Christopher Paul Wild

Summary

Affiliation: University of Leeds
Country: UK

Publications

  1. ncbi request reprint Molecular epidemiology and cancer: promising areas for future research in the post-genomic era
    Christopher P Wild
    Molecular Epidemiology Unit, Academic Unit of Epidemiology and Health Services Research, Algernon Firth Building, University of Leeds, Leeds LS2 9JT, UK
    Mutat Res 499:3-12. 2002
  2. ncbi request reprint Aflatoxin exposure in developing countries: the critical interface of agriculture and health
    Christopher Paul Wild
    Molecular Epidemiology Unit, Centre for Epidemiology and Biostatistics, Leeds Institute of Genetics, Health and Therapeutics, Faculty of Medicine and Health, University of Leeds, Leeds, UK
    Food Nutr Bull 28:S372-80. 2007
  3. pmc Urinary deoxynivalenol is correlated with cereal intake in individuals from the United kingdom
    Paul C Turner
    Molecular Epidemiology Unit Center for Epidemiology and Biostatistics, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds United
    Environ Health Perspect 116:21-5. 2008
  4. ncbi request reprint Environmental and genetic determinants of aflatoxin-albumin adducts in the Gambia
    C P Wild
    Molecular Epidemiology Unit, School of Medicine, University of Leeds, UK
    Int J Cancer 86:1-7. 2000
  5. ncbi request reprint Reflux, Barrett's oesophagus and adenocarcinoma: burning questions
    Christopher P Wild
    Molecular Epidemiology Unit, Epidemiology and Health Services Research, School of Medicine, University of Leeds, Leeds LS2 9JT, UK
    Nat Rev Cancer 3:676-84. 2003
  6. pmc Environmental exposure measurement in cancer epidemiology
    Christopher P Wild
    Molecular Epidemiology Unit, Centre for Epidemiology and Biostatistics, Leeds Institute of Genetics, Health and Therapeutics, LIGHT Laboratories, University of Leeds, Leeds, UK
    Mutagenesis 24:117-25. 2009
  7. doi request reprint A model of interaction: aflatoxins and hepatitis viruses in liver cancer aetiology and prevention
    Christopher P Wild
    Molecular Epidemiology Unit, Centre for Epidemiology and Biostatistics, LIGHT Laboratories, University of Leeds, Leeds, UK
    Cancer Lett 286:22-8. 2009
  8. ncbi request reprint Primary prevention of hepatocellular carcinoma in developing countries
    C P Wild
    Molecular Epidemiology Unit, Algernon Firth Building, School of Medicine, University of Leeds, Leeds, UK
    Mutat Res 462:381-93. 2000
  9. ncbi request reprint The toxicology of aflatoxins as a basis for public health decisions
    C P Wild
    Molecular Epidemiology Unit, Epidemiology and Health Services Research, Algernon Firth Building, School of Medicine, University of Leeds, Leeds LS2 9JT, UK
    Mutagenesis 17:471-81. 2002
  10. ncbi request reprint A critical evaluation of the application of biomarkers in epidemiological studies on diet and health
    C P Wild
    Molecular Epidemiology Unit, Academic Unit of Epidemiology and Health Services Research School of Medicine, University of Leeds, UK
    Br J Nutr 86:S37-53. 2001

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Molecular epidemiology and cancer: promising areas for future research in the post-genomic era
    Christopher P Wild
    Molecular Epidemiology Unit, Academic Unit of Epidemiology and Health Services Research, Algernon Firth Building, University of Leeds, Leeds LS2 9JT, UK
    Mutat Res 499:3-12. 2002
    ..We conclude that in order to progress our understanding of cancer aetiology, a balanced approach integrating molecular measures into well-designed epidemiological studies is required...
  2. ncbi request reprint Aflatoxin exposure in developing countries: the critical interface of agriculture and health
    Christopher Paul Wild
    Molecular Epidemiology Unit, Centre for Epidemiology and Biostatistics, Leeds Institute of Genetics, Health and Therapeutics, Faculty of Medicine and Health, University of Leeds, Leeds, UK
    Food Nutr Bull 28:S372-80. 2007
    ..However, in an agricultural setting, the effects on growth, immune status, and susceptibility to infectious disease in farm animals are also well recognized. These latter effects have been far less explored in human populations...
  3. pmc Urinary deoxynivalenol is correlated with cereal intake in individuals from the United kingdom
    Paul C Turner
    Molecular Epidemiology Unit Center for Epidemiology and Biostatistics, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds United
    Environ Health Perspect 116:21-5. 2008
    ..Deoxynivalenol (DON) is a toxic fungal metabolite that frequently contaminates cereal crops. DON is toxic to animals, but the effects on humans are poorly understood, in part because exposure estimates are of limited precision...
  4. ncbi request reprint Environmental and genetic determinants of aflatoxin-albumin adducts in the Gambia
    C P Wild
    Molecular Epidemiology Unit, School of Medicine, University of Leeds, UK
    Int J Cancer 86:1-7. 2000
    ..This study further emphasises the priority to reduce aflatoxin exposure in these communities by primary prevention measures...
  5. ncbi request reprint Reflux, Barrett's oesophagus and adenocarcinoma: burning questions
    Christopher P Wild
    Molecular Epidemiology Unit, Epidemiology and Health Services Research, School of Medicine, University of Leeds, Leeds LS2 9JT, UK
    Nat Rev Cancer 3:676-84. 2003
    ..This could include a better rationale for screening and surveillance programmes, as well as targeted intervention strategies...
  6. pmc Environmental exposure measurement in cancer epidemiology
    Christopher P Wild
    Molecular Epidemiology Unit, Centre for Epidemiology and Biostatistics, Leeds Institute of Genetics, Health and Therapeutics, LIGHT Laboratories, University of Leeds, Leeds, UK
    Mutagenesis 24:117-25. 2009
    ..It is suggested that a concerted effort is now required, with appropriate funding, to develop and validate the required exposure assessment methodology before these cohorts come to maturity...
  7. doi request reprint A model of interaction: aflatoxins and hepatitis viruses in liver cancer aetiology and prevention
    Christopher P Wild
    Molecular Epidemiology Unit, Centre for Epidemiology and Biostatistics, LIGHT Laboratories, University of Leeds, Leeds, UK
    Cancer Lett 286:22-8. 2009
    ..Priorities for prevention are global HBV vaccination, primary and secondary prevention strategies against aflatoxin and the avoidance of transmission of HCV through good hygiene practices...
  8. ncbi request reprint Primary prevention of hepatocellular carcinoma in developing countries
    C P Wild
    Molecular Epidemiology Unit, Algernon Firth Building, School of Medicine, University of Leeds, Leeds, UK
    Mutat Res 462:381-93. 2000
    ..Thus measures to reduce food spoilage by fungi and the associated dietary exposure to aflatoxins is also a desirable public health goal...
  9. ncbi request reprint The toxicology of aflatoxins as a basis for public health decisions
    C P Wild
    Molecular Epidemiology Unit, Epidemiology and Health Services Research, Algernon Firth Building, School of Medicine, University of Leeds, Leeds LS2 9JT, UK
    Mutagenesis 17:471-81. 2002
    ..Overall, integrated, multidisciplinary research on aflatoxins has provided the platform on which to base decisions regarding acceptable exposures and priorities for interventions to reduce human risk in a public health context...
  10. ncbi request reprint A critical evaluation of the application of biomarkers in epidemiological studies on diet and health
    C P Wild
    Molecular Epidemiology Unit, Academic Unit of Epidemiology and Health Services Research School of Medicine, University of Leeds, UK
    Br J Nutr 86:S37-53. 2001
    ..A combination of methods will probably prove to be most valuable and this approach is being taken in current large prospective studies...
  11. ncbi request reprint Caffeine intake during pregnancy, late miscarriage and stillbirth
    Darren C Greenwood
    Biostatistics Unit, Centre for Epidemiology and Biostatistics, University of Leeds, Worsley Building, Leeds, LS2 9JT, United Kingdom
    Eur J Epidemiol 25:275-80. 2010
    ..Despite remaining uncertainty in the strength of association, our study strengthens the observational evidence base on which current guidance is founded...
  12. ncbi request reprint Dietary wheat reduction decreases the level of urinary deoxynivalenol in UK adults
    Paul C Turner
    Molecular Epidemiology Unit and Nutritional Epidemiology Group, Centre for Epidemiology and Biostatistics, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK
    J Expo Sci Environ Epidemiol 18:392-9. 2008
    ..On the basis of urinary biomarker levels some individuals are predicted to exceed current recommended daily intakes of DON, and thus the health consequences of these exposures merit further investigation...
  13. ncbi request reprint Deoxynivalenol: rationale for development and application of a urinary biomarker
    Paul C Turner
    Molecular Epidemiology Unit, Centre for Epidemiology and Biostatistics, Leeds Institute of Genetics, Health and Therapeutics, Faculty of Medicine and Health, University of Leeds, Leeds LS2 9JJ, UK
    Food Addit Contam Part A Chem Anal Control Expo Risk Assess 25:864-71. 2008
    ..This biomarker requires further validation but our initial data suggest it may provide a useful tool in epidemiological investigations of the potential health consequences of this common environmental toxin...
  14. ncbi request reprint A comparison of deoxynivalenol intake and urinary deoxynivalenol in UK adults
    Paul C Turner
    Molecular Epidemiology Unit, Centre for Epidemiology and Biostatistics, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, UK
    Biomarkers 15:553-62. 2010
    ..83) in models adjusting for age, sex and body mass index. These data demonstrate a quantitative correlation between DON exposure and urinary DON, and serve to validate the use of urinary DON as an exposure biomarker...
  15. ncbi request reprint A comparison of 24 h urinary deoxynivalenol with recent v. average cereal consumption for UK adults
    Paul C Turner
    Molecular Epidemiology Unit, Centre for Epidemiology and Biostatistics, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK
    Br J Nutr 102:1276-9. 2009
    ..27). These data suggest that the inter-individual variation in urinary DON was somewhat better explained by recent cereal intake compared with usual cereal intake assessed over 7 d...
  16. doi request reprint Fumonisin B1 as a urinary biomarker of exposure in a maize intervention study among South African subsistence farmers
    Liana van der Westhuizen
    PROMEC Unit, Medical Research Council, Tygerberg, South Africa
    Cancer Epidemiol Biomarkers Prev 20:483-9. 2011
    ..The aim of this study was to validate a urinary fumonisin B1 (UFB1) biomarker as a measure of fumonisin exposure and to investigate the reduction in exposure following a simple and culturally acceptable intervention...
  17. ncbi request reprint p16 expression in Barrett's esophagus and esophageal adenocarcinoma: association with genetic and epigenetic alterations
    Laura J Hardie
    Molecular Epidemiology Unit and Health Services Research, School of Medicine, Algernon Firth Building, University of Leeds, Leeds LS2 9JT, UK
    Cancer Lett 217:221-30. 2005
    ....
  18. ncbi request reprint Risk factors, DNA damage, and disease progression in Barrett's esophagus
    Joanna R Olliver
    Molecular Epidemiology Unit, Centre for Epidemiology and Biostatistics, Faculty of Medicine and Health, University of Leeds, Leeds LS2 9JT, United Kingdom
    Cancer Epidemiol Biomarkers Prev 14:620-5. 2005
    ..There is an indication for a role for smoking in inducing DNA damage in esophageal mucosa but an understanding of the role of reflux requires further investigation...
  19. pmc Assessment of deoxynivalenol metabolite profiles in UK adults
    Paul C Turner
    Centre for Epidemiology and Biostatistics, Leeds Institute of Genetics, Health and Therapeutics University of Leeds, Leeds, UK
    Food Chem Toxicol 49:132-5. 2011
    ..This study needs to be extended to understand whether the fD / DG ratio provides a phenotypic measure of DON susceptibility...
  20. ncbi request reprint The NAD(P)H:quinone oxidoreductase I C609T polymorphism modifies the risk of Barrett esophagus and esophageal adenocarcinoma
    Erica di Martino
    Molecular Epidemiology Unit, Centre for Epidemiology and Biostatistics, Leeds Institute for Genetics, Health and Therapeutics, University of Leeds, Leeds, United Kingdom
    Genet Med 9:341-7. 2007
    ..This study investigated the effect of polymorphisms in the manganese superoxide dismutase (MnSOD) and NAD(P)H:quinone oxidoreductase 1 (NQO1) genes in modulating the risk of developing Barrett esophagus or esophageal adenocarcinoma...
  21. ncbi request reprint Risk of mortality and cancer incidence in Barrett's esophagus
    Michael B Cook
    Centre for Epidemiology and Biostatistics, Leeds Institute of Genetics, Health, and Therapeutics, University of Leeds, Arthington House, Cookridge Hospital, Leeds LS16 6QB, United Kingdom
    Cancer Epidemiol Biomarkers Prev 16:2090-6. 2007
    ..Such studies are necessary in order to understand the overall risks of cancer and death experienced by patients with BE...
  22. ncbi request reprint Association between the risk of coronary artery disease in South Asians and a deletion polymorphism in glutathione S-transferase M1
    Michael H Wilson
    Molecular Epidemiology Unit, Epidemiology and Health Services Research, University of Leeds, Leeds, UK
    Biomarkers 8:43-50. 2003
    ..1). The results of this study indicate that the GSTM1 null genotype is protective against both CAD and AMI. However, further study is required in order to elucidate the, as yet unexplained, mechanisms underlying this association...
  23. ncbi request reprint Aflatoxin exposure in utero causes growth faltering in Gambian infants
    Paul C Turner
    Molecular Epidemiology Unit, Centre for Epidemiology and Biostatistics, Leeds Institute of Genetics, Health and Therapeutics, Faculty of Medicine and Health, University of Leeds, Leeds, UK LS2 9JT
    Int J Epidemiol 36:1119-25. 2007
    ..However, in animal studies in utero exposure to low levels of aflatoxin also results in growth faltering...
  24. ncbi request reprint Proteomic screening of a cell line model of esophageal carcinogenesis identifies cathepsin D and aldo-keto reductase 1C2 and 1B10 dysregulation in Barrett's esophagus and esophageal adenocarcinoma
    Jean Breton
    Molecular Epidemiology Unit, Centre for Epidemiology and Biostatistics, Leeds Institute of Genetics, Health and Therapeutics, Clarendon Way, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Proteome Res 7:1953-62. 2008
    ..05) in EA. These proteins may contribute to disease development via effects on apoptosis, transport of bile acids and retinoid metabolism and should be considered as candidates for further mechanistic and clinical investigations...
  25. pmc Postweaning exposure to aflatoxin results in impaired child growth: a longitudinal study in Benin, West Africa
    Yunyun Gong
    Molecular Epidemiology Unit, Centre for Epidemiology and Biostatistics, Leeds Institute of Genetics Health and Therapeutics, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom
    Environ Health Perspect 112:1334-8. 2004
    ..Aflatoxin exposure during the weaning period may be critical in terms of adverse health effects in West African children, and intervention measures to reduce exposure merit investigation...
  26. ncbi request reprint Absence of TP53 codon 249 mutations in young Guinean children with high aflatoxin exposure
    Paul C Turner
    Molecular Epidemiology Unit, Centre for Epidemiology and Biostatistics, Leeds Institute of Genetics, Health and Therapeutics, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom LS2 9JT
    Cancer Epidemiol Biomarkers Prev 14:2053-5. 2005
    ....
  27. ncbi request reprint A systematic review and meta-analysis of the risk of increasing adiposity on Barrett's esophagus
    Michael B Cook
    Centre for Epidemiology and Biostatistics, Leeds Institute for Genetics Health and Therapeutics, Faculty of Medicine and Health, University of Leeds, Leeds, England, United Kingdom
    Am J Gastroenterol 103:292-300. 2008
    ..This systematic review and meta-analysis investigated whether increasing BMI is associated with Barrett's esophagus as compared to general population and GERD controls...
  28. pmc Modification of immune function through exposure to dietary aflatoxin in Gambian children
    Paul C Turner
    Molecular Epidemiology Unit, Epidemiology and Health Services Research, University of Leeds, Leeds, United Kingdom
    Environ Health Perspect 111:217-20. 2003
    ..Given the high burden of infection-related mortality in West Africa, further investigation of the immune effects of aflatoxin exposure in children is merited...
  29. ncbi request reprint The role of aflatoxins and hepatitis viruses in the etiopathogenesis of hepatocellular carcinoma: A basis for primary prevention in Guinea-Conakry, West Africa
    Paul C Turner
    Molecular Epidemiology Unit, Epidemiology and Health Services Research, Algernon Firth Building, School of Medicine, University of Leeds, Leeds, UK
    J Gastroenterol Hepatol 17:S441-8. 2002
    ..This study will evaluate the effectiveness of improving the post-harvest processing and storage of the groundnut crop, a major source of aflatoxins, using aflatoxin-albumin adducts as the outcome measurement...
  30. ncbi request reprint Genetic polymorphisms in microsomal epoxide hydrolase and susceptibility to adult acute myeloid leukaemia with defined cytogenetic abnormalities
    Pierre Lebailly
    Molecular Epidemiology Unit, Epidemiology and Health Services Research, School of Medicine, University of Leeds, UK
    Br J Haematol 116:587-94. 2002
    ....
  31. ncbi request reprint Sodium deoxycholate causes nitric oxide mediated DNA damage in oesophageal cells
    Arthur J Jolly
    Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, UK
    Free Radic Res 43:234-40. 2009
    ..In conclusion, NDC-driven NO production may play an important role in inducing DNA damage during episodes of gastro-oesophageal reflux and thereby contribute to reflux-related carcinogenesis...
  32. ncbi request reprint An intron splice acceptor polymorphism in hMSH2 and risk of leukemia after treatment with chemotherapeutic alkylating agents
    Lisa J Worrillow
    Leukaemia Research Fund Epidemiology and Genetics Unit, Academic Unit of Epidemiology, School of Medicine, University of Leeds, Leeds LS2 9JT, United Kingdom
    Clin Cancer Res 9:3012-20. 2003
    ..We also determined the extent of microsatellite instability (MSI) in therapy-related acute myeloid leukemia (t-AML) as a marker of dysfunctional DNA mismatch repair...
  33. doi request reprint Association between tortilla consumption and human urinary fumonisin B1 levels in a Mexican population
    Yun Yun Gong
    Molecular Epidemiology Unit, Centre for Epidemiology and Biostatistics, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds LS2 9JT, United Kingdom
    Cancer Epidemiol Biomarkers Prev 17:688-94. 2008
    ..This study suggests that measurement of urinary FB1 is sufficiently sensitive for fumonisin exposure assessment in human populations and could be a valuable tool in investigating the associated health effects of exposure...
  34. ncbi request reprint Cellular prion protein protects against reactive-oxygen-species-induced DNA damage
    Nicole T Watt
    Proteolysis Research Group, Institute of Molecular and Cellular Biology, Faculty of Biological Sciences and Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds LS2 9JT, UK
    Free Radic Biol Med 43:959-67. 2007
    ....
  35. ncbi request reprint Genotoxicity of size-fractionated samples of urban particulate matter
    Katherine Healey
    Molecular Epidemiology Unit, Centre for Epidemiology and Biostatistics, University of Leeds, Leeds, United Kingdom
    Environ Mol Mutagen 45:380-7. 2005
    ..These results show that finer particulates have the greatest ability to induce DNA damage in lung epithelial cells and naked DNA, and that both organic and inorganic components of the UPM contribute to its genotoxic effects...
  36. ncbi request reprint The mutagenicity of urban particulate matter in an enzyme free system is associated with the generation of reactive oxygen species
    Katherine Healey
    Molecular Epidemiology Unit, Centre for Epidemiology and Biostatistics, Leeds Institute for Genetics Health and Therapeutics, The LIGHT Laboratories, University of Leeds, Leeds LS2 9JT, United Kingdom
    Mutat Res 602:1-6. 2006
    ..Most mutation studies with UPM have focused on organic carcinogens present on UPM. Our results highlight the potential contribution of metal ions to the mutagenicity of UPM...
  37. ncbi request reprint Children and increased susceptibility to environmental carcinogens: evidence or empathy?
    Christopher Paul Wild
    Cancer Epidemiol Biomarkers Prev 12:1389-94. 2003
  38. ncbi request reprint Complementing the genome with an "exposome": the outstanding challenge of environmental exposure measurement in molecular epidemiology
    Christopher Paul Wild
    Cancer Epidemiol Biomarkers Prev 14:1847-50. 2005