David E Whitworth
Affiliation: University of Wales
Livingstone P, Morphew R, Cookson A, Whitworth D. Genome analysis, metabolic potential and predatory capabilities of Herpetosiphon llansteffanense sp. nov. Appl Environ Microbiol. 2018;: pubmed publisher
..This will facilitate future rational exploitation of genus members (and other wolf-pack predators) as sources of novel antimicrobials. ..
Whitworth D, Slade S, Mironas A. Composition of distinct sub-proteomes in Myxococcus xanthus: metabolic cost and amino acid availability. Amino Acids. 2015;47:2521-31 pubmed publisher
..We propose a model of AA reallocation during the M. xanthus life cycle, involving ribophagy during early starvation and sequestration of limiting AAs within cells during development. ..
Whitworth D. Genomes and knowledge - a questionable relationship?. Trends Microbiol. 2008;16:512-9 pubmed publisher
..It appears that quality, rather than quantity, might be the most important factor when comparing genomes. ..
Kara A, Vickers M, Swain M, Whitworth D, Fernandez Fuentes N. Genome-wide prediction of prokaryotic two-component system networks using a sequence-based meta-predictor. BMC Bioinformatics. 2015;16:297 pubmed publisher
..MetaPred2CS outperformed other available systems in our benchmark tests, and is available online at http://metapred2cs.ibers.aber.ac.uk, along with our gold standard dataset of TCS interaction pairs. ..
Whitworth D. Genome-wide analysis of myxobacterial two-component systems: genome relatedness and evolutionary changes. BMC Genomics. 2015;16:780 pubmed publisher
Ortet P, De Luca G, Whitworth D, Barakat M. P2TF: a comprehensive resource for analysis of prokaryotic transcription factors. BMC Genomics. 2012;13:628 pubmed publisher
..There is a need for user-friendly, rigorous and consistent databases to allow researchers to overcome the inherent variability in annotation between genome sequences...