Ann P Wheeler

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi Why three Rho proteins? RhoA, RhoB, RhoC, and cell motility
    Ann P Wheeler
    Laboratory of Cellular Molecular Biology, Ludwig Institute for Cancer Research, London W1W 7BS, United Kingdom
    Exp Cell Res 301:43-9. 2004
  2. ncbi RhoB affects macrophage adhesion, integrin expression and migration
    Ann P Wheeler
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London, UK
    Exp Cell Res 313:3505-16. 2007
  3. ncbi Rac1 and Rac2 regulate macrophage morphology but are not essential for migration
    Ann P Wheeler
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, 91 Riding House Street, London, W1W 7BS, UK
    J Cell Sci 119:2749-57. 2006

Collaborators

Detail Information

Publications3

  1. ncbi Why three Rho proteins? RhoA, RhoB, RhoC, and cell motility
    Ann P Wheeler
    Laboratory of Cellular Molecular Biology, Ludwig Institute for Cancer Research, London W1W 7BS, United Kingdom
    Exp Cell Res 301:43-9. 2004
    ..In cancer cells, the expression and activity of RhoA, B, and C is altered in different ways. Together, this evidence suggests that although the 3 isoforms of Rho are structurally highly homologous, they have different cellular functions...
  2. ncbi RhoB affects macrophage adhesion, integrin expression and migration
    Ann P Wheeler
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London, UK
    Exp Cell Res 313:3505-16. 2007
    ..Since macrophages do not express RhoC, these effects of C3 transferase are due to inhibition of RhoA rather than RhoB. Our results suggest that RhoB affects cell shape and migration by regulating surface integrin levels...
  3. ncbi Rac1 and Rac2 regulate macrophage morphology but are not essential for migration
    Ann P Wheeler
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, 91 Riding House Street, London, W1W 7BS, UK
    J Cell Sci 119:2749-57. 2006
    ..Together, these data show that Rac1 and Rac2 have distinct roles in regulating cell morphology, migration and invasion, but are not essential for macrophage migration or chemotaxis...