Robert George Will

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc A polymorphism in the regulatory region of PRNP is associated with increased risk of sporadic Creutzfeldt-Jakob disease
    Pascual Sanchez-Juan
    Neurology Department, University Hospital Marqués de Valdecilla and CIBERNED, Santander, Spain
    BMC Med Genet 12:73. 2011
  2. pmc PRNP variation in UK sporadic and variant Creutzfeldt Jakob disease highlights genetic risk factors and a novel non-synonymous polymorphism
    Matthew T Bishop
    National CJD Surveillance Unit, University of Edinburgh, Bryan Matthews Building, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK
    BMC Med Genet 10:146. 2009
  3. pmc Comparative evidence for a link between Peyer's patch development and susceptibility to transmissible spongiform encephalopathies
    Suzanne G St Rose
    Centre for Infectious Diseases, University of Edinburgh, King s Buildings, Edinburgh EH9 3JF, UK
    BMC Infect Dis 6:5. 2006
  4. doi request reprint Cold comfort pharm
    R G Will
    Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Pract Neurol 8:60-1. 2008
  5. ncbi request reprint Commentary: The risk of variant Creutzfeldt-Jakob Disease: reassurance and uncertainty
    R G Will
    University of Edinburgh Teviot Place, Edinburgh EH8 9AG, Scotland, UK
    Int J Epidemiol 34:52-3. 2005
  6. ncbi request reprint Variant Creutzfeldt-Jakob disease
    Robert Will
    National CJD Surveillance Unit, Western General Hospital, Edinburgh, Scotland, UK
    Folia Neuropathol 42:77-83. 2004
  7. ncbi request reprint Clinical features of variant Creutzfeldt-Jakob disease
    R G Will
    National Creutzfeldt Jakob Disease Surveillance Unit, Western General Hospital, Edinburgh, UK
    Curr Top Microbiol Immunol 284:121-32. 2004
  8. ncbi request reprint Variant Creutzfeldt-Jakob disease
    Robert George Will
    National CJD Surveillance Unit, Western General Hospital, Edinburgh, Scotland, UK
    Acta Neurobiol Exp (Wars) 62:167-73. 2002
  9. pmc First hundred cases of variant Creutzfeldt-Jakob disease: retrospective case note review of early psychiatric and neurological features
    Michael D Spencer
    Department of Psychiatry, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    BMJ 324:1479-82. 2002
  10. doi request reprint The role of cerebrospinal fluid 14-3-3 and other proteins in the diagnosis of sporadic Creutzfeldt-Jakob disease in the UK: a 10-year review
    G Chohan
    The National CJD Surveillance Unit, University of Edinburgh, Western General Hospital, Edinburgh, UK
    J Neurol Neurosurg Psychiatry 81:1243-8. 2010

Collaborators

Detail Information

Publications33

  1. pmc A polymorphism in the regulatory region of PRNP is associated with increased risk of sporadic Creutzfeldt-Jakob disease
    Pascual Sanchez-Juan
    Neurology Department, University Hospital Marqués de Valdecilla and CIBERNED, Santander, Spain
    BMC Med Genet 12:73. 2011
    ..An important determinant for CJD risk and phenotype is the M129V polymorphism of the human prion protein gene (PRNP), but there are also other coding and non-coding polymorphisms inside this gene...
  2. pmc PRNP variation in UK sporadic and variant Creutzfeldt Jakob disease highlights genetic risk factors and a novel non-synonymous polymorphism
    Matthew T Bishop
    National CJD Surveillance Unit, University of Edinburgh, Bryan Matthews Building, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK
    BMC Med Genet 10:146. 2009
    ..This study aimed to characterise the frequency and effect of PRNP open reading frame polymorphisms other than codon 129 in both disease and control samples sourced from the United Kingdom population...
  3. pmc Comparative evidence for a link between Peyer's patch development and susceptibility to transmissible spongiform encephalopathies
    Suzanne G St Rose
    Centre for Infectious Diseases, University of Edinburgh, King s Buildings, Edinburgh EH9 3JF, UK
    BMC Infect Dis 6:5. 2006
    ....
  4. doi request reprint Cold comfort pharm
    R G Will
    Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Pract Neurol 8:60-1. 2008
    ..Practical issues to do with drug treatment may be just as important as its efficacy...
  5. ncbi request reprint Commentary: The risk of variant Creutzfeldt-Jakob Disease: reassurance and uncertainty
    R G Will
    University of Edinburgh Teviot Place, Edinburgh EH8 9AG, Scotland, UK
    Int J Epidemiol 34:52-3. 2005
  6. ncbi request reprint Variant Creutzfeldt-Jakob disease
    Robert Will
    National CJD Surveillance Unit, Western General Hospital, Edinburgh, Scotland, UK
    Folia Neuropathol 42:77-83. 2004
    ..The number of cases of vCJD in the UK may have peaked, but the total future number of cases of vCJD is uncertain and the possibility of secondary iatrogenic transmission via blood transfusion has recently been identified...
  7. ncbi request reprint Clinical features of variant Creutzfeldt-Jakob disease
    R G Will
    National Creutzfeldt Jakob Disease Surveillance Unit, Western General Hospital, Edinburgh, UK
    Curr Top Microbiol Immunol 284:121-32. 2004
    ..There is a need to try and improve early diagnosis, particularly if effective treatments are developed...
  8. ncbi request reprint Variant Creutzfeldt-Jakob disease
    Robert George Will
    National CJD Surveillance Unit, Western General Hospital, Edinburgh, Scotland, UK
    Acta Neurobiol Exp (Wars) 62:167-73. 2002
    ..The clinical and investigative features of variant CJD are relatively distinct from sporadic CJD. The number of cases of vCJD are increasing with time in the UK, but the total future number of cases of vCJD is uncertain...
  9. pmc First hundred cases of variant Creutzfeldt-Jakob disease: retrospective case note review of early psychiatric and neurological features
    Michael D Spencer
    Department of Psychiatry, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    BMJ 324:1479-82. 2002
    ..To describe the early psychiatric and neurological features of variant Creutzfeldt-Jakob disease...
  10. doi request reprint The role of cerebrospinal fluid 14-3-3 and other proteins in the diagnosis of sporadic Creutzfeldt-Jakob disease in the UK: a 10-year review
    G Chohan
    The National CJD Surveillance Unit, University of Edinburgh, Western General Hospital, Edinburgh, UK
    J Neurol Neurosurg Psychiatry 81:1243-8. 2010
    ..Since that time, other CSF proteins, such as S100b and tau protein, have been proposed as surrogate markers for sCJD. The authors aimed to investigate the diagnostic value of each of these three proteins...
  11. ncbi request reprint Predicting susceptibility and incubation time of human-to-human transmission of vCJD
    M T Bishop
    National CJD Surveillance Unit, Bryan Matthews Building, Western General Hospital, Edinburgh, UK
    Lancet Neurol 5:393-8. 2006
    ..We aimed to model iatrogenic spread to enable a comparison of transmission efficiencies of vCJD and bovine spongiform encephalopathy (BSE) and an assessment of the effect of the codon-129 polymorphism on human susceptibility...
  12. ncbi request reprint Unsuccessful intraventricular pentosan polysulphate treatment of variant Creutzfeldt-Jakob disease
    I R Whittle
    Department of Clinical Neurosciences and National CJD Surveillance Unit, Western General Hospital, Edinburgh, UK
    Acta Neurochir (Wien) 148:677-9; discussion 679. 2006
    ..The patient died from disease progression 16 months after diagnosis and 5 months after pentosan polysulphate treatment was commenced...
  13. ncbi request reprint Laboratory diagnosis of variant Creutzfeldt-Jakob disease
    J W Ironside
    Departments of Pathology, Clinical Neurosciences, CJD Surveillance Unit, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Histopathology 37:1-9. 2000
    ..Continued surveillance is required to further investigate this possibility, with the need to investigate autopsy tissues from suspected cases by histological and biochemical techniques...
  14. pmc Use of 14-3-3 and other brain-specific proteins in CSF in the diagnosis of variant Creutzfeldt-Jakob disease
    A J Green
    The National Creutzfeldt Jakob Disease Surveillance Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    J Neurol Neurosurg Psychiatry 70:744-8. 2001
    ..This study reports and compares the findings of CSF brain specific protein analysis in 45 patients with vCJD and in 34 control patients...
  15. doi request reprint Variant Creutzfeldt-Jakob disease and exposure to fractionated plasma products
    H J T Ward
    National CJD Surveillance Unit, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Vox Sang 97:207-10. 2009
    ....
  16. ncbi request reprint The transmission of prions to humans
    R G Will
    National CJD Surveillance Unit, Western General Hospital, Edinburgh, UK
    Acta Paediatr Suppl 88:28-32. 1999
    ..Laboratory studies, including transmission experiments in mice, provide strong support for the hypothesis that nvCJD is caused by BSE...
  17. pmc Prion diseases
    R S G Knight
    National CJD Surveillance Unit, Western General Hospital, Edinburgh, UK
    J Neurol Neurosurg Psychiatry 75:i36-42. 2004
  18. ncbi request reprint Transmissions to mice indicate that 'new variant' CJD is caused by the BSE agent
    M E Bruce
    Institute for Animal Health, BBSRC MRC Neuropathogenesis Unit, Edinburgh, UK
    Nature 389:498-501. 1997
    ..Here we report the interim results of transmissions of sporadic CJD and vCJD to mice. Our data provide strong evidence that the same agent strain is involved in both BSE and vCJD...
  19. ncbi request reprint Transmissible spongiform encephalopathies and human neurodegenerative disease
    T F Esmonde
    Creutzfeldt Jakob Disease Surveillance Unit, Western General Hospital, Edinburgh
    Br J Hosp Med 49:400-4, 406. 1993
    ..We review the data relating to these diseases in the light of new developments, particularly in the fields of molecular biology and epidemiology...
  20. ncbi request reprint Sporadic Creutzfeldt-Jakob disease in two adolescents
    K Murray
    National Creutzfeldt Jakob Disease Surveillance Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2 XU, UK
    J Neurol Neurosurg Psychiatry 79:14-8. 2008
    ..Sporadic Creutzfeldt-Jakob disease (CJD) is a condition predominantly affecting older age groups, with cases aged less than 45 years rare and an age at onset or death of less than 20 years exceptional...
  21. ncbi request reprint The pulvinar sign on magnetic resonance imaging in variant Creutzfeldt-Jakob disease
    M Zeidler
    National Creutzfeldt Jakob Disease Surveillance Unit, Western General Hospital, Edinburgh, UK
    Lancet 355:1412-8. 2000
    ..We investigated the sensitivity and specificity of bilateral pulvinar high signal on magnetic resonance imaging (MRI) for the diagnosis of vCJD...
  22. ncbi request reprint Dental treatment and risk of variant CJD--a case control study
    D Everington
    National Creutzfeldt Jakob Disease Surveillance Unit, The University of Edinburgh, Western General Hospital, Edinburgh, UK
    Br Dent J 202:E19; discussion 470-1. 2007
    ..This study aimed to identify whether previous dental treatment is a risk factor for development of vCJD...
  23. pmc Dura mater-associated Creutzfeldt-Jakob disease: experience from surveillance in the UK
    C A Heath
    National CJD Surveillance Unit, Bryan Matthews Building, Western General Hospital, Edinburgh EH4 2XU, UK
    J Neurol Neurosurg Psychiatry 77:880-2. 2006
    ..The mean incubation period of the human dura mater cases was 93 (range 45-177) months. The clinico-pathological features of the cases are described and compared with cases previously reported in the world literature...
  24. ncbi request reprint Prions and the oral cavity
    A J Smith
    Infection Research Group, Glasgow Dental Hospital and School, 378 Sauchiehall Street, Glasgow G2 3JZ, Scotland, UK
    J Dent Res 82:769-75. 2003
    ..This article reviews the existing knowledge base on the nature of prions, their distribution in oral tissues, and the implications for dental treatment...
  25. ncbi request reprint The biology and epidemiology of variant Creutzfeldt-Jakob disease
    R G Will
    National CJD Surveillance Unit, Western General Hospital, Edinburgh
    Bull Mem Acad R Med Belg 158:250-6; discussion 256-7. 2003
  26. ncbi request reprint Variant Creutzfeldt-Jakob disease
    H J T Ward
    National Creutzfeldt Jakob Disease Surveillance Unit, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK
    Clin Lab Med 23:87-108. 2003
    ..Indeed a recent publication has suggested that the drugs quinacrine or chloropromazine may be candidates for the treatment of human prion diseases [42]...
  27. ncbi request reprint MRI of Creutzfeldt-Jakob disease: imaging features and recommended MRI protocol
    D A Collie
    Department of Neuroradiology, Western General Hospital, Edinburgh
    Clin Radiol 56:726-39. 2001
    ..These appearances and other imaging features are described in this article. Using appropriate clinical and radiological criteria and tailored imaging protocols, MRI plays an important part in the in vivodiagnosis of this disease...
  28. pmc Isolated visual symptoms at onset in sporadic Creutzfeldt-Jakob disease: the clinical phenotype of the "Heidenhain variant"
    S A Cooper
    The National Creutzfeldt Jakob Disease Surveillance Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Br J Ophthalmol 89:1341-2. 2005
    ..The term is clarified to represent those who present with isolated visual symptoms. This group may pose diagnostic difficulties and often present to ophthalmologists where they may undergo needless invasive procedures...
  29. pmc No clinical evidence of hidden vCJD in UK children
    C M Verity
    Addenbrooke s Hospital, Cambridge, UK
    Arch Dis Child 91:608-9. 2006
    ..There was no clinical evidence of variant Creutzfeldt-Jakob disease (vCJD) in these undiagnosed cases, but without necropsy it is not possible to exclude vCJD completely...
  30. doi request reprint Is there evidence of vertical transmission of variant Creutzfeldt-Jakob disease?
    Katy Murray
    National CreutzfeldteJakob Disease Surveillance Unit, Western General Hospital, Edinburgh, UK
    J Neurol Neurosurg Psychiatry 82:729-31. 2011
    ..The aim of this study is to search for evidence of this type of transmission of vCJD...
  31. doi request reprint Diagnosing variant Creutzfeldt-Jakob disease: a retrospective analysis of the first 150 cases in the UK
    C A Heath
    Western General Hospital, Edinburgh, UK
    J Neurol Neurosurg Psychiatry 82:646-51. 2011
    ..Although diagnostic delay may be a result of the non-specific early clinical features, a systematic analysis of the process of diagnosis was undertaken, with the aim of trying to achieve earlier diagnosis of vCJD...
  32. pmc Ophthalmic surgery and Creutzfeldt-Jakob disease
    P S-Juan
    The National CJD Surveillance Unit, Western General Hospital, Edinburgh EH4 2XU, Scotland, UK
    Br J Ophthalmol 88:446-9. 2004