
    C M Williams
    Hugh Sinclair Unit of Human Nutrition, Department of Food Science and Technology, The University of Reading, UK
    Br J Nutr 87:S261-4. 2002
    ....
  4. ncbi The challenges for molecular nutrition research 1: linking genotype to healthy nutrition
    Christine M Williams
    Hugh Sinclair Unit of Human Nutrition, University of Reading, Reading, RG6 6AP, USA
    Genes Nutr 3:41-9. 2008
    ..New statistical and bioinformatics approaches are becoming available to aid in design and evaluation of these studies. This review discusses the various approaches used and provides concrete recommendations for future research...
  5. ncbi Long-chain n-3 PUFA: plant v. marine sources
    Christine M Williams
    Hihj Sinclair Unit Human Nutrition, School of Food Biosciences, University of Reading, UK
    Proc Nutr Soc 65:42-50. 2006
    ..The effect of oestrogen on DHA concentration in pregnant and lactating women awaits confirmation...
  6. ncbi Dietary fatty acids and chylomicron synthesis and secretion
    C M Williams
    Hugh Sinclair Unit Human Nutrition, School of Food Biosciences, University of Reading, Reading RG6 6AP, UK
    Biochem Soc Trans 32:55-8. 2004
    ....
  7. ncbi Lipid metabolism in women
    Christine M Williams
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Reading RG6 6AP, UK
    Proc Nutr Soc 63:153-60. 2004
    ....
  8. ncbi Nutritional quality of organic food: shades of grey or shades of green?
    Christine M Williams
    High Sinclair Unit of Human Nutrition, School of Human Nutrition, School of Food Biosciences, University of Reading, UK
    Proc Nutr Soc 61:19-24. 2002
    ..If consumer perceptions regarding potential health benefits of organic foods are to be supported, more research of better quality is needed than that which is currently available...
  9. ncbi Beneficial nutritional properties of olive oil: implications for postprandial lipoproteins and factor VII
    C M Williams
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Reading, RG6 6AP, UK
    Nutr Metab Cardiovasc Dis 11:51-6. 2001
    ..The study produced novel findings with respect to potential mechanisms by which diets high in monounsaturated fatty acids (MUFA) can reduce population risk of cardiovascular disease...
  10. ncbi Triacylglycerol-rich lipoprotein-gene interactions in endothelial cells
    C M Williams
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Reading RG6 6AP, UK
    Biochem Soc Trans 32:994-8. 2004
    ..Early concepts of TRL particles as essentially pro-inflammatory stimuli to the endothelium provide an overly simplistic view of their impact on the vascular compartment...
  11. ncbi Cholesterol reduction using manufactured foods high in monounsaturated fatty acids: a randomized crossover study
    C M Williams
    Hugh Sinclair Unit of Human Nutrition, Department of Food Science and Technology, University of Reading, UK
    Br J Nutr 81:439-46. 1999
    ..The dietary approach used to alter fatty acid intakes would be appropriate for achieving reductions in saturated fat intakes in whole populations...
  12. ncbi Soy-isoflavone-enriched foods and markers of lipid and glucose metabolism in postmenopausal women: interactions with genotype and equol production
    Wendy L Hall
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Reading, United Kingdom
    Am J Clin Nutr 83:592-600. 2006
    ..However, beneficial effects of isolated isoflavones on lipid biomarkers of cardiovascular disease risk have not yet been shown...
  13. ncbi Acute effects of meal fatty acids on postprandial NEFA, glucose and apo E response: implications for insulin sensitivity and lipoprotein regulation?
    Kim G Jackson
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Reading, RG6 6AP, UK
    Br J Nutr 93:693-700. 2005
    ..PUFA- and MUFA-rich lipoproteins. Elevated Apo E responses to high-SFA meals may have important implications for the hepatic metabolism of triacylglycerol-rich lipoproteins...
  14. ncbi Plant- and marine-derived n-3 polyunsaturated fatty acids have differential effects on fasting and postprandial blood lipid concentrations and on the susceptibility of LDL to oxidative modification in moderately hyperlipidemic subjects
    Yvonne E Finnegan
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Reading, United Kingdom
    Am J Clin Nutr 77:783-95. 2003
    ..CONCLUSION: At estimated biologically equivalent intakes, dietary ALA and EPA+DHA have different physiologic effects...
  15. ncbi Apolipoprotein E enrichment of immuno-separated chylomicron and chylomicron remnants following saturated fatty acids
    Kim G Jackson
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, The University of Reading, Reading, Berkshire RG6 6AP, UK
    Nutr Metab Cardiovasc Dis 16:405-17. 2006
    ..We examined the effect of meal fatty acids on lipid and apolipoprotein concentrations of very low density lipoprotein (VLDL) and chylomicron/chylomicron remnants in lipid fractions with a Svedberg flotation rate (Sf) 60-400 and Sf 20-60...
  16. ncbi Olive oil increases the number of triacylglycerol-rich chylomicron particles compared with other oils: an effect retained when a second standard meal is fed
    Kim G Jackson
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Reading, United Kingdom
    Am J Clin Nutr 76:942-9. 2002
    ..There is a rapid appearance of chylomicrons in the circulation carrying fat ingested with the first meal, with a peak 1 h after the second meal...
  17. ncbi Effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid on immune cell function in healthy humans
    Sabine Tricon
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, The University of Reading, Reading, United Kingdom
    Am J Clin Nutr 80:1626-33. 2004
    ....
  18. ncbi Apolipoprotein E genotype and the cardiovascular disease risk phenotype: impact of sex and adiposity (the FINGEN study)
    Bettina M Kofler
    Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, Reading RG6 6AP, United Kingdom
    Atherosclerosis 221:467-70. 2012
    ....
  19. ncbi Effects of dairy products naturally enriched with cis-9,trans-11 conjugated linoleic acid on the blood lipid profile in healthy middle-aged men
    Sabine Tricon
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences and the School of Animal and Microbial Sciences, The University of Reading, Whiteknights, Reading RG6 6AP, United Kingdom
    Am J Clin Nutr 83:744-53. 2006
    ..However, feeding regimens that enhance the CLA content of milk also increase concentrations of trans-18:1 fatty acids. The implications for human health are not yet known...
  20. ncbi Interactions between age and apoE genotype on fasting and postprandial triglycerides levels
    Andrew L Carvalho-Wells
    Department of Food and Nutritional Sciences and Institute of Cardiovascular and Metabolic Research, University of Reading, Reading RG6 6AP, UK
    Atherosclerosis 212:481-7. 2010
    ..Here the impact of the common apolipoprotein (apo)E epsilon mutation on the postprandial triglyceride (TG) response is determined, along with an assessment of genotype penetrance according to age, body mass index and gender...
  21. ncbi A sequential two meal challenge reveals abnormalities in postprandial TAG but not glucose in men with increasing numbers of metabolic syndrome components
    Kim G Jackson
    Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, Reading RG6 6AP, UK
    Atherosclerosis 220:237-43. 2012
    ..To examine the impact of increasing numbers of metabolic syndrome (MetS) components on postprandial lipaemia...
  22. ncbi Saturated fat-induced changes in Sf 60-400 particle composition reduces uptake of LDL by HepG2 cells
    Kim G Jackson
    School of Food Biosciences, University of Reading, Reading, Berkshire, United Kingdom
    J Lipid Res 47:393-403. 2006
    ..008). In conclusion, these findings suggest an alternative or additional mechanism whereby acute fat ingestion can influence LDL clearance via competitive apoE-dependent effects of TRL on the LDL receptor...
  23. ncbi Long-term monounsaturated fatty acid diets reduce platelet aggregation in healthy young subjects
    Ruth D Smith
    School of Food Biosciences, University of Reading, Reading RG6 6AP, UK
    Br J Nutr 90:597-606. 2003
    ..Moderate or high substitution of MUFA for SFA achieves similar reductions in fasting blood lipids in young healthy subjects...
  24. ncbi Opposing effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid on blood lipids in healthy humans
    Sabine Tricon
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Whiteknights, Reading RG6 6AP, United Kingdom
    Am J Clin Nutr 80:614-20. 2004
    ....
  25. ncbi Increased n-6 polyunsaturated fatty acids do not attenuate the effects of long-chain n-3 polyunsaturated fatty acids on insulin sensitivity or triacylglycerol reduction in Indian Asians
    Louise M Brady
    School of Food Biosciences, University of Reading, Reading, United Kingdom
    Am J Clin Nutr 79:983-91. 2004
    ..CONCLUSION: The background dietary n-6 PUFA concentration did not modulate the effect of fish-oil supplementation on blood lipids or measures of insulin sensitivity in this ethnic group...
  26. ncbi Lack of effect of dietary n-6:n-3 PUFA ratio on plasma lipids and markers of insulin responses in Indian Asians living in the UK
    Anne M Minihane
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Reading RG6 6AP, UK
    Eur J Nutr 44:26-32. 2005
    ..A low dietary long chain n-3 fatty acid (LC n-3 PUFA) intake and a high dietary n-6 PUFA intake and n-6:n-3 PUFA ratio in Indian Asians have been proposed as contributors to the increased ALP incidence and CHD risk in this subgroup...
  27. ncbi Moderate fish-oil supplementation reverses low-platelet, long-chain n-3 polyunsaturated fatty acid status and reduces plasma triacylglycerol concentrations in British Indo-Asians
    Julie A Lovegrove
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, The University of Reading, Reading, United Kingdom
    Am J Clin Nutr 79:974-82. 2004
    ..The mechanisms involved in the increased mortality from coronary artery disease in British Indo-Asians are not well understood...
  28. ncbi DHA-rich fish oil reverses the detrimental effects of saturated fatty acids on postprandial vascular reactivity
    Katie J Newens
    Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, United Kingdom
    Am J Clin Nutr 94:742-8. 2011
    ..Experimental elevation of nonesterified fatty acids (NEFAs) impairs endothelial function, but the effect of NEFA composition is unknown...
  29. ncbi Meal ingestion provokes entry of lipoproteins containing fat from the previous meal: possible metabolic implications
    K D Renuka R Silva
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, 226, Whiteknights Reading (Berks.) RG6 6AP, UK
    Eur J Nutr 44:377-83. 2005
    ..The results indicate that the degree of TAG "storage" from previous meals might be a function of TAG tolerance and provide a possible site of regulation of the entry of fat into the systemic circulation...
  30. ncbi Measurement of apolipoprotein B-48 in the Svedberg flotation rate (S(f))>400, S(f) 60-400 and S(f) 20-60 lipoprotein fractions reveals novel findings with respect to the effects of dietary fatty acids on triacylglycerol-rich lipoproteins in postmenopausal
    Kim G Jackson
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Reading RG6 6AP, UK
    Clin Sci (Lond) 103:227-37. 2002
    ....
  31. ncbi Does genotype and equol-production status affect response to isoflavones? Data from a pan-European study on the effects of isoflavones on cardiovascular risk markers in post-menopausal women
    Katerina Vafeiadou
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, Whiteknights, University of Reading, UK
    Proc Nutr Soc 65:106-15. 2006
    ..In conclusion, isoflavones have beneficial effects on C-reactive protein, but not other cardiovascular risk markers. However, specific ERbeta gene polymorphic subgroups may benefit from isoflavone supplementation...
  32. ncbi Glu298Asp polymorphism influences the beneficial effects of fish oil fatty acids on postprandial vascular function
    Abby K Thompson
    Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, Reading, RG6 6AP, UK
    J Lipid Res 53:2205-13. 2012
    ..Effects of fat composition appear to be genotype and gender dependent, with the greatest difference in vasodilatory response to the two fat loads seen in the Asp298 females...
  33. ncbi Influence of apoA-V gene variants on postprandial triglyceride metabolism: impact of gender
    Estibaliz Olano-Martin
    Hugh Sinclair Human Nutrition Group, School of Chemistry, Food Biosciences, and Pharmacy, University of Reading, Reading RG6 6AP, United Kingdom
    J Lipid Res 49:945-53. 2008
    ..015). However, in linear regression analysis, a significant independent association with TG AUC (P = 0.007) was only evident for the apoA-V -1131 T>C SNP, indicating a greater relative importance of the apoA-V genotype...
  34. ncbi Greater enrichment of triacylglycerol-rich lipoproteins with apolipoproteins E and C-III after meals rich in saturated fatty acids than after meals rich in unsaturated fatty acids
    Kim G Jackson
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, The University of Reading, Reading, UK
    Am J Clin Nutr 81:25-34. 2005
    ....
  35. ncbi Contribution of apolipoprotein E genotype and docosahexaenoic acid to the LDL-cholesterol response to fish oil
    Estibaliz Olano-Martin
    Hugh Sinclair Unit of Nutrition, School of Chemistry, Food Biosciences and Pharmacy, University of Reading, Reading, UK
    Atherosclerosis 209:104-10. 2010
    ..To investigate the impact of apolipoprotein E (apoE) genotype on the response of the plasma lipoprotein profile to eicosapentaenoic acid (EPA) versus docosahexaenoic acid (DHA) intervention in humans...
  36. ncbi Acute effects of elevated NEFA on vascular function: a comparison of SFA and MUFA
    Katie J Newens
    Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, Reading, UK
    Br J Nutr 105:1343-51. 2011
    ..More studies are needed to fully investigate the impact of NEFA composition on risk factors for CVD...
  37. ncbi Chylomicron particle size and number, factor VII activation and dietary monounsaturated fatty acids
    K D Renuka R Silva
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Whiteknights, P.O. Box 226, Reading, Berkshire RG6 6AP, UK
    Atherosclerosis 166:73-84. 2003
    ..Smaller numbers of larger chylomicrons may explain attenuated activation of factor VII during the postprandial state when the background diet is rich in MUFA...
  38. ncbi The effects of conjugated linoleic acid on human health-related outcomes
    Sabine Tricon
    Hugh Sinclair Unit of Human Nutrition, School of Food Bioscienes, University of Reading, Whiteknights, UK
    Proc Nutr Soc 64:171-82. 2005
    ..These isomer-specific effects need further investigation. Until more is known, CLA supplementation in man should be considered with caution...
  39. ncbi The impact of common gene variants on the response of biomarkers of cardiovascular disease (CVD) risk to increased fish oil fatty acids intakes
    Jacqueline Madden
    Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, Reading, UK
    Annu Rev Nutr 31:203-34. 2011
    ..In the context of a more stratified approach to the provision of dietary advice, there is a need for further research to refine current dietary EPA and DHA recommendations...
  40. ncbi Impact of saturated, polyunsaturated and monounsaturated fatty acid-rich micelles on lipoprotein synthesis and secretion in Caco-2 cells
    Kim G Jackson
    Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, School of Chemistry, Food and Pharmacy, University of Reading, Reading, RG6 6AP, UK
    Lipids 44:1081-9. 2009
    ..Our electron micrographs are suggestive that some endocytotic uptake of MUFA-rich taurocholate micelles may promote greater lipoprotein synthesis and secretion in Caco-2 cells...
  41. ncbi Dietary PUFA and the metabolic syndrome in Indian Asians living in the UK
    Louise M Brady
    Hugh Sinclair Human Nutrition Unit, School of Food Biosciences, PO Box 226, University of Reading, White Knights, Reading RG6 6AP, UK
    Proc Nutr Soc 63:115-25. 2004
    ..The present study concludes that, contrary to the central hypothesis, the prevalence of metabolic abnormalities in Indian Asians compared with Caucasians may not be attributable to differences in intakes of n-6 and n-3 PUFA...
  42. ncbi Differences in cell morphology, lipid and apo B secretory capacity in caco-2 cells following long term treatment with saturated and monounsaturated fatty acids
    Paul A Bateman
    Hugh Sinclair Unit of Human Nutrition, Department of Food Biosciences, School of Chemistry, Food Biosciences and Pharmacy, The University of Reading, Reading Berkshire, UK
    Biochim Biophys Acta 1771:475-85. 2007
    ..In conclusion, previously reported differences in lipoprotein secretion by caco-2 cells supplemented with saturated fatty acids (SFA) and OA may partly reflect early cytotoxic effects of SFA on cellular integrity and function...
  43. ncbi Exaggerated postprandial lipaemia and lower post-heparin lipoprotein lipase activity in middle-aged men
    Kim G Jackson
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, The University of Reading, Whiteknights, Reading RG6 6AP, UK
    Clin Sci (Lond) 105:457-66. 2003
    ..Alternatively, post-heparin lipase activities may not be good markers for the insulin-sensitive component of lipase that is activated postprandially...
  44. ncbi Plant and marine derived (n-3) polyunsaturated fatty acids do not affect blood coagulation and fibrinolytic factors in moderately hyperlipidemic humans
    Yvonne E Finnegan
    Hugh Sinclair Unit of Human Nutrition, University of Reading, Reading, UK
    J Nutr 133:2210-3. 2003
    ..n-3) PUFA of plant or marine origin do not differ from one another or from LA in their effect on a range of blood coagulation and fibrinolytic factors...
  45. ncbi Comparative effects of fatty acids on endothelial inflammatory gene expression
    Danielle I Shaw
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Reading, RG6 6AP, UK
    Eur J Nutr 46:321-8. 2007
    ..Although in vitro studies have failed to show consistent findings, this may reflect the diverse experimental protocols employed and the limited range of FAs and end points studied...
  46. ncbi Use of water-miscible retinyl palmitate as markers of chylomicrons gives earlier peak response of plasma retinyl esters compared with oil-soluble retinyl palmitate
    K D Silva
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Reading, Berkshire RG6 6AP, UK
    Br J Nutr 86:427-32. 2001
    ..The RE response to the water-miscible RP showed better concordance with plasma TAG response than that of oil-soluble RP...
  47. ncbi A review of the evidence for the effects of total dietary fat, saturated, monounsaturated and n-6 polyunsaturated fatty acids on vascular function, endothelial progenitor cells and microparticles
    Katerina Vafeiadou
    Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, Reading, UK
    Br J Nutr 107:303-24. 2012
    ....
  48. ncbi Impact of age and menopausal status on the postprandial triacylglycerol response in healthy women
    Kim G Jackson
    Hugh Sinclair Unit of Human Nutrition, Department of Food Biosciences, University of Reading, Reading, United Kingdom
    Atherosclerosis 208:246-52. 2010
    ..To examine the impact of age and the natural menopause on the postprandial triacylglycerol (TAG) response in healthy women...
  49. ncbi Soy-isoflavone-enriched foods and inflammatory biomarkers of cardiovascular disease risk in postmenopausal women: interactions with genotype and equol production
    Wendy L Hall
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Reading, United Kingdom
    Am J Clin Nutr 82:1260-8; quiz 1365-6. 2005
    ..The reduction of concentrations of circulating inflammatory markers by estrogen may be one of the mechanisms by which premenopausal women are protected against cardiovascular disease...
  50. ncbi Eicosapentaenoic acid and docosahexaenoic acid from fish oils: differential associations with lipid responses
    Elizabeth C Leigh-Firbank
    The Hugh Sinclair Unit of Human Nutrition, The University of Reading, UK
    Br J Nutr 87:435-45. 2002
    ..Increases in platelet EPA+DHA were independently and positively associated with the increase in LDL oxidation (P=0.011). EPA and DHA may have differential effects on plasma lipids in mildly hypertriacylglycerolaemic men...
  51. ncbi Achievement of dietary fatty acid intakes in long-term controlled intervention studies: approach and methodology
    M C Nydahl
    Hugh Sinclair Unit of Human Nutrition, Department of Food Biosciences, University of Reading, Reading RG6 6AP, UK
    Public Health Nutr 6:31-40. 2003
    ..CONCLUSIONS: This study has revealed important theoretical considerations that should be taken into account when designing diets of specific fatty acid composition, as well as practical issues of implementation...
  52. ncbi Apolipoprotein B-48: comparison of fasting concentrations measured in normolipidaemic individuals using SDS-PAGE, immunoblotting and ELISA
    Kim G Jackson
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, The University of Reading, Reading, Berkshire, UK
    Atherosclerosis 176:207-17. 2004
    ..A high degree of variability was observed in the apo B-48 concentrations reported in the literature both within and between the SDS-PAGE, immunoblotting and ELISA methods...
  53. ncbi Revised QUICKI provides a strong surrogate estimate of insulin sensitivity when compared with the minimal model
    L M Brady
    School of Food Biosciences, The University of Reading, Whiteknights, UK
    Int J Obes Relat Metab Disord 28:222-7. 2004
    ..Future larger studies in population groups with varying degrees of insulin sensitivity are recommended to investigate the general applicability of the revised QUICKI surrogate technique...
  54. ncbi Dietary monounsaturated fatty acids and haemostasis
    C M Kelly
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, UK
    Proc Nutr Soc 60:161-70. 2001
    ....
  55. ncbi Dietary fat manipulation has a greater impact on postprandial lipid metabolism than the apolipoprotein E (epsilon) genotype-insights from the SATgenε study
    Kim G Jackson
    Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, Reading, UK
    Mol Nutr Food Res 56:1761-70. 2012
    ..Our aim was to determine the effects of chronic dietary fat manipulation on postprandial lipaemia according to apolipoprotein (APO)E genotype...
  56. ncbi The leptin receptor Gln223Arg polymorphism (rs1137101) mediates the postprandial lipaemic response, but only in males
    Kim G Jackson
    Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences and Institute for Cardiovascular and Metabolic Research, PO Box 226, Whiteknights, University of Reading, Reading RG6 6AP, UK Electronic address
    Atherosclerosis 225:135-41. 2012
    ....
  57. ncbi Trans-fatty acids and cancer: the evidence reviewed
    Abby K Thompson
    Department of Food Biosciences, University of Reading, Reading RG6 6AP, UK
    Nutr Res Rev 21:174-88. 2008
    ..There is insufficient evidence to allow any differentiation between the effects of trans-FA from animal or vegetable origin on cancer risk...
  58. ncbi Influence of the APOC3 -2854T>G polymorphism on plasma lipid levels: effect of age and gender
    Anne Marie Minihane
    The Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, The University of Reading, Whiteknights, UK
    Biochim Biophys Acta 1583:311-4. 2002
    ..Age and gender had a significant impact on genotype-triglyceride interactions...
  59. ncbi Lack of association between lipaemia and central adiposity in subjects with an atherogenic lipoprotein phenotype (ALP)
    A M Minihane
    Department of Food Science and Technology, University of Reading, Whiteknights, UK
    Int J Obes Relat Metab Disord 24:1097-106. 2000
    ..To investigate the associations between indices of adiposity and cardiovascular risk factors in individuals with an atherogenic lipoprotein phenotype (ALP)...
  60. ncbi Second meal effect: modified sham feeding does not provoke the release of stored triacylglycerol from a previous high-fat meal
    K G Jackson
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Reading RG6 6AP, UK
    Br J Nutr 85:149-56. 2001
    ....
  61. ncbi Synergistic efects of opioid and cannabinoid antagonists on food intake
    T C Kirkham
    Department of Psychology, University of Reading, Whiteknights, UK
    Psychopharmacology (Berl) 153:267-70. 2001
    ..These effects may involve activation of reward systems and be mediated in part by opioidergic processes...
  62. ncbi Adiposity, insulin and lipid metabolism in post-menopausal women
    J A Lovegrove
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Berkshire, UK
    Int J Obes Relat Metab Disord 26:475-86. 2002
    ..To investigate relationships between body fat and its distribution and carbohydrate and lipid tolerance using statistical comparisons in post-menopausal women...
  63. ncbi ApoE polymorphism and fish oil supplementation in subjects with an atherogenic lipoprotein phenotype
    A M Minihane
    Hugh Sinclair Unit of Human Nutrition, Department of Food Science and Technology, University of Reading, Reading, UK
    Arterioscler Thromb Vasc Biol 20:1990-7. 2000
    ..Our data demonstrate the efficacy of fish oil fatty acids in counteracting the proatherogenic lipid profile of the ALP but also that the apoE genotype influences responsiveness to this dietary treatment...
  64. ncbi Modest doses of beta-glucan do not reduce concentrations of potentially atherogenic lipoproteins
    J A Lovegrove
    Hugh Sinclair Unit of Human Nutrition, The University of Reading, Reading, United Kingdom, and Nestle, Vivey, Switzerland
    Am J Clin Nutr 72:49-55. 2000
    ..In 1997, the US Food and Drug Administration passed a unique ruling that allowed oat bran to be registered as the first cholesterol-reducing food at a dosage of 3 g beta-glucan/d...
  65. ncbi Lack of association between central adiposity and lipaemia in UK Sikh men
    J A Lovegrove
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Whiteknights, Reading, Berkshire, UK
    Int J Obes Relat Metab Disord 27:1373-82. 2003
    ..To determine whether the positive statistical associations between measures of total and regional adiposity and measures of glucose, insulin and triacylglycerol (TAG) metabolism reported in Caucasian men, are also observed in UK Sikhs...
  66. ncbi The effect of the daily intake of inulin on fasting lipid, insulin and glucose concentrations in middle-aged men and women
    K G Jackson
    Department of Food Science and Technology, University of Reading, UK
    Br J Nutr 82:23-30. 1999
    ....
  67. ncbi Differences in glucose-dependent insulinotrophic polypeptide hormone and hepatic lipase in subjects of southern and northern Europe: implications for postprandial lipemia
    K G Jackson
    Centre for Nutrition and Food Safety, School of Biological Sciences, University of Surrey, United Kingdom
    Am J Clin Nutr 71:13-20. 2000
    ..This study was an extension of a previous study that showed different lipemic responses to standard test meals in subjects from southern and northern Europe...
  68. ncbi Lack of influence of test meal fatty acid composition on the contribution of intestinally-derived lipoproteins to postprandial lipaemia
    K G Jackson
    Centre for Nutrition and Food Safety, School of Biological Sciences, University of Surrey, Guildford, UK
    Br J Nutr 81:51-7. 1999
    ..The value of the two markers in investigating dietary fat absorption and metabolism is discussed...
  69. ncbi Metabolic syndrome: what is it and what are the implications?
    D I Shaw
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Reading RG6 6AP, UK
    Proc Nutr Soc 64:349-57. 2005
    ..The LIPGENE project will investigate dietary fat quality as a strategy for the prevention of metabolic syndrome and identify food chain approaches that can support consumer attempts to alter their dietary patterns...
  70. ncbi Trans fatty acids and weight gain
    A K Thompson
    Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, Reading, UK
    Int J Obes (Lond) 35:315-24. 2011
    ....
  71. ncbi Chemical, physical, and sensory properties of dairy products enriched with conjugated linoleic acid
    E L Jones
    School of Food Biosciences, The University of Reading, Reading RG6 6AP, UK
    J Dairy Sci 88:2923-37. 2005
    ..In conclusion, it is feasible to produce CLA-enriched dairy products with acceptable storage and sensory characteristics...
  72. ncbi Combined oral contraceptive pills containing desogestrel or drospirenone enhance large vessel and microvasculature vasodilation in healthy premenopausal women
    Abby K Thompson
    Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutrition Science, University of Reading, Reading, UK
    Microcirculation 18:339-46. 2011
    ..To determine the effects of different COCs on endothelial function...
  73. ncbi Minimum recovery time between reactive hyperemia stimulus in the repeated measurement of brachial flow-mediated dilatation
    Matthew Barton
    Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutrition Science, University of Reading, Reading, United Kingdom
    Ultrasound Med Biol 37:879-83. 2011
    ....
  74. ncbi Differential uptake of subfractions of triglyceride-rich lipoproteins by THP-1 macrophages
    Anna M Palmer
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, The University of Reading, Whiteknights, P.O. Box 226, Reading RG6 6AP, United Kingdom
    Atherosclerosis 180:233-44. 2005
    ..In conclusion, THP monocyte-derived macrophages demonstrate a preference for VLDL-1, both through the LPL pathway and by direct uptake of whole particles...
  75. ncbi Prebiotics and lipid metabolism
    Nathalie M Delzenne
    UCL Université Catholique de Louvain, School of Pharmacy, Brussels, Belgium
    Curr Opin Lipidol 13:61-7. 2002
    ....
  76. ncbi Dietary long-chain n-3 PUFAs increase LPL gene expression in adipose tissue of subjects with an atherogenic lipoprotein phenotype
    Syrah Khan
    School of Biomedical and Life Sciences, University of Surrey, Guildford, United Kingdom
    J Lipid Res 43:979-85. 2002
    ..We conclude that the favorable influence of dietary n-3 PUFA on the ALP may be mediated, in part, through an increase in the plasma activity and gene expression of lipoprotein lipase in human adipose tissue...
  77. ncbi Absorption of isoflavones in humans: effects of food matrix and processing
    Sonia de Pascual-Teresa
    Department of Plant Food Sciences and Technology, CSIC, Instituto del Frio, José Anotonio Novais 10, Ciudad Universitaria, Madrid, Spain
    J Nutr Biochem 17:257-64. 2006
    ....
  78. ncbi Incorporation of cis-9, trans-11 conjugated linoleic acid and vaccenic acid (trans-11 18 : 1) into plasma and leucocyte lipids in healthy men consuming dairy products naturally enriched in these fatty acids
    Graham C Burdge
    Institute of Human Nutrition, Biomedical Sciences Building, University of Southhampton, Bassett Crescent East, Southhampton, S016 7PX, UK
    Br J Nutr 94:237-43. 2005
    ..001) and PBMC (84 %; P = 0.004). Overall, the present study shows that consumption of naturally enriched dairy products in amounts similar to habitual intakes of these foods increased the c9,t11 CLA content of plasma and cellular lipids...
  79. ncbi Incorporation of cis-9,trans-11 or trans-10,cis-12 conjugated linoleic acid into plasma and cellular lipids in healthy men
    Graham C Burdge
    Institute of Human Nutrition, University of Southampton, Southampton, SO16 7PX UK
    J Lipid Res 45:736-41. 2004
    ..These data suggest that the level of intake is a major determinant of plasma and PBMC CLA content, although PBMCs appear to incorporate both CLA isomers less readily...
  80. ncbi Consumption of soy isoflavones does not affect plasma total homocysteine or asymmetric dimethylarginine concentrations in healthy postmenopausal women
    Manja Reimann
    German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    J Nutr 136:100-5. 2006
    ..Changes from baseline in plasma ADMA and folate were negatively correlated (r = -0.18, P = 0.017). These results challenge the overall health effect of isoflavone supplementation in healthy postmenopausal women...
  81. ncbi Effect of altered dietary n-3 fatty acid intake upon plasma lipid fatty acid composition, conversion of [13C]alpha-linolenic acid to longer-chain fatty acids and partitioning towards beta-oxidation in older men
    Graham C Burdge
    Institute of Human Nutrition, University of Southampton, UK
    Br J Nutr 90:311-21. 2003
    ..This suggests regulation of ALNA conversion may limit the influence of variations in dietary n-3 fatty acid intake on plasma lipid compositions...
  82. ncbi Lack of effect of foods enriched with plant- or marine-derived n-3 fatty acids on human immune function
    Samantha Kew
    Institute of Human Nutrition, University of Southampton, Southampton, United Kingdom
    Am J Clin Nutr 77:1287-95. 2003
    ..CONCLUSION: An intake of <or= 9.5 g ALA/d or <or= 1.7 g EPA+DHA/d does not alter the functional activity of neutrophils, monocytes, or lymphocytes, but it changes the fatty acid composition of mononuclear cells...
  83. ncbi Relation between the fatty acid composition of peripheral blood mononuclear cells and measures of immune cell function in healthy, free-living subjects aged 25-72 y
    Samantha Kew
    Institute of Human Nutrition, University of Southampton, Southampton, United Kingdom
    Am J Clin Nutr 77:1278-86. 2003
    ..CONCLUSION: Variations in the fatty acid composition of PBMC phospholipids account for some of the variability in immune cell functions among healthy adults...
  84. ncbi UK Food Standards Agency alpha-linolenic acid workshop report
    Peter Sanderson
    Nutrition Division, Food Standards Agency, Aviation House, 125 Kingsway, London WC2 6NH, UK
    Br J Nutr 88:573-9. 2002
    ..The workshop also highlighted the possibility of feeding livestock ALA-rich oils to provide a means of increasing the dietary intake in human consumers of EPA and DHA...
  85. ncbi Proteomic biomarkers of peripheral blood mononuclear cells obtained from postmenopausal women undergoing an intervention with soy isoflavones
    Dagmar Fuchs
    Department of Food and Nutrition, Molecular Nutrition Unit, Technical University of Munich, Freising, Federal Republic of Germany
    Am J Clin Nutr 86:1369-75. 2007
    ..The incidence of cardiovascular diseases increases after menopause, and soy consumption is suggested to inhibit disease development...
  86. ncbi UK Food Standards Agency cis-monounsaturated fatty acid workshop report
    Peter Sanderson
    Nutrition Division, Food Standards Agency, Aviation House, 125 Kingsway, London, WC2 6NH, UK
    Br J Nutr 88:99-104. 2002
    ..Recommendations for studies investigating the mechanistic effects of MUFA were also made. Methods of manipulating the food chain to increase MUFA at the expense of saturated fatty acids were also discussed...
  87. ncbi Effect of sex and genotype on cardiovascular biomarker response to fish oils: the FINGEN Study
    Muriel J Caslake
    Department of Vascular Biochemistry, Faculty of Medicine, University of Glasgow, Glasgow, United Kingdom
    Am J Clin Nutr 88:618-29. 2008
    ..The lipid-modulatory effects of high intakes of the fish-oil fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are well established and likely to contribute to cardioprotective benefits...
  88. ncbi Acute ingestion of a meal rich in n-3 polyunsaturated fatty acids results in rapid gastric emptying in humans
    M Denise Robertson
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
    Am J Clin Nutr 76:232-8. 2002
    ..The effects on atherosclerosis may be partly mediated by the observed reduction in fasting and postprandial triacylglycerol concentrations after both acute and chronic n-3 PUFA ingestion...
  89. ncbi Personalised nutrition: status and perspectives
    Hans Georg Joost
    German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, Nuthetal, Germany
    Br J Nutr 98:26-31. 2007
    ..These issues need to be addressed before genotyping can become an acceptable method to guide nutritional recommendations...