B Williams

Summary

Affiliation: University of Leicester
Country: UK

Publications

  1. doi Development and validation of a novel method to derive central aortic systolic pressure from the radial pressure waveform using an n-point moving average method
    Bryan Williams
    Department of Cardiovascular Sciences, University of Leicester, and the Leicester NIHR Biomedical Research Unit in Cardiovascular Diseases, Leicester, United Kingdom
    J Am Coll Cardiol 57:951-61. 2011
  2. doi Evaluating interventions to reduce central aortic pressure, arterial stiffness and morbidity--mortality
    Bryan Williams
    Department of Cardiovascular Sciences and NIHR Biomedical Research Unit in Cardiovascular Diseases, University of Leicester School of Medicine, Leicester, UK
    J Hypertens 30:S13-8. 2012
  3. pmc Protocol for a randomised controlled trial of telemonitoring and self-management in the control of hypertension: telemonitoring and self-management in hypertension. [ISRCTN17585681]
    Richard J McManus
    Primary Care Clinical Sciences, Primary Care and Clinical Sciences Building, University of Birmingham, Birmingham, UK
    BMC Cardiovasc Disord 9:6. 2009
  4. ncbi Guidelines for management of hypertension: report of the fourth working party of the British Hypertension Society, 2004-BHS IV
    B Williams
    Department of Cardiovascular Sciences, Clinical Sciences Building, Leicester Royal Infirmary, University of Leicester, UK
    J Hum Hypertens 18:139-85. 2004
  5. pmc British Hypertension Society guidelines for hypertension management 2004 (BHS-IV): summary
    Bryan Williams
    Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Building, Leicester Royal Infirmary, Leicester
    BMJ 328:634-40. 2004
  6. ncbi The Hypertension in Diabetes Study (HDS): a catalyst for change
    B Williams
    Department of Cardiovascular Sciences, University of Leicester School of Medicine, Leicester, UK
    Diabet Med 25:13-9. 2008
  7. doi Systolic pressure is all that matters
    Bryan Williams
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Lancet 371:2219-21. 2008
  8. doi The year in hypertension
    Bryan Williams
    Department of Cardiovascular Sciences, University of Leicester School of Medicine, Leicester, United Kingdom
    J Am Coll Cardiol 51:1803-17. 2008
  9. ncbi Protection against stroke and dementia: an update on the latest clinical trial evidence
    Bryan Williams
    Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Building, PO Box 65, Leicester Royal Infirmary, Leicester, LE2 7LX, UK
    Curr Hypertens Rep 6:307-13. 2004
  10. ncbi Blood pressure and outcomes in clinical trials
    Bryan Williams
    Department of Cardiovascular Sciences, University of Leicester School of Medicine, Leicester Royal Infirmary, Leicester, UK
    J Hypertens 23:487-8. 2005

Collaborators

Detail Information

Publications61

  1. doi Development and validation of a novel method to derive central aortic systolic pressure from the radial pressure waveform using an n-point moving average method
    Bryan Williams
    Department of Cardiovascular Sciences, University of Leicester, and the Leicester NIHR Biomedical Research Unit in Cardiovascular Diseases, Leicester, United Kingdom
    J Am Coll Cardiol 57:951-61. 2011
    ....
  2. doi Evaluating interventions to reduce central aortic pressure, arterial stiffness and morbidity--mortality
    Bryan Williams
    Department of Cardiovascular Sciences and NIHR Biomedical Research Unit in Cardiovascular Diseases, University of Leicester School of Medicine, Leicester, UK
    J Hypertens 30:S13-8. 2012
    ..A remaining challenge is to link any potentially favorable changes in aortic pressure and/or stiffness to improvements in morbidity and mortality over and above those expected from conventional BP lowering...
  3. pmc Protocol for a randomised controlled trial of telemonitoring and self-management in the control of hypertension: telemonitoring and self-management in hypertension. [ISRCTN17585681]
    Richard J McManus
    Primary Care Clinical Sciences, Primary Care and Clinical Sciences Building, University of Birmingham, Birmingham, UK
    BMC Cardiovasc Disord 9:6. 2009
    ..Self-management of hypertension is an under researched area in which potential benefits for both patients and professionals are great...
  4. ncbi Guidelines for management of hypertension: report of the fourth working party of the British Hypertension Society, 2004-BHS IV
    B Williams
    Department of Cardiovascular Sciences, Clinical Sciences Building, Leicester Royal Infirmary, University of Leicester, UK
    J Hum Hypertens 18:139-85. 2004
  5. pmc British Hypertension Society guidelines for hypertension management 2004 (BHS-IV): summary
    Bryan Williams
    Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Building, Leicester Royal Infirmary, Leicester
    BMJ 328:634-40. 2004
  6. ncbi The Hypertension in Diabetes Study (HDS): a catalyst for change
    B Williams
    Department of Cardiovascular Sciences, University of Leicester School of Medicine, Leicester, UK
    Diabet Med 25:13-9. 2008
    ....
  7. doi Systolic pressure is all that matters
    Bryan Williams
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Lancet 371:2219-21. 2008
  8. doi The year in hypertension
    Bryan Williams
    Department of Cardiovascular Sciences, University of Leicester School of Medicine, Leicester, United Kingdom
    J Am Coll Cardiol 51:1803-17. 2008
  9. ncbi Protection against stroke and dementia: an update on the latest clinical trial evidence
    Bryan Williams
    Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Building, PO Box 65, Leicester Royal Infirmary, Leicester, LE2 7LX, UK
    Curr Hypertens Rep 6:307-13. 2004
    ..Ultimately, however, all agree that for patients with the highest risk for cardiovascular and cerebrovascular complications, the strategy of intervention is immaterial, and drug therapy, including low-dose aspirin, is vital...
  10. ncbi Blood pressure and outcomes in clinical trials
    Bryan Williams
    Department of Cardiovascular Sciences, University of Leicester School of Medicine, Leicester Royal Infirmary, Leicester, UK
    J Hypertens 23:487-8. 2005
  11. ncbi Recent hypertension trials: implications and controversies
    Bryan Williams
    Department of Cardiovascular Sciences, University of Leicester School of Medicine, Leicester, United Kingdom
    J Am Coll Cardiol 45:813-27. 2005
    ..Undoubtedly, the most effective way to "go beyond blood pressure" is to add a statin...
  12. ncbi The prospective, randomized investigation of the safety and efficacy of telmisartan versus ramipril using ambulatory blood pressure monitoring (PRISMA I)
    Bryan Williams
    Department of Cardiovascular Sciences, University of Leicester School of Medicine, Leicester, UK
    J Hypertens 24:193-200. 2006
    ..To compare the efficacy and safety of once-daily telmisartan and ramipril on blood pressure (BP) reductions during the last 6 h of the dosing interval...
  13. ncbi Mechanical influences on vascular smooth muscle cell function
    B Williams
    Cardiovascular Research Institute, University of Leicester, UK
    J Hypertens 16:1921-9. 1998
    ..The study of vascular mechanotransduction has begun to delineate the complex cellular basis of cardiovascular structural and functional modification in hypertension...
  14. doi The changing face of hypertension treatment: treatment strategies from the 2007 ESH/ESC hypertension Guidelines
    Bryan Williams
    Department of Cardiovascular Sciences, University of Leicester School of Medicine, Leicester, UK
    J Hypertens Suppl 27:S19-26. 2009
    ....
  15. doi Impact of heart rate on central aortic pressures and hemodynamics: analysis from the CAFE (Conduit Artery Function Evaluation) study: CAFE-Heart Rate
    Bryan Williams
    Department of Cardiovascular Sciences, University of Leicester School of Medicine, and the Leicester NIHR Cardiovascular Biomedical Research Unit, Leicester, UK
    J Am Coll Cardiol 54:705-13. 2009
    ..The present study examined the importance of heart rate (HR) as a determinant of this effect...
  16. ncbi A potential role for angiotensin II-induced vascular endothelial growth factor expression in the pathogenesis of diabetic nephropathy?
    B Williams
    Cardiovascular Research Institute, University of Leicester, UK
    Miner Electrolyte Metab 24:400-5. 1998
    ..This review considers the potential clinical significance of Ang II-induced VEGF expression, if any, in the pathogenesis of diabetic nephropathy and retinopathy...
  17. doi Impact of statin therapy on central aortic pressures and hemodynamics: principal results of the Conduit Artery Function Evaluation-Lipid-Lowering Arm (CAFE-LLA) Study
    Bryan Williams
    Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Building, Leicester Royal Infirmary, Leicester, UK
    Circulation 119:53-61. 2009
    ....
  18. doi Impact of metabolic indices on central artery stiffness: independent association of insulin resistance and glucose with aortic pulse wave velocity
    D R Webb
    Diabetes and Vascular Research Group, Department of Cardiovascular Sciences, University of Leicester, Leicester LE1 5WW, UK
    Diabetologia 53:1190-8. 2010
    ..We used carotid-femoral pulse wave velocity ((cf)PWV) to quantify independent associations of fasting glucose, post-challenge glucose and derived insulin resistance (HOMA-IR) with aortic stiffness...
  19. doi Antihypertensive efficacy of telmisartan vs ramipril over the 24-h dosing period, including the critical early morning hours: a pooled analysis of the PRISMA I and II randomized trials
    B Williams
    Department of Cardiovascular Sciences, Clinical Sciences Building, Leicester Royal Infirmary, Leicester, UK
    J Hum Hypertens 23:610-9. 2009
    ....
  20. ncbi Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study
    Bryan Williams
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Circulation 113:1213-25. 2006
    ....
  21. ncbi Angiotensin II and the pathophysiology of cardiovascular remodeling
    B Williams
    Cardiovascular Research Institute, Leicester University Medical School, Leicester, UK
    Am J Cardiol 87:10C-17C. 2001
    ..Mechanical strain also induces fibrosis in a mechanism mediated by TGF-beta(1). This cytokine thus represents a common pathway by which angiotensin II and increased arterial pressure may induce cardiovascular fibrosis...
  22. ncbi Telomere attrition and accumulation of senescent cells in cultured human endothelial cells
    R Hastings
    Department of Cardiovascular Sciences, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, UK
    Cell Prolif 37:317-24. 2004
    ..They suggest that DNA damage and subsequent telomere attrition are likely to be key mechanisms driving the development of endothelial senescence in the pathogenesis of vascular disease...
  23. ncbi The year in hypertension
    Bryan Williams
    Department of Cardiovascular Sciences, University of Leicester School of Medicine, Leicester, United Kingdom
    J Am Coll Cardiol 48:1698-711. 2006
  24. ncbi Rapid telomere attrition in cardiac tissue of the ageing Wistar rat
    Richard Hastings
    Department of Cardiovascular Sciences, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, UK
    Exp Gerontol 39:855-7. 2004
    ..Moreover, we show differential rates of telomere attrition in rat tissues, the heart being most susceptible to telomere loss. These observations could have important implications for the study of age-specific changes in tissue function...
  25. pmc A novel foundation-year-two post in academic medicine
    Adrian G Stanley
    Department of Cardiovascular Sciences, University of Leicester, Robert Kilpatrick Building, Leicester Royal Infirmary, Leicester LE2 7LX, UK
    J R Soc Med 98:10-3. 2005
  26. ncbi Galectin 1 inhibits incorporation of vitronectin and chondroitin sulfate B into the extracellular matrix of human vascular smooth muscle cells
    Elena P Moiseeva
    Division of Cardiology, Department of Medicine, University of Leicester, Clinical Sciences Wing, Glenfield General Hospital, Leicester LE3 9QP, UK
    Biochim Biophys Acta 1619:125-32. 2003
    ..These results suggest that galectin-1 is likely to be involved in the ECM assembly affecting incorporation of some ECM components important for SMC behaviour...
  27. ncbi Increased pulse wave velocity is not associated with elevated augmentation index in patients with diabetes
    Peter S Lacy
    Department of Cardiovascular Sciences, Cardiovascular Research Institute, University of Leicester, Leicester LE2 7LX, UK
    J Hypertens 22:1937-44. 2004
    ..This study compares the relationship between PWV and AI in people with and without diabetes...
  28. ncbi Evolution of hypertensive disease: a revolution in guidelines
    Bryan Williams
    University of Leicester School of Medicine, Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, UK
    Lancet 368:6-8. 2006
  29. ncbi Calcium channel blockade in combination with angiotensin-converting enzyme inhibition or angiotensin II (AT(1)-receptor) antagonism in hypertensive diabetics and patients with renal disease and hypertension
    Philip Swales
    Cardiovascular Research Institute, University of Leicester, Leicester Royal Infirmary, UK
    J Renin Angiotensin Aldosterone Syst 3:79-89. 2002
    ..The choice of antihypertensive combination therapy should not override the fundamental necessity of lowering BP to target levels...
  30. ncbi Mechanical strain-induced human vascular matrix synthesis: the role of angiotensin II
    A G Stanley
    Cardiovascular Research Institute, Leicester Royal Infirmary, Leicester, LE2 7LX, UK
    J Renin Angiotensin Aldosterone Syst 1:32-5. 2000
    ....
  31. ncbi Reduced glomerular filtration rate in pre-dialysis non-diabetic chronic kidney disease patients is associated with impaired baroreceptor sensitivity and reduced vascular compliance
    Peter Lacy
    Department of Cardiovascular Science, Leicester Warwick Medical Schools, Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, UK
    Clin Sci (Lond) 110:101-8. 2006
    ..This may have important prognostic and therapeutic consequences for the management of vascular disease in a pre-dialysis population...
  32. ncbi Galectin-1 interacts with beta-1 subunit of integrin
    Elena P Moiseeva
    Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield General Hospital, Leicester, UK
    Biochem Biophys Res Commun 310:1010-6. 2003
    ..Galectin-1 is likely to affect SMC adhesion by interacting with beta1 integrin on the cell surface of SMCs and inducing outside-in signalling...
  33. ncbi Differential effects of vascular endothelial growth factor-C and placental growth factor-1 on the hydraulic conductivity of frog mesenteric capillaries
    N J Hillman
    Cardiovascular Research Institute, University of Leicester, Leicester, UK
    J Vasc Res 38:176-86. 2001
    ..This supports the hypothesis that chronic increases in microvascular permeability induced by VEGF are mediated via activation of VEGF-R2 rather than VEGF-R1...
  34. ncbi Telomere length in small-for-gestational-age babies
    A Akkad
    Fetal Growth and Development Research Group, Reproductive Science Section, Department of Cancer Studies and Molecular Medicine, Univerity of Leicester, Leicester, UK
    BJOG 113:318-23. 2006
    ..Short telomeres are associated with adult cardiovascular disease. Our aim was to determine whether small-for-gestational-age (SGA) newborns have shortened telomeres compared with appropriately grown controls...
  35. ncbi Mechanical stretch has contrasting effects on mediator release from bronchial epithelial cells, with a rho-kinase-dependent component to the mechanotransduction pathway
    R A Thomas
    Institute for Lung Health, University of Leicester, UK
    Respir Med 100:1588-97. 2006
    ..We have used a model of cell deformation to measure the effect of stretch on inflammatory cytokine release by the BEAS 2B cell line, and to examine the method of mechanotransduction in these cells...
  36. pmc Angiotensin II-mediated oxidative DNA damage accelerates cellular senescence in cultured human vascular smooth muscle cells via telomere-dependent and independent pathways
    Karl E Herbert
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Circ Res 102:201-8. 2008
    ....
  37. ncbi The diabetogenic potential of thiazide-type diuretic and beta-blocker combinations in patients with hypertension
    James M Mason
    School for Health, University of Durham, Queen s Campus, Wolfson Research Unit, University Boulevard, Stockton on Tees, Newcastle upon Tyne, UK
    J Hypertens 23:1777-81. 2005
    ..Thiazide-type diuretics (thiazides) and beta-blockers have been individually implicated, but these drugs are frequently combined, and the magnitude of risk associated with their combined use has not been quantified...
  38. ncbi Lifestyle interventions to reduce raised blood pressure: a systematic review of randomized controlled trials
    Heather O Dickinson
    University of Newcastle upon Tyne, Centre for Health Services Research, Newcastle upon Tyne, UK
    J Hypertens 24:215-33. 2006
    ..To quantify effectiveness of lifestyle interventions for hypertension...
  39. ncbi Pharmacological management of hypertension
    Bernard Higgins
    National Collaborating Centre for Chronic Conditions, Regent s Park, London
    Clin Med 7:612-6. 2007
    ....
  40. ncbi VALUE and supremacy of blood pressure control for cardiovascular protection
    Bryan Williams
    J Hypertens 22:1435-7. 2004
  41. pmc Treatment of hypertension in the UK: simple as ABCD?
    Bryan Williams
    J R Soc Med 96:521-2. 2003
  42. ncbi Treating hypertension: it is not how you start but where you end that matters
    Bryan Williams
    J Hypertens 21:455-7. 2003
  43. ncbi [ESH/ESC 2007 Guidelines for the management of arterial hypertension]
    Giuseppe Mancia
    Clinica Medica, Ospedale San Gerardo, Universita Milano Bicocca, Monza, Milano, Italia
    Rev Esp Cardiol 60:968.e1-94. 2007
  44. ncbi Essential hypertension
    Franz H Messerli
    Division of Cardiology, St Luke s Roosevelt Hospital Center, Columbia University, College of Physicians and Surgeons, New York, NY 10019, USA
    Lancet 370:591-603. 2007
    ..Despite the availability of effective and safe antihypertensive drugs, hypertension and its concomitant risk factors remain uncontrolled in most patients...
  45. ncbi Beta-blockers and the treatment of hypertension
    Bryan Williams
    J Hypertens 25:1351-3. 2007
  46. ncbi 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)
    Giuseppe Mancia
    Clinica Medica, Ospedale San Gerardo, Universita Milano Bicocca, Via Pergolesi, 33 20052 MONZA Milano, Italy
    J Hypertens 25:1105-87. 2007
  47. ncbi Central blood pressure measurements and antihypertensive therapy: a consensus document
    Enrico Agabiti-Rosei
    Clinica Medica and Department of Medicine, University Hospital, Brescia, Italy
    Hypertension 50:154-60. 2007
  48. ncbi Angiotensin-converting enzyme inhibitors versus angiotensin receptor blockers. A mini-symposium held at the British Hypertension Society Meeting, September 2005
    Neil Poulter
    J Renin Angiotensin Aldosterone Syst 7:104-21. 2006
  49. ncbi Hypertension in the young: preventing the evolution of disease versus prevention of clinical events
    Bryan Williams
    J Am Coll Cardiol 50:840-2. 2007
  50. ncbi Drug specific benefits and cardiovascular and stroke outcomes
    Bryan Williams
    J Hypertens 21:1609-10. 2003
  51. pmc Drug treatment of hypertension
    Bryan Williams
    BMJ 326:61-2. 2003
  52. ncbi Microalbuminuria in essential hypertension: redefining the threshold
    Josep Redon
    J Hypertens 20:353-5. 2002
  53. ncbi The regulation of human vascular smooth muscle extracellular matrix protein production by alpha- and beta-adrenoceptor stimulation
    Christopher J O'Callaghan
    Department of Clinical Pharmacology, Austin and Repatriation Medical Centre, Heidelberg, Australia
    J Hypertens 20:287-94. 2002
    ..The present study thus investigated the direct effect of adrenergic stimulation on ECM protein production by cultured human vascular smooth muscle (VSM) cells...
  54. ncbi Transient bacteremia induced by toothbrushing a comparison of the Sonicare toothbrush with a conventional toothbrush
    Shamsi Bhanji
    Dental Medicine, Children s Hospital, Seattle, Wash, USA
    Pediatr Dent 24:295-9. 2002
    ..This study assessed bacteremia levels after brushing with either the Sonicare electric toothbrush or a manual toothbrush...
  55. ncbi Efficacy of indapamide SR compared with enalapril in elderly hypertensive patients with type 2 diabetes
    Juan Garcia Puig
    Servicio de Medicina Interna, Hospital La Paz, Paseo de la Castellana 261, 28046 Madrid, Spain
    Am J Hypertens 20:90-7. 2007
    ....
  56. ncbi Pulse wave analysis and hypertension: evangelism versus scepticism
    Bryan Williams
    J Hypertens 22:447-9. 2004
  57. ncbi The obese hypertensive: the weight of evidence against beta-blockers
    Bryan Williams
    Circulation 115:1973-4. 2007
  58. doi Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes
    Anushka Patel
    N Engl J Med 358:2560-72. 2008
    ..In patients with type 2 diabetes, the effects of intensive glucose control on vascular outcomes remain uncertain...
  59. ncbi Equivalence of indapamide SR and enalapril on microalbuminuria reduction in hypertensive patients with type 2 diabetes: the NESTOR Study
    Michel Marre
    Hopital Bichat, Service de Diab├ętologie et d Endocrinologie, Paris, France
    J Hypertens 22:1613-22. 2004
    ....
  60. ncbi 2007 Guidelines for the management of arterial hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)
    Giuseppe Mancia
    Clinica Medica, Ospedale San Gerardo, Universita Milano Bicocca, Via Pergolesi, 33 20052 MONZA Milano, Italy
    Eur Heart J 28:1462-536. 2007
  61. doi Retinal vascular lesions in patients of Caucasian and Asian origin with type 2 diabetes: baseline results from the ADVANCE Retinal Measurements (AdRem) study
    Ronald P Stolk
    Department of Epidemiology, University Medical Center Groningen, P O Box 30 001, 9700RB Groningen, The Netherlands
    Diabetes Care 31:708-13. 2008
    ....