Ann L White
Affiliation: University of Southampton
- FcγRΙΙB controls the potency of agonistic anti-TNFR mAbsAnn L White
Antibody and Vaccine Group, MP88, Cancer Sciences Unit, Faculty of Medicine, Southampton University Hospital, Tremona Road, Southampton, SO16 0XA, UK
Cancer Immunol Immunother 62:941-8. 2013..Thus, modifying the A/I binding ratio of human IgG Fc can be used to optimise different types of therapeutic activity by enhancing cytotoxic or hyper-crosslinking function...
- Interaction with FcγRIIB is critical for the agonistic activity of anti-CD40 monoclonal antibodyAnn L White
Division of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, United Kingdom
J Immunol 187:1754-63. 2011..In conclusion, we demonstrate an essential cross-linking role for the inhibitory FcγRIIB in anti-CD40 immunostimulatory activity and suggest that isotype will be an important issue when optimizing reagents for clinical use...
- Ligation of CD11c during vaccination promotes germinal centre induction and robust humoral responses without adjuvantAnn L White
Tenovus Research Laboratory, Cancer Sciences Division, Southampton University School of Medicine, General Hospital, Southampton, UK
Immunology 131:141-51. 2010..They also point to an interesting role for CR4 on DC in triggering B cells during humoral immunity...
- CD11c provides an effective immunotarget for the generation of both CD4 and CD8 T cell responsesFernanda V V Castro
Tenovus Research Laboratory, Cancer Sciences Division, Southampton University School of Medicine, Southampton, UK
Eur J Immunol 38:2263-73. 2008..These results suggest that targeting antigen via CD11c offers a previously unappreciated strategy for vaccine development which, unlike most targets, delivers robust responses of both CD4 and CD8 T cells...