Martin Widschwendter

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc Relationship between genome and epigenome - challenges and requirements for future research
    Genevieve Almouzni
    Department of Women s Cancer, UCL Elizabeth Garrett Anderson Institute for Women s Health, University College London, 74 Huntley Street, London WC1E 6AU, UK
    BMC Genomics 15:487. 2014
  2. pmc 5-methylcytosine--the fifth base of DNA: the fifth wheel on a car or a highly promising diagnostic and therapeutic target in cancer?
    Martin Widschwendter
    Dis Markers 23:1-3. 2007
  3. pmc The dynamics and prognostic potential of DNA methylation changes at stem cell gene loci in women's cancer
    Joanna Zhuang
    Department of Women s Cancer, University College London Elizabeth Garrett Anderson Institute for Women s Health, London, UK
    PLoS Genet 8:e1002517. 2012
  4. pmc Corruption of the intra-gene DNA methylation architecture is a hallmark of cancer
    Thomas E Bartlett
    CoMPLEX, University College London, London, United Kingdom
    PLoS ONE 8:e68285. 2013
  5. doi request reprint The sex hormone system in carriers of BRCA1/2 mutations: a case-control study
    Martin Widschwendter
    Department of Women s Cancer, UCL EGA Institute for Women s Health, University College London, London, UK Electronic address
    Lancet Oncol 14:1226-32. 2013
  6. doi request reprint Epigenetics makes its mark on women-specific cancers--an opportunity to redefine oncological approaches?
    Martin Widschwendter
    Department of Women s Cancer, UCL Elizabeth Garrett Anderson Institute for Women s Health, University College London, UK
    Gynecol Oncol 128:134-43. 2013
  7. pmc Inactivation of FBXW7/hCDC4-β expression by promoter hypermethylation is associated with favorable prognosis in primary breast cancer
    Shahab Akhoondi
    Departments of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden
    Breast Cancer Res 12:R105. 2010
  8. pmc Serum oestrogen receptor alpha and beta bioactivity are independently associated with breast cancer: a proof of principle study
    M Widschwendter
    The Institute for Women s Health, University College London, London, UK
    Br J Cancer 101:160-5. 2009
  9. pmc Epigenotyping in peripheral blood cell DNA and breast cancer risk: a proof of principle study
    Martin Widschwendter
    Department of Gynecological Oncology, UCL Institute for Women s Health, University College London, London, United Kingdom
    PLoS ONE 3:e2656. 2008
  10. doi request reprint HOXA methylation in normal endometrium from premenopausal women is associated with the presence of ovarian cancer: a proof of principle study
    Martin Widschwendter
    Department of Gynecological Oncology, Institute for Women s Health, University College London, United Kingdom
    Int J Cancer 125:2214-8. 2009

Detail Information

Publications58

  1. pmc Relationship between genome and epigenome - challenges and requirements for future research
    Genevieve Almouzni
    Department of Women s Cancer, UCL Elizabeth Garrett Anderson Institute for Women s Health, University College London, 74 Huntley Street, London WC1E 6AU, UK
    BMC Genomics 15:487. 2014
    ..To overcome the numerous challenges, we have come up with nine major conclusions to set the vision for future policies and research agendas at the European level. ..
  2. pmc 5-methylcytosine--the fifth base of DNA: the fifth wheel on a car or a highly promising diagnostic and therapeutic target in cancer?
    Martin Widschwendter
    Dis Markers 23:1-3. 2007
  3. pmc The dynamics and prognostic potential of DNA methylation changes at stem cell gene loci in women's cancer
    Joanna Zhuang
    Department of Women s Cancer, University College London Elizabeth Garrett Anderson Institute for Women s Health, London, UK
    PLoS Genet 8:e1002517. 2012
    ..These findings have major implications for cancer and embryonic stem cell biology and establish the importance of systemic DNA hypomethylation for predicting prognosis in a wide range of different cancers...
  4. pmc Corruption of the intra-gene DNA methylation architecture is a hallmark of cancer
    Thomas E Bartlett
    CoMPLEX, University College London, London, United Kingdom
    PLoS ONE 8:e68285. 2013
    ..Our findings strongly support the view that intra-gene methylation architecture has great clinical potential for the development of DNA-based cancer biomarkers...
  5. doi request reprint The sex hormone system in carriers of BRCA1/2 mutations: a case-control study
    Martin Widschwendter
    Department of Women s Cancer, UCL EGA Institute for Women s Health, University College London, London, UK Electronic address
    Lancet Oncol 14:1226-32. 2013
    ..We sought to identify differences in hormone regulation between carriers of BRCA1/2 and women who are negative for BRCA1/2 mutations...
  6. doi request reprint Epigenetics makes its mark on women-specific cancers--an opportunity to redefine oncological approaches?
    Martin Widschwendter
    Department of Women s Cancer, UCL Elizabeth Garrett Anderson Institute for Women s Health, University College London, UK
    Gynecol Oncol 128:134-43. 2013
    ..This review focuses attention on DNA methylation-a core epigenetic mechanism that can be readily detected in body fluids and has the potential to substantially reform cancer screening and treatment...
  7. pmc Inactivation of FBXW7/hCDC4-β expression by promoter hypermethylation is associated with favorable prognosis in primary breast cancer
    Shahab Akhoondi
    Departments of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden
    Breast Cancer Res 12:R105. 2010
    ..Mutational inactivation of the FBXW7/hCDC4 tumor suppressor gene (TSG) is common in many cancer types, but infrequent in breast cancers. This study investigates the presence and impact of FBXW7/hCDC4 promoter methylation in breast cancer...
  8. pmc Serum oestrogen receptor alpha and beta bioactivity are independently associated with breast cancer: a proof of principle study
    M Widschwendter
    The Institute for Women s Health, University College London, London, UK
    Br J Cancer 101:160-5. 2009
    ..In this study, we analysed the capacity of serum from breast cancer cases and controls to transactivate the oestrogen receptor alpha (ER-alpha) and beta (ER-beta)...
  9. pmc Epigenotyping in peripheral blood cell DNA and breast cancer risk: a proof of principle study
    Martin Widschwendter
    Department of Gynecological Oncology, UCL Institute for Women s Health, University College London, London, United Kingdom
    PLoS ONE 3:e2656. 2008
    ..However, whether DNA methylation in normal unrelated cells is associated with BC risk and whether these imprints can be related to factors which can be modified by the environment, is unclear...
  10. doi request reprint HOXA methylation in normal endometrium from premenopausal women is associated with the presence of ovarian cancer: a proof of principle study
    Martin Widschwendter
    Department of Gynecological Oncology, Institute for Women s Health, University College London, United Kingdom
    Int J Cancer 125:2214-8. 2009
    ....
  11. ncbi request reprint Circulating methylated DNA: a new generation of tumor markers
    Martin Widschwendter
    Department of Gynaecological Oncology, UCL Elizabeth Garrett Institute for Women s Health, University College London, London, United Kingdom
    Clin Cancer Res 12:7205-8. 2006
  12. ncbi request reprint Epigenetic stem cell signature in cancer
    Martin Widschwendter
    Department of Gynecological Oncology, Institute for Women s Health, University College London, London WC1E 6DH, UK
    Nat Genet 39:157-8. 2007
    ....
  13. doi request reprint DNA methylation of polycomb group target genes in cores taken from breast cancer centre and periphery
    Evangelia Ourania Fourkala
    Department of Gynaecological Oncology, Institute for Women s Health, University College London, 1st Floor, Maple House, 149 Tottenham Court Road, London, W1T 7DN, UK
    Breast Cancer Res Treat 120:345-55. 2010
    ..Further work will reveal if methylation of PCGT genes will serve as a robust means for the clinical detection and assessment of breast cancer...
  14. pmc Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer
    Andrew E Teschendorff
    University College London, London WC1E 6BT, UK
    Genome Res 20:440-6. 2010
    ..These findings shed substantial novel insights into the epigenetic effects of aging and support the view that age may predispose to malignant transformation by irreversibly stabilizing stem cell features...
  15. pmc An epigenetic signature in peripheral blood predicts active ovarian cancer
    Andrew E Teschendorff
    Medical Genomics Group, University College London Cancer Institute, University College London, London, United Kingdom
    PLoS ONE 4:e8274. 2009
    ..However, to date no study has evaluated the diagnostic and predictive potential of such markers in a large case control cohort and on a genome-wide basis...
  16. pmc Role of DNA methylation and epigenetic silencing of HAND2 in endometrial cancer development
    Allison Jones
    Department of Women s Cancer, UCL Elizabeth Garrett Anderson Institute for Women s Health, University College London, London, United Kingdom
    PLoS Med 10:e1001551. 2013
    ..The objective of this study was to determine the functional role of epigenetic factors in endometrial cancer development...
  17. pmc Association of serum sex steroid receptor bioactivity and sex steroid hormones with breast cancer risk in postmenopausal women
    Evangelia Ourania Fourkala
    Department of Gynecological Oncology, Institute for Women s Health, Gynecological Cancer Research Centre, University College London, London, UK
    Endocr Relat Cancer 19:137-47. 2012
    ..This study provides further evidence on the association of androgens and estrogens with breast cancer. In addition, it reports that high ER but not AR SB is associated with increased breast risk >2 years before diagnosis...
  18. doi request reprint DNA methylation analysis in liquid-based cytology for cervical cancer screening
    Sophia Apostolidou
    Department of Gynecological Oncology, Institute for Women s Health, University College London, London WC1E 6DH, United Kingdom
    Int J Cancer 125:2995-3002. 2009
    ..Further assessment of these preliminary estimates will need to be performed in a larger cohort to confirm clinical utility...
  19. doi request reprint GALR1 methylation in vaginal swabs is highly accurate in identifying women with endometrial cancer
    Konstantinos Doufekas
    Department of Women s Cancer, University College London Elizabeth Garrett Anderson Institute for Women s Health, University College London, United Kingdom
    Int J Gynecol Cancer 23:1050-5. 2013
    ..7% and a specificity of 78.9%. ..
  20. doi request reprint HOXA11 DNA methylation--a novel prognostic biomarker in ovarian cancer
    Heidi Fiegl
    Department of Gynecological Oncology, UCL EGA Institute for Women s Health, University College London, United Kingdom
    Int J Cancer 123:725-9. 2008
    ..03)]. These findings support the view that the technical inability to optimally cytoreduce ovarian cancer is associated with particular molecular alterations in the tumor which per se define a subgroup of patients with poor outcome...
  21. doi request reprint Differential variability improves the identification of cancer risk markers in DNA methylation studies profiling precursor cancer lesions
    Andrew E Teschendorff
    Statistical Genomics Group, Paul O Gorman Building, UCL Cancer Institute, University College London, 72 Huntley Street, London, UK
    Bioinformatics 28:1487-94. 2012
    ....
  22. doi request reprint Methylated NEUROD1 promoter is a marker for chemosensitivity in breast cancer
    Heidi Fiegl
    Department of Gynecological Oncology, UCL Institute for Women s Health, University College London, London, United Kingdom
    Clin Cancer Res 14:3494-502. 2008
    ..The aim of this proof-of-principle study was to assess whether NEUROD1 DNA methylation is able to predict the response to neoadjuvant and adjuvant chemotherapy...
  23. pmc Cellular network entropy as the energy potential in Waddington's differentiation landscape
    Christopher R S Banerji
    1 Statistical Cancer Genomics, Paul O Gorman Building, UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, United Kingdom 2 Centre for Mathematics and Physics in the Life Sciences and Experimental Biology, University College London, London WC1E6BT United Kingdom
    Sci Rep 3:3039. 2013
    ..In summary, network entropy provides a quantitative measure of a cell's undifferentiated state, defining its elevation in Waddington's landscape. ..
  24. pmc A comparison of feature selection and classification methods in DNA methylation studies using the Illumina Infinium platform
    Joanna Zhuang
    Statistical Genomics Group, Paul O Gorman Building, UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, UK
    BMC Bioinformatics 13:59. 2012
    ....
  25. doi request reprint Emerging promise of epigenetics and DNA methylation for the diagnosis and management of women's cancers
    Allison Jones
    Department of Gynecological Oncology, Institute for Women s Health, University College London, 149 Tottenham Court Road, London, UK
    Epigenomics 2:9-38. 2010
    ..Finally, we comment on the potential impact of epigenetic analyses on the future of women's health...
  26. pmc Epigenetic variability in cells of normal cytology is associated with the risk of future morphological transformation
    Andrew E Teschendorff
    Statistical Genomics Group, Paul O Gorman Building, UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, UK
    Genome Med 4:24. 2012
    ..We aimed to demonstrate that epigenetic changes in normal cells, collected years in advance of the first signs of morphological transformation, can predict the risk of such transformation...
  27. doi request reprint Recruitment of newly diagnosed ovarian cancer patients proved challenging in a multicentre biobanking study
    Nyaladzi Balogun
    Gynaecological Cancer Research Centre, EGA Institute for Women s Health, University College London, London W1T 7DN, UK
    J Clin Epidemiol 64:525-30. 2011
    ..To explore the challenges of recruiting ovarian cancer patients and healthy controls to a cancer biobanking study...
  28. doi request reprint Independent surrogate variable analysis to deconvolve confounding factors in large-scale microarray profiling studies
    Andrew E Teschendorff
    Statistical Genomics Group, Paul O Gorman Building, UCL Cancer Institute, London WC1E 6BT, UK
    Bioinformatics 27:1496-505. 2011
    ..To deal with these difficulties, an algorithmic framework known as Surrogate Variable Analysis (SVA) was recently proposed...
  29. pmc Distinctive topology of age-associated epigenetic drift in the human interactome
    James West
    Statistical Cancer Genomics, University College London Cancer Institute, University College London, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 110:14138-43. 2013
    ..Thus, these results point toward a potentially distinct mechanistic and biological role of DNA methylation in dictating the complex aging and disease phenotypes. ..
  30. doi request reprint Genome-wide DNA methylation analysis of archival formalin-fixed paraffin-embedded tissue using the Illumina Infinium HumanMethylation27 BeadChip
    Christina Thirlwell
    Medical Genomics Group, UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, UK
    Methods 52:248-54. 2010
    ..Here, we describe a protocol for the analysis of FFPE samples using the Infinium HumanMethylation27 BeadChip...
  31. ncbi request reprint The dynamics of DNA methylation covariation patterns in carcinogenesis
    Andrew E Teschendorff
    CAS MPG Partner Institute for Computational Biology, Chinese Academy of Sciences, Shanghai Institute for Biological Sciences, Shanghai, China Statistical Genomics Group, UCL Cancer Institute, University College London, London, United Kingdom
    PLoS Comput Biol 10:e1003709. 2014
    ..The model and algorithm proposed here may allow, in future, network biomarkers predicting the risk of neoplastic transformation to be identified. ..
  32. ncbi request reprint A prospective validation of the IOTA logistic regression models (LR1 and LR2) in comparison to subjective pattern recognition for the diagnosis of ovarian cancer
    Natalie Nunes
    Gynaecological Diagnostic Outpatient Treatment Unit, University College Hospital Department of Statistical Science, University College London and Department of Women s Cancer, University College London, Elizabeth Garrett Anderson, Institute for Women s Health, London, United Kingdom
    Int J Gynecol Cancer 23:1583-9. 2013
    ..This study aimed to assess the accuracy of the International Ovarian Tumour Analysis (IOTA) logistic regression models (LR1 and LR2) and that of subjective pattern recognition (PR) for the diagnosis of ovarian cancer...
  33. doi request reprint Noninvasive nutritional management of ovarian cancer patients: beyond intestinal obstruction
    Nyaladzi Balogun
    Department of Women s Cancer, EGA Institute for Women s Health, University College London, London, United Kingdom
    Int J Gynecol Cancer 22:1089-95. 2012
    ..This review outlines the nutritional challenges faced by women with ovarian cancer and evaluates the evidence base for current practice and possible opportunities for intervention in clinical settings...
  34. pmc PP2A-B55β antagonizes cyclin E1 proteolysis and promotes its dysregulation in cancer
    YingMeei Tan
    Authors Affiliations Tumor Initiation and Maintenance Program, Cancer Center, Sanford Burnham Medical Research Institute, La Jolla Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, California and Department of Gynaecological Oncology, University College London, London, United Kingdom
    Cancer Res 74:2006-14. 2014
    ..Therefore, PP2A-B55β promotes cyclin E1 overexpression by antagonizing its degradation and its inhibition could represent a therapeutic mechanism for abrogating cyclin E1 function in cancers...
  35. ncbi request reprint FBXW7/hCDC4 is a general tumor suppressor in human cancer
    Shahab Akhoondi
    Cancer Center Karolinska, Karolinska Hospital, Stockholm, Sweden
    Cancer Res 67:9006-12. 2007
    ..Our study is the first comprehensive screen of FBXW7 mutations in various human malignancies and shows that FBXW7 is a general tumor suppressor in human cancer...
  36. ncbi request reprint CDH1 and CDH13 methylation in serum is an independent prognostic marker in cervical cancer patients
    Andreas Widschwendter
    Department of Obstetrics and Gynecology, Innsbruck University Hospital, Innsbruck, Austria
    Int J Cancer 109:163-6. 2004
    ..Our results suggest that detection of aberrant methylation of CDH1/CDH13 may be of potential use as a marker for selecting cervical cancer patients at high risk for relapse who could benefit from additional systemic therapy...
  37. ncbi request reprint DNA methylation in serum of breast cancer patients: an independent prognostic marker
    Hannes M Müller
    Department of Obstetrics and Gynecology, Innsbruck University Hospital, University of Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Cancer Res 63:7641-5. 2003
    ..7. DNA methylation of particular genes in pretherapeutic sera of breast cancer patients, especially of RASSF1A/APC, is more powerful than standard prognostic parameters...
  38. ncbi request reprint Association of breast cancer DNA methylation profiles with hormone receptor status and response to tamoxifen
    Martin Widschwendter
    Department of Urology, University of Southern California, Keck School of Medicine, Norris Comprehensive Cancer Center, Los Angeles, California, 90089 9176, USA
    Cancer Res 64:3807-13. 2004
    ....
  39. ncbi request reprint Methylated DNA as a possible screening marker for neoplastic disease in several body fluids
    Hannes M Müller
    Department of Obstetrics and Gynecology, Innsbruck University Hospital, Austria
    Expert Rev Mol Diagn 3:443-58. 2003
    ..Due to the ubiquity of DNA methylation changes and the possibility to detect methylated DNA in several body fluids, this specifically altered DNA may serve as a potential new screening marker for neoplastic disease...
  40. ncbi request reprint DNA methylation and breast carcinogenesis
    Martin Widschwendter
    USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, 1441 Eastlake Avenue, MS 8302L, Los Angeles, California, CA 90089 9181, USA
    Oncogene 21:5462-82. 2002
    ....
  41. ncbi request reprint The potential prognostic, predictive, and therapeutic values of DNA methylation in cancer. Commentary re: J. Kwong et al., Promoter hypermethylation of multiple genes in nasopharyngeal carcinoma. Clin. Cancer Res., 8: 131-137, 2002, and H-Z. Zou et al., D
    Martin Widschwendter
    University of Southern California Norris Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California 90089 9181, USA
    Clin Cancer Res 8:17-21. 2002
  42. ncbi request reprint A DNA methylation pattern similar to normal tissue is associated with better prognosis in human cervical cancer
    Hannes M Müller
    Department of Obstetrics and Gynecology, Innsbruck University Hospital, Anichstrasse 35, A 6020 Innsbruck, Austria
    Cancer Lett 209:231-6. 2004
    ..This study shows for the first time that working solely with DNA methylation pattern a subgroup of cervical cancer patients can be defined that demonstrated strong similarity to non-neoplastic probands and had a better prognosis...
  43. ncbi request reprint Methylated DNA collected by tampons--a new tool to detect endometrial cancer
    Heidi Fiegl
    Department of Obstetrics and Gynecology, Innsbruck University Hospital, Anichstrasse 35, A 6020 Innsbruck, Austria
    Cancer Epidemiol Biomarkers Prev 13:882-8. 2004
    ..The methods developed in this study provide the basis for a prospective clinical trial to screen asymptomatic women who are at high risk for endometrial cancer...
  44. ncbi request reprint CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer
    Daniel J Weisenberger
    Department of Surgery, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90089 9176, USA
    Nat Genet 38:787-93. 2006
    ..Sporadic cases of mismatch repair deficiency occur almost exclusively as a consequence of CIMP-associated methylation of MLH1 . We propose a robust new marker panel to classify CIMP+ tumors...
  45. ncbi request reprint Circulating tumor-specific DNA: a marker for monitoring efficacy of adjuvant therapy in cancer patients
    Heidi Fiegl
    Department of Obstetrics and Gynecology, Innsbruck Medical University, Innsbruck, Austria
    Cancer Res 65:1141-5. 2005
    ..It remains to be seen whether modifications made in adjuvant therapeutic strategies based on detection of circulating nucleic acids will improve survival as well as quality of life...
  46. ncbi request reprint DNA hypomethylation is prevalent even in low-grade breast cancers
    Kesmic Jackson
    Department of Biochemistry, Tulane Cancer Center and Human Genetics Program, Tulane Medical School, New Orleans, Louisiana 70112, USA
    Cancer Biol Ther 3:1225-31. 2004
    ....
  47. ncbi request reprint Prognostic DNA methylation marker in serum of cancer patients
    Hannes M Müller
    Department of General and Transplant Surgery, Innsbruck Medical University, A 6020 Innsbruck, Austria
    Ann N Y Acad Sci 1022:44-9. 2004
    ..This finding indicates great potential for the use of these epigenetic markers in clinical, routine risk assessment in patients with various malignancies...
  48. ncbi request reprint Analysis of aberrant DNA methylation and human papillomavirus DNA in cervicovaginal specimens to detect invasive cervical cancer and its precursors
    Andreas Widschwendter
    Department of Obstetrics and Gynecology, Innsbruck University Hospital, Innsbruck, Austria
    Clin Cancer Res 10:3396-400. 2004
    ....
  49. ncbi request reprint Breast cancer DNA methylation profiles in cancer cells and tumor stroma: association with HER-2/neu status in primary breast cancer
    Heidi Fiegl
    Department of Obstetrics and Gynecology, Innsbruck Medical University, Innsbruck, Austria
    Cancer Res 66:29-33. 2006
    ..04). These data support the view that in addition to HER-2/neu-associated signaling, epigenetic changes in cancer as well as in tumor stroma cells might attribute to the specific biological features of HER-2/neu-positive cancers...
  50. ncbi request reprint Hypomethylation and hypermethylation of DNA in Wilms tumors
    Melanie Ehrlich
    Tulane Cancer Center and Human Genetics Program, Tulane Medical School, New Orleans, Louisiana, LA 70112, USA
    Oncogene 21:6694-702. 2002
    ..This suggests that the DNA hypomethylation contributes independently to oncogenesis or tumor progression...
  51. ncbi request reprint Analysis of methylated genes in peritoneal fluids of ovarian cancer patients: a new prognostic tool
    Hannes M Müller
    Departments of Obstetrics and Gynecology and Biostatistics and Documentation, Medical University Innsbruck, Innsbruck, Austria
    Clin Chem 50:2171-3. 2004
  52. ncbi request reprint Detection of low molecular weight derivatives of cyclin E1 is a function of cyclin E1 protein levels in breast cancer
    Charles Spruck
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Cancer Res 66:7355-60. 2006
    ..Therefore, the detection of LMW derivatives of cyclin E1 is likely a function of cyclin E1 protein levels, and the activity of the proteolytic machinery responsible for their generation is not a tumor-specific property...
  53. ncbi request reprint DNA hypomethylation and ovarian cancer biology
    Martin Widschwendter
    Department of Obstetrics and Gynecology, Medical University Innsbruck, Innsbruck, Austria
    Cancer Res 64:4472-80. 2004
    ....
  54. ncbi request reprint DNA methylation in serum and tumors of cervical cancer patients
    Andreas Widschwendter
    Department of Obstetrics and Gynecology, Innsbruck University Hospital, Innsbruck, Austria
    Clin Cancer Res 10:565-71. 2004
    ..The aim of this study was to investigate the methylation status of various genes in cervical cancer patients and their association with clinicopathological characteristics and outcome of the disease...
  55. ncbi request reprint Mutation of hCDC4 leads to cell cycle deregulation of cyclin E in cancer
    Susanna Ekholm-Reed
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, USA
    Cancer Res 64:795-800. 2004
    ..These results indicate that hCdc4 function is an absolute prerequisite for cell cycle regulation of cyclin E levels, and loss of hCdc4 function is sufficient to deregulate cyclin E...
  56. ncbi request reprint Methylation changes in faecal DNA: a marker for colorectal cancer screening?
    Hannes M Müller
    Department of General and Transplant Surgery, Medical University Innsbruck, A 6020 Innsbruck, Austria
    Lancet 363:1283-5. 2004
    ..Whether a combination of genetic and epigenetic markers will identify colorectal cancer at an early stage remains to be shown...
  57. ncbi request reprint DNA methylation changes in sera of women in early pregnancy are similar to those in advanced breast cancer patients
    Hannes M Müller
    Department of Obstetrics and Gynecology, Central Blood Transfusion and Immunology, Medical University Innsbruck, Innsbruck, Austria
    Clin Chem 50:1065-8. 2004
  58. ncbi request reprint Methylation status and expression of human telomerase reverse transcriptase in ovarian and cervical cancer
    Andreas Widschwendter
    Department of Obstetrics and Gynecology, Innsbruck University Hospital, A 6020 Innsbruck, Austria
    Gynecol Oncol 93:407-16. 2004
    ..The aim of this study was to investigate the expression and methylation pattern of hTERT in ovarian and cervical cancer tissue and their correlation with clinicopathological features and outcome of the disease...