Robert J White

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. ncbi request reprint RNA polymerases I and III, growth control and cancer
    Robert J White
    Institute of Biomedical and Life Sciences, Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow, G12 8QQ, UK
    Nat Rev Mol Cell Biol 6:69-78. 2005
  2. pmc mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1
    Theodoros Kantidakis
    Beatson Institute for Cancer Research, Glasgow G61 1BD, United Kingdom
    Proc Natl Acad Sci U S A 107:11823-8. 2010
  3. pmc Regulation of TFIIIB during F9 cell differentiation
    Dimitris Athineos
    Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK
    BMC Mol Biol 11:21. 2010
  4. doi request reprint Transcription by RNA polymerase III: more complex than we thought
    Robert J White
    Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK
    Nat Rev Genet 12:459-63. 2011
  5. doi request reprint Direct regulation of tRNA and 5S rRNA gene transcription by Polo-like kinase 1
    Jennifer A Fairley
    Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK
    Mol Cell 45:541-52. 2012
  6. doi request reprint Non-coding RNA production by RNA polymerase III is implicated in cancer
    Lynne Marshall
    Beatson Institute for Cancer Research, Bearsden, Glasgow, UK
    Nat Rev Cancer 8:911-4. 2008
  7. doi request reprint RNA polymerases I and III, non-coding RNAs and cancer
    Robert J White
    Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, UK
    Trends Genet 24:622-9. 2008
  8. ncbi request reprint RNA polymerase III transcription and cancer
    Robert J White
    Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Davidson Building, Glasgow G12 8QQ, UK
    Oncogene 23:3208-16. 2004
  9. doi request reprint Coordinated control of the gene expression machinery
    Robert J White
    Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, UK
    Trends Genet 26:214-20. 2010
  10. pmc Dr1 (NC2) is present at tRNA genes and represses their transcription in human cells
    Theodoros Kantidakis
    Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, UK
    Nucleic Acids Res 38:1228-39. 2010

Collaborators

Detail Information

Publications10

  1. ncbi request reprint RNA polymerases I and III, growth control and cancer
    Robert J White
    Institute of Biomedical and Life Sciences, Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow, G12 8QQ, UK
    Nat Rev Mol Cell Biol 6:69-78. 2005
    ..Such events might have a significant impact on the growth potential of tumours...
  2. pmc mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1
    Theodoros Kantidakis
    Beatson Institute for Cancer Research, Glasgow G61 1BD, United Kingdom
    Proc Natl Acad Sci U S A 107:11823-8. 2010
    ..We conclude that mTOR associates with TFIIIC, is recruited to pol III-transcribed genes, and relieves their repression by Maf1...
  3. pmc Regulation of TFIIIB during F9 cell differentiation
    Dimitris Athineos
    Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK
    BMC Mol Biol 11:21. 2010
    ..The goal of this study was to identify molecular changes that can account for the low activity of TFIIIB following F9 cell differentiation...
  4. doi request reprint Transcription by RNA polymerase III: more complex than we thought
    Robert J White
    Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK
    Nat Rev Genet 12:459-63. 2011
    ..Here I describe these novel insights and consider their implications and the questions that remain...
  5. doi request reprint Direct regulation of tRNA and 5S rRNA gene transcription by Polo-like kinase 1
    Jennifer A Fairley
    Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK
    Mol Cell 45:541-52. 2012
    ..Genomic instability is apparent in cells with Brf1 T270 mutated to alanine to resist Plk1-directed inactivation, suggesting that chromosome segregation is vulnerable to inappropriate pol III activity...
  6. doi request reprint Non-coding RNA production by RNA polymerase III is implicated in cancer
    Lynne Marshall
    Beatson Institute for Cancer Research, Bearsden, Glasgow, UK
    Nat Rev Cancer 8:911-4. 2008
    ..New evidence suggests that Pol III output can substantially affect transformation...
  7. doi request reprint RNA polymerases I and III, non-coding RNAs and cancer
    Robert J White
    Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, UK
    Trends Genet 24:622-9. 2008
    ..The resultant increases in rRNA and tRNA expression might promote the generation of cancers...
  8. ncbi request reprint RNA polymerase III transcription and cancer
    Robert J White
    Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Davidson Building, Glasgow G12 8QQ, UK
    Oncogene 23:3208-16. 2004
    ..In addition to effects on protein synthesis and growth, there is a precedent for a pol III product having oncogenic activity...
  9. doi request reprint Coordinated control of the gene expression machinery
    Robert J White
    Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, UK
    Trends Genet 26:214-20. 2010
    ..This occurs at both the transcriptional level, through the coordinate regulation of RNA polymerases I-III and downstream in the coordinate regulation of transcription with RNA processing and translation...
  10. pmc Dr1 (NC2) is present at tRNA genes and represses their transcription in human cells
    Theodoros Kantidakis
    Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, UK
    Nucleic Acids Res 38:1228-39. 2010
    ..On the basis of these data, we conclude that the physiological functions of human Dr1 include regulation of pol III transcription...