P S Whitton

Summary

Affiliation: University of London
Country: UK

Publications

  1. ncbi request reprint Neuroinflammation and the prospects for anti-inflammatory treatment of Parkinson's disease
    Peter S Whitton
    The School of Pharmacy, Department of Pharmacology, 29 39 Brunswick Square, London, UK
    Curr Opin Investig Drugs 11:788-94. 2010
  2. pmc Urocortin, a CRF-like peptide, restores key indicators of damage in the substantia nigra in a neuroinflammatory model of Parkinson's disease
    Amjad Abuirmeileh
    Department of Pharmacology, The School of Pharmacy, London, UK
    J Neuroinflammation 4:19. 2007
  3. pmc Glucagon-like peptide 1 receptor stimulation reverses key deficits in distinct rodent models of Parkinson's disease
    Alexander Harkavyi
    Department of Pharmacology, The School of Pharmacy, 29 39 Brunswick Square, London WC1N 1AX, UK
    J Neuroinflammation 5:19. 2008
  4. pmc Inflammation as a causative factor in the aetiology of Parkinson's disease
    P S Whitton
    1Department of Pharmacology, The School of Pharmacy, London, UK
    Br J Pharmacol 150:963-76. 2007
  5. ncbi request reprint Nitric oxide modulates N-methyl-D-aspartate-evoked serotonin release in the raphe nuclei and frontal cortex of the freely moving rat
    J C Smith
    Department of Pharmacology, The School of Pharmacy, 29 39 Brunswick Square, WC1N 1AX, London, UK
    Neurosci Lett 291:5-8. 2000
  6. doi request reprint Exendin-4 reverses biochemical and behavioral deficits in a pre-motor rodent model of Parkinson's disease with combined noradrenergic and serotonergic lesions
    N Rampersaud
    UCL School of Pharmacy, 29 39 Brunswick Square, London WC1N 1AX, UK
    Neuropeptides 46:183-93. 2012
  7. ncbi request reprint The regulation of NMDA-evoked dopamine release by nitric oxide in the frontal cortex and raphe nuclei of the freely moving rat
    J C Smith
    Department of Pharmacology, The School of Pharmacy, 29 39 Brunswick Square, WC1N 1AX, London, UK
    Brain Res 889:57-62. 2001
  8. ncbi request reprint Regulatory role of nitric oxide over hippocampal 5-HT release in vivo
    J Segieth
    Department of Pharmacology, The School of Pharmacy, London, UK
    Naunyn Schmiedebergs Arch Pharmacol 363:302-6. 2001

Collaborators

Detail Information

Publications8

  1. ncbi request reprint Neuroinflammation and the prospects for anti-inflammatory treatment of Parkinson's disease
    Peter S Whitton
    The School of Pharmacy, Department of Pharmacology, 29 39 Brunswick Square, London, UK
    Curr Opin Investig Drugs 11:788-94. 2010
    ..This review discusses the anti-inflammatory agents that have been suggested to have potential for the treatment of PD...
  2. pmc Urocortin, a CRF-like peptide, restores key indicators of damage in the substantia nigra in a neuroinflammatory model of Parkinson's disease
    Amjad Abuirmeileh
    Department of Pharmacology, The School of Pharmacy, London, UK
    J Neuroinflammation 4:19. 2007
    ..Our data therefore indicate that UCN is capable of maintaining adequate nigrostriatal function in vivo, via CRF1 receptors following a neuro-inflammatory challenge. This has potential therapeutic implications in PD...
  3. pmc Glucagon-like peptide 1 receptor stimulation reverses key deficits in distinct rodent models of Parkinson's disease
    Alexander Harkavyi
    Department of Pharmacology, The School of Pharmacy, 29 39 Brunswick Square, London WC1N 1AX, UK
    J Neuroinflammation 5:19. 2008
    ..The potential neuroprotective action of the glucagon-like peptide 1 receptor (GLP-1R) agonist exendin-4 (EX-4), which is protective against cytokine mediated apoptosis and may stimulate neurogenesis, was investigated In paradigms of PD...
  4. pmc Inflammation as a causative factor in the aetiology of Parkinson's disease
    P S Whitton
    1Department of Pharmacology, The School of Pharmacy, London, UK
    Br J Pharmacol 150:963-76. 2007
    ..These factors are examined in this review along with a consideration of the possible use of anti-inflammatory drugs in PD...
  5. ncbi request reprint Nitric oxide modulates N-methyl-D-aspartate-evoked serotonin release in the raphe nuclei and frontal cortex of the freely moving rat
    J C Smith
    Department of Pharmacology, The School of Pharmacy, 29 39 Brunswick Square, WC1N 1AX, London, UK
    Neurosci Lett 291:5-8. 2000
    ..These data suggest that NO plays a role in mediating both basal and NMDA-evoked changes in serotonergic transmission between the raphe and frontal cortex...
  6. doi request reprint Exendin-4 reverses biochemical and behavioral deficits in a pre-motor rodent model of Parkinson's disease with combined noradrenergic and serotonergic lesions
    N Rampersaud
    UCL School of Pharmacy, 29 39 Brunswick Square, London WC1N 1AX, UK
    Neuropeptides 46:183-93. 2012
    ..These symptoms and causative physiology are ameliorated upon treatment with EX-4 and thus it could be used as a possible therapy for the non-motor symptoms prominent in the early stages of PD...
  7. ncbi request reprint The regulation of NMDA-evoked dopamine release by nitric oxide in the frontal cortex and raphe nuclei of the freely moving rat
    J C Smith
    Department of Pharmacology, The School of Pharmacy, 29 39 Brunswick Square, WC1N 1AX, London, UK
    Brain Res 889:57-62. 2001
    ..These results suggest that the regulation of NMDA-evoked DA release by NO occurs in both of the brain regions studied, although the manner in which the regulation occurs seems to differ between the two...
  8. ncbi request reprint Regulatory role of nitric oxide over hippocampal 5-HT release in vivo
    J Segieth
    Department of Pharmacology, The School of Pharmacy, London, UK
    Naunyn Schmiedebergs Arch Pharmacol 363:302-6. 2001
    ..It may be that the recorded changes in 5-HT release are secondary to changes in the release of amino acid transmitters which we have previously found to be dependent on the prevailing extracellular NO concentration...