Bryan Williams

Summary

Affiliation: University College London
Country: UK

Publications

  1. doi request reprint Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial
    Bryan Williams
    Institute of Cardiovascular Sciences University College London and National Institute for Health Research NIHR UCL UCL Hospitals Biomedical Research Centre, London, UK Electronic address
    Lancet 386:2059-68. 2015
  2. pmc 24-hour central aortic systolic pressure and 24-hour central pulse pressure are related to diabetic complications in type 1 diabetes - a cross-sectional study
    Simone Theilade
    Steno Diabetes Center, Niels Steensensvej 1, 2820 Gentofte, Denmark
    Cardiovasc Diabetol 12:122. 2013
  3. pmc Targets and self-management for the control of blood pressure in stroke and at risk groups (TASMIN-SR): protocol for a randomised controlled trial
    Claire O'Brien
    Primary Care Clinical Sciences, NIHR School for Primary Care Research, University of Birmingham, Edgbaston, Birmingham, UK
    BMC Cardiovasc Disord 13:21. 2013
  4. doi request reprint Novel description of the 24-hour circadian rhythms of brachial versus central aortic blood pressure and the impact of blood pressure treatment in a randomized controlled clinical trial: The Ambulatory Central Aortic Pressure (AmCAP) Study
    Bryan Williams
    Institute of Cardiovascular Science, University College London, 170 Tottenham Court Rd, London W1T 7HA, UK
    Hypertension 61:1168-76. 2013
  5. doi request reprint Blood pressure and plasma renin activity responses to different strategies to inhibit the renin-angiotensin-aldosterone system during exercise
    Bryan Williams
    Department of Cardiovascular Sciences, University of Leicester, UK
    J Renin Angiotensin Aldosterone Syst 14:56-66. 2013
  6. doi request reprint Impact of statin therapy on central aortic pressures and hemodynamics: principal results of the Conduit Artery Function Evaluation-Lipid-Lowering Arm (CAFE-LLA) Study
    Bryan Williams
    Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Building, Leicester Royal Infirmary, Leicester, UK
    Circulation 119:53-61. 2009
  7. doi request reprint Prevention And Treatment of Hypertension With Algorithm-based therapy (PATHWAY) number 2: protocol for a randomised crossover trial to determine optimal treatment for drug-resistant hypertension
    Bryan Williams
    Institute of Cardiovascular Sciences University College London UCL and National Institute for Health Research NIHR UCL UCL Hospitals Biomedical Research Centre, London, UK
    BMJ Open 5:e008951. 2015
  8. pmc Excess pressure integral predicts cardiovascular events independent of other risk factors in the conduit artery functional evaluation substudy of Anglo-Scandinavian Cardiac Outcomes Trial
    Justin E Davies
    From the International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College Healthcare NHS Trust J E D, D P F, A M, J M, S A M T and Department of Bioengineering K H P, Imperial College London, London, United Kingdom Institute of Cardiovascular Science and National Institute for Health Research NIHR, University College London Hospitals Biomedical Research Centre, University College London, London, United Kingdom P L, T T, B W, A D H Department of Clinical Pharmacology, William Harvey Research Institute, Bart s and The London, Queen Mary s School of Medicine and Dentistry, London, United Kingdom D C Cardiovascular Medicine and Nutrition at King s College London, London, United Kingdom J K C and Royal College of Surgeons in Ireland, St Stephen s Green, Dublin, Ireland A S
    Hypertension 64:60-8. 2014
  9. doi request reprint Impact of heart rate on central aortic pressures and hemodynamics: analysis from the CAFE (Conduit Artery Function Evaluation) study: CAFE-Heart Rate
    Bryan Williams
    Department of Cardiovascular Sciences, University of Leicester School of Medicine, and the Leicester NIHR Cardiovascular Biomedical Research Unit, Leicester, UK
    J Am Coll Cardiol 54:705-13. 2009
  10. ncbi request reprint The prospective, randomized investigation of the safety and efficacy of telmisartan versus ramipril using ambulatory blood pressure monitoring (PRISMA I)
    Bryan Williams
    Department of Cardiovascular Sciences, University of Leicester School of Medicine, Leicester, UK
    J Hypertens 24:193-200. 2006

Collaborators

Detail Information

Publications31

  1. doi request reprint Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial
    Bryan Williams
    Institute of Cardiovascular Sciences University College London and National Institute for Health Research NIHR UCL UCL Hospitals Biomedical Research Centre, London, UK Electronic address
    Lancet 386:2059-68. 2015
    ..We aimed to test the hypotheses that resistant hypertension is most often caused by excessive sodium retention, and that spironolactone would therefore be superior to non-diuretic add-on drugs at lowering blood pressure...
  2. pmc 24-hour central aortic systolic pressure and 24-hour central pulse pressure are related to diabetic complications in type 1 diabetes - a cross-sectional study
    Simone Theilade
    Steno Diabetes Center, Niels Steensensvej 1, 2820 Gentofte, Denmark
    Cardiovasc Diabetol 12:122. 2013
    ..We evaluate the relationship between 24 h central blood pressure and diabetes-related complications in patients with type 1 diabetes...
  3. pmc Targets and self-management for the control of blood pressure in stroke and at risk groups (TASMIN-SR): protocol for a randomised controlled trial
    Claire O'Brien
    Primary Care Clinical Sciences, NIHR School for Primary Care Research, University of Birmingham, Edgbaston, Birmingham, UK
    BMC Cardiovasc Disord 13:21. 2013
    ..This trial therefore aims to assess the added value of self-management in high risk groups over and above usual care...
  4. doi request reprint Novel description of the 24-hour circadian rhythms of brachial versus central aortic blood pressure and the impact of blood pressure treatment in a randomized controlled clinical trial: The Ambulatory Central Aortic Pressure (AmCAP) Study
    Bryan Williams
    Institute of Cardiovascular Science, University College London, 170 Tottenham Court Rd, London W1T 7HA, UK
    Hypertension 61:1168-76. 2013
    ..These novel data indicate that night-time central BP may provide prognostic importance and warrants further investigation. Clinical Trial Registration- URL: http://www.clinicaltrials.gov. Unique identifier: NCT00865020...
  5. doi request reprint Blood pressure and plasma renin activity responses to different strategies to inhibit the renin-angiotensin-aldosterone system during exercise
    Bryan Williams
    Department of Cardiovascular Sciences, University of Leicester, UK
    J Renin Angiotensin Aldosterone Syst 14:56-66. 2013
    ....
  6. doi request reprint Impact of statin therapy on central aortic pressures and hemodynamics: principal results of the Conduit Artery Function Evaluation-Lipid-Lowering Arm (CAFE-LLA) Study
    Bryan Williams
    Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Building, Leicester Royal Infirmary, Leicester, UK
    Circulation 119:53-61. 2009
    ....
  7. doi request reprint Prevention And Treatment of Hypertension With Algorithm-based therapy (PATHWAY) number 2: protocol for a randomised crossover trial to determine optimal treatment for drug-resistant hypertension
    Bryan Williams
    Institute of Cardiovascular Sciences University College London UCL and National Institute for Health Research NIHR UCL UCL Hospitals Biomedical Research Centre, London, UK
    BMJ Open 5:e008951. 2015
    ..A popular hypothesis is that resistant hypertension is due to excessive Na(+)-retention, and that 'further diuretic therapy' will be superior to alternative add-on drugs...
  8. pmc Excess pressure integral predicts cardiovascular events independent of other risk factors in the conduit artery functional evaluation substudy of Anglo-Scandinavian Cardiac Outcomes Trial
    Justin E Davies
    From the International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College Healthcare NHS Trust J E D, D P F, A M, J M, S A M T and Department of Bioengineering K H P, Imperial College London, London, United Kingdom Institute of Cardiovascular Science and National Institute for Health Research NIHR, University College London Hospitals Biomedical Research Centre, University College London, London, United Kingdom P L, T T, B W, A D H Department of Clinical Pharmacology, William Harvey Research Institute, Bart s and The London, Queen Mary s School of Medicine and Dentistry, London, United Kingdom D C Cardiovascular Medicine and Nutrition at King s College London, London, United Kingdom J K C and Royal College of Surgeons in Ireland, St Stephen s Green, Dublin, Ireland A S
    Hypertension 64:60-8. 2014
    ..XSPI is a novel indicator of cardiovascular dysfunction and independently predicts cardiovascular events and targets organ damage in a prospective clinical trial. ..
  9. doi request reprint Impact of heart rate on central aortic pressures and hemodynamics: analysis from the CAFE (Conduit Artery Function Evaluation) study: CAFE-Heart Rate
    Bryan Williams
    Department of Cardiovascular Sciences, University of Leicester School of Medicine, and the Leicester NIHR Cardiovascular Biomedical Research Unit, Leicester, UK
    J Am Coll Cardiol 54:705-13. 2009
    ..The present study examined the importance of heart rate (HR) as a determinant of this effect...
  10. ncbi request reprint The prospective, randomized investigation of the safety and efficacy of telmisartan versus ramipril using ambulatory blood pressure monitoring (PRISMA I)
    Bryan Williams
    Department of Cardiovascular Sciences, University of Leicester School of Medicine, Leicester, UK
    J Hypertens 24:193-200. 2006
    ..To compare the efficacy and safety of once-daily telmisartan and ramipril on blood pressure (BP) reductions during the last 6 h of the dosing interval...
  11. doi request reprint Development and validation of a novel method to derive central aortic systolic pressure from the radial pressure waveform using an n-point moving average method
    Bryan Williams
    Department of Cardiovascular Sciences, University of Leicester, and the Leicester NIHR Biomedical Research Unit in Cardiovascular Diseases, Leicester, United Kingdom
    J Am Coll Cardiol 57:951-61. 2011
    ....
  12. pmc Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1·25 million people
    Eleni Rapsomaniki
    The Farr Institute of Health Informatics Research, London, UK Epidemiology and Public Health, University College London, London, UK Electronic address
    Lancet 383:1899-911. 2014
    ..In this study, we aimed to analyse the associations of blood pressure with 12 different presentations of cardiovascular disease...
  13. ncbi request reprint Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study
    Bryan Williams
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Circulation 113:1213-25. 2006
    ....
  14. doi request reprint Systolic pressure is all that matters
    Bryan Williams
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Lancet 371:2219-21. 2008
  15. doi request reprint The changing face of hypertension treatment: treatment strategies from the 2007 ESH/ESC hypertension Guidelines
    Bryan Williams
    Department of Cardiovascular Sciences, University of Leicester School of Medicine, Leicester, UK
    J Hypertens Suppl 27:S19-26. 2009
    ....
  16. doi request reprint Time to re-appraise the role of alpha-1 adrenoceptor antagonists in the management of hypertension?
    Neil Chapman
    International Centre for Circulatory Health, Imperial College, London, UK
    J Hypertens 28:1796-803. 2010
    ..Overall, currently available data support the use of alpha-blockers as safe, well tolerated and effective add-on antihypertensive drugs, which have additional favourable metabolic effects...
  17. doi request reprint Effects of treatment withdrawal on brachial and central aortic pressure after direct renin inhibition or angiotensin receptor blockade
    Peter S Lacy
    Institute of Cardiovascular Science and National Institute for Health Research University College London Hospitals Biomedical Research Centre, University College London, UK
    J Renin Angiotensin Aldosterone Syst 16:614-22. 2015
    ..In this ASSERTIVE sub-study, we hypothesised that aliskiren would similarly exert more sustained control of CASP than telmisartan during treatment withdrawal...
  18. doi request reprint Conduit vessel stiffness in British south Asians of Indian descent relates to 25-hydroxyvitamin D status
    David R Webb
    Department of Cardiovascular Sciences, Leicester Royal Infirmary University of Leicester, Leicester, Bedfordshire, UK
    J Hypertens 30:1588-96. 2012
    ..Vitamin D deficiency is common in this group and may play an important role mediating vascular wall senescence in response to central pressure effects...
  19. ncbi request reprint Blood pressure and outcomes in clinical trials
    Bryan Williams
    Department of Cardiovascular Sciences, University of Leicester School of Medicine, Leicester Royal Infirmary, Leicester, UK
    J Hypertens 23:487-8. 2005
  20. doi request reprint Cost-effectiveness of options for the diagnosis of high blood pressure in primary care: a modelling study
    Kate Lovibond
    National Clinical Guideline Centre, Royal College of Physicians, London, UK
    Lancet 378:1219-30. 2011
    ..We aimed to compare the cost-effectiveness of different diagnostic strategies for hypertension...
  21. pmc A role for mitochondrial oxidants in stress-induced premature senescence of human vascular smooth muscle cells
    Yogita Mistry
    Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK
    Redox Biol 1:411-7. 2013
    ....
  22. ncbi request reprint Protection against stroke and dementia: an update on the latest clinical trial evidence
    Bryan Williams
    Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Building, PO Box 65, Leicester Royal Infirmary, Leicester, LE2 7LX, UK
    Curr Hypertens Rep 6:307-13. 2004
    ..Ultimately, however, all agree that for patients with the highest risk for cardiovascular and cerebrovascular complications, the strategy of intervention is immaterial, and drug therapy, including low-dose aspirin, is vital...
  23. pmc Angiotensin II-mediated oxidative DNA damage accelerates cellular senescence in cultured human vascular smooth muscle cells via telomere-dependent and independent pathways
    Karl E Herbert
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Circ Res 102:201-8. 2008
    ....
  24. ncbi request reprint Increased pulse wave velocity is not associated with elevated augmentation index in patients with diabetes
    Peter S Lacy
    Department of Cardiovascular Sciences, Cardiovascular Research Institute, University of Leicester, Leicester LE2 7LX, UK
    J Hypertens 22:1937-44. 2004
    ..This study compares the relationship between PWV and AI in people with and without diabetes...
  25. doi request reprint Effects of visit-to-visit variability in systolic blood pressure on macrovascular and microvascular complications in patients with type 2 diabetes mellitus: the ADVANCE trial
    Jun Hata
    From The George Institute for Global Health, University of Sydney, Sydney, Australia J H, H A, M W, S Z, C A, A P, B N, S M, J C University of Oxford, Oxford, United Kingdom P M R, S M School of Public Health, Monash University, Clayton, Australia S Z Bond University, Gold Coast, Australia P G Université de Montréal, Montreal, Canada P H University of Milan Bicocca, Milan, Italy G M Imperial College, London, United Kingdom N P and University College London UCL and the National Institute for Health Research UCL Hospitals Biomedical Research Centre, London, United Kingdom B W
    Circulation 128:1325-34. 2013
    ..However, it remains uncertain whether these parameters predict the risks of macrovascular and microvascular complications in patients with type 2 diabetes mellitus...
  26. pmc Predicting out-of-office blood pressure level using repeated measurements in the clinic: an observational cohort study
    James P Sheppard
    aNuffield Department of Primary Care Health Sciences, University of Oxford bNational Institute for Health Research School for Primary Care Research, Radcliffe Observatory Quarter, Woodstock Road, Oxford cPrimary Care Clinical Sciences, University of Birmingham, Edgbaston, Birmingham dSchool of Psychology, Darwin Building, University of Central Lancashire, Preston, Lancashire ePrimary Care Unit, Institute of Public Health, University of Cambridge, Cambridge, Cambridgeshire fSchool of Medicine, University of Southampton, University Road, Southampton gInstitute of Cardiovascular Sciences, University College London UCL and National Institute for Health Research UCL Hospitals Biomedical Research Centre, London, UK
    J Hypertens 32:2171-8; discussion 2178. 2014
    ..This study assessed whether changes in SBP with repeated measurement at a single clinic predict subsequent differences between clinic and home measurements...
  27. pmc High rates of non-adherence to antihypertensive treatment revealed by high-performance liquid chromatography-tandem mass spectrometry (HP LC-MS/MS) urine analysis
    Maciej Tomaszewski
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Heart 100:855-61. 2014
    ..We used a simple urine-based assay to evaluate the prevalence of antihypertensive treatment non-adherence and its impact on blood pressure in a specialist hypertension centre...
  28. pmc Rationale and study design of the Prospective comparison of Angiotensin Receptor neprilysin inhibitor with Angiotensin receptor blocker MEasuring arterial sTiffness in the eldERly (PARAMETER) study
    Bryan Williams
    Department of Cardiovascular Sciences and National Institute for Health Research NIHR University College London UCL Hospitals Biomedical Research Centre, University College London, London, UK
    BMJ Open 4:e004254. 2014
    ....
  29. ncbi request reprint Rapid telomere attrition in cardiac tissue of the ageing Wistar rat
    Richard Hastings
    Department of Cardiovascular Sciences, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, UK
    Exp Gerontol 39:855-7. 2004
    ..Moreover, we show differential rates of telomere attrition in rat tissues, the heart being most susceptible to telomere loss. These observations could have important implications for the study of age-specific changes in tissue function...
  30. pmc A novel foundation-year-two post in academic medicine
    Adrian G Stanley
    Department of Cardiovascular Sciences, University of Leicester, Robert Kilpatrick Building, Leicester Royal Infirmary, Leicester LE2 7LX, UK
    J R Soc Med 98:10-3. 2005
  31. pmc British Hypertension Society guidelines for hypertension management 2004 (BHS-IV): summary
    Bryan Williams
    Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Building, Leicester Royal Infirmary, Leicester
    BMJ 328:634-40. 2004