Vihandha O Wickramasinghe

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc Functional and structural characterization of the mammalian TREX-2 complex that links transcription with nuclear messenger RNA export
    Divyang Jani
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Nucleic Acids Res 40:4562-73. 2012
  2. pmc GANP enhances the efficiency of mRNA nuclear export in mammalian cells
    Vihandha O Wickramasinghe
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge, UK
    Nucleus 1:393-6. 2010
  3. pmc MCM3AP is transcribed from a promoter within an intron of the overlapping gene for GANP
    Vihandha O Wickramasinghe
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 0XZ, UK
    J Mol Biol 406:355-61. 2011
  4. pmc mRNA export from mammalian cell nuclei is dependent on GANP
    Vihandha O Wickramasinghe
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 0XZ, UK
    Curr Biol 20:25-31. 2010
  5. pmc Selective nuclear export of specific classes of mRNA from mammalian nuclei is promoted by GANP
    Vihandha O Wickramasinghe
    MRC Cancer Unit, University of Cambridge, Hutchison MRC Research Centre, Box 197, Biomedical Campus, Cambridge CB2 0XZ, UK, The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, UK, Wellcome Trust, Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, UK, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK and Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    Nucleic Acids Res 42:5059-71. 2014
  6. doi request reprint Human inositol polyphosphate multikinase regulates transcript-selective nuclear mRNA export to preserve genome integrity
    Vihandha O Wickramasinghe
    The Medical Research Council Cancer Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 0XZ, UK
    Mol Cell 51:737-50. 2013

Detail Information

Publications6

  1. pmc Functional and structural characterization of the mammalian TREX-2 complex that links transcription with nuclear messenger RNA export
    Divyang Jani
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Nucleic Acids Res 40:4562-73. 2012
    ..Thus, we implicate TREX-2 as an integral component of the mammalian mRNA export machinery where it links transcription and nuclear export by facilitating the transfer of mature mRNPs from the nuclear interior to NPCs...
  2. pmc GANP enhances the efficiency of mRNA nuclear export in mammalian cells
    Vihandha O Wickramasinghe
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge, UK
    Nucleus 1:393-6. 2010
    ..Here, we discuss the model for GANP function presented in our recent paper and its implications for the mechanism of mRNA export in mammalian cells...
  3. pmc MCM3AP is transcribed from a promoter within an intron of the overlapping gene for GANP
    Vihandha O Wickramasinghe
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 0XZ, UK
    J Mol Biol 406:355-61. 2011
    ..Therefore, to avoid further confusion, they should now be referred to as separate but overlapping genes...
  4. pmc mRNA export from mammalian cell nuclei is dependent on GANP
    Vihandha O Wickramasinghe
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 0XZ, UK
    Curr Biol 20:25-31. 2010
    ..These results establish GANP as an integral component of the mammalian mRNA export machinery and suggest a model whereby GANP facilitates the transfer of NXF1-containing mRNPs to NPCs...
  5. pmc Selective nuclear export of specific classes of mRNA from mammalian nuclei is promoted by GANP
    Vihandha O Wickramasinghe
    MRC Cancer Unit, University of Cambridge, Hutchison MRC Research Centre, Box 197, Biomedical Campus, Cambridge CB2 0XZ, UK, The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, UK, Wellcome Trust, Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, UK, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK and Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    Nucleic Acids Res 42:5059-71. 2014
    ..We propose that GANP promotes the nuclear export of specific classes of mRNAs that may facilitate rapid changes in gene expression. ..
  6. doi request reprint Human inositol polyphosphate multikinase regulates transcript-selective nuclear mRNA export to preserve genome integrity
    Vihandha O Wickramasinghe
    The Medical Research Council Cancer Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 0XZ, UK
    Mol Cell 51:737-50. 2013
    ..Our findings implicate IPMK in a transcript-selective mRNA export pathway controlled by phosphoinositide turnover that preserves genome integrity in humans. ..