Thomas Wileman

Summary

Affiliation: University of East Anglia
Country: UK

Publications

  1. ncbi request reprint A guide to viral inclusions, membrane rearrangements, factories, and viroplasm produced during virus replication
    Christopher Netherton
    Vaccinology Group, Pirbright Laboratories, Institute for Animal Health, Surrey, United Kingdom
    Adv Virus Res 70:101-82. 2007
  2. doi request reprint Modulation of membrane traffic between endoplasmic reticulum, ERGIC and Golgi to generate compartments for the replication of bacteria and viruses
    Roberto Pierini
    Institute of Biomedical and Clinical Sciences, School of Medicine, University of East Anglia, Norfolk NR47TJ, UK
    Semin Cell Dev Biol 20:828-33. 2009
  3. pmc Foot-and-mouth disease virus 3C protease induces fragmentation of the Golgi compartment and blocks intra-Golgi transport
    Zhigang Zhou
    Norwich Medical School, Faculty of Medicine and Health, University of East Anglia, Norwich, United Kingdom
    J Virol 87:11721-9. 2013
  4. ncbi request reprint Aggresomes and pericentriolar sites of virus assembly: cellular defense or viral design?
    Thomas Wileman
    Infection and Immunity, School of Medicine, Faculty of Health, University of East Anglia, Norfolk NR4 7TJ, United Kingdom
    Annu Rev Microbiol 61:149-67. 2007
  5. ncbi request reprint Aggresomes and autophagy generate sites for virus replication
    Thomas Wileman
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich NR4 7TJ, UK
    Science 312:875-8. 2006
  6. pmc Autophagy and formation of tubulovesicular autophagosomes provide a barrier against nonviral gene delivery
    Rebecca Roberts
    Norwich Medical School, University of East Anglia, Norfolk, UK
    Autophagy 9:667-82. 2013
  7. ncbi request reprint Reduced redox potential of the cytosol is important for African swine fever virus capsid assembly and maturation
    Christian Cobbold
    Department of Biomedical and Biomolecular Sciences, Griffith University, Nathan, QLD 4111, Australia
    J Gen Virol 88:77-85. 2007
  8. ncbi request reprint Intracellular accumulation of hepatitis C virus proteins in a human hepatoma cell line
    Michela Brazzoli
    Novartis Vaccines and Diagnostics, Via Fiorentina 1, 53100 Siena, Italy
    J Hepatol 46:53-9. 2007
  9. pmc Vimentin rearrangement during African swine fever virus infection involves retrograde transport along microtubules and phosphorylation of vimentin by calcium calmodulin kinase II
    Sandra Stefanovic
    Division of Immunology, Pirbright Laboratories, Institute for Animal Health, Surrey Ash Road, Woking, Surrey GU24 ONF, United Kingdom
    J Virol 79:11766-75. 2005
  10. pmc Effects of foot-and-mouth disease virus nonstructural proteins on the structure and function of the early secretory pathway: 2BC but not 3A blocks endoplasmic reticulum-to-Golgi transport
    Katy Moffat
    Pirbright Laboratory, Institute for Animal Health, Pirbright, Surrey GU24 0NF, United Kingdom
    J Virol 79:4382-95. 2005

Collaborators

  • Kostas Kostarelos
  • Mette M Mogensen
  • Rebecca Roberts
  • Katy Moffat
  • Nolwenn Jouvenet
  • Zhigang Zhou
  • Penny P Powell
  • Paul Monaghan
  • Caroline Knox
  • Miriam Windsor
  • Roberto Pierini
  • Michela Brazzoli
  • Christopher Netherton
  • Christian Cobbold
  • Sandra Stefanovic
  • Colin M Heath
  • Stephen Curry
  • Wafa T Al-Jamal
  • Paul Thomas
  • Matthew Whelband
  • Jeroen Van den Bossche
  • Matthew Jefferson
  • Eleanor Cottam
  • Marcello Merola
  • Stefania Crotta
  • Elizabeth Brooks
  • Sergio Abrignani
  • Alessia Bianchi
  • Ben Baldwin
  • James Parsley
  • Fabio Bagnoli
  • Martin D Ryan
  • Masaki Inagaki
  • Graham J Belsham
  • Koh Ici Nagata
  • Gareth Howell
  • Shireen Ali
  • Martin Ryan
  • Michael Way

Detail Information

Publications14

  1. ncbi request reprint A guide to viral inclusions, membrane rearrangements, factories, and viroplasm produced during virus replication
    Christopher Netherton
    Vaccinology Group, Pirbright Laboratories, Institute for Animal Health, Surrey, United Kingdom
    Adv Virus Res 70:101-82. 2007
    ....
  2. doi request reprint Modulation of membrane traffic between endoplasmic reticulum, ERGIC and Golgi to generate compartments for the replication of bacteria and viruses
    Roberto Pierini
    Institute of Biomedical and Clinical Sciences, School of Medicine, University of East Anglia, Norfolk NR47TJ, UK
    Semin Cell Dev Biol 20:828-33. 2009
    ..In many cases this involves modulation of Rab and Arf GTPases...
  3. pmc Foot-and-mouth disease virus 3C protease induces fragmentation of the Golgi compartment and blocks intra-Golgi transport
    Zhigang Zhou
    Norwich Medical School, Faculty of Medicine and Health, University of East Anglia, Norwich, United Kingdom
    J Virol 87:11721-9. 2013
    ..It is likely that the block of intra-Golgi transport is imposed by separate actions of 3C(pro), possibly through degradation of proteins required for intra-Golgi transport. ..
  4. ncbi request reprint Aggresomes and pericentriolar sites of virus assembly: cellular defense or viral design?
    Thomas Wileman
    Infection and Immunity, School of Medicine, Faculty of Health, University of East Anglia, Norfolk NR4 7TJ, United Kingdom
    Annu Rev Microbiol 61:149-67. 2007
    ..Insights into the possible roles played by aggresomes during virus assembly are emerging from an understanding of how virus inclusions form and how viral proteins are targeted to them...
  5. ncbi request reprint Aggresomes and autophagy generate sites for virus replication
    Thomas Wileman
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich NR4 7TJ, UK
    Science 312:875-8. 2006
    ..Here I review the evidence that some viruses induce aggresomes and autophagosomes to generate sites of replication...
  6. pmc Autophagy and formation of tubulovesicular autophagosomes provide a barrier against nonviral gene delivery
    Rebecca Roberts
    Norwich Medical School, University of East Anglia, Norfolk, UK
    Autophagy 9:667-82. 2013
    ..Activation of autophagy and capture within tubulovesicular autophagosomes therefore provides a new cellular barrier against efficient gene transfer and should be considered when designing efficient nonviral gene delivery vectors...
  7. ncbi request reprint Reduced redox potential of the cytosol is important for African swine fever virus capsid assembly and maturation
    Christian Cobbold
    Department of Biomedical and Biomolecular Sciences, Griffith University, Nathan, QLD 4111, Australia
    J Gen Virol 88:77-85. 2007
    ..These data show that assembly of ASFV requires the reducing environment that prevails in the cytosol, but as the virus matures, it becomes resistant to oxidation, possibly indicating preparation for release from the cell...
  8. ncbi request reprint Intracellular accumulation of hepatitis C virus proteins in a human hepatoma cell line
    Michela Brazzoli
    Novartis Vaccines and Diagnostics, Via Fiorentina 1, 53100 Siena, Italy
    J Hepatol 46:53-9. 2007
    ....
  9. pmc Vimentin rearrangement during African swine fever virus infection involves retrograde transport along microtubules and phosphorylation of vimentin by calcium calmodulin kinase II
    Sandra Stefanovic
    Division of Immunology, Pirbright Laboratories, Institute for Animal Health, Surrey Ash Road, Woking, Surrey GU24 ONF, United Kingdom
    J Virol 79:11766-75. 2005
    ..The vimentin cage may serve a cytoprotective function and prevent movement of viral components into the cytoplasm and at the same time concentrate late structural proteins at sites of virus assembly...
  10. pmc Effects of foot-and-mouth disease virus nonstructural proteins on the structure and function of the early secretory pathway: 2BC but not 3A blocks endoplasmic reticulum-to-Golgi transport
    Katy Moffat
    Pirbright Laboratory, Institute for Animal Health, Pirbright, Surrey GU24 0NF, United Kingdom
    J Virol 79:4382-95. 2005
    ..Since FMDV 2BC can block the delivery of proteins to the cell surface, it may, as shown for PV 3A, play a role in immune evasion and contribute to the persistent infections observed in ruminants...
  11. ncbi request reprint Foot-and-mouth disease virus replication sites form next to the nucleus and close to the Golgi apparatus, but exclude marker proteins associated with host membrane compartments
    Caroline Knox
    University of St Andrews, School of Biology, Centre for Biomolecular Sciences, Biomolecular Sciences Building, North Haugh, St Andrews KY16 9ST, UK
    J Gen Virol 86:687-96. 2005
    ..The results suggest that the membranes generated at FMDV assembly sites are able to exclude organelle-specific marker proteins, or that FMDV uses an alternative source of membranes as a platform for assembly and replication...
  12. ncbi request reprint African swine fever virus infection disrupts centrosome assembly and function
    Nolwenn Jouvenet
    Department of Immunology and Pathology, Pirbright Laboratories, Institute for Animal Health, Ash Road, Woking, Surrey GU24 0NF, UK
    J Gen Virol 86:589-94. 2005
    ..The reorganization of microtubules seen in ASFV-infected cells may therefore be mediated by gamma-tubulin and pericentrin redistribution, and consequent disruption of centrosome assembly and function...
  13. pmc Transport of African swine fever virus from assembly sites to the plasma membrane is dependent on microtubules and conventional kinesin
    Nolwenn Jouvenet
    Department of Immunology and Pathology, Institute for Animal Health, Surrey GU24 0NF, United Kingdom
    J Virol 78:7990-8001. 2004
    ..Based on our observations, we propose that ASFV is recognized as cargo by conventional kinesin and uses this plus-end microtubule motor to move from perinuclear assembly sites to the plasma membrane...
  14. pmc Membrane association facilitates the correct processing of pp220 during production of the major matrix proteins of African swine fever virus
    Colin M Heath
    Institute for Animal Health, Pirbright Laboratories, Woking, Surrey GU24 0NF, United Kingdom
    J Virol 77:1682-90. 2003
    ..Taken together, these results suggest that association with cellular membranes is important for regulating the correct processing of pp220 and the packaging of matrix proteins into virions...