I R White

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc Nonadherence to treatment protocol in published randomised controlled trials: a review
    Susanna Dodd
    Department of Biostatistics, Institute of Translational Medicine, University of Liverpool, Liverpool L69 3GS, UK
    Trials 13:84. 2012
  2. pmc An exploration of the missing data mechanism in an Internet based smoking cessation trial
    Dan Jackson
    MRC Biostatistics Unit, Cambridge, UK
    BMC Med Res Methodol 12:157. 2012
  3. pmc Multiple imputation of missing covariates with non-linear effects and interactions: an evaluation of statistical methods
    Shaun R Seaman
    MRC Biostatistics Unit, Institute of Public Health, Cambridge CB2 0SR, UK
    BMC Med Res Methodol 12:46. 2012
  4. pmc Including all individuals is not enough: lessons for intention-to-treat analysis
    Ian R White
    MRC Biostatistics Unit, Cambridge, UK
    Clin Trials 9:396-407. 2012
  5. pmc The DYD-RCT protocol: an on-line randomised controlled trial of an interactive computer-based intervention compared with a standard information website to reduce alcohol consumption among hazardous drinkers
    Elizabeth Murray
    e Health Unit, Department of Primary Care and Population Sciences, University College London, Highgate Hill, London N19 5LW, UK
    BMC Public Health 7:306. 2007
  6. pmc An investigation of factors associated with psychiatric hospital admission despite the presence of crisis resolution teams
    Mary Anne Cotton
    Department of Mental Health Sciences, Royal Free and University College Medical Schools, UCL, London, UK
    BMC Psychiatry 7:52. 2007
  7. pmc Study protocol. A prospective cohort study of unselected primiparous women: the pregnancy outcome prediction study
    Dharmintra Pasupathy
    Department of Obstetrics and Gynaecology, University of Cambridge, Cambridge, UK
    BMC Pregnancy Childbirth 8:51. 2008
  8. pmc Imputing missing covariate values for the Cox model
    Ian R White
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 0SR, UK
    Stat Med 28:1982-98. 2009
  9. ncbi request reprint Uses and limitations of randomization-based efficacy estimators
    Ian R White
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, UK
    Stat Methods Med Res 14:327-47. 2005
  10. ncbi request reprint Standardized mean differences in individually-randomized and cluster-randomized trials, with applications to meta-analysis
    Ian R White
    MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK
    Clin Trials 2:141-51. 2005

Collaborators

Detail Information

Publications72

  1. pmc Nonadherence to treatment protocol in published randomised controlled trials: a review
    Susanna Dodd
    Department of Biostatistics, Institute of Translational Medicine, University of Liverpool, Liverpool L69 3GS, UK
    Trials 13:84. 2012
    ....
  2. pmc An exploration of the missing data mechanism in an Internet based smoking cessation trial
    Dan Jackson
    MRC Biostatistics Unit, Cambridge, UK
    BMC Med Res Methodol 12:157. 2012
    ....
  3. pmc Multiple imputation of missing covariates with non-linear effects and interactions: an evaluation of statistical methods
    Shaun R Seaman
    MRC Biostatistics Unit, Institute of Public Health, Cambridge CB2 0SR, UK
    BMC Med Res Methodol 12:46. 2012
    ..In 'passive imputation' a value X* is imputed for X and then X2 is imputed as (X*)2. A recent proposal is to treat X2 as 'just another variable' (JAV) and impute X and X2 under multivariate normality...
  4. pmc Including all individuals is not enough: lessons for intention-to-treat analysis
    Ian R White
    MRC Biostatistics Unit, Cambridge, UK
    Clin Trials 9:396-407. 2012
    ..However, there is confusion about how ITT analysis should be performed in the presence of missing outcome data...
  5. pmc The DYD-RCT protocol: an on-line randomised controlled trial of an interactive computer-based intervention compared with a standard information website to reduce alcohol consumption among hazardous drinkers
    Elizabeth Murray
    e Health Unit, Department of Primary Care and Population Sciences, University College London, Highgate Hill, London N19 5LW, UK
    BMC Public Health 7:306. 2007
    ..Researchers internationally are looking at the potential of Internet interventions in this area...
  6. pmc An investigation of factors associated with psychiatric hospital admission despite the presence of crisis resolution teams
    Mary Anne Cotton
    Department of Mental Health Sciences, Royal Free and University College Medical Schools, UCL, London, UK
    BMC Psychiatry 7:52. 2007
    ..Crisis resolution teams (CRTs) provide a community alternative to psychiatric hospital admission for patients presenting in crisis. Little is known about the characteristics of patients admitted despite the availability of such teams...
  7. pmc Study protocol. A prospective cohort study of unselected primiparous women: the pregnancy outcome prediction study
    Dharmintra Pasupathy
    Department of Obstetrics and Gynaecology, University of Cambridge, Cambridge, UK
    BMC Pregnancy Childbirth 8:51. 2008
    ..Here, we report a study design where the primary aim is to generate clinically useful methods to screen women to assess their risk of adverse pregnancy outcome...
  8. pmc Imputing missing covariate values for the Cox model
    Ian R White
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 0SR, UK
    Stat Med 28:1982-98. 2009
    ..We find that using logT biases covariate-outcome associations towards the null, while the new methods have lower bias. Overall, we recommend including the event indicator and the Nelson-Aalen estimator of H(T) in the imputation model...
  9. ncbi request reprint Uses and limitations of randomization-based efficacy estimators
    Ian R White
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, UK
    Stat Methods Med Res 14:327-47. 2005
    ....
  10. ncbi request reprint Standardized mean differences in individually-randomized and cluster-randomized trials, with applications to meta-analysis
    Ian R White
    MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK
    Clin Trials 2:141-51. 2005
    ..We also describe methods for estimating the standard deviation. Various pitfalls are identified which can lead to major errors especially in the cluster-randomized setting...
  11. ncbi request reprint Eliciting and using expert opinions about influence of patient characteristics on treatment effects: a Bayesian analysis of the CHARM trials
    Ian R White
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, U K
    Stat Med 24:3805-21. 2005
    ....
  12. ncbi request reprint Choice of test for comparing two groups, with particular application to skewed outcomes
    Ian R White
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, UK
    Stat Med 22:1205-15. 2003
    ..We show that a comparison of sample means is a reasonable choice in this case despite the skewness...
  13. ncbi request reprint Commentary: dealing with measurement error: multiple imputation or regression calibration?
    Ian R White
    MRC Biostatistics Unit, Institute of Public Health, Cambridge CB2 2SR, UK
    Int J Epidemiol 35:1081-2. 2006
  14. ncbi request reprint Eliciting and using expert opinions about dropout bias in randomized controlled trials
    Ian R White
    MRC Biostatistics Unit, Cambridge UK
    Clin Trials 4:125-39. 2007
    ..However, in many settings this assumption is implausible, so it is sensible to assess the robustness of conclusions to departures from missing at random...
  15. ncbi request reprint Allowing for uncertainty due to missing data in meta-analysis--part 1: two-stage methods
    Ian R White
    MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK
    Stat Med 27:711-27. 2008
    ..We illustrate the methods using a meta-analysis on psychiatric interventions in deliberate self-harm...
  16. ncbi request reprint Allowing for uncertainty due to missing data in meta-analysis--part 2: hierarchical models
    Ian R White
    MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK
    Stat Med 27:728-45. 2008
    ..By applying the method in three different data sets, we show that it is possible to appropriately capture the extra uncertainty due to missing data, and we discuss in what circumstances it is possible to learn about the IMOR...
  17. pmc Allowing for missing outcome data and incomplete uptake of randomised interventions, with application to an Internet-based alcohol trial
    Ian R White
    Medical Research Council Biostatistics Unit, Cambridge, UK
    Stat Med 30:3192-207. 2011
    ..More generally, the analyses proposed are applicable to many trials with missing outcome data or incomplete intervention uptake. To facilitate use by others, Stata code is provided for all methods...
  18. doi request reprint Multiple imputation using chained equations: Issues and guidance for practice
    Ian R White
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 0SR, U K
    Stat Med 30:377-99. 2011
    ..We stress the limitations of the method and discuss the possible pitfalls. We illustrate the ideas using a data set in mental health, giving Stata code fragments...
  19. doi request reprint Bias and efficiency of multiple imputation compared with complete-case analysis for missing covariate values
    Ian R White
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 0SR, U K
    Stat Med 29:2920-31. 2010
    ....
  20. pmc Assessing subgroup effects with binary data: can the use of different effect measures lead to different conclusions?
    Ian R White
    Institute of Public Health, Robinson Way, Cambridge CB2 2SR, UK
    BMC Med Res Methodol 5:15. 2005
    ..Risk ratios were similar between subgroups defined by level of clinical suspicion (P = 0.14), but odds ratios and risk differences differed strongly between subgroups (P < 0.001)...
  21. ncbi request reprint Adjusting for partially missing baseline measurements in randomized trials
    Ian R White
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, U K
    Stat Med 24:993-1007. 2005
    ..The methods are illustrated in a randomized trial in community psychiatry...
  22. pmc Alcohol consumption and mortality: modelling risks for men and women at different ages
    Ian R White
    Medical Statistics Unit, London School of Hygiene and Tropical Medicine, London WC1E 7HT
    BMJ 325:191. 2002
    ..To estimate the relation between alcohol consumption and risk of death, the level of alcohol consumption at which risk is least, and how these vary with age and sex...
  23. ncbi request reprint Adjusting treatment comparisons to account for non-randomized interventions: an example from an angina trial
    Ian R White
    Medical Statistics Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Stat Med 22:781-93. 2003
    ..Such methods may be of interest to many pragmatic randomized trials in which the effects of the initial randomized treatments and the effects of the overall treatment strategies as implemented are both of interest...
  24. ncbi request reprint Mortality in England and Wales attributable to any drinking, drinking above sensible limits and drinking above lowest-risk level
    Ian R White
    London School of Hygiene and Tropical Medicine, London, UK
    Addiction 99:749-56. 2004
    ..To quantify mortality attributable to any alcohol consumption, and mortality attributable to consumption above different levels...
  25. ncbi request reprint Correcting for measurement error in binary and continuous variables using replicates
    I White
    Medical Statistics Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Stat Med 20:3441-57. 2001
    ..5...
  26. ncbi request reprint Randomized clinical trials with added rescue medication: some approaches to their analysis and interpretation
    I R White
    Medical Statistics Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, U K
    Stat Med 20:2995-3008. 2001
    ..It appears that adjustment for rescue medication will not radically alter the randomized treatment comparison unless rescue medication is substantially imbalanced between randomized groups and has a substantial effect on the outcome...
  27. ncbi request reprint The use of regression models for medians when observed outcomes may be modified by interventions
    Ian R White
    Medical Statistics Unit, London School of Hygiene and Tropical Medicine, Keppel Street, UK
    Stat Med 22:1083-96. 2003
    ..We show that the significance levels are comparable to those derived from logistic regression. We also discuss the effect of grouping of blood pressure and the need for bootstrap standard errors...
  28. ncbi request reprint A modelling strategy for the analysis of clinical trials with partly missing longitudinal data
    Ian R White
    MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK
    Int J Methods Psychiatr Res 12:139-50. 2003
    ..All models give similar estimates of the intervention effect and we conclude that non-response bias is likely to be small...
  29. ncbi request reprint Assessing correlation between reporting errors and true values: untestable assumptions are unavoidable
    Ian R White
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, UK
    Int J Epidemiol 33:1400-1; discussion 1402-3. 2004
  30. pmc Statistical methods for the time-to-event analysis of individual participant data from multiple epidemiological studies
    Simon Thompson
    MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK
    Int J Epidemiol 39:1345-59. 2010
    ..Meta-analysis of individual participant time-to-event data from multiple prospective epidemiological studies enables detailed investigation of exposure-risk relationships, but involves a number of analytical challenges...
  31. ncbi request reprint Maternal and biochemical predictors of antepartum stillbirth among nulliparous women in relation to gestational age of fetal death
    G C S Smith
    Department of Obstetrics and Gynaecology, Cambridge University, Rosie Maternity Hospital, Cambridge, UK
    BJOG 114:705-14. 2007
    ..To determine whether maternal serum levels of alphafetoprotein (alpha-FP) and human chorionic gonadotrophin (hCG) at 15-21 weeks provided clinically useful prediction of stillbirth in first pregnancies...
  32. pmc Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies
    Nadeem Sarwar
    Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Wort s Causeway, Cambridge CB1 8RN, UK
    Lancet 375:1634-9. 2010
    ..Whether triglyceride-mediated pathways are causally relevant to coronary heart disease is uncertain. We studied a genetic variant that regulates triglyceride concentration to help judge likelihood of causality...
  33. pmc Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies
    David Wormser
    Emerging Risk Factors Collaboration Coordinating Centre, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK
    Lancet 377:1085-95. 2011
    ..We studied the separate and combined associations of body-mass index (BMI), waist circumference, and waist-to-hip ratio with risk of first-onset cardiovascular disease...
  34. pmc Neonatal respiratory morbidity at term and the risk of childhood asthma
    G C S Smith
    Department of Obstetrics and Gynaecology, Cambridge University, Cambridge, UK
    Arch Dis Child 89:956-60. 2004
    ..To determine whether neonatal respiratory morbidity at term is associated with an increased risk of later asthma and whether this may explain previously described associations between caesarean delivery and asthma...
  35. ncbi request reprint Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis
    John Danesh
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, England
    JAMA 294:1799-809. 2005
    ..Plasma fibrinogen levels may be associated with the risk of coronary heart disease (CHD) and stroke...
  36. ncbi request reprint Systematic review of the prospective cohort studies on meat consumption and colorectal cancer risk: a meta-analytical approach
    M S Sandhu
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Strangeways Research Laboratory, Cambridge, CB1 8RN, UK
    Cancer Epidemiol Biomarkers Prev 10:439-46. 2001
    ....
  37. pmc National level promotion of physical activity: results from England's ACTIVE for LIFE campaign
    M Hillsdon
    Health Promotion Research Unit, London School of Hygiene and Tropical Medicine, London, UK
    J Epidemiol Community Health 55:755-61. 2001
    ..To assess the impact of a national campaign on awareness of the campaign, change in knowledge of physical activity recommendations and self reported physical activity...
  38. doi request reprint Regaining power lost by non-compliance via full probability modelling
    T Becque
    MRC Biostatistics Unit, Institute of Public Health, Forvie Site, Robinson Way, Cambridge CB2 0SR, U K
    Stat Med 27:5640-63. 2008
    ..This implies that a large gain in power obtained using as-treated or per-protocol analyses is likely to be due to the strong and often implausible assumptions such analyses require to be valid...
  39. ncbi request reprint A retrospective analysis of contact allergy to lanolin
    S H Wakelin
    St John's Institute of Dermatology, London, UK
    Br J Dermatol 145:28-31. 2001
    ..CONCLUSIONS: This study illustrates that lanolin sensitization has remained at a relatively low and constant rate even in a high-risk population (i.e. patients with recent or active eczema)...
  40. ncbi request reprint Effects of training community staff in interventions for substance misuse in dual diagnosis patients with psychosis (COMO study): cluster randomised trial
    S Johnson
    Department of Mental Health Sciences, University College London, 67 73 Riding House Street, London, UK
    Br J Psychiatry 191:451-2. 2007
    ..Current UK policy guidance advocates training CMHT professionals to deliver dual diagnosis interventions, but the effectiveness of this strategy has not so far been demonstrated...
  41. ncbi request reprint Sensitivity analysis after multiple imputation under missing at random: a weighting approach
    James R Carpenter
    Medical Statistics Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Stat Methods Med Res 16:259-75. 2007
    ..We illustrate our approach with a small simulation study, and the analysis of data from a trial of interventions to improve the quality of peer review...
  42. pmc Imputation methods for missing outcome data in meta-analysis of clinical trials
    Julian P T Higgins
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge, UK
    Clin Trials 5:225-39. 2008
    ..An intention-to-treat analysis should take account of all randomized participants even if they have missing observations...
  43. pmc Birth order of twins and risk of perinatal death related to delivery in England, Northern Ireland, and Wales, 1994-2003: retrospective cohort study
    Gordon C S Smith
    Department of Obstetrics and Gynaecology, Cambridge University, Box 223, The Rosie Hospital, Cambridge CB2 2QQ
    BMJ 334:576. 2007
    ..To determine the effect of birth order on the risk of perinatal death in twin pregnancies...
  44. ncbi request reprint Analysis of cluster randomized cross-over trial data: a comparison of methods
    Rebecca M Turner
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, UK
    Stat Med 26:274-89. 2007
    ..We conclude that choice between hierarchical models and cluster-level methods should be influenced by the extent of complexity in the planned analysis...
  45. ncbi request reprint Parametric randomization-based methods for correcting for treatment changes in the assessment of the causal effect of treatment
    A Sarah Walker
    MRC Clinical Trials Unit, HIV Division, 222 Euston Road, London NW1 2DA, U K
    Stat Med 23:571-90. 2004
    ..The Concorde trial of immediate versus deferred zidovudine in HIV infection is used as a motivating example and illustration of the methods...
  46. ncbi request reprint Combined logistic and Bayesian modeling of cesarean section risk
    Gordon C S Smith
    Department of Obstetrics and Gynaecology, Cambridge University, Box 223, The Rosie Hospital, Robinson Way, Cambridge, CB2 2QQ, United Kingdom
    Am J Obstet Gynecol 191:2029-34. 2004
    ..This study was undertaken to develop a simple and robust method for predicting risk of cesarean section...
  47. ncbi request reprint Maternal and biochemical predictors of spontaneous preterm birth among nulliparous women: a systematic analysis in relation to the degree of prematurity
    Gordon C S Smith
    Department of Obstetrics and Gynaecology, Cambridge University, Cambridge, CB2 2QQ, UK
    Int J Epidemiol 35:1169-77. 2006
    ..However, it is unclear whether these associations are strong enough to offer clinically useful prediction. It is also unclear whether the predictive power of these factors varies in relation to the degree of prematurity...
  48. ncbi request reprint Comparison of imputation and modelling methods in the analysis of a physical activity trial with missing outcomes
    Angela M Wood
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, UK
    Int J Epidemiol 34:89-99. 2005
    ..Here we review a wide range of methods to handle missing outcomes in single and repeated measures data and discuss which methods are most appropriate...
  49. ncbi request reprint Predicting the risk for sudden infant death syndrome from obstetric characteristics: a retrospective cohort study of 505,011 live births
    Gordon C S Smith
    Department of Obstetrics and Gynaecology, Cambridge University, Cambridge, United Kingdom
    Pediatrics 117:60-6. 2006
    ..We sought to develop a simple robust method for assessing the risk for sudden infant death syndrome (SIDS) on the basis of obstetric characteristics...
  50. ncbi request reprint Second-trimester maternal serum levels of alpha-fetoprotein and the subsequent risk of sudden infant death syndrome
    Gordon C S Smith
    Department of Obstetrics and Gynaecology, Cambridge University, Cambridge, United Kingdom
    N Engl J Med 351:978-86. 2004
    ..It is unknown whether alpha-fetoprotein levels also predict the risk of SIDS...
  51. ncbi request reprint Are missing outcome data adequately handled? A review of published randomized controlled trials in major medical journals
    Angela M Wood
    MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK
    Clin Trials 1:368-76. 2004
    ..We examine how missing outcome data are handled in randomized controlled trials in order to assess whether adequate steps have been taken to reduce nonresponse bias and to identify ways to improve procedures for missing data...
  52. pmc Predicting cesarean section and uterine rupture among women attempting vaginal birth after prior cesarean section
    Gordon C S Smith
    Department of Obstetrics and Gynaecology, Cambridge University, Cambridge, United Kingdom
    PLoS Med 2:e252. 2005
    ....
  53. ncbi request reprint The effect of measurement error in risk factors that change over time in cohort studies: do simple methods overcorrect for 'regression dilution'?
    Chris Frost
    Department of Epidemiology and Population Health, Medical Statistics Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Int J Epidemiol 34:1359-68. 2005
    ..Here we investigate the bias that is introduced if this assumption is invalid...
  54. ncbi request reprint Mode of delivery and the risk of delivery-related perinatal death among twins at term: a retrospective cohort study of 8073 births
    Gordon C S Smith
    Department of Obstetrics and Gynaecology, Cambridge University, UK
    BJOG 112:1139-44. 2005
    ..To determine the risk of perinatal death among twins born at term in relation to mode of delivery...
  55. ncbi request reprint Instrumental variables and interactions in the causal analysis of a complex clinical trial
    Simon J Bond
    Medical Research Council Biostatistics Unit, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge, CB2 2SR, UK
    Stat Med 26:1473-96. 2007
    ..Estimated treatment effects were sensitive to inclusion of interactions, and we show how such sensitivity can be explored and explained...
  56. ncbi request reprint Bayesian synthesis of epidemiological evidence with different combinations of exposure groups: application to a gene-gene-environment interaction
    Georgia Salanti
    MRC Biostatistics Unit, Cambridge, U K
    Stat Med 25:4147-63. 2006
    ..The methodology is implemented in an original meta-analysis of studies relating the risk of bladder cancer to two N-acetyltransferase genes, NAT1 and NAT2, and smoking status...
  57. ncbi request reprint Previous preeclampsia, preterm delivery, and delivery of a small for gestational age infant and the risk of unexplained stillbirth in the second pregnancy: a retrospective cohort study, Scotland, 1992-2001
    Gordon C S Smith
    Department of Obstetrics and Gynaecology, Cambridge University, The Rosie Hospital, Cambridge, UK
    Am J Epidemiol 165:194-202. 2007
    ..63, 9.32). Associations were stronger with SGA unexplained stillbirths. The authors conclude that complicated first births of liveborn infants are associated with an increased risk of unexplained stillbirth in the next pregnancy...
  58. pmc Randomised trial of a parenting intervention during neonatal intensive care
    Cris Glazebrook
    Division of Psychiatry, School of Community Health Sciences, A Floor, South Block, Queens Medical Centre, Nottingham NG7 2UH, UK
    Arch Dis Child Fetal Neonatal Ed 92:F438-43. 2007
    ..To evaluate the influence of parenting intervention on maternal responsiveness and infant neurobehavioural development following a very premature birth...
  59. doi request reprint Hand eczema severity and quality of life: a cross-sectional, multicentre study of hand eczema patients
    Tove Agner
    Department of Dermatology, Roskilde Hospital, University of Copenhagen, 4000 Roskilde, Denmark
    Contact Dermatitis 59:43-7. 2008
    ..Hand eczema is a chronic disease with negative impact on quality of life (QoL). In this study, QoL in hand eczema patients is assessed and related to age, sex, severity, and diagnostic subgroups...
  60. ncbi request reprint Analyzing the duration of recurrent events in clinical trials: a comparison of approaches using data from the UK700 trial of psychiatric case management
    Chris Metcalfe
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol, BS8 2PR, United Kingdom
    Contemp Clin Trials 26:443-58. 2005
    ..We conclude that total duration is an appropriate primary outcome for clinical trials, but that multi-state models deserve greater use as an informative secondary analysis...
  61. ncbi request reprint Outcomes of crises before and after introduction of a crisis resolution team
    Sonia Johnson
    Department of Mental Health Sciences, Royal Free and University College London Medical Schools, Wolfson Building, 48 Riding House Street, London W1W 7EY, UK
    Br J Psychiatry 187:68-75. 2005
    ..Crisis resolution teams (CRTs) are being introduced throughout England, but their evidence base is limited...
  62. ncbi request reprint Evidence that two alkyl ester quaternary ammonium compounds lack substantial human skin-sensitizing potential
    Ian R Jowsey
    Unilever Safety and Environmental Assurance Centre, Colworth Park, Sharnbrook, Bedforshire, UK
    Dermatitis 18:32-9. 2007
    ..It is important to document in the literature the outcome of historical studies that were performed to assess the risk of adverse skin effects associated with their use...
  63. ncbi request reprint Lower incidence of sesquiterpene lactone sensitivity in a population in Asia versus a population in Europe: an effect of chrysanthemum tea?
    Rose K H Mak
    Department of Cutaneous Allergy, St John s Institute of Dermatology, London SE1 7EH, UK
    Contact Dermatitis 57:163-4. 2007
    ..They belong to the Compositae family of plants. Sensitivity to SL may be airborne or via the topical route [topical herbal remedies, cosmetic products, and in many occupations such as gardeners and florists]...
  64. ncbi request reprint Intensive case management for severe psychotic illness: is there a general benefit for patients with complex needs? A secondary analysis of the UK700 trial data
    Chris Metcalfe
    Dept of Social Medicine, University of Bristol, Canynge Hall, Bristol, BS8 2PR, UK
    Soc Psychiatry Psychiatr Epidemiol 40:718-24. 2005
    ..The benefit of ICM for patients with borderline intelligence is an isolated effect which should be interpreted cautiously until further data are available...
  65. ncbi request reprint A statistical comparison of silver and SYPRO Ruby staining for proteomic analysis
    Ian R White
    Genomic and Proteomic Sciences, GlaxoSmithKline Pharmaceuticals, Stevenage, UK
    Electrophoresis 25:3048-54. 2004
    ..The data confirms that as well as offering sensitivity similar to silver, SYPRO Ruby staining is reproducible, linear, and offers a higher level of compatibility with the identification of proteins by mass spectrometry...
  66. ncbi request reprint Fragrance allergy in patients with hand eczema - a clinical study
    Siri Heydorn
    Department of Dermatology, University of Copenhagen, Gentofte Hospital, Hellerup, Denmark
    Contact Dermatitis 48:317-23. 2003
    ..This observation is the basis for the hypothesis concerning cross-reactivity and the effect of simultaneous exposure. The study found that fragrance allergy could be a common problem in patients with eczema on the hands...
  67. pmc Allergy to hair dye
    John P McFadden
    BMJ 334:220. 2007
  68. ncbi request reprint On the issue of 'multiple' first failures in competing risks analysis
    Bee Choo Tai
    NMRC Clinical Trials and Epidemiology Research Unit, 10 College Road, Singapore 169851
    Stat Med 21:2243-55. 2002
    ..However, it takes a longer computer running time, especially when the number of replicates is large. The weighted Cox approach is the method of choice where statistical software allows its implementation without extra programming effort...
  69. ncbi request reprint High frequency of simultaneous sensitivity to Disperse Orange 3 in patients with positive patch tests to para-phenylenediamine
    Anthony T J Goon
    St John s Institute of Dermatology, St Thomas Hospital, London, UK
    Contact Dermatitis 48:248-50. 2003
    ..06%), Disperse Blue 3 (1.56%) and Disperse Red 11 (2.13%). We interpreted the simultaneous patch test reactions to PPD and DO3 as due either to cross-sensitivity proper, or to metabolic conversion of textile dyes in the skin to PPD...
  70. doi request reprint SF-36 scales, and simple sums of scales, were reliable quality-of-life summaries for patients with schizophrenia
    Morven Leese
    Health Services and Population Research Department, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    J Clin Epidemiol 61:588-96. 2008
    ..To examine the feasibility and reliability of the Medical Outcomes Study 36 Item Short Form Health Survey (SF-36) for patients with schizophrenia, focusing on the eight scales and various aggregate summary measures...
  71. pmc Randomised controlled trial of acute mental health care by a crisis resolution team: the north Islington crisis study
    Sonia Johnson
    Department of Mental Health Sciences, Royal Free and University College Medical Schools, University College London, London W1W 7EY
    BMJ 331:599. 2005
    ..To evaluate the effectiveness of a crisis resolution team...