Vihandha O Wickramasinghe

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc Functional and structural characterization of the mammalian TREX-2 complex that links transcription with nuclear messenger RNA export
    Divyang Jani
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Nucleic Acids Res 40:4562-73. 2012
  2. pmc GANP enhances the efficiency of mRNA nuclear export in mammalian cells
    Vihandha O Wickramasinghe
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge, UK
    Nucleus 1:393-6. 2010
  3. pmc MCM3AP is transcribed from a promoter within an intron of the overlapping gene for GANP
    Vihandha O Wickramasinghe
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 0XZ, UK
    J Mol Biol 406:355-61. 2011
  4. pmc mRNA export from mammalian cell nuclei is dependent on GANP
    Vihandha O Wickramasinghe
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 0XZ, UK
    Curr Biol 20:25-31. 2010

Collaborators

Detail Information

Publications4

  1. pmc Functional and structural characterization of the mammalian TREX-2 complex that links transcription with nuclear messenger RNA export
    Divyang Jani
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Nucleic Acids Res 40:4562-73. 2012
    ..Thus, we implicate TREX-2 as an integral component of the mammalian mRNA export machinery where it links transcription and nuclear export by facilitating the transfer of mature mRNPs from the nuclear interior to NPCs...
  2. pmc GANP enhances the efficiency of mRNA nuclear export in mammalian cells
    Vihandha O Wickramasinghe
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge, UK
    Nucleus 1:393-6. 2010
    ..Here, we discuss the model for GANP function presented in our recent paper and its implications for the mechanism of mRNA export in mammalian cells...
  3. pmc MCM3AP is transcribed from a promoter within an intron of the overlapping gene for GANP
    Vihandha O Wickramasinghe
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 0XZ, UK
    J Mol Biol 406:355-61. 2011
    ..Therefore, to avoid further confusion, they should now be referred to as separate but overlapping genes...
  4. pmc mRNA export from mammalian cell nuclei is dependent on GANP
    Vihandha O Wickramasinghe
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 0XZ, UK
    Curr Biol 20:25-31. 2010
    ..These results establish GANP as an integral component of the mammalian mRNA export machinery and suggest a model whereby GANP facilitates the transfer of NXF1-containing mRNPs to NPCs...