Research Topics
Genomes and Genes | Caroline R M WilkinsonSummaryAffiliation: University of Manchester Country: UK Publications
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Publications
New tricks for ubiquitin and friendsCaroline R M Wilkinson
Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK
Trends Cell Biol 12:545-6. 2002..As a result, delegates were treated to a diverse and highly stimulating meeting...
Stress-induced phosphorylation of S. pombe Atf1 abrogates its interaction with F box protein Fbh1Clare L Lawrence
Paterson Institute for Cancer Research, University of Manchester, UK
Curr Biol 19:1907-11. 2009..Thus, our findings represent a novel means of regulating the interaction between an F box protein and its substrate. Moreover, Atf1 is the first target described in any organism for the Fbh1 F box protein...- Ubiquitin-like proteins: meet the familyCaroline R M Wilkinson
Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK
Semin Cell Dev Biol 15:199-200. 2004 - Ubiquitin-like protein Hub1 is required for pre-mRNA splicing and localization of an essential splicing factor in fission yeastCaroline R M Wilkinson
Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
Curr Biol 14:2283-8. 2004.... 
H₂O₂ stress-specific regulation of S. pombe MAPK Sty1 by mitochondrial protein phosphatase Ptc4Yujun Di
Cell Regulation Group, Paterson Institute for Cancer Research, University of Manchester, Manchester, UK
EMBO J 31:563-75. 2012....- A novel pathway determining multidrug sensitivity in Schizosaccharomyces pombeGemma Thornton
Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Manchester, M20 4BX, UK
Genes Cells 10:941-51. 2005..pombe. We propose that this pathway and its role in regulating the plasma membrane potential may act as a pleiotropic determinant of sensitivity to chemotherapeutic agents... - Fission yeast MAP kinase Sty1 is recruited to stress-induced genesWolfgang Reiter
Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester, UK
J Biol Chem 283:9945-56. 2008..Consistent with this delay, Sty1 and Atf1 cannot be detected at these promoters in this condition, suggesting that their association with chromatin is weak or transient in the absence of Pcr1... - Role of a ubiquitin-like modification in polarized morphogenesisGunnar A G Dittmar
Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
Science 295:2442-6. 2002..Consistent with these polarization defects, the hub1Delta mutant was deficient in mating... - Interaction of the anaphase-promoting complex/cyclosome and proteasome protein complexes with multiubiquitin chain-binding proteinsMichael Seeger
Medical Research Council Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, United Kingdom
J Biol Chem 278:16791-6. 2003..The putative role of Pus1 as a factor involved in allocation of ubiquitinylated substrates for the proteasome is discussed... - Multiple pathways differentially regulate global oxidative stress responses in fission yeastDongrong Chen
Cancer Research UK Fission Yeast Functional Genomics Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, United Kingdom
Mol Biol Cell 19:308-17. 2008..These data reveal a considerable plasticity and differential control of regulatory pathways in distinct oxidative stress conditions, providing both specificity and backup for protection from oxidative damage... - A parallel proteomic and metabolomic analysis of the hydrogen peroxide- and Sty1p-dependent stress response in Schizosaccharomyces pombeMark E Weeks
Ludwig Institute for Cancer Research, University College London, Cruciform Building, London, UK
Proteomics 6:2772-96. 2006..This combined analysis identifies a number of interlinked metabolic pathways that exhibit stress- and Sty1-dependent patterns of regulation... - Loss of regulators of vacuolar ATPase function and ceramide synthesis results in multidrug sensitivity in Schizosaccharomyces pombeKeren Dawson
Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester M20 4BX, United Kingdom
Eukaryot Cell 7:926-37. 2008..The rav1 and lac1 genes are conserved in both higher eukaryotes and various pathogenic fungi. Thus, our data could provide the basis for strategies to sensitize tumor cells or drug-resistant pathogenic fungi to drugs... - Int6/eIF3e promotes general translation and Atf1 abundance to modulate Sty1 MAPK-dependent stress response in fission yeastTsuyoshi Udagawa
Molecular Cellular and Developmental Biology Program, Division of Biology, Kansas State University, Manhattan, Kansas 66506, USA
J Biol Chem 283:22063-75. 2008..Thus, the robust protein synthesis promoted by intact eIF3 appears to be a part of the requisites for sound Sty1 MAPK-dependent signaling governed by the activity of the Atf1 transcription factor... - Regulation of Schizosaccharomyces pombe Atf1 protein levels by Sty1-mediated phosphorylation and heterodimerization with Pcr1Clare L Lawrence
Cancer Research UK Cell Regulation Laboratory, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester M20 4BX, United Kingdom
J Biol Chem 282:5160-70. 2007..Taken together, these data suggest that Sty1 phosphorylation of Atf1 is not required for activation of Atf1 per se but rather for modulating its stability...