Claudia A M Wheeler-Kingshott

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Investigating cervical spinal cord structure using axial diffusion tensor imaging
    Claudia A M Wheeler-Kingshott
    NMR Research Unit, University Department of Clinical Neurology, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, United Kingdom
    Neuroimage 16:93-102. 2002
  2. pmc A new approach to structural integrity assessment based on axial and radial diffusivities
    Claudia A M Wheeler-Kingshott
    NMR Research Unit, Queen Square MS Centre, Department of Neuroinflamtion, UCL Institute of Neurology, London, UK
    Funct Neurol 27:85-90. 2012
  3. ncbi request reprint In vivo diffusion tensor imaging of the human optic nerve: pilot study in normal controls
    C A M Wheeler-Kingshott
    Department of Neuroinflammation, Institute of Neurology, University College London, London, UK
    Magn Reson Med 56:446-51. 2006
  4. ncbi request reprint Burst excitation for quantitative diffusion imaging with multiple b-values
    C A Wheeler-Kingshott
    NMR Unit, Department of Clinical Neurology, Institute of Neurology, UCL, London, UK
    Magn Reson Med 44:737-45. 2000
  5. doi request reprint About "axial" and "radial" diffusivities
    Claudia A M Wheeler-Kingshott
    University College London, Institute of Neurology, Department of Neuroinflammation, London, UK
    Magn Reson Med 61:1255-60. 2009
  6. ncbi request reprint ADC mapping of the human optic nerve: increased resolution, coverage, and reliability with CSF-suppressed ZOOM-EPI
    Claudia A M Wheeler-Kingshott
    NMR Research Unit, University Department of Clinical Neurology, Institute of Neurology, University College London, London, UK
    Magn Reson Med 47:24-31. 2002
  7. ncbi request reprint Abnormalities of language networks in temporal lobe epilepsy
    H W Robert Powell
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    Neuroimage 36:209-21. 2007
  8. ncbi request reprint Optic radiation changes after optic neuritis detected by tractography-based group mapping
    Olga Ciccarelli
    Department of Headache, Brain Injury and Neurorehabilitation, Institute of Neurology, University College London, Queen Square, London, United Kingdom
    Hum Brain Mapp 25:308-16. 2005
  9. ncbi request reprint Characterizing function-structure relationships in the human visual system with functional MRI and diffusion tensor imaging
    Ahmed T Toosy
    NMR Research Unit, Institute of Neurology, University College London, London WC1N 3BG, UK
    Neuroimage 21:1452-63. 2004
  10. doi request reprint Diffusion MRI-based cortical complexity alterations associated with executive function in multiple sclerosis
    Nils Muhlert
    NMR Unit, Department of Neuroinflammation, UCL Institute of Neurology, London, UK
    J Magn Reson Imaging 38:54-63. 2013

Detail Information

Publications41

  1. ncbi request reprint Investigating cervical spinal cord structure using axial diffusion tensor imaging
    Claudia A M Wheeler-Kingshott
    NMR Research Unit, University Department of Clinical Neurology, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, United Kingdom
    Neuroimage 16:93-102. 2002
    ..The high axial resolution allowed preliminary evaluation of fiber connectivity using the fast-marching tractography algorithm, which generated traces of fiber paths consistent with the well-known cord anatomy...
  2. pmc A new approach to structural integrity assessment based on axial and radial diffusivities
    Claudia A M Wheeler-Kingshott
    NMR Research Unit, Queen Square MS Centre, Department of Neuroinflamtion, UCL Institute of Neurology, London, UK
    Funct Neurol 27:85-90. 2012
    ..The projected diffusivities are promising new parameters for studying white matter pathology...
  3. ncbi request reprint In vivo diffusion tensor imaging of the human optic nerve: pilot study in normal controls
    C A M Wheeler-Kingshott
    Department of Neuroinflammation, Institute of Neurology, University College London, London, UK
    Magn Reson Med 56:446-51. 2006
    ..Measurements of the principal eigenvalue of the DT and its orthogonal component were also in agreement with those expected from a highly directional structural organization...
  4. ncbi request reprint Burst excitation for quantitative diffusion imaging with multiple b-values
    C A Wheeler-Kingshott
    NMR Unit, Department of Clinical Neurology, Institute of Neurology, UCL, London, UK
    Magn Reson Med 44:737-45. 2000
    ..Problems with the sequence include a lower signal-to-noise ratio than is achievable with diffusion-weighted spin-echo imaging, the limitation of measuring only in-plane components of diffusion and, at present, single-slice acquisition...
  5. doi request reprint About "axial" and "radial" diffusivities
    Claudia A M Wheeler-Kingshott
    University College London, Institute of Neurology, Department of Neuroinflammation, London, UK
    Magn Reson Med 61:1255-60. 2009
    ....
  6. ncbi request reprint ADC mapping of the human optic nerve: increased resolution, coverage, and reliability with CSF-suppressed ZOOM-EPI
    Claudia A M Wheeler-Kingshott
    NMR Research Unit, University Department of Clinical Neurology, Institute of Neurology, University College London, London, UK
    Magn Reson Med 47:24-31. 2002
    ..Averaging of magnitude images is used to compensate for the inherently low signal-to-noise ratio (SNR) of the acquired images; the effects of the Rayleigh distributed noise in such images are allowed for during ADC calculations...
  7. ncbi request reprint Abnormalities of language networks in temporal lobe epilepsy
    H W Robert Powell
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    Neuroimage 36:209-21. 2007
    ..The combination of fMRI and tractography offers a promising tool for studying the reorganisation of language functions in many neurological conditions and may prove useful in predicting language deficits following temporal lobe surgery...
  8. ncbi request reprint Optic radiation changes after optic neuritis detected by tractography-based group mapping
    Olga Ciccarelli
    Department of Headache, Brain Injury and Neurorehabilitation, Institute of Neurology, University College London, Queen Square, London, United Kingdom
    Hum Brain Mapp 25:308-16. 2005
    ..These findings suggest that the group mapping techniques might be used to assess changes in the optic radiations in patients after an episode of optic neuritis. The changes we have observed may be secondary to the optic nerve damage...
  9. ncbi request reprint Characterizing function-structure relationships in the human visual system with functional MRI and diffusion tensor imaging
    Ahmed T Toosy
    NMR Research Unit, Institute of Neurology, University College London, London WC1N 3BG, UK
    Neuroimage 21:1452-63. 2004
    ..The results support the hypothesis that the visual cortical fMRI response is constrained by the external anatomical connections of the subserving optic radiations...
  10. doi request reprint Diffusion MRI-based cortical complexity alterations associated with executive function in multiple sclerosis
    Nils Muhlert
    NMR Unit, Department of Neuroinflammation, UCL Institute of Neurology, London, UK
    J Magn Reson Imaging 38:54-63. 2013
    ....
  11. pmc Cerebral arterial bolus arrival time is prolonged in multiple sclerosis and associated with disability
    David Paling
    Department of Neuroinflammation, UCL Institute of Neurology, Queen Square MS Centre, London, UK
    J Cereb Blood Flow Metab 34:34-42. 2014
    ..Bolus arrival time was longer in patients with greater disability independent of atrophy and T2 lesion load, suggesting alterations in cerebral arterial hemodynamics may be a marker of clinically relevant pathology. ..
  12. pmc Combining tractography and cortical measures to test system-specific hypotheses in multiple sclerosis
    Nikos Gorgoraptis
    Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, Queen Square, London, UK
    Mult Scler 16:555-65. 2010
    ..Combining tractography and cortical measures is a useful approach in testing hypotheses which are specific to clinically relevant functional systems in multiple sclerosis, and can be applied to other neurological diseases...
  13. doi request reprint Contiguous-slice zonally oblique multislice (CO-ZOOM) diffusion tensor imaging: examples of in vivo spinal cord and optic nerve applications
    Nicholas G Dowell
    NMR Research Unit, Institute of Neurology, University College London, London, UK
    J Magn Reson Imaging 29:454-60. 2009
    ..To describe and demonstrate a new technique that allows diffusion tensor imaging of small structures such as the spinal cord (SC) and optic nerve (ON) with contiguous slices and reduced image distortions using a narrow field of view (FOV)...
  14. doi request reprint Sodium accumulation is associated with disability and a progressive course in multiple sclerosis
    David Paling
    NMR Research Unit, Department of Neuroinflammation, Queen Square Multiple Sclerosis Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    Brain 136:2305-17. 2013
    ..Increased total sodium concentration is likely to reflect neuroaxonal pathophysiology leading to clinical progression and increased disability...
  15. ncbi request reprint Combined functional MRI and tractography to demonstrate the connectivity of the human primary motor cortex in vivo
    Maxime Guye
    The National Society of Epilepsy MRI Unit, Department of Clinical and Experimental Epilepsy, University College London, London, UK
    Neuroimage 19:1349-60. 2003
    ..The patient had differences in M1 connectivity from the control group. Thus, fMRI-correlated DTI-FMT is a promising tool to study the structural basis of functional networks in the human brain in vivo...
  16. ncbi request reprint In-vivo estimates of axonal characteristics using optimized diffusion MRI protocols for single fibre orientation
    Torben Schneider
    NMR Unit, Department of Neuroinflammation, UCL Institute of Neurology, University College London, UK
    Med Image Comput Comput Assist Interv 13:623-30. 2010
    ..Furthermore, we acquire the 20 minute long SF protocol and the 1 hour long OI protocol in a scan/rescan study on two healthy subjects and compare the axonal parameter maps from both protocols...
  17. pmc Assessing neuronal metabolism in vivo by modeling imaging measures
    Olga Ciccarelli
    Department of Brain Repair and Rehabilitation, NMR Unit, UCL Institute of Neurology, London WC1N 3BG, United Kingdom
    J Neurosci 30:15030-3. 2010
    ..Lower residual variance in NAA, reflecting reduced mitochondrial metabolism, was associated with greater clinical disability in MS, independent of structural damage...
  18. pmc Diffusion tensor imaging of post mortem multiple sclerosis brain
    Klaus Schmierer
    Institute of Neurology, University College London, NMR Research Unit, Box 117, Queen Square, London WC1N 3BG, UK
    Neuroimage 35:467-77. 2007
    ..70, p<0.001) and (ii) MD (r=-0.66, p<0.001). In conclusion, this study suggests that FA and MD are affected by myelin content and - to a lesser degree - axonal count in post mortem MS brain...
  19. pmc Quantitative magnetic resonance of postmortem multiple sclerosis brain before and after fixation
    Klaus Schmierer
    NMR Research Unit, Institute of Neurology, University College London, Queen Square, London, UK
    Magn Reson Med 59:268-77. 2008
    ..01) whereas postfixation T(2) (r = 0.92; P < 0.01), T(1) (r = 0.89; P < 0.01), and f(B) (r = -0.86; P < 0.01) were superior. All diffusivity measures (except for D(ax) in unfixed tissue) were predictors of myelin content...
  20. doi request reprint Assessing structure and function of the afferent visual pathway in multiple sclerosis and associated optic neuritis
    Madhan Kolappan
    NMR Research Unit, Institute of Neurology, University College London, London, WC1N 3BG, UK
    J Neurol 256:305-19. 2009
    ..These collective investigative methods have advanced knowledge of pathophysiological mechanisms in MS and optic neuritis. Relevant ongoing studies and future directions are discussed...
  21. ncbi request reprint Memory in multiple sclerosis is linked to glutamate concentration in grey matter regions
    Nils Muhlert
    Department of Neuroinflammation, NMR Research Unit, UCL Institute of Neurology, London, UK Cognitive Neuroscience, Department of Psychology, Cardiff University, Cardiff, UK
    J Neurol Neurosurg Psychiatry 85:833-9. 2014
    ..We used structural and metabolic brain imaging to test two hypotheses: (i) glutamate levels in grey matter regions are abnormal in MS, and (ii) patients show a relationship between glutamate concentration and memory performance...
  22. ncbi request reprint Hemispheric asymmetries in language-related pathways: a combined functional MRI and tractography study
    H W Robert Powell
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    Neuroimage 32:388-99. 2006
    ..These structural asymmetries are in keeping with the lateralization of language function and indicate the major structural connections underlying this function...
  23. ncbi request reprint A method for measuring the cross sectional area of the anterior portion of the optic nerve in vivo using a fast 3D MRI sequence
    Marios C Yiannakas
    Department of Neuroinflammation, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    J Magn Reson Imaging 31:1486-91. 2010
    ....
  24. ncbi request reprint Exploring white matter tracts in band heterotopia using diffusion tractography
    Sofia H Eriksson
    MRI Unit, National Society for Epilepsy, Department of Clinical and Experimental Epilepsy, National Hospital for Neurology and Neurosurgery, Institute of Neurology, University College London, London, United Kingdom
    Ann Neurol 52:327-34. 2002
    ..The results are in agreement with previous histopathological studies and indicate the structural basis of the functional connectivity and absence of focal deficits in these patients...
  25. ncbi request reprint Postictal diffusion tensor imaging
    Beate Diehl
    NSE MRI Unit, Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College, London, UK
    Epilepsy Res 65:137-46. 2005
    ..Further systematic studies are needed and correlation with outcome after epilepsy surgery will determine the role of postictal diffusion measures in the presurgical evaluation of epilepsy patients...
  26. doi request reprint ADvanced IMage Algebra (ADIMA): a novel method for depicting multiple sclerosis lesion heterogeneity, as demonstrated by quantitative MRI
    Marios C Yiannakas
    Department of Neuroinflammation, University College London, Institute of Neurology, London, UK
    Mult Scler 19:732-41. 2013
    ..This may partly reflect pathological heterogeneity in WMLs, which is not apparent on T2w scans...
  27. ncbi request reprint A simple correction for B1 field errors in magnetization transfer ratio measurements
    Rebecca S Samson
    NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, UCL, WC1N 3BG London, UK
    Magn Reson Imaging 24:255-63. 2006
    ..Therefore, correction schemes will differ for different MTR sequences, and new data sets would be required to calculate these different correction schemes...
  28. ncbi request reprint A study of the mechanisms of normal-appearing white matter damage in multiple sclerosis using diffusion tensor imaging--evidence of Wallerian degeneration
    Olga Ciccarelli
    NMR Research Unit, Institute of Neurology, National Hospital for Neurology and Neurosurgery, London WC1N 3BG, UK
    J Neurol 250:287-92. 2003
    ....
  29. ncbi request reprint Improved MRI quantification of spinal cord atrophy in multiple sclerosis
    Hugh Kearney
    NMR Research Unit, Queen Square MS Centre, UCL Institute of Neurology, London, UK
    J Magn Reson Imaging 39:617-23. 2014
    ..To identify an improved method for measuring spinal cord cross-sectional area (CSA) using magnetic resonance imaging (MRI) in multiple sclerosis (MS)...
  30. ncbi request reprint Spatial variability and changes of metabolite concentrations in the cortico-spinal tract in multiple sclerosis using coronal CSI
    Carmen Tur
    Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom Department of Medicine, Clinical Neuroimmunology Unit, Multiple Sclerosis Centre of Catalonia CEM Cat, Autonomous University of Barcelona, CARM Vall d Hebron University Hospital, Barcelona, Spain
    Hum Brain Mapp 35:993-1003. 2014
    ..Hum Brain Mapp 35:993-1003, 2014. © 2012 Wiley Periodicals, Inc. ..
  31. doi request reprint Metabolic changes in the spinal cord after brachial plexus root re-implantation
    Carolina Kachramanoglou
    UCL Institute of Neurology, London, UK
    Neurorehabil Neural Repair 27:118-24. 2013
    ....
  32. ncbi request reprint Initial demonstration of in vivo tracing of axonal projections in the macaque brain and comparison with the human brain using diffusion tensor imaging and fast marching tractography
    Geoffrey J M Parker
    NMR Research Unit, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, United Kingdom
    Neuroimage 15:797-809. 2002
    ..Analogous human anatomical connectivity is also presented for the first time using the FMT method, and the results are compared. The current limitations of the methodology and possibilities available for further studies are discussed...
  33. ncbi request reprint Optic nerve diffusion measurement from diffusion-weighted imaging in optic neuritis
    Simon J Hickman
    NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London, United Kingdom
    AJNR Am J Neuroradiol 26:951-6. 2005
    ..DW imaging of the optic nerves, however, presents many challenges. The goal of this study was to measure ADC in patients with optic neuritis by using zonal oblique multisection echoplanar imaging...
  34. doi request reprint Reducing the impact of white matter lesions on automated measures of brain gray and white matter volumes
    Declan T Chard
    NMR Research Unit, Department of Neuroinflammation, UCL Institute of Neurology, London, UK
    J Magn Reson Imaging 32:223-8. 2010
    ....
  35. pmc Sodium ((23)Na) ultra-short echo time imaging in the human brain using a 3D-Cones trajectory
    Frank Riemer
    NMR Research Unit, Department of Neuroinflammation, Queen Square MS Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    MAGMA 27:35-46. 2014
    ..To improve scan times and image quality, we have implemented the 3D-Cones (CN) sequence for in vivo (23)Na brain MRI...
  36. doi request reprint Sodium quantification in the spinal cord at 3T
    Bhavana S Solanky
    NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, London, UK
    Magn Reson Med 69:1201-8. 2013
    ..Here we propose for the first time a clinically feasible non-invasive method for quantifying sodium in the spine using magnetic resonance spectroscopy...
  37. doi request reprint IQ and the fronto-temporal cortex in bipolar disorder
    Leticia Gutiérrez-Galve
    UCL Institute of Neurology, Queen Square, London, United Kingdom
    J Int Neuropsychol Soc 18:370-4. 2012
    ..The pattern of cortico-cognitive associations in BPI and BPII patients merits further consideration...
  38. pmc Method for simultaneous voxel-based morphometry of the brain and cervical spinal cord area measurements using 3D-MDEFT
    Patrick A B Freund
    Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom
    J Magn Reson Imaging 32:1242-7. 2010
    ..To investigate whether a 3D-modified driven equilibrium Fourier transform (MDEFT)-based acquisition protocol established for brain morphometry also yields reliable information about the cross-sectional spinal cord area (SCA)...
  39. ncbi request reprint A framework for a streamline-based probabilistic index of connectivity (PICo) using a structural interpretation of MRI diffusion measurements
    Geoffrey J M Parker
    Imaging Science and Biomedical Engineering, University of Manchester, Manchester, UK
    J Magn Reson Imaging 18:242-54. 2003
    ..To establish a general methodology for quantifying streamline-based diffusion fiber tracking methods in terms of probability of connection between points and/or regions...
  40. ncbi request reprint Lateralization of ventral and dorsal auditory-language pathways in the human brain
    Geoffrey J M Parker
    Imaging Science and Biomedical Engineering, University of Manchester, Manchester M13 9PT, UK
    Neuroimage 24:656-66. 2005
    ..The connections are stronger in the dominant hemisphere, in agreement with previous studies of functional lateralization of auditory-language processing...
  41. ncbi request reprint Estimating distributed anatomical connectivity using fast marching methods and diffusion tensor imaging
    Geoffrey J M Parker
    Division of Imaging Science and Biomedical Engineering, University of Manchester, UK
    IEEE Trans Med Imaging 21:505-12. 2002
    ..Maps of connectivity between brain regions are also determined. Four options are described for estimating the degree of connectivity between regions...