Richard J Whitby

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. ncbi Small molecule agonists of the orphan nuclear receptors steroidogenic factor-1 (SF-1, NR5A1) and liver receptor homologue-1 (LRH-1, NR5A2)
    Richard J Whitby
    School of Chemistry, University of Southampton, Southampton, Hants, SO17 1BJ, United Kingdom
    J Med Chem 54:2266-81. 2011
  2. ncbi The first total synthesis of (+)-mucosin
    Alan R Henderson
    Chemistry, University of Southampton, Southampton, Hampshire SO17 1BJ, UK
    Chem Commun (Camb) 48:3409-11. 2012
  3. ncbi An Efficient Flow-Photochemical Synthesis of 5H-Furanones Leads to an Understanding of Torquoselectivity in Cyclobutenone Rearrangements
    David C Harrowven
    Chemistry, University of Southampton, Highfield, Southampton, SO17 1BJ UK
    Angew Chem Int Ed Engl 51:4405-8. 2012
  4. ncbi Tandem insertion of halocarbenoids and lithium acetylides into zirconacycles: a novel rearrangement to zirconium alkenylidenates by β-addition to an alkynyl zirconocene
    Jozef Stec
    School of Chemistry, University of Southampton, Highfield, Southampton, Hampshire SO17 1BJ, UK
    Chemistry 17:4896-904. 2011
  5. ncbi Identification of small molecule agonists of the orphan nuclear receptors liver receptor homolog-1 and steroidogenic factor-1
    Richard J Whitby
    School of Chemistry, University of Southampton, Southampton, Hants, SO17 1BJ, UK
    J Med Chem 49:6652-5. 2006
  6. ncbi New insights into cyclobutenone rearrangements: a total synthesis of the natural ROS-generating anti-cancer agent cribrostatin 6
    Mubina Mohamed
    Chemistry, University of Southampton, Highfield, Southampton, Hampshire, SO17 1BJ, UK
    Chemistry 17:13698-705. 2011

Collaborators

Detail Information

Publications6

  1. ncbi Small molecule agonists of the orphan nuclear receptors steroidogenic factor-1 (SF-1, NR5A1) and liver receptor homologue-1 (LRH-1, NR5A2)
    Richard J Whitby
    School of Chemistry, University of Southampton, Southampton, Hants, SO17 1BJ, United Kingdom
    J Med Chem 54:2266-81. 2011
    ..Initial studies on the regulation of gene expression in human cell lines showed excellent, reproducible activity at endogenous target genes...
  2. ncbi The first total synthesis of (+)-mucosin
    Alan R Henderson
    Chemistry, University of Southampton, Southampton, Hampshire SO17 1BJ, UK
    Chem Commun (Camb) 48:3409-11. 2012
    ..A zirconium induced co-cyclisation was utilised to install the correct stereochemistry of the four contiguous stereocentres around the unusual bicyclo[4.3.0]nonene core...
  3. ncbi An Efficient Flow-Photochemical Synthesis of 5H-Furanones Leads to an Understanding of Torquoselectivity in Cyclobutenone Rearrangements
    David C Harrowven
    Chemistry, University of Southampton, Highfield, Southampton, SO17 1BJ UK
    Angew Chem Int Ed Engl 51:4405-8. 2012
    ..Selectivity in the photochemical rearrangement is due a dichotomous reactivity of the (E)- and (Z)-vinylketene intermediates...
  4. ncbi Tandem insertion of halocarbenoids and lithium acetylides into zirconacycles: a novel rearrangement to zirconium alkenylidenates by β-addition to an alkynyl zirconocene
    Jozef Stec
    School of Chemistry, University of Southampton, Highfield, Southampton, Hampshire SO17 1BJ, UK
    Chemistry 17:4896-904. 2011
    ..The main side reaction, which becomes exclusive in some cases, is β-hydride elimination of an intermediate cyclopentyl- or cyclopentenyl zirconocene...
  5. ncbi Identification of small molecule agonists of the orphan nuclear receptors liver receptor homolog-1 and steroidogenic factor-1
    Richard J Whitby
    School of Chemistry, University of Southampton, Southampton, Hants, SO17 1BJ, UK
    J Med Chem 49:6652-5. 2006
    ..Synthesis of analogues modified at three positions led to the development of compounds with functional selectivity between LRH-1 and SF-1...
  6. ncbi New insights into cyclobutenone rearrangements: a total synthesis of the natural ROS-generating anti-cancer agent cribrostatin 6
    Mubina Mohamed
    Chemistry, University of Southampton, Highfield, Southampton, Hampshire, SO17 1BJ, UK
    Chemistry 17:13698-705. 2011
    ..A short and efficient total synthesis of cribrostatin 6, an anti-neoplastic and anti-microbial agent, provides a topical demonstration of the value of this method...