Miles A Whittington

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. doi request reprint High-frequency network oscillations in cerebellar cortex
    Steven J Middleton
    Institute of Neuroscience, The Medical School, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
    Neuron 58:763-74. 2008
  2. doi request reprint Multiple origins of the cortical γ rhythm
    Miles A Whittington
    Institute of Neuroscience, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom
    Dev Neurobiol 71:92-106. 2011
  3. doi request reprint Circuits and brain rhythms in schizophrenia: a wealth of convergent targets
    Miles A Whittington
    Institute of Neuroscience, The Medical School, Framlington Place, Newcastle University, Newcastle NE2 4HH, UK
    Curr Opin Pharmacol 11:508-14. 2011
  4. ncbi request reprint Can brain rhythms inform on underlying pathology in schizophrenia?
    Miles A Whittington
    Institute of Neuroscience, The Medical School, Newcastle University, Newcastle, United Kingdom
    Biol Psychiatry 63:728-9. 2008
  5. pmc Glissandi: transient fast electrocorticographic oscillations of steadily increasing frequency, explained by temporally increasing gap junction conductance
    Mark O Cunningham
    Institute of Neuroscience, The Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom
    Epilepsia 53:1205-14. 2012
  6. pmc A neocortical delta rhythm facilitates reciprocal interlaminar interactions via nested theta rhythms
    Lucy M Carracedo
    Institute of Neuroscience, The Medical School, Newcastle University, Newcastle upon Tyne, NE2 4HH, United Kingdom
    J Neurosci 33:10750-61. 2013
  7. pmc A nonsynaptic mechanism underlying interictal discharges in human epileptic neocortex
    Anita K Roopun
    Institute of Neuroscience, The Medical School, Framlington Place, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
    Proc Natl Acad Sci U S A 107:338-43. 2010
  8. pmc Region-specific changes in gamma and beta2 rhythms in NMDA receptor dysfunction models of schizophrenia
    Anita K Roopun
    Institute of Neuroscience, The Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne, UK
    Schizophr Bull 34:962-73. 2008
  9. pmc NMDA receptor-dependent switching between different gamma rhythm-generating microcircuits in entorhinal cortex
    Steven Middleton
    Institute of Neuroscience, Newcastle University, Newcastle NE2 4HH, United Kingdom
    Proc Natl Acad Sci U S A 105:18572-7. 2008
  10. pmc A beta2-frequency (20-30 Hz) oscillation in nonsynaptic networks of somatosensory cortex
    Anita K Roopun
    Medical School, University of Newcastle, Newcastle NE2 4HH, United Kingdom
    Proc Natl Acad Sci U S A 103:15646-50. 2006

Collaborators

Detail Information

Publications45

  1. doi request reprint High-frequency network oscillations in cerebellar cortex
    Steven J Middleton
    Institute of Neuroscience, The Medical School, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
    Neuron 58:763-74. 2008
    ..The ability of cerebellar cortex to generate population rhythms within the same frequency bands as neocortex suggests that they act as a common spatiotemporal code within which corticocerebellar dialog may occur...
  2. doi request reprint Multiple origins of the cortical γ rhythm
    Miles A Whittington
    Institute of Neuroscience, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom
    Dev Neurobiol 71:92-106. 2011
    ..Finally, we suggest that developmental disruption of the endophenotype for certain subsets of gamma-generating interneuron may underlie cognitive deficit in psychiatric illness...
  3. doi request reprint Circuits and brain rhythms in schizophrenia: a wealth of convergent targets
    Miles A Whittington
    Institute of Neuroscience, The Medical School, Framlington Place, Newcastle University, Newcastle NE2 4HH, UK
    Curr Opin Pharmacol 11:508-14. 2011
    ..This approach suggests that evidence-based design of multi-target therapies may take advantage of hierarchical patterns of convergence to improve both efficacy and selectivity of disease-intervention...
  4. ncbi request reprint Can brain rhythms inform on underlying pathology in schizophrenia?
    Miles A Whittington
    Institute of Neuroscience, The Medical School, Newcastle University, Newcastle, United Kingdom
    Biol Psychiatry 63:728-9. 2008
  5. pmc Glissandi: transient fast electrocorticographic oscillations of steadily increasing frequency, explained by temporally increasing gap junction conductance
    Mark O Cunningham
    Institute of Neuroscience, The Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom
    Epilepsia 53:1205-14. 2012
    ..We dub these events "glissandi" and describe a possible model for them...
  6. pmc A neocortical delta rhythm facilitates reciprocal interlaminar interactions via nested theta rhythms
    Lucy M Carracedo
    Institute of Neuroscience, The Medical School, Newcastle University, Newcastle upon Tyne, NE2 4HH, United Kingdom
    J Neurosci 33:10750-61. 2013
    ..We suggest that these reciprocal, interlaminar interactions may represent a "Helmholtz machine"-like process to control synaptic rescaling during deep sleep. ..
  7. pmc A nonsynaptic mechanism underlying interictal discharges in human epileptic neocortex
    Anita K Roopun
    Institute of Neuroscience, The Medical School, Framlington Place, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
    Proc Natl Acad Sci U S A 107:338-43. 2010
    ..These data suggest a lack of a causal role for interneurons, and favor a nonsynaptic pyramidal cell network origin for VFO in epileptic human neocortex...
  8. pmc Region-specific changes in gamma and beta2 rhythms in NMDA receptor dysfunction models of schizophrenia
    Anita K Roopun
    Institute of Neuroscience, The Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne, UK
    Schizophr Bull 34:962-73. 2008
    ....
  9. pmc NMDA receptor-dependent switching between different gamma rhythm-generating microcircuits in entorhinal cortex
    Steven Middleton
    Institute of Neuroscience, Newcastle University, Newcastle NE2 4HH, United Kingdom
    Proc Natl Acad Sci U S A 105:18572-7. 2008
    ....
  10. pmc A beta2-frequency (20-30 Hz) oscillation in nonsynaptic networks of somatosensory cortex
    Anita K Roopun
    Medical School, University of Newcastle, Newcastle NE2 4HH, United Kingdom
    Proc Natl Acad Sci U S A 103:15646-50. 2006
    ..The oscillation period is determined by the M type of K+ current...
  11. doi request reprint Rates and rhythms: a synergistic view of frequency and temporal coding in neuronal networks
    Matt Ainsworth
    Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
    Neuron 75:572-83. 2012
    ..The coincident expression of multiple types of gamma rhythm in sensory cortex suggests a mechanistic substrate for combining rate and temporal codes on the basis of stimulus strength...
  12. pmc Temporal Interactions between Cortical Rhythms
    Anita K Roopun
    Institute of Neuroscience, Newcastle University Newcastle, UK
    Front Neurosci 2:145-54. 2008
    ....
  13. doi request reprint Gap junction networks can generate both ripple-like and fast ripple-like oscillations
    Anna Simon
    Institute of Neuroscience, The Medical School, Newcastle University, Newcastle upon Tyne, UK
    Eur J Neurosci 39:46-60. 2014
    ..If axonal gap junctions indeed occur in epileptic tissue, and are mediated by connexin 26 (recently shown to mediate coupling between immature neocortical pyramidal cells), then this prediction is testable. ..
  14. ncbi request reprint Region-specific reduction in entorhinal gamma oscillations and parvalbumin-immunoreactive neurons in animal models of psychiatric illness
    Mark O Cunningham
    School of Neurology, Neurobiology, and Psychiatry, University of Newcastle, Newcastle NE2 4HH, United Kingdom
    J Neurosci 26:2767-76. 2006
    ....
  15. pmc Dual γ rhythm generators control interlaminar synchrony in auditory cortex
    Matthew Ainsworth
    Institute of Neuroscience, Newcastle University, Newcastle, NE2 4HH, United Kingdom
    J Neurosci 31:17040-51. 2011
    ..The data suggest that different strategies are used by primary auditory cortex to represent weak and strong inputs, with principal cell firing rate becoming increasingly important as excitation strength increases...
  16. pmc Fast oscillatory activity induced by kainate receptor activation in the rat basolateral amygdala in vitro
    Fiona E Randall
    Institute of Neuroscience, Newcastle University, Framlington Place, Newcastle upon Tyne, UK
    Eur J Neurosci 33:914-22. 2011
    ..Understanding how BLA networks produce synchronous activity is paramount to understanding how the BLA executes influence on important cognitive processes such as emotional learning...
  17. pmc Cholinergic neuromodulation controls directed temporal communication in neocortex in vitro
    Anita K Roopun
    Institute of Neuroscience, The Medical School, Newcastle University Newcastle, UK
    Front Neural Circuits 4:8. 2010
    ..Furthermore, the contrasting mechanisms underlying these beta2 rhythms produced a high degree of directionality, favouring an influence of association cortex over primary auditory cortex...
  18. pmc Period Concatenation Underlies Interactions between Gamma and Beta Rhythms in Neocortex
    Anita K Roopun
    Institute of Neuroscience, Newcastle University Newcastle, UK
    Front Cell Neurosci 2:1. 2008
    ..The resulting temporal landscape may provide a framework for multiplexing - parallel information processing on multiple temporal scales...
  19. pmc Mitochondrial DNA mutations affect calcium handling in differentiated neurons
    Andrew J Trevelyan
    Mitochondrial Research Group, Institute for Ageing and Health Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, England
    Brain 133:787-96. 2010
    ..These results suggest that calcium-handling deficits are likely to contribute to the pathological phenotype seen in patients with mitochondrial DNA mutations...
  20. pmc Axonal properties determine somatic firing in a model of in vitro CA1 hippocampal sharp wave/ripples and persistent gamma oscillations
    Roger D Traub
    Department of Physical Sciences, IBM T J Watson Research Center, Yorktown Heights, NY, USA
    Eur J Neurosci 36:2650-60. 2012
    ..Combining the models, so as to generate gamma followed by sharp waves, leads to strong overlap between the population of cells firing during gamma and the population of cells firing during a subsequent sharp wave, as observed in vivo...
  21. ncbi request reprint Transient depression of excitatory synapses on interneurons contributes to epileptiform bursts during gamma oscillations in the mouse hippocampal slice
    Roger D Traub
    Departments of Physiology and Pharmacology, and Neurology, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
    J Neurophysiol 94:1225-35. 2005
    ..Thus the same neuronal network can generate either gamma oscillations or epileptiform bursts, in a manner depending on the degree of network drive and network-induced fluctuations in synaptic efficacies...
  22. ncbi request reprint Sharp wave-like activity in the hippocampus in vitro in mice lacking the gap junction protein connexin 36
    Isabel Pais
    School of Biomedical Sciences, University of Leeds, Leeds LS2 9NQ, United Kingdom
    J Neurophysiol 89:2046-54. 2003
    ..This suggests a complex role for electrically coupled interneurons in the generation of hippocampal network activity...
  23. ncbi request reprint Recruitment of parvalbumin-positive interneurons determines hippocampal function and associated behavior
    Elke C Fuchs
    Department of Clinical Neurobiology, University Hospital of Neurology, IZN, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany
    Neuron 53:591-604. 2007
    ..These findings directly show the effects of insufficient recruitment of fast-spiking cells at the network and behavioral level and demonstrate the role of this subpopulation for working and episodic-like memory...
  24. pmc Rhythm generation through period concatenation in rat somatosensory cortex
    Mark A Kramer
    Department of Mathematics and Statistics, Boston University, Boston, Massachusetts, United States of America
    PLoS Comput Biol 4:e1000169. 2008
    ..We conclude that neural activity in the superficial and deep cortical layers may temporally combine to generate a slower oscillation...
  25. ncbi request reprint Beta rhythms (15-20 Hz) generated by nonreciprocal communication in hippocampus
    Andrea Bibbig
    Department of Physiology and Pharmacology, State University of New York Health Sciences Center, Brooklyn, New York, USA
    J Neurophysiol 97:2812-23. 2007
    ..These findings demonstrate that in nonreciprocally connected networks, the frequency of population rhythms in target areas serves to code for degree of principal cell recruitment by afferent input...
  26. ncbi request reprint Low-dimensional maps encoding dynamics in entorhinal cortex and hippocampus
    Dmitri D Pervouchine
    Department of Mathematics and Statistics and Center for BioDynamics, Boston University, Boston, MA 02215, USA
    Neural Comput 18:2617-50. 2006
    ..The results obtained in the dynamic clamp experiments are in a good agreement with the analytical framework...
  27. ncbi request reprint Interneuron diversity series: inhibitory interneurons and network oscillations in vitro
    Miles A Whittington
    School of Biomedical Sciences, University of Leeds, LS2 9NQ, Leeds, UK
    Trends Neurosci 26:676-82. 2003
    ....
  28. ncbi request reprint The role of electrical signaling via gap junctions in the generation of fast network oscillations
    Fiona E N LeBeau
    School of Biomedical Sciences, University of Leeds, LS2 9NQ, Leeds, UK
    Brain Res Bull 62:3-13. 2003
    ..Recent work also now suggests that a number of different, anatomically discrete, gap junction-mediated networks may exist which could both function and be modulated independently...
  29. ncbi request reprint Gamma oscillations induced by kainate receptor activation in the entorhinal cortex in vitro
    Mark O Cunningham
    School of Biomedical Sciences, Worsley Building, University of Leeds, Leeds, LS2 9NQ, United Kingdom
    J Neurosci 23:9761-9. 2003
    ..We propose that similar cellular and network mechanisms to those seen in the hippocampus generate and modulate persistent gamma oscillations in the entorhinal cortex...
  30. ncbi request reprint A novel network of multipolar bursting interneurons generates theta frequency oscillations in neocortex
    Maria Blatow
    Department of Clinical Neurobiology, University Hospital for Neurology, Im Neuenheimer Feld 364, 69120, Heidelberg, Germany
    Neuron 38:805-17. 2003
    ..Hence, MB cells form a distinct inhibitory network, which upon cholinergic drive can generate rhythmic and synchronous theta frequency activity, providing temporal coordination of pyramidal cell output...
  31. ncbi request reprint Fast rhythmic bursting can be induced in layer 2/3 cortical neurons by enhancing persistent Na+ conductance or by blocking BK channels
    Roger D Traub
    Department of Physiology and Pharmacology, State University of New York Health Science Center, Brooklyn, New York 11203, USA
    J Neurophysiol 89:909-21. 2003
    ....
  32. pmc Contrasting roles of axonal (pyramidal cell) and dendritic (interneuron) electrical coupling in the generation of neuronal network oscillations
    Roger D Traub
    Department of Physiology and Pharmacology, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Box 31, Brooklyn, NY 11203, USA
    Proc Natl Acad Sci U S A 100:1370-4. 2003
    ..In our model, axonal electrical coupling is required for the gamma oscillation to occur at all; interneuron dendritic gap junctions exert a modulatory effect...
  33. ncbi request reprint New roles for the gamma rhythm: population tuning and preprocessing for the Beta rhythm
    Mette S Olufsen
    Department of Mathematics, North Carolina State University, Raleigh, NC 27659 8205, USA
    J Comput Neurosci 14:33-54. 2003
    ..We present experimental evidence showing that such a separation can occur in hippocampal slices...
  34. ncbi request reprint Long-range synchronization of gamma and beta oscillations and the plasticity of excitatory and inhibitory synapses: a network model
    Andrea Bibbig
    Department of Physiology and Pharmacology, State University of New York Health Science Center, Brooklyn, New York 11203, USA
    J Neurophysiol 88:1634-54. 2002
    ..It is reached with the help of a "synchronizing-weak-beat," which induces sudden changes in the oscillation period length of the two assemblies...
  35. pmc A role for fast rhythmic bursting neurons in cortical gamma oscillations in vitro
    Mark O Cunningham
    School of Biomedical Sciences, The Worsley Building, University of Leeds, Leeds LS2 9JT, United Kingdom
    Proc Natl Acad Sci U S A 101:7152-7. 2004
    ..The resulting network gamma oscillation shares all of the properties of gamma oscillations generated in the hippocampus but with the additional critical dependence on multiple spiking in FRB cells...
  36. ncbi request reprint Cellular mechanisms of neuronal population oscillations in the hippocampus in vitro
    Roger D Traub
    Department of Physiology and Pharmacology, State University of New York Downstate Medical Center, Brooklyn, New York 11203, USA
    Annu Rev Neurosci 27:247-78. 2004
    ..Oscillations at gamma frequencies and below probably create conditions under which synaptic plasticity can occur, between selected neurons-even those separated by significant axonal conduction delays...
  37. ncbi request reprint Combined experimental/simulation studies of cellular and network mechanisms of epileptogenesis in vitro and in vivo
    Roger D Traub
    Department of Physiology, SUNY Downstate Medical Center, Brooklyn, New York 11203, USA
    J Clin Neurophysiol 22:330-42. 2005
    ..Also reviewed are some of the data suggesting that the requisite gap junctions are located on the axons of glutamatergic neurons...
  38. pmc Orthogonal arrangement of rhythm-generating microcircuits in the hippocampus
    Tengis Gloveli
    Institute of Neurophysiology, Charite Universitatsmedizin Berlin, Tucholskystrasse 2, 10117 Berlin, Germany
    Proc Natl Acad Sci U S A 102:13295-300. 2005
    ..Thus, the axonal arborization patterns of hippocampal inhibitory cells may represent a structural framework for the spatiotemporal distribution of activity observed within the hippocampus...
  39. ncbi request reprint Slow and fast inhibition and an H-current interact to create a theta rhythm in a model of CA1 interneuron network
    Horacio G Rotstein
    Department of Mathematics and Statistics and Center for BioDynamics, Boston University, Boston, MA 02215, USA
    J Neurophysiol 94:1509-18. 2005
    ..A component of the model O-LM cell critical to the synchronization mechanism is the hyperpolarization-activated h-current. The model can robustly reproduce relative phases of theta frequency activity in O-LM and FS cells...
  40. pmc Structure/function correlates of neuronal and network activity--an overview
    Fiona E N LeBeau
    J Physiol 562:1-2. 2005
  41. ncbi request reprint Single-column thalamocortical network model exhibiting gamma oscillations, sleep spindles, and epileptogenic bursts
    Roger D Traub
    Department of Physiology, State University of New York, Downstate Medical Center, 450 Clarkson Ave, Box 31, Brooklyn, NY 11203, USA
    J Neurophysiol 93:2194-232. 2005
    ..The degree of recurrent synaptic excitation between spiny stellate cells, and their tendency to fire throughout multiple bursts, also appears critical in shaping epileptogenic events...
  42. pmc Persistent gamma oscillations in superficial layers of rat auditory neocortex: experiment and model
    Roger D Traub
    Department of Physiology, SUNY Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203, USA
    J Physiol 562:3-8. 2005
    ....
  43. pmc Differential involvement of oriens/pyramidale interneurones in hippocampal network oscillations in vitro
    Tengis Gloveli
    School of Biomedical Sciences, University of Leeds, Leeds LS2 9JT, UK
    J Physiol 562:131-47. 2005
    ..Therefore a division of labour appears to exist whereby different frequencies and spatiotemporal properties of hippocampal rhythms are mediated by different interneurone subtypes...
  44. ncbi request reprint Gap junctions, fast oscillations and the initiation of seizures
    Roger D Traub
    Department of Pshysiology, SUNY Downstate Medical Center, Brooklyn, New York, USA
    Adv Exp Med Biol 548:110-22. 2004
  45. ncbi request reprint Axonal gap junctions between principal neurons: a novel source of network oscillations, and perhaps epileptogenesis
    Roger D Traub
    Department of Physiology, SUNY Downstate Medical Center, Brooklyn 11203, USA
    Rev Neurosci 13:1-30. 2002
    ....