I B Wilkinson

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc The influence of heart rate on augmentation index and central arterial pressure in humans
    I B Wilkinson
    Clinical Pharmacology Unit, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK
    J Physiol 525:263-70. 2000
  2. ncbi request reprint Increased augmentation index and systolic stress in type 1 diabetes mellitus
    I B Wilkinson
    Clinical Pharmacology Unit and Research Centre, University of Edinburgh, Western General Hospital, Edinburgh, UK
    QJM 93:441-8. 2000
  3. pmc Adrenomedullin (ADM) in the human forearm vascular bed: effect of neutral endopeptidase inhibition and comparison with proadrenomedullin NH2-terminal 20 peptide (PAMP)
    I B Wilkinson
    Clinical Pharmacology Unit, Department of Medical Sciences, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU
    Br J Clin Pharmacol 52:159-64. 2001
  4. ncbi request reprint Acute methionine loading does not alter arterial stiffness in humans
    I B Wilkinson
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, UK
    J Cardiovasc Pharmacol 37:1-5. 2001
  5. pmc Changes in the derived central pressure waveform and pulse pressure in response to angiotensin II and noradrenaline in man
    I B Wilkinson
    Clinical Pharmacology Unit, Department of Medicine, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    J Physiol 530:541-50. 2001
  6. ncbi request reprint Comparison of brachial artery pressure and derived central pressure in the measurement of abdominal aortic aneurysm distensibility
    K Wilson
    Vascular Surgery Unit, University Department of Clinical and Surgical Sciences, Edinburgh, UK
    Eur J Vasc Endovasc Surg 22:355-60. 2001
  7. ncbi request reprint Increased arterial stiffness in patients with chronic obstructive pulmonary disease: a mechanism for increased cardiovascular risk
    N L Mills
    Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK
    Thorax 63:306-11. 2008
  8. ncbi request reprint Large artery stiffness and inflammation
    C M McEniery
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, UK
    J Hum Hypertens 19:507-9. 2005
  9. ncbi request reprint Systemic blockade of the endothelin-B receptor increases peripheral vascular resistance in healthy men
    F E Strachan
    Clinical Pharmacology Unit, University of Edinburgh, Western General Hospital, and Department of Pharmacology, University of Edinburgh
    Hypertension 33:581-5. 1999
  10. doi request reprint Unsafe health and safety: sphygmomanometer cuffs are not interchangeable
    K C Shaw
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    J Hum Hypertens 27:434-6. 2013

Collaborators

Detail Information

Publications12

  1. pmc The influence of heart rate on augmentation index and central arterial pressure in humans
    I B Wilkinson
    Clinical Pharmacology Unit, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK
    J Physiol 525:263-70. 2000
    ..Consideration of wave reflection and aortic pressure augmentation may explain the lack of rise in central systolic pressure during incremental pacing despite an increase in peripheral pressure...
  2. ncbi request reprint Increased augmentation index and systolic stress in type 1 diabetes mellitus
    I B Wilkinson
    Clinical Pharmacology Unit and Research Centre, University of Edinburgh, Western General Hospital, Edinburgh, UK
    QJM 93:441-8. 2000
    ..Such haemodynamic effects may contribute to the increased left ventricular mass and risk of cardiovascular disease associated with type 1 diabetes mellitus...
  3. pmc Adrenomedullin (ADM) in the human forearm vascular bed: effect of neutral endopeptidase inhibition and comparison with proadrenomedullin NH2-terminal 20 peptide (PAMP)
    I B Wilkinson
    Clinical Pharmacology Unit, Department of Medical Sciences, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU
    Br J Clin Pharmacol 52:159-64. 2001
    ..However, in pathophysiological conditions such as hypertension and heart failure, NEP inhibition may exert a beneficial effect by increasing the biological activity of ADM...
  4. ncbi request reprint Acute methionine loading does not alter arterial stiffness in humans
    I B Wilkinson
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, UK
    J Cardiovasc Pharmacol 37:1-5. 2001
    ..These data reinforce evidence that vitamin C reduces arterial stiffness but do not indicate any important interaction with oral methionine...
  5. pmc Changes in the derived central pressure waveform and pulse pressure in response to angiotensin II and noradrenaline in man
    I B Wilkinson
    Clinical Pharmacology Unit, Department of Medicine, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    J Physiol 530:541-50. 2001
    ..These data reveal that assessment of peripheral pulse pressure does not always reliably predict changes in central pulse pressure or arterial stiffness...
  6. ncbi request reprint Comparison of brachial artery pressure and derived central pressure in the measurement of abdominal aortic aneurysm distensibility
    K Wilson
    Vascular Surgery Unit, University Department of Clinical and Surgical Sciences, Edinburgh, UK
    Eur J Vasc Endovasc Surg 22:355-60. 2001
    ..001). CONCLUSION: the use of brachial pressure leads to a small, systematic overestimate of Ep (18%) and beta (11%) independent of age and AAA diameter. This systematic error will not bias follow-up of changes in distensibility...
  7. ncbi request reprint Increased arterial stiffness in patients with chronic obstructive pulmonary disease: a mechanism for increased cardiovascular risk
    N L Mills
    Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK
    Thorax 63:306-11. 2008
    ..The mechanisms responsible for this association are not clear and appear to be independent of smoking history...
  8. ncbi request reprint Large artery stiffness and inflammation
    C M McEniery
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, UK
    J Hum Hypertens 19:507-9. 2005
  9. ncbi request reprint Systemic blockade of the endothelin-B receptor increases peripheral vascular resistance in healthy men
    F E Strachan
    Clinical Pharmacology Unit, University of Edinburgh, Western General Hospital, and Department of Pharmacology, University of Edinburgh
    Hypertension 33:581-5. 1999
    ..Further investigation is now clearly required to address whether selective ETA or combined ETA/ETB receptor blockade will be more effective in the clinical setting...
  10. doi request reprint Unsafe health and safety: sphygmomanometer cuffs are not interchangeable
    K C Shaw
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    J Hum Hypertens 27:434-6. 2013
    ..Sphygmomanometer cuffs are not interchangeable between devices and a modicum of common sense should be shown to prevent changes made in the name of Health and Safety from having the opposite effect to that intended...
  11. ncbi request reprint Assessment of arterial stiffness in clinical practice
    I S Mackenzie
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    QJM 95:67-74. 2002
  12. ncbi request reprint Infliximab improves endothelial dysfunction in systemic vasculitis: a model of vascular inflammation
    A D Booth
    Clinical Pharmacology Unit, University of Cambridge, Box 110, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2QQ, UK
    Circulation 109:1718-23. 2004
    ....