A R W Williams

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. doi request reprint Endometrial morphology after treatment of uterine fibroids with the selective progesterone receptor modulator, ulipristal acetate
    Alistair R W Williams
    Department of Pathology, Edinburgh University Medical School, Edinburgh, UK
    Int J Gynecol Pathol 31:556-69. 2012
  2. ncbi request reprint The effects of the selective progesterone receptor modulator asoprisnil on the morphology of uterine tissues after 3 months treatment in patients with symptomatic uterine leiomyomata
    A R W Williams
    Department of Pathology, University of Edinburgh, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, Scotland, UK
    Hum Reprod 22:1696-704. 2007
  3. ncbi request reprint Does liquid-based cytology really offer any advantage?
    Alistair R W Williams
    Department of Pathology, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, UK
    J Fam Plann Reprod Health Care 32:149. 2006
  4. doi request reprint Effect of asoprisnil on uterine proliferation markers and endometrial expression of the tumour suppressor gene, PTEN
    J Wilkens
    Division of Reproductive and Developmental Sciences, Centre for Reproductive Biology, University of Edinburgh, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Hum Reprod 24:1036-44. 2009
  5. ncbi request reprint Evaluation of PTEN expression in cervical adenocarcinoma by tissue microarray
    M Tawfik El-Mansi
    Department of Pathology, University of Edinburgh, Edinburgh, Scotland, UK
    Int J Gynecol Cancer 16:1254-60. 2006
  6. doi request reprint Factors affecting adequacy of Pipelle and Tao Brush endometrial sampling
    A R W Williams
    Department of Pathology, University of Edinburgh Medical School, Royal Infirmary of Edinburgh, Edinburgh, UK
    BJOG 115:1028-36. 2008
  7. ncbi request reprint A novel estrogen-free oral contraceptive pill for women: multicentre, double-blind, randomized controlled trial of mifepristone and progestogen-only pill (levonorgestrel)
    F Lakha
    Centre for Reproductive Biology, Simpson Centre for Reproductive Health, University of Edinburgh, 51 Little France Crescent, Edinburgh EH16 4SA, UK
    Hum Reprod 22:2428-36. 2007
  8. ncbi request reprint The role of matrix metalloproteinases-2, -7 and -9 and beta-catenin in high grade endometrial carcinoma
    H Monaghan
    Department of Laboratory Services Pathology, Royal Infirmary of Edinburgh, Edinburgh, UK
    Histopathology 50:348-57. 2007
  9. ncbi request reprint Validation of tissue microarray technology using cervical adenocarcinoma and its precursors as a model system
    M Tawfik El-Mansi
    Department of Pathology, Royal Infirmary of Edinburgh and University of Edinburgh, Edinburgh, Scotland, UK
    Int J Gynecol Cancer 16:1225-33. 2006
  10. pmc Distribution of HPV types associated with cervical cancers in Scotland and implications for the impact of HPV vaccines
    K Cuschieri
    Scottish HPV Reference Laboratory, Specialist Virology Centre, Royal Infirmary of Edinburgh, Edinburgh, UK
    Br J Cancer 102:930-2. 2010

Collaborators

Detail Information

Publications26

  1. doi request reprint Endometrial morphology after treatment of uterine fibroids with the selective progesterone receptor modulator, ulipristal acetate
    Alistair R W Williams
    Department of Pathology, Edinburgh University Medical School, Edinburgh, UK
    Int J Gynecol Pathol 31:556-69. 2012
    ..Mild reversible thickening of the endometrium occurs in a minority of cases. It is important that pathologists are aware of the spectrum of changes induced by SPRMs to avoid misdiagnoses of endometrial hyperplasia or polyps...
  2. ncbi request reprint The effects of the selective progesterone receptor modulator asoprisnil on the morphology of uterine tissues after 3 months treatment in patients with symptomatic uterine leiomyomata
    A R W Williams
    Department of Pathology, University of Edinburgh, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, Scotland, UK
    Hum Reprod 22:1696-704. 2007
    ..This study examined full-thickness endometrial, leiomyoma and myometrial morphology in hysterectomy specimens from patients with uterine leiomyomata, after treatment with asoprisnil for 3 months...
  3. ncbi request reprint Does liquid-based cytology really offer any advantage?
    Alistair R W Williams
    Department of Pathology, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, UK
    J Fam Plann Reprod Health Care 32:149. 2006
  4. doi request reprint Effect of asoprisnil on uterine proliferation markers and endometrial expression of the tumour suppressor gene, PTEN
    J Wilkens
    Division of Reproductive and Developmental Sciences, Centre for Reproductive Biology, University of Edinburgh, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Hum Reprod 24:1036-44. 2009
    ..For safety of potential clinical applications, any proliferative effect of asoprisnil on uterine tissues, particularly endometrium, needs to be established...
  5. ncbi request reprint Evaluation of PTEN expression in cervical adenocarcinoma by tissue microarray
    M Tawfik El-Mansi
    Department of Pathology, University of Edinburgh, Edinburgh, Scotland, UK
    Int J Gynecol Cancer 16:1254-60. 2006
    ..There is, however, evidence of altered distribution and intensity of PTEN expression in cervical adenocarcinoma cells...
  6. doi request reprint Factors affecting adequacy of Pipelle and Tao Brush endometrial sampling
    A R W Williams
    Department of Pathology, University of Edinburgh Medical School, Royal Infirmary of Edinburgh, Edinburgh, UK
    BJOG 115:1028-36. 2008
    ..To compare factors influencing adequacy of endometrial samples obtained using two outpatient sampling devices--Pipelle and Tao Brush...
  7. ncbi request reprint A novel estrogen-free oral contraceptive pill for women: multicentre, double-blind, randomized controlled trial of mifepristone and progestogen-only pill (levonorgestrel)
    F Lakha
    Centre for Reproductive Biology, Simpson Centre for Reproductive Health, University of Edinburgh, 51 Little France Crescent, Edinburgh EH16 4SA, UK
    Hum Reprod 22:2428-36. 2007
    ..By inhibiting ovulation and by altering the receptivity of the endometrium, antagonists of progesterone, such as mifepristone, could be developed as estrogen-free novel contraceptives...
  8. ncbi request reprint The role of matrix metalloproteinases-2, -7 and -9 and beta-catenin in high grade endometrial carcinoma
    H Monaghan
    Department of Laboratory Services Pathology, Royal Infirmary of Edinburgh, Edinburgh, UK
    Histopathology 50:348-57. 2007
    ....
  9. ncbi request reprint Validation of tissue microarray technology using cervical adenocarcinoma and its precursors as a model system
    M Tawfik El-Mansi
    Department of Pathology, Royal Infirmary of Edinburgh and University of Edinburgh, Edinburgh, Scotland, UK
    Int J Gynecol Cancer 16:1225-33. 2006
    ..Our results suggest that TMAs can be successfully used for immunohistochemical studies of cervical adenocarcinomas. The areas sampled from donor blocks must be selected by careful review of sections from the original blocks...
  10. pmc Distribution of HPV types associated with cervical cancers in Scotland and implications for the impact of HPV vaccines
    K Cuschieri
    Scottish HPV Reference Laboratory, Specialist Virology Centre, Royal Infirmary of Edinburgh, Edinburgh, UK
    Br J Cancer 102:930-2. 2010
    ..This study evaluated human papillomavirus (HPV) type prevalence in 370 Scottish invasive cervical cancers (ICCs) using HPV genotyping and HPV mRNA detection...
  11. ncbi request reprint Prevalence of human papillomavirus types 16 and 18 in cervical adenocarcinoma and its precursors in Scottish patients
    M Tawfik El-Mansi
    Department of Pathology, University of Edinburgh, Edinburgh, Scotland, UK
    Int J Gynecol Cancer 16:1025-31. 2006
    ....
  12. ncbi request reprint Liquid-based cytology and conventional smears compared over two 12-month periods
    A R W Williams
    Department of Pathology, Royal Infirmary of Edinburgh, UK
    Cytopathology 17:82-5. 2006
    ....
  13. ncbi request reprint Estrogen-regulated gene expression predicts response to endocrine therapy in patients with ovarian cancer
    Graeme Walker
    Edinburgh Cancer Research Centre, and Department of Pathology, University of Edinburgh, Edinburgh, UK
    Gynecol Oncol 106:461-8. 2007
    ..To explore the predictive value of estrogen-regulated gene changes as indicators of sensitivity in ovarian cancer patients treated with the aromatase inhibitor Letrozole...
  14. ncbi request reprint Mid-luteal endometrial intracrinology following controlled ovarian hyperstimulation involving use of a gonadotrophin releasing hormone antagonist
    Susheel Vani
    Reproductive and Developmental Sciences, Centre for Reproductive Biology, University of Edinburgh, Edinburgh, UK
    Hum Reprod 22:2981-91. 2007
    ....
  15. doi request reprint The spectrum of endometrial pathology induced by progesterone receptor modulators
    George L Mutter
    Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
    Mod Pathol 21:591-8. 2008
    ..The panel has designated these changes as PRM-associated endometrial changes (PAEC). Additional follow-up studies will be needed to fully define their natural history and relationship to specific agents and administration regimens...
  16. ncbi request reprint Antiestrogen therapy is active in selected ovarian cancer cases: the use of letrozole in estrogen receptor-positive patients
    John F Smyth
    Cancer Research UK Centre, University of Edinburgh, Crewe Road South, Edinburgh, Scotland, United Kingdom
    Clin Cancer Res 13:3617-22. 2007
    ..To evaluate the efficacy of the aromatase inhibitor letrozole in preselected estrogen receptor (ER)-positive relapsed epithelial ovarian cancer patients and to identify markers that predict endocrine-sensitive disease...
  17. ncbi request reprint Hormonal contraception can suppress natural antimicrobial gene transcription in human endometrium
    Diana C Fleming
    Human Reproductive Sciences Unit, Medical Research Council, Academic Centre, Edinburgh, United Kingdom
    Fertil Steril 79:856-63. 2003
    ....
  18. ncbi request reprint Changes in vaginal morphology, steroid receptor and natural antimicrobial content following treatment with low-dose mifepristone
    Nitish Narvekar
    Contraceptive Development Network, Centre for Reproductive Biology, University of Edinburgh, The Queen s Medical Research Institute, 47 Little France Crescent, EH16 4TJ Edinburgh, UK
    Contraception 75:271-80. 2007
    ..We investigate the effects of mifepristone on vaginal thickness, steroid receptor and natural antimicrobial content and pharmacokinetics of mifepristone...
  19. ncbi request reprint Insulin-like growth factor binding proteins IGFBP3, IGFBP4, and IGFBP5 predict endocrine responsiveness in patients with ovarian cancer
    Graeme Walker
    Edinburgh Cancer Research Center, University of Edinburgh, Edinburgh, United Kingdom
    Clin Cancer Res 13:1438-44. 2007
    ..This study sought to explore the predictive value of the insulin-like growth factor (IGF) binding proteins (IGFBP) as markers of response in ovarian cancer patients treated with the aromatase inhibitor letrozole...
  20. ncbi request reprint Gene expression profiling of mid to late secretory phase endometrial biopsies from women with menstrual complaint
    Hilary O D Critchley
    Centre for Reproductive Biology, Queens Medical Research Institute, The University of Edinburgh, Scotland, UK
    Am J Obstet Gynecol 195:406.e1-16. 2006
    ....
  21. ncbi request reprint Mifepristone: a novel estrogen-free daily contraceptive pill
    David T Baird
    Contraceptive Development Network, Centre for Reproductive Biology, University of Edinburgh, The Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    Steroids 68:1099-105. 2003
    ..g. venous thromboembolism. The health benefits of avoiding the morbidity associated with menstruation are considerable. Recent surveys suggest that amenorrhoea would be popular with many women...
  22. ncbi request reprint Expression, localization, and signaling of prostaglandin F2 alpha receptor in human endometrial adenocarcinoma: regulation of proliferation by activation of the epidermal growth factor receptor and mitogen-activated protein kinase signaling pathways
    Kurt J Sales
    Medical Research Council Human Reproductive Sciences Unit, Center for Reproductive Biology, University of Edinburgh Academic Center, Edinburgh, United Kingdom EH16 4SB
    J Clin Endocrinol Metab 89:986-93. 2004
    ..These data suggest that PGF(2 alpha)-FP receptor promote endometrial tumorigenesis via a phospholipase C-mediated phosphorylation of the EGFR and MAPK signaling pathways...
  23. ncbi request reprint Carcinosarcoma of the ovary: 19 years of prospective data from a single center
    Ewan Brown
    Cancer Research UK, University of Edinburgh Cancer Research Centre, Edinburgh, United Kingdom
    Cancer 100:2148-53. 2004
    ..A review of clinicopathologic features and outcome in women with carcinosarcoma of the ovary (also known as malignant mixed mesodermal tumor [MMMT]) compared with a group of women with serous adenocarcinoma (SAC) of the ovary was conducted...
  24. ncbi request reprint Prostaglandin E2 mediates phosphorylation and down-regulation of the tuberous sclerosis-2 tumor suppressor (tuberin) in human endometrial adenocarcinoma cells via the Akt signaling pathway
    Kurt J Sales
    MRC Human Reproductive Sciences Unit, Center for Reproductive Biology, The University of Edinburgh Academic Center, Edinburgh EH16 4SB, United Kingdom
    J Clin Endocrinol Metab 89:6112-8. 2004
    ..These data suggest that PGE2 signaling may promote endometrial tumorigenesis by inactivation of tuberin after its phosphorylation via the Akt signaling pathway...
  25. ncbi request reprint A positive feedback loop that regulates cyclooxygenase-2 expression and prostaglandin F2alpha synthesis via the F-series-prostanoid receptor and extracellular signal-regulated kinase 1/2 signaling pathway
    Henry N Jabbour
    Medical Research Council Human Reproductive Sciences Unit, The Queen s Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, United Kingdom
    Endocrinology 146:4657-64. 2005
    ..Finally, we have shown that PGF2alpha could potentiate tumorigenesis in endometrial adenocarcinoma explants by inducing the expression of COX-2 mRNA...
  26. ncbi request reprint F-prostanoid receptor regulation of fibroblast growth factor 2 signaling in endometrial adenocarcinoma cells
    Kurt J Sales
    Medical Research Council Human Reproductive Sciences Unit, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, Scotland EH16 4TJ, United Kingdom
    Endocrinology 148:3635-44. 2007
    ....