Ann L White

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. ncbi FcγRΙΙB controls the potency of agonistic anti-TNFR mAbs
    Ann L White
    Antibody and Vaccine Group, MP88, Cancer Sciences Unit, Faculty of Medicine, Southampton University Hospital, Tremona Road, Southampton, SO16 0XA, UK
    Cancer Immunol Immunother 62:941-8. 2013
  2. ncbi Interaction with FcγRIIB is critical for the agonistic activity of anti-CD40 monoclonal antibody
    Ann L White
    Division of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, United Kingdom
    J Immunol 187:1754-63. 2011
  3. ncbi Ligation of CD11c during vaccination promotes germinal centre induction and robust humoral responses without adjuvant
    Ann L White
    Tenovus Research Laboratory, Cancer Sciences Division, Southampton University School of Medicine, General Hospital, Southampton, UK
    Immunology 131:141-51. 2010
  4. ncbi CD11c provides an effective immunotarget for the generation of both CD4 and CD8 T cell responses
    Fernanda V V Castro
    Tenovus Research Laboratory, Cancer Sciences Division, Southampton University School of Medicine, Southampton, UK
    Eur J Immunol 38:2263-73. 2008

Collaborators

Detail Information

Publications4

  1. ncbi FcγRΙΙB controls the potency of agonistic anti-TNFR mAbs
    Ann L White
    Antibody and Vaccine Group, MP88, Cancer Sciences Unit, Faculty of Medicine, Southampton University Hospital, Tremona Road, Southampton, SO16 0XA, UK
    Cancer Immunol Immunother 62:941-8. 2013
    ..Thus, modifying the A/I binding ratio of human IgG Fc can be used to optimise different types of therapeutic activity by enhancing cytotoxic or hyper-crosslinking function...
  2. ncbi Interaction with FcγRIIB is critical for the agonistic activity of anti-CD40 monoclonal antibody
    Ann L White
    Division of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, United Kingdom
    J Immunol 187:1754-63. 2011
    ..In conclusion, we demonstrate an essential cross-linking role for the inhibitory FcγRIIB in anti-CD40 immunostimulatory activity and suggest that isotype will be an important issue when optimizing reagents for clinical use...
  3. ncbi Ligation of CD11c during vaccination promotes germinal centre induction and robust humoral responses without adjuvant
    Ann L White
    Tenovus Research Laboratory, Cancer Sciences Division, Southampton University School of Medicine, General Hospital, Southampton, UK
    Immunology 131:141-51. 2010
    ..They also point to an interesting role for CR4 on DC in triggering B cells during humoral immunity...
  4. ncbi CD11c provides an effective immunotarget for the generation of both CD4 and CD8 T cell responses
    Fernanda V V Castro
    Tenovus Research Laboratory, Cancer Sciences Division, Southampton University School of Medicine, Southampton, UK
    Eur J Immunol 38:2263-73. 2008
    ..These results suggest that targeting antigen via CD11c offers a previously unappreciated strategy for vaccine development which, unlike most targets, delivers robust responses of both CD4 and CD8 T cells...