Richard J Whitby

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. doi request reprint An optimised scalable synthesis of H2O@C60 and a new synthesis of H2@C60
    Andrea Krachmalnicoff
    Chemistry, University of Southampton, Southampton SO17 1BJ, UK
    Chem Commun (Camb) 50:13037-40. 2014
  2. doi request reprint Synthesis and characterisation of an open-cage fullerene encapsulating hydrogen fluoride
    Andrea Krachmalnicoff
    Chemistry, University of Southampton, Southampton SO17 1BJ, UK
    Chem Commun (Camb) 51:4993-6. 2015
  3. pmc Small molecule agonists of the orphan nuclear receptors steroidogenic factor-1 (SF-1, NR5A1) and liver receptor homologue-1 (LRH-1, NR5A2)
    Richard J Whitby
    School of Chemistry, University of Southampton, Southampton, Hants, SO17 1BJ, United Kingdom
    J Med Chem 54:2266-81. 2011
  4. doi request reprint The first total synthesis of (+)-mucosin
    Alan R Henderson
    Chemistry, University of Southampton, Southampton, Hampshire SO17 1BJ, UK
    Chem Commun (Camb) 48:3409-11. 2012
  5. ncbi request reprint An Efficient Flow-Photochemical Synthesis of 5H-Furanones Leads to an Understanding of Torquoselectivity in Cyclobutenone Rearrangements
    David C Harrowven
    Chemistry, University of Southampton, Highfield, Southampton, SO17 1BJ UK
    Angew Chem Int Ed Engl 51:4405-8. 2012
  6. doi request reprint Tandem insertion of halocarbenoids and lithium acetylides into zirconacycles: a novel rearrangement to zirconium alkenylidenates by β-addition to an alkynyl zirconocene
    Jozef Stec
    School of Chemistry, University of Southampton, Highfield, Southampton, Hampshire SO17 1BJ, UK
    Chemistry 17:4896-904. 2011
  7. ncbi request reprint Nuclear spin conversion of water inside fullerene cages detected by low-temperature nuclear magnetic resonance
    Salvatore Mamone
    School of Chemistry, University of Southampton, Southampton SO17 1BJ, United Kingdom
    J Chem Phys 140:194306. 2014
  8. ncbi request reprint Identification of small molecule agonists of the orphan nuclear receptors liver receptor homolog-1 and steroidogenic factor-1
    Richard J Whitby
    School of Chemistry, University of Southampton, Southampton, Hants, SO17 1BJ, UK
    J Med Chem 49:6652-5. 2006
  9. doi request reprint New insights into cyclobutenone rearrangements: a total synthesis of the natural ROS-generating anti-cancer agent cribrostatin 6
    Mubina Mohamed
    Chemistry, University of Southampton, Highfield, Southampton, Hampshire, SO17 1BJ, UK
    Chemistry 17:13698-705. 2011

Collaborators

Detail Information

Publications9

  1. doi request reprint An optimised scalable synthesis of H2O@C60 and a new synthesis of H2@C60
    Andrea Krachmalnicoff
    Chemistry, University of Southampton, Southampton SO17 1BJ, UK
    Chem Commun (Camb) 50:13037-40. 2014
    ..A new partial closure step using PPh3, and final suturing using a novel Diels-Alder/retro-Diels-Alder sequence are amongst the advances reported. ..
  2. doi request reprint Synthesis and characterisation of an open-cage fullerene encapsulating hydrogen fluoride
    Andrea Krachmalnicoff
    Chemistry, University of Southampton, Southampton SO17 1BJ, UK
    Chem Commun (Camb) 51:4993-6. 2015
    ..The first encapsulation of hydrogen fluoride in an open-cage fullerene is reported. Solution and solid-state NMR spectra of the novel open-cage endofullerene are described. ..
  3. pmc Small molecule agonists of the orphan nuclear receptors steroidogenic factor-1 (SF-1, NR5A1) and liver receptor homologue-1 (LRH-1, NR5A2)
    Richard J Whitby
    School of Chemistry, University of Southampton, Southampton, Hants, SO17 1BJ, United Kingdom
    J Med Chem 54:2266-81. 2011
    ..Initial studies on the regulation of gene expression in human cell lines showed excellent, reproducible activity at endogenous target genes...
  4. doi request reprint The first total synthesis of (+)-mucosin
    Alan R Henderson
    Chemistry, University of Southampton, Southampton, Hampshire SO17 1BJ, UK
    Chem Commun (Camb) 48:3409-11. 2012
    ..A zirconium induced co-cyclisation was utilised to install the correct stereochemistry of the four contiguous stereocentres around the unusual bicyclo[4.3.0]nonene core...
  5. ncbi request reprint An Efficient Flow-Photochemical Synthesis of 5H-Furanones Leads to an Understanding of Torquoselectivity in Cyclobutenone Rearrangements
    David C Harrowven
    Chemistry, University of Southampton, Highfield, Southampton, SO17 1BJ UK
    Angew Chem Int Ed Engl 51:4405-8. 2012
    ..Selectivity in the photochemical rearrangement is due a dichotomous reactivity of the (E)- and (Z)-vinylketene intermediates...
  6. doi request reprint Tandem insertion of halocarbenoids and lithium acetylides into zirconacycles: a novel rearrangement to zirconium alkenylidenates by β-addition to an alkynyl zirconocene
    Jozef Stec
    School of Chemistry, University of Southampton, Highfield, Southampton, Hampshire SO17 1BJ, UK
    Chemistry 17:4896-904. 2011
    ..The main side reaction, which becomes exclusive in some cases, is β-hydride elimination of an intermediate cyclopentyl- or cyclopentenyl zirconocene...
  7. ncbi request reprint Nuclear spin conversion of water inside fullerene cages detected by low-temperature nuclear magnetic resonance
    Salvatore Mamone
    School of Chemistry, University of Southampton, Southampton SO17 1BJ, United Kingdom
    J Chem Phys 140:194306. 2014
    ..Cross-polarization experiments found no evidence that the spin conversion of the endohedral H2O molecules is catalysed by (13)C nuclei present in the cages. ..
  8. ncbi request reprint Identification of small molecule agonists of the orphan nuclear receptors liver receptor homolog-1 and steroidogenic factor-1
    Richard J Whitby
    School of Chemistry, University of Southampton, Southampton, Hants, SO17 1BJ, UK
    J Med Chem 49:6652-5. 2006
    ..Synthesis of analogues modified at three positions led to the development of compounds with functional selectivity between LRH-1 and SF-1...
  9. doi request reprint New insights into cyclobutenone rearrangements: a total synthesis of the natural ROS-generating anti-cancer agent cribrostatin 6
    Mubina Mohamed
    Chemistry, University of Southampton, Highfield, Southampton, Hampshire, SO17 1BJ, UK
    Chemistry 17:13698-705. 2011
    ..A short and efficient total synthesis of cribrostatin 6, an anti-neoplastic and anti-microbial agent, provides a topical demonstration of the value of this method...