I B Wilkinson

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Nitric oxide regulates local arterial distensibility in vivo
    Ian B Wilkinson
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Circulation 105:213-7. 2002
  2. ncbi request reprint Arterial stiffness, endothelial function and novel pharmacological approaches
    Ian B Wilkinson
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Clin Exp Pharmacol Physiol 31:795-9. 2004
  3. pmc The accuracy of diagnostic coding for acute kidney injury in England - a single centre study
    Laurie A Tomlinson
    Clinical Pharmacology Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    BMC Nephrol 14:58. 2013
  4. pmc Inhibition of basal nitric oxide synthesis increases aortic augmentation index and pulse wave velocity in vivo
    Ian B Wilkinson
    Clinical Pharmacology Unit, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, Scotland, UK
    Br J Clin Pharmacol 53:189-92. 2002
  5. ncbi request reprint Heart rate dependency of pulse pressure amplification and arterial stiffness
    Ian B Wilkinson
    Clinical Pharmacology Unit, University of Edinburgh, Western General Hospital, United Kingdom
    Am J Hypertens 15:24-30. 2002
  6. ncbi request reprint Pulse-wave analysis: clinical evaluation of a noninvasive, widely applicable method for assessing endothelial function
    Ian B Wilkinson
    Clinical Pharmacology Units, University of Cambridge, Addenbrooke s Hospital, Cambridge, England
    Arterioscler Thromb Vasc Biol 22:147-52. 2002
  7. ncbi request reprint Pressure amplification explains why pulse pressure is unrelated to risk in young subjects
    I B Wilkinson
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    Hypertension 38:1461-6. 2001
  8. pmc Changes in the derived central pressure waveform and pulse pressure in response to angiotensin II and noradrenaline in man
    I B Wilkinson
    Clinical Pharmacology Unit, Department of Medicine, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    J Physiol 530:541-50. 2001
  9. ncbi request reprint Acute methionine loading does not alter arterial stiffness in humans
    I B Wilkinson
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, UK
    J Cardiovasc Pharmacol 37:1-5. 2001
  10. ncbi request reprint Infliximab improves endothelial dysfunction in systemic vasculitis: a model of vascular inflammation
    A D Booth
    Clinical Pharmacology Unit, University of Cambridge, Box 110, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2QQ, UK
    Circulation 109:1718-23. 2004

Detail Information

Publications86

  1. ncbi request reprint Nitric oxide regulates local arterial distensibility in vivo
    Ian B Wilkinson
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Circulation 105:213-7. 2002
    ..We hypothesized that nitric oxide (NO) acting locally regulates arterial stiffness in vivo, and the aim of this experiment was to test this hypothesis in an ovine hind-limb preparation...
  2. ncbi request reprint Arterial stiffness, endothelial function and novel pharmacological approaches
    Ian B Wilkinson
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Clin Exp Pharmacol Physiol 31:795-9. 2004
    ..Furthermore, differences in the effect of existing drugs on larger artery stiffness may explain, in part, why some drugs produce better clinical outcomes than others...
  3. pmc The accuracy of diagnostic coding for acute kidney injury in England - a single centre study
    Laurie A Tomlinson
    Clinical Pharmacology Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    BMC Nephrol 14:58. 2013
    ..However, the accuracy of coding for AKI and changes in coding over time have not been studied in England...
  4. pmc Inhibition of basal nitric oxide synthesis increases aortic augmentation index and pulse wave velocity in vivo
    Ian B Wilkinson
    Clinical Pharmacology Unit, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, Scotland, UK
    Br J Clin Pharmacol 53:189-92. 2002
    ..To investigate the role of basal nitric oxide (NO) production in regulating large artery stiffness in vivo...
  5. ncbi request reprint Heart rate dependency of pulse pressure amplification and arterial stiffness
    Ian B Wilkinson
    Clinical Pharmacology Unit, University of Edinburgh, Western General Hospital, United Kingdom
    Am J Hypertens 15:24-30. 2002
    ..The aim of the present study was to assess the effect of acute changes in heart rate on arterial stiffness and on peripheral and central pulse pressure in healthy subjects...
  6. ncbi request reprint Pulse-wave analysis: clinical evaluation of a noninvasive, widely applicable method for assessing endothelial function
    Ian B Wilkinson
    Clinical Pharmacology Units, University of Cambridge, Addenbrooke s Hospital, Cambridge, England
    Arterioscler Thromb Vasc Biol 22:147-52. 2002
    ..This methodology provides a simple, repeatable, noninvasive means of assessing endothelial function in vivo...
  7. ncbi request reprint Pressure amplification explains why pulse pressure is unrelated to risk in young subjects
    I B Wilkinson
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    Hypertension 38:1461-6. 2001
    ..This may explain why diastolic pressure is a better predictor of risk in this age group and suggests that assessment of central pressure may improve risk stratification further...
  8. pmc Changes in the derived central pressure waveform and pulse pressure in response to angiotensin II and noradrenaline in man
    I B Wilkinson
    Clinical Pharmacology Unit, Department of Medicine, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    J Physiol 530:541-50. 2001
    ..These data reveal that assessment of peripheral pulse pressure does not always reliably predict changes in central pulse pressure or arterial stiffness...
  9. ncbi request reprint Acute methionine loading does not alter arterial stiffness in humans
    I B Wilkinson
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, UK
    J Cardiovasc Pharmacol 37:1-5. 2001
    ..These data reinforce evidence that vitamin C reduces arterial stiffness but do not indicate any important interaction with oral methionine...
  10. ncbi request reprint Infliximab improves endothelial dysfunction in systemic vasculitis: a model of vascular inflammation
    A D Booth
    Clinical Pharmacology Unit, University of Cambridge, Box 110, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2QQ, UK
    Circulation 109:1718-23. 2004
    ....
  11. pmc Adrenomedullin (ADM) in the human forearm vascular bed: effect of neutral endopeptidase inhibition and comparison with proadrenomedullin NH2-terminal 20 peptide (PAMP)
    I B Wilkinson
    Clinical Pharmacology Unit, Department of Medical Sciences, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU
    Br J Clin Pharmacol 52:159-64. 2001
    ..However, in pathophysiological conditions such as hypertension and heart failure, NEP inhibition may exert a beneficial effect by increasing the biological activity of ADM...
  12. ncbi request reprint Increased augmentation index and systolic stress in type 1 diabetes mellitus
    I B Wilkinson
    Clinical Pharmacology Unit and Research Centre, University of Edinburgh, Western General Hospital, Edinburgh, UK
    QJM 93:441-8. 2000
    ..Such haemodynamic effects may contribute to the increased left ventricular mass and risk of cardiovascular disease associated with type 1 diabetes mellitus...
  13. ncbi request reprint A comparison of atenolol and nebivolol in isolated systolic hypertension
    Zahid Dhakam
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, CB2 2QQ, UK
    J Hypertens 26:351-6. 2008
    ..The aim of the present study was to test this in a double-blind, randomized, cross-over study, in a cohort of subjects with isolated systolic hypertension...
  14. ncbi request reprint Comparison of the effects of antihypertensive agents on central blood pressure and arterial stiffness in isolated systolic hypertension
    Isla S Mackenzie
    Clinical Pharmacology Unit, Addenbrooke s Hospital Box 110, Cambridge, CB2 0QQ United Kingdom
    Hypertension 54:409-13. 2009
    ..Because central PP and increased wave reflections are considered important risk factors in patients with isolated systolic hypertension, the choice of therapy may be influenced by these findings in the future...
  15. ncbi request reprint Isolated systolic hypertension is characterized by increased aortic stiffness and endothelial dysfunction
    Sharon M L Wallace
    Clinical Pharmacology, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    Hypertension 50:228-33. 2007
    ..Our results suggest that endothelial function contributes significantly to increased arterial stiffness in patients with isolated systolic hypertension and with age...
  16. pmc The influence of heart rate on augmentation index and central arterial pressure in humans
    I B Wilkinson
    Clinical Pharmacology Unit, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK
    J Physiol 525:263-70. 2000
    ..Consideration of wave reflection and aortic pressure augmentation may explain the lack of rise in central systolic pressure during incremental pacing despite an increase in peripheral pressure...
  17. ncbi request reprint High plasma concentrations of human urotensin II do not alter local or systemic hemodynamics in man
    Ian B Wilkinson
    Clinical Pharmacology Unit, Department of Medical Sciences, University of Edinburgh, Western General Hospital, Edinburgh EH4 2LH, Scotland, UK
    Cardiovasc Res 53:341-7. 2002
    ..We examined, for the first time, the local and systemic hemodynamic response to hUII in man in vivo...
  18. ncbi request reprint C-reactive protein is associated with arterial stiffness in apparently healthy individuals
    - Yasmin
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Arterioscler Thromb Vasc Biol 24:969-74. 2004
    ..The aim of this study was to investigate the relationship between stiffness and inflammation in a cohort of healthy individuals...
  19. ncbi request reprint Rheumatoid arthritis is associated with increased aortic pulse-wave velocity, which is reduced by anti-tumor necrosis factor-alpha therapy
    Kaisa M Maki-Petaja
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Box 110, Cambridge CB2 2QQ, United Kingdom
    Circulation 114:1185-92. 2006
    ..In addition, we tested the hypothesis that aortic stiffness could be reduced with anti-tumor necrosis factor-alpha (TNF-alpha) therapy...
  20. ncbi request reprint Atenolol and eprosartan: differential effects on central blood pressure and aortic pulse wave velocity
    Zahid Dhakam
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, England
    Am J Hypertens 19:214-9. 2006
    ..We hypothesized that that atenolol fails to reduce central BP as much as other agents. The aim of the present study was to compare the hemodynamic effects of atenolol and eprosartan in a double-blind, randomized, cross-over study...
  21. ncbi request reprint Assessment of arterial stiffness in clinical practice
    I S Mackenzie
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    QJM 95:67-74. 2002
  22. pmc No effect on central or peripheral blood pressure of systemic urotensin II infusion in humans
    Jonathan T Affolter
    Clinical Research Centre, Department of Medical Sciences, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK
    Br J Clin Pharmacol 54:617-21. 2002
    ..The aim of the present study was to assess systemic haemodynamic responses to intravenous urotensin II infusion in humans...
  23. ncbi request reprint Nitric oxide and the regulation of large artery stiffness: from physiology to pharmacology
    Ian B Wilkinson
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Hypertension 44:112-6. 2004
  24. pmc Local nitric oxide release does not affect tachyphylaxis to angiotensin II in dorsal hand veins in man in the presence of prostaglandin synthesis inhibition
    S L de Haas
    Clinical Pharmacology Unit, University of Edinburgh, Western General Hospital, Edinburgh EH4 2LH, Scotland, UK
    Br J Clin Pharmacol 53:193-5. 2002
    ..Our aim was to assess the hypothesis that local nitric oxide (NO) generation is also, in part, responsible for tachyphylaxis to ANGII in veins, using the Aellig dorsal hand vein technique...
  25. pmc The effects of urotensin II and urantide on forearm blood flow and systemic haemodynamics in humans
    Joseph Cheriyan
    Clinical Pharmacology Unit, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 2QQ, UK
    Br J Clin Pharmacol 68:518-23. 2009
    ....
  26. doi request reprint Impact of ovulation and implantation timing on first-trimester crown-rump length and gestational age
    A A Mahendru
    Fetal Medicine Department, Rosie Hospital, Addenbrooke s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    Ultrasound Obstet Gynecol 40:630-5. 2012
    ..To determine the impact of ovulation and implantation timing on first-trimester crown-rump length (CRL) and the derived gestational age (GA)...
  27. ncbi request reprint Increased arterial stiffness in patients with chronic obstructive pulmonary disease: a mechanism for increased cardiovascular risk
    N L Mills
    Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK
    Thorax 63:306-11. 2008
    ..The mechanisms responsible for this association are not clear and appear to be independent of smoking history...
  28. ncbi request reprint Systemic blockade of the endothelin-B receptor increases peripheral vascular resistance in healthy men
    F E Strachan
    Clinical Pharmacology Unit, University of Edinburgh, Western General Hospital, and Department of Pharmacology, University of Edinburgh
    Hypertension 33:581-5. 1999
    ..Further investigation is now clearly required to address whether selective ETA or combined ETA/ETB receptor blockade will be more effective in the clinical setting...
  29. doi request reprint Raised uterine artery impedance is associated with increased maternal arterial stiffness in the late second trimester
    T R Everett
    Department of Fetal Medicine, Rosie Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    Placenta 33:572-7. 2012
    ..To assess the relationship between uterine artery Doppler pulsatility index (PI) and maternal global arterial stiffness and aortic stiffness in women at high a priori risk of preeclampsia in the late second trimester of pregnancy...
  30. ncbi request reprint Inflammation and arterial stiffness in systemic vasculitis: a model of vascular inflammation
    A D Booth
    University of Cambridge, and Addenbrooke s Hospital, Cambridge, UK
    Arthritis Rheum 50:581-8. 2004
    ..The aim of this study was to investigate the relationship between inflammation and arterial stiffness in patients with antineutrophil cytoplasmic antibody-associated systemic vasculitis (AASV) as a model of systemic inflammation...
  31. ncbi request reprint Large artery stiffness and inflammation
    C M McEniery
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, UK
    J Hum Hypertens 19:507-9. 2005
  32. ncbi request reprint The accuracy of central SBP determined from the second systolic peak of the peripheral pressure waveform
    Stacey S Hickson
    University of Cambridge, Addenbrooke s Hospital, UK
    J Hypertens 27:1784-8. 2009
    ..We also compared pSBP(2) with the true cSBP measured by cardiac catheterization [invasively measured cSBP (cSBPi)]...
  33. ncbi request reprint Genetic variation in fibrillin-1 gene is not associated with arterial stiffness in apparently healthy individuals
    - Yasmin
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    J Hypertens 24:499-502. 2006
    ..The aim of this study was to investigate the possible influence of the common FBN-1 genotypes on arterial stiffness in a large cohort of healthy individuals...
  34. ncbi request reprint Atenolol and cardiovascular risk: an issue close to the heart
    Ian B Wilkinson
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Lancet 367:627-9. 2006
  35. ncbi request reprint Aortic calcification is associated with aortic stiffness and isolated systolic hypertension in healthy individuals
    Carmel M McEniery
    Clinical Pharmacology Unit, Box 100, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 0QQ, United Kingdom
    Hypertension 53:524-31. 2009
    ..These data suggest that calcification may be important in the process of aortic stiffening and the development of ISH. Calcification may underlie treatment resistance in ISH, and anticalcification strategies may present a novel therapy...
  36. ncbi request reprint Use of antihypertension agents for the suppression of arterial pulse pressure waveforms in patients with intracranial aneurysms
    Carole L Turner
    Academic Department of Neurosurgery and Department of Clinical Pharmacology, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Neurosurg 104:531-6. 2006
    ....
  37. ncbi request reprint Anti-inflammatory drugs and statins for arterial stiffness reduction
    Kaisa M Maki-Petaja
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Box 110, Cambridge, CB2 0QQ, UK
    Curr Pharm Des 15:290-303. 2009
    ....
  38. ncbi request reprint Increased stroke volume and aortic stiffness contribute to isolated systolic hypertension in young adults
    Carmel M McEniery
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Hypertension 46:221-6. 2005
    ..Long-term follow-up of these individuals is now required to determine whether they are at increased risk compared with age-matched normotensive individuals...
  39. ncbi request reprint Variation in the human matrix metalloproteinase-9 gene is associated with arterial stiffness in healthy individuals
    - Yasmin
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Box 110, Cambridge CB2 2QQ, UK
    Arterioscler Thromb Vasc Biol 26:1799-805. 2006
    ..Therefore, we investigated the influence of known MMP-9 (-1562C>T, R279Q) polymorphisms on arterial stiffness in a large cohort of healthy individuals (n=865)...
  40. ncbi request reprint Endothelial function is associated with pulse pressure, pulse wave velocity, and augmentation index in healthy humans
    Carmel M McEniery
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    Hypertension 48:602-8. 2006
    ..001), which remained independent after adjusting for confounding factors. In healthy individuals, a decline in endothelial function is associated with increased large artery stiffness, wave reflections, and central pulse pressure...
  41. ncbi request reprint Central pressure: variability and impact of cardiovascular risk factors: the Anglo-Cardiff Collaborative Trial II
    Carmel M McEniery
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital Box 110, Cambridge CB2 2QQ, United Kingdom
    Hypertension 51:1476-82. 2008
    ..However, assessment of central pressure may improve the identification and management of patients with elevated cardiovascular risk...
  42. ncbi request reprint Endogenous endothelin-1 limits exercise-induced vasodilation in hypertensive humans
    Carmel M McEniery
    Clinical Pharmacology Unit and Research Centre, University of Endinburgh, Western General Hospital, United Kingdom
    Hypertension 40:202-6. 2002
    ..Treatment with endothelin receptor antagonists may, therefore, increase exercise capacity in essential hypertension...
  43. ncbi request reprint Ezetimibe and simvastatin reduce inflammation, disease activity, and aortic stiffness and improve endothelial function in rheumatoid arthritis
    Kaisa M Maki-Petaja
    Clinical Pharmacology Unit, University of Cambridge, Cambridge, United Kingdom
    J Am Coll Cardiol 50:852-8. 2007
    ..The aim of this study was to investigate the effect of simvastatin and ezetimibe on inflammation, disease activity, endothelial dysfunction, and arterial stiffness in a cohort of rheumatoid arthritis (RA) patients...
  44. ncbi request reprint Normal vascular aging: differential effects on wave reflection and aortic pulse wave velocity: the Anglo-Cardiff Collaborative Trial (ACCT)
    Carmel M McEniery
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Am Coll Cardiol 46:1753-60. 2005
    ....
  45. ncbi request reprint Aldehyde dehydrogenase 2 plays a role in the bioactivation of nitroglycerin in humans
    Isla S Mackenzie
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Arterioscler Thromb Vasc Biol 25:1891-5. 2005
    ..We investigated the role of ALDH2 in the vascular effects of nitroglycerin (NTG) in humans in vivo...
  46. ncbi request reprint Validity and repeatability of the Vicorder apparatus: a comparison with the SphygmoCor device
    Stacey S Hickson
    University of Cambridge, Addenbrooke s Hospital, UK
    Hypertens Res 32:1079-85. 2009
    ..This difference in transit time and inherent bias was reduced when adjustment for the additional femoral artery segment measured by the Vicorder device was made...
  47. ncbi request reprint Nebivolol increases arterial distensibility in vivo
    Carmel M McEniery
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Hypertension 44:305-10. 2004
    ..This effect of nebivolol is mediated through the release of NO via a beta2 adrenoceptor-dependent mechanism. Thus, nebivolol may be of benefit in conditions of increased large artery stiffness, such as isolated systolic hypertension...
  48. ncbi request reprint The impact of cardiovascular risk factors on aortic stiffness and wave reflections depends on age: the Anglo-Cardiff Collaborative Trial (ACCT III)
    Carmel M McEniery
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Box 110, Hills Rd, Cambridge CB2 0QQ, UK
    Hypertension 56:591-7. 2010
    ..Additional studies are required to assess the impact of these arterial measures on cardiovascular outcome within a single population...
  49. ncbi request reprint Matrix metalloproteinase-9 (MMP-9), MMP-2, and serum elastase activity are associated with systolic hypertension and arterial stiffness
    - Yasmin
    Clinical Pharmacology Unit, University of Cambridge Addenbrooke s Hospital Cambridge, United Kingdom
    Arterioscler Thromb Vasc Biol 25:372. 2005
    ..We hypothesized that elastase activity would be related to arterial stiffness and tested this using isolated systolic hypertension (ISH) as a model of stiffening and separately in a large cohort of healthy individuals...
  50. ncbi request reprint Endothelin-1 regulates arterial pulse wave velocity in vivo
    Carmel M McEniery
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Am Coll Cardiol 42:1975-81. 2003
    ..The aim of this study was to investigate whether endothelin-1, acting locally, regulates arterial distensibility, assessed by measuring pulse-wave velocity in vivo...
  51. doi request reprint Inhibition of p38 mitogen-activated protein kinase improves nitric oxide-mediated vasodilatation and reduces inflammation in hypercholesterolemia
    Joseph Cheriyan
    Cambridge University Hospitals NHS Foundation Trust, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    Circulation 123:515-23. 2011
    ..We hypothesized that a selective p38α/β MAPK inhibitor (losmapimod; GW856553) would improve compromised nitric oxide-mediated vasoregulation in patients with hypercholesterolemia...
  52. doi request reprint The relationship of age with regional aortic stiffness and diameter
    Stacey S Hickson
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    JACC Cardiovasc Imaging 3:1247-55. 2010
    ..The purpose of this study was to determine the impact of age on regional aortic pulse wave velocity (aPWV)...
  53. doi request reprint Age-related changes of regional pulse wave velocity in the descending aorta using Fourier velocity encoded M-mode
    Valentina Taviani
    Department of Radiology, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    Magn Reson Med 65:261-8. 2011
    ..There was a preferential stiffening of the thoracic aorta with age, which may be due to progressive fragmentation of elastin fibers in this region...
  54. ncbi request reprint An analysis of prospective risk factors for aortic stiffness in men: 20-year follow-up from the Caerphilly prospective study
    Carmel M McEniery
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Box 110, Cambridge CB2 0QQ, UK
    Hypertension 56:36-43. 2010
    ..Adequate control of pulse pressure and heart rate, as well as reducing inflammation, may, in the long-term, retard aortic stiffening, although this remains to be tested directly...
  55. ncbi request reprint Age, hypertension and arterial function
    Carmel M McEniery
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Clin Exp Pharmacol Physiol 34:665-71. 2007
    ..In addition, inhibitors or breakers of advanced glycation end-product cross-links between proteins, such as collagen and elastin, hold substantial promise...
  56. doi request reprint Unsafe health and safety: sphygmomanometer cuffs are not interchangeable
    K C Shaw
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    J Hum Hypertens 27:434-6. 2013
    ..Sphygmomanometer cuffs are not interchangeable between devices and a modicum of common sense should be shown to prevent changes made in the name of Health and Safety from having the opposite effect to that intended...
  57. ncbi request reprint Vessel wall stiffness in type 1 diabetes and the central hemodynamic effects of acute hypoglycemia
    Andrew J Sommerfield
    Department of Diabetes, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, Scotland, UK
    Am J Physiol Endocrinol Metab 293:E1274-9. 2007
    ..To examine the effects of intravenous insulin and acute hypoglycemia on arterial wall stiffness and central hemodynamic responses in adults with and without type 1 diabetes...
  58. ncbi request reprint Increased central pulse pressure and augmentation index in subjects with hypercholesterolemia
    Ian B Wilkinson
    Clinical Pharmacology Unit, Department of Medical Sciences, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom
    J Am Coll Cardiol 39:1005-11. 2002
    ..The goal of this study was to investigate the relation between serum cholesterol, arterial stiffness and central blood pressure...
  59. ncbi request reprint Commentary: birthweight arterial stiffness and blood pressure: in search of a unifying hypothesis
    Ian B Wilkinson
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Int J Epidemiol 33:161-2. 2004
  60. ncbi request reprint Endothelin antagonism: physiology or pharmacology?
    Carmel M McEniery
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, UK
    Clin Sci (Lond) 102:667-8. 2002
  61. ncbi request reprint Non-invasive measures of pulse wave velocity correlate with coronary arterial plaque load in humans
    Andrew L McLeod
    Department of Cardiology, Western General Hospital, Edinburgh, UK
    J Hypertens 22:363-8. 2004
    ..Arterial stiffness is an emerging major risk factor for cardiovascular morbidity and mortality. The aim of the present study was to assess if coronary artery plaque load correlates with non-invasive measures of arterial stiffness...
  62. ncbi request reprint Hemodynamic effects of amlodipine, bisoprolol, and lisinopril in hypertensive patients after liver transplantation
    David A J Neal
    Department of Medicine, Addenbrooke s Hospital, Cambridge, United Kingdom
    Transplantation 77:748-50. 2004
    ..Hypertension is common after liver transplantation. There are few published data on optimum treatment. Augmentation index (AIx) is a measure of arterial wave reflection determined by pulse wave analysis...
  63. ncbi request reprint A rational approach to hypertension
    Fraz A Mir
    Clinical Pharmacology Unit, Department of Medicine, Addenbrooke s Hospital, University of Cambridge
    Practitioner 248:176, 179, 182-9 passim. 2004
  64. ncbi request reprint Role of increased aortic stiffness in the pathogenesis of heart failure
    J Cheriyan
    Clinical Pharmacology, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2QQ, United Kingdom
    Curr Heart Fail Rep 4:121-6. 2007
    ..This review summarizes some important trials of aortic stiffness in cardiovascular disease risk prediction and progression to heart failure. Emerging targets for therapeutics and areas requiring more research are also discussed...
  65. ncbi request reprint Mechanisms of hypertension after liver transplantation
    David A J Neal
    University Department of Medicine, Addenbrooke s Hospital, Cambridge CB2 2QQ, England, UK
    Transplantation 79:935-40. 2005
    ..Elevation in plasma ET-1 and increases in arterial stiffness are potential important mechanisms underlying the development of hypertension after liver transplant...
  66. ncbi request reprint Evaluation of methods to measure endothelium-dependent vasodilation
    John R Cockcroft
    Clin Sci (Lond) 104:367-8; author reply 368. 2003
  67. ncbi request reprint Nitric oxide and the regulation of arterial elasticity: right idea, wrong vascular bed?
    Ian B Wilkinson
    Hypertension 39:e26-7. 2002
  68. ncbi request reprint Basal NO locally modulates human iliac artery function in vivo
    Matthias Schmitt
    Department of Cardiology, Wales Heart Research Institute, College of Medicine, University Hospital of Wales, Cardiff, UK
    Hypertension 46:227-31. 2005
    ..These data indicate that under resting conditions, local NO production modulates human iliac artery distensibility and that exogenous NO increases arterial distensibility...
  69. ncbi request reprint Systolic hypertension in young adults: spurious definition of a genuine condition
    Carmel M McEniery
    J Hypertens 24:2316-7; author reply 2317-9. 2006
  70. ncbi request reprint Role of natriuretic peptides in regulation of conduit artery distensibility
    Matthias Schmitt
    Wales Heart Research Institute, Cardiff, United Kingdom
    Am J Physiol Heart Circ Physiol 287:H1167-71. 2004
    ..In conclusion, ANP, and to a lesser extent BNP, modify large artery distensibility via the NPRA receptor. Neither CNP nor cANF altered PWV, suggesting that the NPRB and NPRC receptors do not acutely influence distensibility in vivo...
  71. ncbi request reprint Pulse waveform analysis and arterial stiffness: realism can replace evangelism and scepticism
    Ian B Wilkinson
    J Hypertens 23:213; author reply 213-4. 2005
  72. ncbi request reprint Use of arterial transfer functions for the derivation of central aortic waveform characteristics in subjects with type 2 diabetes and cardiovascular disease
    Ian B Wilkinson
    Diabetes Care 27:2564; author reply 2565-7. 2004
  73. ncbi request reprint Estimation of central aortic pressure: shedding new light or clouding the issue?
    Ian B Wilkinson
    Clin Sci (Lond) 106:433-4. 2004
  74. ncbi request reprint Pulse pressure predicts cardiovascular risk in patients with type 2 diabetes mellitus
    John R Cockcroft
    Department of Cardiology, University of Wales College of Medicine, University Hospital, Cardiff, Wales
    Am J Hypertens 18:1463-7; discussion 1468-9. 2005
    ..Whether this is also true in subjects with type 2 diabetes, who are at increased risk for cardiovascular disease, is unknown...
  75. ncbi request reprint Pseudo hypertension of youth: too much of a good thing?
    John R Cockcroft
    Am J Hypertens 16:262-4. 2003
  76. ncbi request reprint Central blood pressure measurements and antihypertensive therapy: a consensus document
    Enrico Agabiti-Rosei
    Clinica Medica and Department of Medicine, University Hospital, Brescia, Italy
    Hypertension 50:154-60. 2007
  77. ncbi request reprint Arterial stiffness and pulse contour analysis: an age old concept revisited
    John R Cockcroft
    Department of Cardiology, Wales Heart Research Institute, Cardiff CF14 4XN, Wales, UK
    Clin Sci (Lond) 103:379-80. 2002
  78. ncbi request reprint Influence of fibrillin-1 genotype on aortic stiffness in men: a note of caution
    - Yasmin
    J Appl Physiol 100:1431; author reply 1431-2. 2006
  79. ncbi request reprint Nitric oxide and regulation of arterial elasticity: right idea, wrong vascular bed?
    Ian B Wilkinson
    Hypertension 40:e3-4; author reply e3-4. 2002
  80. ncbi request reprint Arterial stiffness and osteoporosis in chronic obstructive pulmonary disease
    Ramsey Sabit
    Department of Respiratory Medicine, Cardiff University, Academic Centre, Llandough Hospital, Penlan Road, Penarth, Vale of Glamorgan CF64 2XX, UK
    Am J Respir Crit Care Med 175:1259-65. 2007
    ..Chronic obstructive pulmonary disease (COPD) is associated with an increased risk of cardiovascular events and osteoporosis. Increased arterial stiffness is an independent predictor of cardiovascular disease...
  81. ncbi request reprint Nitric oxide does not significantly contribute to changes in pulse pressure amplification during light aerobic exercise
    James E Sharman
    Department of Medicine, University of Queensland, Brisbane, Australia
    Hypertension 51:856-61. 2008
    ....
  82. ncbi request reprint Effects of arterial stiffness, pulse wave velocity, and wave reflections on the central aortic pressure waveform
    Wilmer W Nichols
    Division of Cardiovascular Medicine, Department of Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA
    J Clin Hypertens (Greenwich) 10:295-303. 2008
    ..The decrease in systolic BP brought about by this mechanism is grossly underestimated when systolic BP is measured in the brachial artery...
  83. pmc Effect of integration of supplemental nutrition with public health programmes in pregnancy and early childhood on cardiovascular risk in rural Indian adolescents: long term follow-up of Hyderabad nutrition trial
    Sanjay Kinra
    Non communicable Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, London WC1E 7HT
    BMJ 337:a605. 2008
    ..To determine whether integration of nutritional supplementation with other public health programmes in early life reduces the risk of cardiovascular disease in undernourished populations...
  84. ncbi request reprint Validation of a generalized transfer function to noninvasively derive central blood pressure during exercise
    James E Sharman
    Department of Medicine, School of Human Movement Studies, University of Queensland, Princess Alexandra Hospital, Queensland, Australia
    Hypertension 47:1203-8. 2006
    ..001). True myocardial afterload is not reliably estimated by peripheral systolic BP. Radial tonometry and pulse wave analysis is an accurate technique for the noninvasive determination of central BP at rest and during exercise...
  85. ncbi request reprint Pulse pressure amplification during exercise is significantly reduced with age and hypercholesterolemia
    James E Sharman
    The University of Queensland, Department of Medicine, Princess Alexandra Hospital, Woolloongabba, Brisbane, Australia
    J Hypertens 25:1249-54. 2007
    ..This study aimed to assess the central and peripheral BP response to exercise with aging and hypercholesterolemia...
  86. ncbi request reprint Genetic variation at the growth hormone (GH1) and growth hormone receptor (GHR) loci as a risk factor for hypertension and stroke
    Martin Horan
    Institute of Medical Genetics, Cardiff University, Heath Park, CF14 4XN, Cardiff, UK
    Hum Genet 119:527-40. 2006
    ..Although the underlying mechanisms are still unclear, our findings are consistent with a complex relationship between height, hypertension, GH1 promoter haplotype, GHR polymorphism and the risk of stroke...