J P Wilding

Summary

Affiliation: University of Liverpool
Country: UK

Publications

  1. ncbi Tesaglitazar, as add-on therapy to sulphonylurea, dose-dependently improves glucose and lipid abnormalities in patients with type 2 diabetes
    John P H Wilding
    Clinical Sciences Centre, University Hospital Aintree, Longmoor Lane, Liverpool L9 7AL, UK
    Diab Vasc Dis Res 4:194-203. 2007
  2. ncbi A study of dapagliflozin in patients with type 2 diabetes receiving high doses of insulin plus insulin sensitizers: applicability of a novel insulin-independent treatment
    John P H Wilding
    University of Liverpool, School of Clinical Sciences, Liverpool, England
    Diabetes Care 32:1656-62. 2009
  3. ncbi Neuropeptides and appetite control
    J P H Wilding
    Clinical Sciences Centre, University Hospital Aintree, Longmoor Lane, Liverpool L9 7AL, Liverpool, UK
    Diabet Med 19:619-27. 2002
  4. ncbi The importance of free fatty acids in the development of Type 2 diabetes
    J P H Wilding
    Clinical Sciences Centre, University Hospital Aintree, Liverpool, UK
    Diabet Med 24:934-45. 2007
  5. ncbi Leptin and the control of obesity
    J P Wilding
    Clinical Sciences Centre, University Hospital Aintree, Liverpool, UK
    Curr Opin Pharmacol 1:656-61. 2001
  6. ncbi Clinical evaluation of anti-obesity drugs
    John Wilding
    Diabetes and Endocrinology Clinical Research Group, Department of Medicine, Clinical Sciences Centre, University Hospital Aintree, Longmoor Lane, Liverpool L9 7AL, UK
    Curr Drug Targets 5:325-32. 2004
  7. ncbi AOD-9604 Metabolic
    John Wilding
    Diabetes and Endocrinology Research Group, Clinical Sciences Centre, University Hospital Aintree, Longmoor Lane, Liverpool, L9 7AL, UK
    Curr Opin Investig Drugs 5:436-40. 2004
  8. ncbi Treatment strategies for obesity
    J P H Wilding
    Diabetes and Endocrinology Clinical Research Group, University Hospital Aintree, Clinical Sciences Centre, University of Liverpool, Liverpool, UK
    Obes Rev 8:137-44. 2007
  9. ncbi Troglitazone corrects metabolic changes but not vascular dysfunction in dietary-obese rats
    E K Naderali
    Diabetes and Endocrinology Research Unit, Department of Medicine, University of Liverpool, UCD, Daulby Street, L69 3GA, Liverpool, UK
    Eur J Pharmacol 416:133-9. 2001
  10. ncbi Diet-induced endothelial dysfunction in the rat is independent of the degree of increase in total body weight
    E K Naderali
    Diabetes and Endocrinology Research Unit, Department of Medicine, University of Liverpool, UCD, Daulby Street, Liverpool L693GA, UK
    Clin Sci (Lond) 100:635-41. 2001

Collaborators

Detail Information

Publications47

  1. ncbi Tesaglitazar, as add-on therapy to sulphonylurea, dose-dependently improves glucose and lipid abnormalities in patients with type 2 diabetes
    John P H Wilding
    Clinical Sciences Centre, University Hospital Aintree, Longmoor Lane, Liverpool L9 7AL, UK
    Diab Vasc Dis Res 4:194-203. 2007
    ..Although tesaglitazar has now been discontinued from clinical development, these results remain relevant to future research into PPAR agonists...
  2. ncbi A study of dapagliflozin in patients with type 2 diabetes receiving high doses of insulin plus insulin sensitizers: applicability of a novel insulin-independent treatment
    John P H Wilding
    University of Liverpool, School of Clinical Sciences, Liverpool, England
    Diabetes Care 32:1656-62. 2009
    ..To determine whether dapagliflozin, which selectively inhibits renal glucose reabsorption, lowers hyperglycemia in patients with type 2 diabetes that is poorly controlled with high insulin doses plus oral antidiabetic agents (OADs)...
  3. ncbi Neuropeptides and appetite control
    J P H Wilding
    Clinical Sciences Centre, University Hospital Aintree, Longmoor Lane, Liverpool L9 7AL, Liverpool, UK
    Diabet Med 19:619-27. 2002
    ..This new understanding may eventually lead to new treatments for obesity that will be of particular benefit in the prevention and treatment of type 2 diabetes...
  4. ncbi The importance of free fatty acids in the development of Type 2 diabetes
    J P H Wilding
    Clinical Sciences Centre, University Hospital Aintree, Liverpool, UK
    Diabet Med 24:934-45. 2007
    ..However, in light of concerns over the apparent increase in congestive heart failure with PPARgamma agonists, their place in the prevention of Type 2 diabetes remains to be determined...
  5. ncbi Leptin and the control of obesity
    J P Wilding
    Clinical Sciences Centre, University Hospital Aintree, Liverpool, UK
    Curr Opin Pharmacol 1:656-61. 2001
    ..Leptin itself seems ineffective in treating most human obesity, but alternative means of activating appetite-regulatory pathways downstream of leptin are targets for future pharmacological approaches to aid weight loss...
  6. ncbi Clinical evaluation of anti-obesity drugs
    John Wilding
    Diabetes and Endocrinology Clinical Research Group, Department of Medicine, Clinical Sciences Centre, University Hospital Aintree, Longmoor Lane, Liverpool L9 7AL, UK
    Curr Drug Targets 5:325-32. 2004
    ....
  7. ncbi AOD-9604 Metabolic
    John Wilding
    Diabetes and Endocrinology Research Group, Clinical Sciences Centre, University Hospital Aintree, Longmoor Lane, Liverpool, L9 7AL, UK
    Curr Opin Investig Drugs 5:436-40. 2004
    ..Metabolic is developing AOD-9604 for the potential treatment of obesity. By February 2002, phase IIa trials were underway...
  8. ncbi Treatment strategies for obesity
    J P H Wilding
    Diabetes and Endocrinology Clinical Research Group, University Hospital Aintree, Clinical Sciences Centre, University of Liverpool, Liverpool, UK
    Obes Rev 8:137-44. 2007
  9. ncbi Troglitazone corrects metabolic changes but not vascular dysfunction in dietary-obese rats
    E K Naderali
    Diabetes and Endocrinology Research Unit, Department of Medicine, University of Liverpool, UCD, Daulby Street, L69 3GA, Liverpool, UK
    Eur J Pharmacol 416:133-9. 2001
    ..Our data show that although troglitazone markedly improved obesity-induced metabolic changes, it failed to correct vascular dysfunction associated with obesity in female Wistar rats...
  10. ncbi Diet-induced endothelial dysfunction in the rat is independent of the degree of increase in total body weight
    E K Naderali
    Diabetes and Endocrinology Research Unit, Department of Medicine, University of Liverpool, UCD, Daulby Street, Liverpool L693GA, UK
    Clin Sci (Lond) 100:635-41. 2001
    ..05) associated with the amount of fat-pad mass. These data suggest that diet-induced vascular dysfunction can occur in the absence of insulin resistance, and that plasma TGs may have a detrimental effect on vascular reactivity...
  11. ncbi Dietary obesity in the rat induces endothelial dysfunction without causing insulin resistance: a possible role for triacylglycerols
    E K Naderali
    Diabetes and Endocrinology Research Unit, Department of Medicine, University of Liverpool, UCD, Daulby Street, Liverpool L69 3GA, UK
    Clin Sci (Lond) 101:499-506. 2001
    ..Dietary-induced obesity severely impaired arterial relaxation in both sexes, particularly at the endothelial level. This is not attributable to insulin resistance, but may be related to moderate hypertriglyceridaemia...
  12. ncbi Insulin-sensitizing action of rosiglitazone is enhanced by preventing hyperphagia
    L C Pickavance
    Department of Medicine, University of Liverpool, Liverpool, UK
    Diabetes Obes Metab 3:171-80. 2001
    ..CONCLUSIONS: Food restriction potentiates the insulin-sensitizing effect of rosiglitazone in rats, and this effect is independent of a fall in FFAs...
  13. ncbi Nurse-led clinics for strict hypertension control are effective long term: a 7 year follow-up study
    A Woodward
    Aintree University Hospitals, Liverpool, UK
    Diabet Med 27:933-7. 2010
    ..The secondary aim was to assess modifiable cardiovascular risk factor status...
  14. ncbi Metformin prolongs the postprandial fall in plasma ghrelin concentrations in type 2 diabetes
    P J English
    Diabetes and Endocrinology Research Group, University Hospital Aintree, Liverpool, UK
    Diabetes Metab Res Rev 23:299-303. 2007
    ..We studied the effects of metformin on energy expenditure, appetite and the regulation of PYY and ghrelin in type 2 diabetes...
  15. ncbi Intensified treatment of type 2 diabetes--positive effects on blood pressure, but not glycaemic control
    G V Gill
    Department of Diabetes and Endocrinology, University Hospital Aintree, Liverpool, UK
    QJM 96:833-6. 2003
    ..Since publication of the UK Prospective Diabetes Study (UKPDS) in 1998, there has been a clear evidence base for tight glycaemic (HBA(1c) < 7.0%) and blood pressure (BP < 140/85 mmHg) control...
  16. ncbi The effects of sibutramine on the microstructure of eating behaviour and energy expenditure in obese women
    J C G Halford
    Kissileff Laboratory, School of Psychology, University of Liverpool, Liverpool, UK
    J Psychopharmacol 24:99-109. 2010
    ..Changes in within-meal appetite ratings appear particularly sensitive to drug-induced enhancement of satiation, and may provide key indices for assessing the therapeutic potential of novel anti-obesity drugs...
  17. ncbi Gut peptides and the regulation of appetite
    M S B Huda
    Diabetes and Endocrinology Research Group, University Hospital Aintree, Longmoor Lane, Liverpool, UK
    Obes Rev 7:163-82. 2006
    ..Finally, we propose an integrated model to describe the complex interplay of these hormones in the broader physiology of energy balance...
  18. ncbi Insulin resistance and inflammatory activation in older patients with systolic and diastolic heart failure
    N Wisniacki
    Diabetes and Endocrinology Research Group, Department of Medicine, University of Liverpool, Liverpool, UK
    Heart 91:32-7. 2005
    ..To evaluate insulin resistance and systemic inflammation in older patients with systolic (SHF) or diastolic heart failure (DHF)...
  19. ncbi Ghrelin inhibits autonomic function in healthy controls, but has no effect on obese and vagotomized subjects
    M S B Huda
    University of Liverpool Diabetes and Endocrinology Research Group, Clinical Sciences Centre School of Psychology, University of Liverpool, Liverpool, UK
    Clin Endocrinol (Oxf) 73:678-85. 2010
    ..Ghrelin inhibits sympathetic nervous system (SNS) activity in rodents. We studied the effect of ghrelin on healthy humans, in obesity and in vagotomized subjects...
  20. ncbi Plasma obestatin levels are lower in obese and post-gastrectomy subjects, but do not change in response to a meal
    M S B Huda
    Diabetes and Endocrinology Research Group, Clinical Sciences Centre, University Hospital Aintree, Liverpool, UK
    Int J Obes (Lond) 32:129-35. 2008
    ..To investigate a potential role for obestatin in humans by examining response to a fixed energy meal...
  21. ncbi Ghrelin restores 'lean-type' hunger and energy expenditure profiles in morbidly obese subjects but has no effect on postgastrectomy subjects
    M S B Huda
    University of Liverpool Diabetes and Endocrinology Research Group, Clinical Sciences Centre, University Hospital Aintree, Liverpool, UK
    Int J Obes (Lond) 33:317-25. 2009
    ..To examine the effects of ghrelin on appetite and energy expenditure in lean, obese and postgastrectomy subjects...
  22. ncbi Assessment of quality of life in adults receiving long-term growth hormone replacement compared to control subjects
    I A Malik
    Department of Diabetes, Clinical Sciences Centre, University Hospital Aintree, Liverpool, UK
    Clin Endocrinol (Oxf) 59:75-81. 2003
    ..These have shown impairments in a variety of QOL measures, which improve but do not normalize after short-term replacement with GH. There is little information on QOL in long-term treated GHD patients compared with controls without GHD...
  23. ncbi Adipokines and the insulin resistance syndrome in familial partial lipodystrophy caused by a mutation in lamin A/C
    S P Y Wong
    Clinical Sciences Centre, University Hospital Aintree, Liverpool, UK
    Diabetologia 48:2641-9. 2005
    ....
  24. ncbi Effects of S 15511, a therapeutic metabolite of the insulin-sensitizing agent S 15261, in the Zucker Diabetic Fatty rat
    L C Pickavance
    Department of Veterinary Preclinical Sciences, University of Liverpool, Liverpool, UK
    Diabetes Obes Metab 9:114-20. 2007
    ..The study was designed to determine the biological activity of its two major metabolites, S 15511 and Y 415, and whether or not they have an additive effect...
  25. ncbi A parametric analysis of olanzapine-induced weight gain in female rats
    G D Cooper
    School of Psychology, Liverpool University, Eleanor Rathbone Building, Bedford Street, Liverpool, L69 7ZA, UK
    Psychopharmacology (Berl) 181:80-9. 2005
    ..Prolactin elevation appears likely not to be involved in the weight gain, adiposity and metabolic changes seen in this model...
  26. ncbi Prevalence of obesity in type 2 diabetes in secondary care: association with cardiovascular risk factors
    C Daousi
    Diabetes and Endocrinology Research Group, University Hospital Aintree, Liverpool, UK
    Postgrad Med J 82:280-4. 2006
    ....
  27. ncbi Effects of peripheral administration of synthetic human glucose-dependent insulinotropic peptide (GIP) on energy expenditure and subjective appetite sensations in healthy normal weight subjects and obese patients with type 2 diabetes
    C Daousi
    University Hospital Aintree, Clinical Sciences Center, Liverpool, UK
    Clin Endocrinol (Oxf) 71:195-201. 2009
    ....
  28. ncbi Food fails to suppress ghrelin levels in obese humans
    P J English
    Diabetes and Endocrinology Research Group, Clinical Sciences Centre, University Hospital Aintree, Liverpool L9 7AL, UK
    J Clin Endocrinol Metab 87:2984. 2002
    ....
  29. ncbi Effects of chronic treatment with metformin on dipeptidyl peptidase-4 activity, glucagon-like peptide 1 and ghrelin in obese patients with Type 2 diabetes mellitus
    S K Thondam
    Diabetes and Endocrinology Clinical Research Group, University Hospital Aintree, Clinical Sciences Centre, Liverpool, UK
    Diabet Med 29:e205-10. 2012
    ..We therefore studied the effects of chronic treatment with metformin on endogenous glucagon-like peptide 1, dipeptidyl peptidase-4 activity and active ghrelin (an orexigenic hormone) in obese patients with Type 2 diabetes mellitus...
  30. ncbi Growth hormone and changes in energy balance in growth hormone deficient adults
    D Deepak
    Clinical Sciences Centre, University Hospital Aintree, Liverpool, UK
    Eur J Clin Invest 38:622-7. 2008
    ..It is not known whether growth hormone replacement (GHR) results in alterations in energy intake (EI) and/or energy expenditure (EE). The aim of the study was to investigate the effects of GHR on EI and EE...
  31. ncbi Cardiovascular and metabolic effects of CPAP in obese males with OSA
    S R Coughlin
    School of Clinical Sciences, Clinical Sciences Centre, University of Liverpool, UK
    Eur Respir J 29:720-7. 2007
    ..The mechanisms underlying this difference in the time course of blood pressure and metabolic response to continuous positive airway pressure in obstructive sleep apnoea requires further exploration...
  32. ncbi Effects of olanzapine in male rats: enhanced adiposity in the absence of hyperphagia, weight gain or metabolic abnormalities
    G D Cooper
    School of Psychology, University of Liverpool, Liverpool, UK
    J Psychopharmacol 21:405-13. 2007
    ..Possible mechanisms involved in the effects reported are discussed...
  33. ncbi Lack of an acute effect of ghrelin on markers of bone turnover in healthy controls and post-gastrectomy subjects
    M S B Huda
    Clinical Sciences Centre, University of Liverpool Diabetes and Endocrinology Research Group, University Hospital Aintree, Longmoor Lane, Liverpool L9 7AL, UK
    Bone 41:406-13. 2007
    ..Little is known about the effects of ghrelin on bone turnover in humans. As the stomach is the main site of ghrelin synthesis, gastrectomy patients are deficient in ghrelin; they are also prone to osteopenia and osteomalacia...
  34. ncbi The influence of growth hormone replacement on heart rate variability in adults with growth hormone deficiency
    K S Leong
    Department of Medicine, Clinical Sciences Centre, University Hospital Aintree, Longmoor Lane, Liverpool L9 7AL, UK
    Clin Endocrinol (Oxf) 54:819-26. 2001
    ..Longer duration of prospective follow-up will be required to determine at what time point improvements in the other frequency bands occur...
  35. ncbi A role for glucagon-like peptide-1 in the central regulation of feeding
    M D Turton
    Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK
    Nature 379:69-72. 1996
    ..Both of these regions of the brain are of primary importance in the regulation of feeding. These findings suggest that central GLP-1 is a new physiological mediator of satiety...
  36. ncbi Cardiovascular disease, hypertension, dyslipidaemia and obesity in patients with hypothalamic-pituitary disease
    D Deepak
    University Department of Diabetes and Endocrinology, Clinical Sciences Centre, University Hospital Aintree, Liverpool, UK
    Postgrad Med J 83:277-80. 2007
    ..Therefore, the prevalence of CVD and adequacy of treatment of cardiovascular risk factors (according to current treatment guidelines) was studied in a large group of patients with hypothalamic-pituitary disease...
  37. ncbi Reduced ventromedial hypothalamic neuronal nitric oxide synthase and increased sensitivity to NOS inhibition in dietary obese rats: further evidence of a role for nitric oxide in the regulation of energy balance
    C J Sadler
    Neuroendocrine and Obesity Biology Unit, Department of Medicine, University of Liverpool, Liverpool L69 3GA, UK
    Brain Res 1016:222-8. 2004
    ..Despite having reduced nNOS, dietary obese rats were more sensitive to the effects of NOS inhibition than lean controls, suggesting a role for NO in the development of hyperphagia and obesity in rats fed a palatable diet...
  38. ncbi Chronic treatment with the thiazolidinedione, MCC-555, is associated with reductions in nitric oxide synthase activity and beta-cell apoptosis in the pancreas of the Zucker Diabetic Fatty rat
    Lucy C Pickavance
    Department of Medicine, University of Liverpool, Liverpool, Merseyside, UK
    Int J Exp Pathol 84:83-9. 2003
    ....
  39. ncbi Plasma adiponectin increases postprandially in obese, but not in lean, subjects
    Patrick J English
    The University of Liverpool Diabetes and Endocrinology Research Group, Clinical Sciences Centre, Liverpool, United Kingdom
    Obes Res 11:839-44. 2003
    ..We investigated the acute responses of plasma adiponectin levels to a test meal in lean and obese subjects...
  40. ncbi Obstructive sleep apnoea is independently associated with an increased prevalence of metabolic syndrome
    Steven R Coughlin
    Department of Medicine, Clinical Sciences Centre, University of Liverpool, Lower Lane, Liverpool L9 7AL, UK
    Eur Heart J 25:735-41. 2004
    ..This may help explain the increased cardiovascular morbidity and mortality associated with this condition...
  41. ncbi A randomized, placebo-controlled trial assessing the effects of rosiglitazone on echocardiographic function and cardiac status in type 2 diabetic patients with New York Heart Association Functional Class I or II Heart Failure
    Henry J Dargie
    Department of Cardiology, Western Infirmary, Glasgow, Scotland
    J Am Coll Cardiol 49:1696-704. 2007
    ....
  42. ncbi Effects of insulin-induced hypoglycaemia on energy intake and food choice at a subsequent test meal
    Shivani Dewan
    Diabetes and Endocrinology Research Group, University Hospital Aintree, Liverpool, UK
    Diabetes Metab Res Rev 20:405-10. 2004
    ..High-fat foods can lead to passive overconsumption and have a low glycaemic index, which may prolong hypoglycaemia. Both factors could ultimately promote weight gain in individuals with recurrent hypoglycaemia...
  43. ncbi The dual PPARalpha/gamma agonist, ragaglitazar, improves insulin sensitivity and metabolic profile equally with pioglitazone in diabetic and dietary obese ZDF rats
    Lucy C Pickavance
    Department of Veterinary Preclinical Sciences, University of Liverpool, Brownlow Hill Crown St, Liverpool L69 7ZJ, UK
    Br J Pharmacol 144:308-16. 2005
    ..They also improve beta-cell function, although this is better demonstrated through indices incorporating fasting insulin and glucose concentrations than through the hyperglycaemic clamp technique in this model...
  44. ncbi The relationship of ghrelin to biochemical and anthropometric markers of adult growth hormone deficiency
    Iqbal A Malik
    Diabetes and Endocrinology Research Group, University Hospital Aintree, Liverpool, UK
    Clin Endocrinol (Oxf) 60:137-41. 2004
    ....
  45. ncbi Obesity and type-2 diabetes in the elderly
    Shivani Dewan
    Department of Medicine, Clinical Sciences Centre, University Hospital Aintree, Liverpool, UK
    Gerontology 49:137-45. 2003
    ..Obesity should not be viewed as a cosmetic problem that affects a few individuals, but a major health hazard that is both preventable and amenable to treatment...
  46. ncbi Ghrelin: sweet regulation?
    Patrick J English
    Diabetes and Endocrinology Research Group, Clinical Sciences Centre, University Hospital Aintree, Lower Lane, Liverpool L9 7AL, U K
    Clin Sci (Lond) 103:329-30. 2002
  47. ncbi Is there a role for ghrelin and peptide-YY in the pathogenesis of obesity in adults with acquired structural hypothalamic damage?
    Christina Daousi
    University Hospital Aintree, Diabetes and Endocrinology Research Group, Clinical Sciences Center, Longmoor Lane, Liverpool L9 7AL, United Kingdom
    J Clin Endocrinol Metab 90:5025-30. 2005
    ..Obesity is a common sequel to hypothalamic tumors and their treatment, but the underlying mechanisms are not fully established...