A Whitehead

Summary

Affiliation: University of Reading
Country: UK

Publications

  1. ncbi request reprint Donepezil for the symptomatic treatment of patients with mild to moderate Alzheimer's disease: a meta-analysis of individual patient data from randomised controlled trials
    Anne Whitehead
    The University of Reading, Medical and Pharmaceutical Statistics Research Unit, Reading, UK
    Int J Geriatr Psychiatry 19:624-33. 2004
  2. ncbi request reprint Opportunities for reduction in acute toxicity testing via improved design
    Anne Whitehead
    Medical and Pharmaceutical Statistics MPS Research Unit, The University of Reading, P O Box 240, Earley Gate, Reading, Berkshire RG6 6FN, UK
    Altern Lab Anim 32:73-80. 2004
  3. ncbi request reprint Incorporating intermediate binary responses into interim analyses of clinical trials: a comparison of four methods
    Anne Whitehead
    The University of Reading, Reading RG6 6FN, U K
    Stat Med 27:1646-66. 2008
  4. ncbi request reprint Meta-analysis of ordinal outcomes using individual patient data
    A Whitehead
    Medical and Pharmaceutical Statistics Research Unit, The University of Reading, P O Box 240, Earley Gate, Reading RG6 6FN, U K
    Stat Med 20:2243-60. 2001
  5. pmc Stopping rules for phase II studies
    N Stallard
    Medical and Pharmaceutical Statistics Research Unit, The University of Reading, PO Box 240, Earley Gate, Reading, Berkshire, RG6 6FN, UK
    Br J Clin Pharmacol 51:523-9. 2001
  6. pmc Interim analyses and sequential designs in phase III studies
    S Todd
    Medical and Pharmaceutical Statistics Research Unit, The University of Reading, PO Box 240, Earley Gate, Reading, Berkshire, RG6 6FN
    Br J Clin Pharmacol 51:394-9. 2001
  7. ncbi request reprint Mid-trial design reviews for sequential clinical trials
    J Whitehead
    Medical and Pharmaceutical Statistics Research Unit, The University of Reading, P.O. Box 240, Earley Gate, Reading RG6 6FN, UK
    Stat Med 20:165-76. 2001
  8. pmc Learning from previous responses in phase I dose-escalation studies
    J Whitehead
    Medical and Pharmaceutical Statistics Research Unit, The University of Reading, PO Box 240, Earley Gate, Reading, Berkshire, RG6 6FN
    Br J Clin Pharmacol 52:1-7. 2001
  9. ncbi request reprint Statistical evaluation of the revised fixed-dose procedure
    N Stalla
    Medical and Pharmaceutical Statistics Research Unit, The University of Reading, UK
    Hum Exp Toxicol 21:183-96. 2002
  10. pmc Strategies to prevent falls and fractures in hospitals and care homes and effect of cognitive impairment: systematic review and meta-analyses
    David Oliver
    University of Reading Institute of Health Sciences, Reading RG1 5AG
    BMJ 334:82. 2007

Detail Information

Publications17

  1. ncbi request reprint Donepezil for the symptomatic treatment of patients with mild to moderate Alzheimer's disease: a meta-analysis of individual patient data from randomised controlled trials
    Anne Whitehead
    The University of Reading, Medical and Pharmaceutical Statistics Research Unit, Reading, UK
    Int J Geriatr Psychiatry 19:624-33. 2004
    ..The objective was to evaluate the efficacy and tolerability of donepezil (5 and 10 mg/day) compared with placebo in alleviating manifestations of mild to moderate Alzheimer's disease (AD)...
  2. ncbi request reprint Opportunities for reduction in acute toxicity testing via improved design
    Anne Whitehead
    Medical and Pharmaceutical Statistics MPS Research Unit, The University of Reading, P O Box 240, Earley Gate, Reading, Berkshire RG6 6FN, UK
    Altern Lab Anim 32:73-80. 2004
    ..This paper describes a statistical modelling approach for the evaluation of acute oral toxicity tests, by using the revised FDP for illustration. Opportunities for further design improvements are discussed...
  3. ncbi request reprint Incorporating intermediate binary responses into interim analyses of clinical trials: a comparison of four methods
    Anne Whitehead
    The University of Reading, Reading RG6 6FN, U K
    Stat Med 27:1646-66. 2008
    ..The methods are the score and Wald approaches, each with the log-odds ratio and probability difference parameterizations. Simulations show that all four approaches have good properties in moderate to large sample sizes...
  4. ncbi request reprint Meta-analysis of ordinal outcomes using individual patient data
    A Whitehead
    Medical and Pharmaceutical Statistics Research Unit, The University of Reading, P O Box 240, Earley Gate, Reading RG6 6FN, U K
    Stat Med 20:2243-60. 2001
    ..The methods are illustrated on two data sets, in a classical framework using SAS and MLn and in a Bayesian framework using BUGS. The relative merits of the three software packages for such meta-analyses are discussed...
  5. pmc Stopping rules for phase II studies
    N Stallard
    Medical and Pharmaceutical Statistics Research Unit, The University of Reading, PO Box 240, Earley Gate, Reading, Berkshire, RG6 6FN, UK
    Br J Clin Pharmacol 51:523-9. 2001
    ..In most cases the stopping rules can be described and implemented easily without knowledge of the detailed statistical and computational methods used to obtain the rules...
  6. pmc Interim analyses and sequential designs in phase III studies
    S Todd
    Medical and Pharmaceutical Statistics Research Unit, The University of Reading, PO Box 240, Earley Gate, Reading, Berkshire, RG6 6FN
    Br J Clin Pharmacol 51:394-9. 2001
    ..Examples are given of completed trials, which have been carried out sequentially, and references to relevant literature and software are provided...
  7. ncbi request reprint Mid-trial design reviews for sequential clinical trials
    J Whitehead
    Medical and Pharmaceutical Statistics Research Unit, The University of Reading, P.O. Box 240, Earley Gate, Reading RG6 6FN, UK
    Stat Med 20:165-76. 2001
    ..Examples are given of the various situations considered, and extensive simulations are reported demonstrating the validity of the review procedure in the case of normally distributed responses...
  8. pmc Learning from previous responses in phase I dose-escalation studies
    J Whitehead
    Medical and Pharmaceutical Statistics Research Unit, The University of Reading, PO Box 240, Earley Gate, Reading, Berkshire, RG6 6FN
    Br J Clin Pharmacol 52:1-7. 2001
    ..Certain limitations are discussed, which will be best overcome by collaboration between clinical pharmacologists and statisticians...
  9. ncbi request reprint Statistical evaluation of the revised fixed-dose procedure
    N Stalla
    Medical and Pharmaceutical Statistics Research Unit, The University of Reading, UK
    Hum Exp Toxicol 21:183-96. 2002
    ..The revised FDP usually requires five or six animals with two or fewer dying as a result of treatment in most cases...
  10. pmc Strategies to prevent falls and fractures in hospitals and care homes and effect of cognitive impairment: systematic review and meta-analyses
    David Oliver
    University of Reading Institute of Health Sciences, Reading RG1 5AG
    BMJ 334:82. 2007
    ..To evaluate the evidence for strategies to prevent falls or fractures in residents in care homes and hospital inpatients and to investigate the effect of dementia and cognitive impairment...
  11. ncbi request reprint The sequential analysis of repeated binary responses: a score test for the case of three time points
    Marina Roshini Sooriyarachchi
    Department of Statistics and Computer Science, University of Colombo, Sri Lanka
    Stat Med 25:2196-214. 2006
    ..Extensions to more than three time points and to allow for stratification are discussed...
  12. ncbi request reprint Incorporating data received after a sequential trial has stopped into the final analysis: implementation and comparison of methods
    Marina Roshini Sooriyarachchi
    Department of Statistics, University of Colombo, Sri Lanka
    Biometrics 59:701-9. 2003
    ..The effect on power resulting from the incorporation of "overrunning data" using the two procedures is evaluated...
  13. ncbi request reprint A statistical evaluation of the fixed dose procedure
    Nigel Stallard
    Medical and Pharmaceutical Statistics MPS Research Unit, The University of Reading, P O Box 240, Earley Gate, Reading, Berkshire RG6 6FN, UK
    Altern Lab Anim 32:13-21. 2004
    ..It illustrates how statistical modelling and simulation can be used to increase the efficiency of a test procedure and reduce the number of animals needed for an in vivo validation of the procedure...
  14. ncbi request reprint Statistical evaluation of an acute dermal toxicity test using the dermal fixed dose procedure
    Nigel Stallard
    Medical and Pharmaceutical Statistics Research Unit, The University of Reading, Reading, UK
    Hum Exp Toxicol 23:405-12. 2004
    ....
  15. ncbi request reprint Statistical evaluation of the fixed concentration procedure for acute inhalation toxicity assessment
    Nigel Stallard
    Medical and Pharmaceutical Statistics Research Unit, The University of Reading, Reading, UK
    Hum Exp Toxicol 22:575-85. 2003
    ....
  16. ncbi request reprint An illustration of the modelling of cost and efficacy data from a clinical trial
    Seokyung Hahn
    Department of Health Sciences, Seebohm Rowntree Building, University of York, UK
    Stat Med 22:1009-24. 2003
    ..The advantages and disadvantages of the different approaches are discussed. In January 2001, NICE issued guidance on the type of surgery to be used for inguinal hernia repair. We discuss our example in the light of this information...
  17. ncbi request reprint Active-control trials with binary data: a comparison of methods for testing superiority or non-inferiority using the odds ratio
    Arminda Lucia Siqueira
    Departamento de Estatistica, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    Stat Med 27:353-70. 2008
    ..In general, the highest power is obtained from the score test, although all three tests are similar and the observed differences in power are not of practical importance...