Alistair J K Williams

Summary

Affiliation: University of Bristol
Country: UK

Publications

  1. pmc The core cysteines, (C909) of islet antigen-2 and (C945) of islet antigen-2β, are crucial to autoantibody binding in type 1 diabetes
    Karen T Elvers
    School of Clinical Sciences, Learning and Research, University of Bristol, Southmead Hospital, Bristol, UK
    Diabetes 62:214-22. 2013
  2. pmc Rising incidence of type 1 diabetes is associated with altered immunophenotype at diagnosis
    Anna E Long
    School of Clinical Sciences, University of Bristol, Bristol, UK
    Diabetes 61:683-6. 2012
  3. doi request reprint Pancreatic volume is reduced in adult patients with recently diagnosed type 1 diabetes
    Alistair J K Williams
    School of Clinical Sciences, Learning and Research Building, Southmead Hospital, Bristol BS10 5NB, United Kingdom
    J Clin Endocrinol Metab 97:E2109-13. 2012
  4. doi request reprint Worth the wait: type 1 diabetes prospective birth cohort studies enter adolescence
    A J K Williams
    University of Bristol School of Clinical Sciences, Learning and Research Building, Southmead Hospital, Bristol BS10 5NB, UK
    Diabetologia 55:1873-6. 2012
  5. ncbi request reprint Magnetic resonance imaging: a reliable method for measuring pancreatic volume in Type 1 diabetes
    A J K Williams
    Clinical Science at North Bristol, University of Bristol, UK
    Diabet Med 24:35-40. 2007
  6. pmc Azide and Tween-20 reduce binding to autoantibody epitopes of islet antigen-2; implications for assay performance and reproducibility
    Alistair J K Williams
    Clinical Science at North Bristol, Southmead Hospital, Bristol, UK
    J Immunol Methods 351:75-9. 2009
  7. ncbi request reprint Non-specific binding to protein A Sepharose and protein G Sepharose in insulin autoantibody assays may be reduced by pre-treatment with glycine or ethanolamine
    Alistair J K Williams
    Clinical Science at North Bristol, University of Bristol, UK
    J Immunol Methods 314:170-3. 2006
  8. doi request reprint Anti-BSA antibodies are a major cause of non-specific binding in insulin autoantibody radiobinding assays
    Alistair J K Williams
    School of Clinical Sciences, University of Bristol, Bristol, UK
    J Immunol Methods 362:199-203. 2010
  9. doi request reprint The role of autoantibodies to zinc transporter 8 in prediction of type 1 diabetes in relatives: lessons from the European Nicotinamide Diabetes Intervention Trial (ENDIT) cohort
    Anna E Long
    School of Clinical Sciences, University of Bristol, Bristol BS10 5NB, UK
    J Clin Endocrinol Metab 97:632-7. 2012
  10. pmc Humoral responses to islet antigen-2 and zinc transporter 8 are attenuated in patients carrying HLA-A*24 alleles at the onset of type 1 diabetes
    Anna E Long
    School of Clinical Sciences, University of Bristol, Bristol, UK
    Diabetes 62:2067-71. 2013

Detail Information

Publications19

  1. pmc The core cysteines, (C909) of islet antigen-2 and (C945) of islet antigen-2β, are crucial to autoantibody binding in type 1 diabetes
    Karen T Elvers
    School of Clinical Sciences, Learning and Research, University of Bristol, Southmead Hospital, Bristol, UK
    Diabetes 62:214-22. 2013
    ..In most patients, at disease onset, >90% of antibodies binding to the PTP domain of IA-2 recognize just two epitope regions...
  2. pmc Rising incidence of type 1 diabetes is associated with altered immunophenotype at diagnosis
    Anna E Long
    School of Clinical Sciences, University of Bristol, Bristol, UK
    Diabetes 61:683-6. 2012
    ..Understanding how changes in environment or lifestyle alter the humoral autoimmune response to islet antigens should help explain why the incidence of type 1 diabetes is increasing and may suggest new strategies for preventing disease...
  3. doi request reprint Pancreatic volume is reduced in adult patients with recently diagnosed type 1 diabetes
    Alistair J K Williams
    School of Clinical Sciences, Learning and Research Building, Southmead Hospital, Bristol BS10 5NB, United Kingdom
    J Clin Endocrinol Metab 97:E2109-13. 2012
    ..Pancreatic atrophy is common in longstanding type 1 diabetes, but there are limited data concerning pancreas size at diagnosis...
  4. doi request reprint Worth the wait: type 1 diabetes prospective birth cohort studies enter adolescence
    A J K Williams
    University of Bristol School of Clinical Sciences, Learning and Research Building, Southmead Hospital, Bristol BS10 5NB, UK
    Diabetologia 55:1873-6. 2012
    ..These findings emphasise the importance of early life events in disease pathogenesis and have major implications for efforts aimed at preventing type 1 diabetes...
  5. ncbi request reprint Magnetic resonance imaging: a reliable method for measuring pancreatic volume in Type 1 diabetes
    A J K Williams
    Clinical Science at North Bristol, University of Bristol, UK
    Diabet Med 24:35-40. 2007
    ..To validate magnetic resonance imaging (MRI) for monitoring pancreatic atrophy in Type 1 diabetes...
  6. pmc Azide and Tween-20 reduce binding to autoantibody epitopes of islet antigen-2; implications for assay performance and reproducibility
    Alistair J K Williams
    Clinical Science at North Bristol, Southmead Hospital, Bristol, UK
    J Immunol Methods 351:75-9. 2009
    ..We conclude that common assay reagents such as azide and Tween-20 can strongly influence IA-2A binding in an epitope-related manner, and their use may explain some of the differences between laboratories in IA-2A measurement...
  7. ncbi request reprint Non-specific binding to protein A Sepharose and protein G Sepharose in insulin autoantibody assays may be reduced by pre-treatment with glycine or ethanolamine
    Alistair J K Williams
    Clinical Science at North Bristol, University of Bristol, UK
    J Immunol Methods 314:170-3. 2006
    ..6. Pre-treatment with glycine or ethanolamine allows "poor" batches of PAS or PGS to be used in sensitive IAA assays, improving both consistency and performance...
  8. doi request reprint Anti-BSA antibodies are a major cause of non-specific binding in insulin autoantibody radiobinding assays
    Alistair J K Williams
    School of Clinical Sciences, University of Bristol, Bristol, UK
    J Immunol Methods 362:199-203. 2010
    ..High titre BSA antibodies interfere with IAA measurement because of (125)I-BSA present in some insulin labels. Improved purification of insulin labels should obviate the need for competitive displacement...
  9. doi request reprint The role of autoantibodies to zinc transporter 8 in prediction of type 1 diabetes in relatives: lessons from the European Nicotinamide Diabetes Intervention Trial (ENDIT) cohort
    Anna E Long
    School of Clinical Sciences, University of Bristol, Bristol BS10 5NB, UK
    J Clin Endocrinol Metab 97:632-7. 2012
    ..Antibodies to islet autoantigens are detectable many years before clinical onset of type 1 diabetes and can be used to identify individuals at increased risk of diabetes. Zinc transporter 8 is a recently identified islet autoantigen...
  10. pmc Humoral responses to islet antigen-2 and zinc transporter 8 are attenuated in patients carrying HLA-A*24 alleles at the onset of type 1 diabetes
    Anna E Long
    School of Clinical Sciences, University of Bristol, Bristol, UK
    Diabetes 62:2067-71. 2013
    ..Association of an HLA class I susceptibility allele with altered islet autoantibody phenotype at diagnosis suggests CD8 T-cell and/or natural killer cell-mediated killing modulates humoral autoimmune responses...
  11. doi request reprint Early onset of diabetes in the proband is the major determinant of risk in HLA DR3-DQ2/DR4-DQ8 siblings
    Kathleen M Gillespie
    Diabetes and Metabolism, School of Clinical Sciences, University of Bristol, Bristol, U K
    Diabetes 63:1041-7. 2014
    ..This suggests that non-HLA genes or epigenetic/environmental factors that accelerate the progression of type 1 diabetes in the proband strongly affect risk in siblings. ..
  12. ncbi request reprint Islet autoimmunity in children with Down's syndrome
    Kathleen M Gillespie
    Medical School Unit, Southmead Hospital, Bristol BS10 5NB, UK
    Diabetes 55:3185-8. 2006
    ..Other factors, possibly including genes on chromosome 21, may increase the penetrance of type 1 diabetes in Down's syndrome...
  13. pmc Measurement of islet cell antibodies in the Type 1 Diabetes Genetics Consortium: efforts to harmonize procedures among the laboratories
    Polly J Bingley
    Department of Clinical Science at North Bristol, University of Bristol, Bristol, UK
    Clin Trials 7:S56-64. 2010
    ..and..
  14. ncbi request reprint Validation of autoantibody assays in type 1 diabetes: workshop programme
    Polly J Bingley
    Department of Clinical Science at North Bristol, University of Bristol, UK
    Autoimmunity 37:257-60. 2004
  15. pmc Undiagnosed coeliac disease at age seven: population based prospective birth cohort study
    Polly J Bingley
    Division of Medicine, University of Bristol, Southmead Hospital, Bristol BS10 5NB
    BMJ 328:322-3. 2004
  16. doi request reprint Autoantibodies to islet antigen-2 are associated with HLA-DRB1*07 and DRB1*09 haplotypes as well as DRB1*04 at onset of type 1 diabetes: the possible role of HLA-DQA in autoimmunity to IA-2
    A J K Williams
    Diabetes and Metabolism, Clinical Science at North Bristol, University of Bristol Medical School Unit, Southmead Hospital, Bristol, BS10 5NB, UK
    Diabetologia 51:1444-8. 2008
    ..To further our understanding of antigen presentation by HLA class II molecules, we have examined the influence of HLA class II genotype on expression of autoantibodies to islet antigen-2 (IA-2A)...
  17. ncbi request reprint Islet autoantibodies, nationality and gender: a multinational screening study in first-degree relatives of patients with Type I diabetes
    A J K Williams
    Diabetes and Metabolism, Division of Medicine, University of Bristol, UK
    Diabetologia 45:217-23. 2002
    ..Our aim was to evaluate the influence of age, gender, proband characteristics and nationality on the prevalence of ICA and co-existence of autoantibodies to GAD, IA-2 and insulin...
  18. ncbi request reprint Combined testing of antibody titer and affinity improves insulin autoantibody measurement: Diabetes Antibody Standardization Program
    Peter Achenbach
    Diabetes Research Institute, Koelner Platz 1, 80804 Munich, Germany
    Clin Immunol 122:85-90. 2007
    ..This workshop has demonstrated that different laboratories are able to reproduce IAA affinity results and that considering IAA affinity is likely to improve the diagnostic performance of IAA assays...
  19. ncbi request reprint Stratification of type 1 diabetes risk on the basis of islet autoantibody characteristics
    Peter Achenbach
    Diabetes Research Institute and 3rd Medical Department, Hospital München Schwabing, Munich, Germany
    Diabetes 53:384-92. 2004
    ..Using models based on these antibody characteristics, autoantibody-positive relatives can be classified into groups with risks of diabetes ranging from 7 to 89% within 5 years...