- Why three Rho proteins? RhoA, RhoB, RhoC, and cell motilityAnn P Wheeler
Laboratory of Cellular Molecular Biology, Ludwig Institute for Cancer Research, London W1W 7BS, United Kingdom
Exp Cell Res 301:43-9. 2004..In cancer cells, the expression and activity of RhoA, B, and C is altered in different ways. Together, this evidence suggests that although the 3 isoforms of Rho are structurally highly homologous, they have different cellular functions...
- RhoB affects macrophage adhesion, integrin expression and migrationAnn P Wheeler
Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London, UK
Exp Cell Res 313:3505-16. 2007..Since macrophages do not express RhoC, these effects of C3 transferase are due to inhibition of RhoA rather than RhoB. Our results suggest that RhoB affects cell shape and migration by regulating surface integrin levels...
- Rac1 and Rac2 regulate macrophage morphology but are not essential for migrationAnn P Wheeler
Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, 91 Riding House Street, London, W1W 7BS, UK
J Cell Sci 119:2749-57. 2006..Together, these data show that Rac1 and Rac2 have distinct roles in regulating cell morphology, migration and invasion, but are not essential for macrophage migration or chemotaxis...