Affiliation: University of East Anglia
- A guide to viral inclusions, membrane rearrangements, factories, and viroplasm produced during virus replicationChristopher Netherton
Vaccinology Group, Pirbright Laboratories, Institute for Animal Health, Surrey, United Kingdom
Adv Virus Res 70:101-82. 2007....
- Modulation of membrane traffic between endoplasmic reticulum, ERGIC and Golgi to generate compartments for the replication of bacteria and virusesRoberto Pierini
Institute of Biomedical and Clinical Sciences, School of Medicine, University of East Anglia, Norfolk NR47TJ, UK
Semin Cell Dev Biol 20:828-33. 2009..In many cases this involves modulation of Rab and Arf GTPases...
- Aggresomes and pericentriolar sites of virus assembly: cellular defense or viral design?Thomas Wileman
Infection and Immunity, School of Medicine, Faculty of Health, University of East Anglia, Norfolk NR4 7TJ, United Kingdom
Annu Rev Microbiol 61:149-67. 2007..Insights into the possible roles played by aggresomes during virus assembly are emerging from an understanding of how virus inclusions form and how viral proteins are targeted to them...
- Aggresomes and autophagy generate sites for virus replicationThomas Wileman
School of Medicine, Health Policy and Practice, University of East Anglia, Norwich NR4 7TJ, UK
Science 312:875-8. 2006..Here I review the evidence that some viruses induce aggresomes and autophagosomes to generate sites of replication...
- Foot-and-mouth disease virus 3C protease induces fragmentation of the Golgi compartment and blocks intra-Golgi transportZhigang Zhou
Norwich Medical School, Faculty of Medicine and Health, University of East Anglia, Norwich, United Kingdom
J Virol 87:11721-9. 2013..It is likely that the block of intra-Golgi transport is imposed by separate actions of 3C(pro), possibly through degradation of proteins required for intra-Golgi transport. ..
- Autophagy and formation of tubulovesicular autophagosomes provide a barrier against nonviral gene deliveryRebecca Roberts
Norwich Medical School, University of East Anglia, Norfolk, UK
Autophagy 9:667-82. 2013..Activation of autophagy and capture within tubulovesicular autophagosomes therefore provides a new cellular barrier against efficient gene transfer and should be considered when designing efficient nonviral gene delivery vectors...
- Reduced redox potential of the cytosol is important for African swine fever virus capsid assembly and maturationChristian Cobbold
Department of Biomedical and Biomolecular Sciences, Griffith University, Nathan, QLD 4111, Australia
J Gen Virol 88:77-85. 2007..These data show that assembly of ASFV requires the reducing environment that prevails in the cytosol, but as the virus matures, it becomes resistant to oxidation, possibly indicating preparation for release from the cell...
- Intracellular accumulation of hepatitis C virus proteins in a human hepatoma cell lineMichela Brazzoli
Novartis Vaccines and Diagnostics, Via Fiorentina 1, 53100 Siena, Italy
J Hepatol 46:53-9. 2007....
- Vimentin rearrangement during African swine fever virus infection involves retrograde transport along microtubules and phosphorylation of vimentin by calcium calmodulin kinase IISandra Stefanovic
Division of Immunology, Pirbright Laboratories, Institute for Animal Health, Surrey Ash Road, Woking, Surrey GU24 ONF, United Kingdom
J Virol 79:11766-75. 2005..The vimentin cage may serve a cytoprotective function and prevent movement of viral components into the cytoplasm and at the same time concentrate late structural proteins at sites of virus assembly...
- Effects of foot-and-mouth disease virus nonstructural proteins on the structure and function of the early secretory pathway: 2BC but not 3A blocks endoplasmic reticulum-to-Golgi transportKaty Moffat
Pirbright Laboratory, Institute for Animal Health, Pirbright, Surrey GU24 0NF, United Kingdom
J Virol 79:4382-95. 2005..Since FMDV 2BC can block the delivery of proteins to the cell surface, it may, as shown for PV 3A, play a role in immune evasion and contribute to the persistent infections observed in ruminants...
- Foot-and-mouth disease virus replication sites form next to the nucleus and close to the Golgi apparatus, but exclude marker proteins associated with host membrane compartmentsCaroline Knox
University of St Andrews, School of Biology, Centre for Biomolecular Sciences, Biomolecular Sciences Building, North Haugh, St Andrews KY16 9ST, UK
J Gen Virol 86:687-96. 2005..The results suggest that the membranes generated at FMDV assembly sites are able to exclude organelle-specific marker proteins, or that FMDV uses an alternative source of membranes as a platform for assembly and replication...
- African swine fever virus infection disrupts centrosome assembly and functionNolwenn Jouvenet
Department of Immunology and Pathology, Pirbright Laboratories, Institute for Animal Health, Ash Road, Woking, Surrey GU24 0NF, UK
J Gen Virol 86:589-94. 2005..The reorganization of microtubules seen in ASFV-infected cells may therefore be mediated by gamma-tubulin and pericentrin redistribution, and consequent disruption of centrosome assembly and function...
- Transport of African swine fever virus from assembly sites to the plasma membrane is dependent on microtubules and conventional kinesinNolwenn Jouvenet
Department of Immunology and Pathology, Institute for Animal Health, Surrey GU24 0NF, United Kingdom
J Virol 78:7990-8001. 2004..Based on our observations, we propose that ASFV is recognized as cargo by conventional kinesin and uses this plus-end microtubule motor to move from perinuclear assembly sites to the plasma membrane...
- Membrane association facilitates the correct processing of pp220 during production of the major matrix proteins of African swine fever virusColin M Heath
Institute for Animal Health, Pirbright Laboratories, Woking, Surrey GU24 0NF, United Kingdom
J Virol 77:1682-90. 2003..Taken together, these results suggest that association with cellular membranes is important for regulating the correct processing of pp220 and the packaging of matrix proteins into virions...