S B Wharton

Summary

Affiliation: University of Sheffield
Country: UK

Publications

  1. pmc Population studies of sporadic cerebral amyloid angiopathy and dementia: a systematic review
    Hannah A D Keage
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    BMC Neurol 9:3. 2009
  2. ncbi request reprint Replicative Mcm2 protein as a novel proliferation marker in oligodendrogliomas and its relationship to Ki67 labelling index, histological grade and prognosis
    S B Wharton
    Academic Unit of Pathology, University of Sheffield, Medical School, UK
    Neuropathol Appl Neurobiol 27:305-13. 2001
  3. ncbi request reprint Expression of Ki67, PCNA and the chromosome replication licensing protein Mcm2 in glial cells of the ageing human hippocampus increases with the burden of Alzheimer-type pathology
    Stephen B Wharton
    Academic Unit of Pathology, University of Sheffield, Medical School, UK
    Neurosci Lett 383:33-8. 2005
  4. doi request reprint Population variation in glial fibrillary acidic protein levels in brain ageing: relationship to Alzheimer-type pathology and dementia
    S B Wharton
    Academic Unit of Pathology, University of Sheffield Medical School, Sheffield, UK
    Dement Geriatr Cogn Disord 27:465-73. 2009
  5. pmc Subtypes of oligodendroglioma defined by 1p,19q deletions, differ in the proportion of apoptotic cells but not in replication-licensed non-proliferating cells
    S B Wharton
    Department of Histopathology, Sheffield Teaching Hospitals, and Academic Unit of Pathology, University of Sheffield, Medical School, UK
    Acta Neuropathol 113:119-27. 2007
  6. ncbi request reprint The cellular and molecular pathology of the motor system in hereditary spastic paraparesis due to mutation of the spastin gene
    Stephen B Wharton
    Academic Unit of Pathology, University of Sheffield, Sheffield, United Kingdom
    J Neuropathol Exp Neurol 62:1166-77. 2003
  7. ncbi request reprint Gliosarcoma with areas of primitive neuroepithelial differentiation and extracranial metastasis
    S B Wharton
    Academic Unit of Pathology, University of Sheffield Medical School, UK
    Clin Neuropathol 20:212-8. 2001
  8. doi request reprint Mesial temporal astrocyte tau pathology in the MRC-CFAS ageing brain cohort
    G Lace
    Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK
    Dement Geriatr Cogn Disord 34:15-24. 2012
  9. doi request reprint Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain
    J E Simpson
    Academic Unit of Pathology, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, UK
    Neurobiol Aging 31:578-90. 2010
  10. pmc DNA replication licensing and cell cycle kinetics of oligodendroglial tumours
    S B Wharton
    1Academic Unit of Pathology, University of Sheffield, UK
    Br J Cancer 91:262-9. 2004

Collaborators

Detail Information

Publications35

  1. pmc Population studies of sporadic cerebral amyloid angiopathy and dementia: a systematic review
    Hannah A D Keage
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    BMC Neurol 9:3. 2009
    ..We searched the literature for prospective population-based epidemiological clinicopathological studies, free of the biases of other sampling techniques, which were used as a comparison...
  2. ncbi request reprint Replicative Mcm2 protein as a novel proliferation marker in oligodendrogliomas and its relationship to Ki67 labelling index, histological grade and prognosis
    S B Wharton
    Academic Unit of Pathology, University of Sheffield, Medical School, UK
    Neuropathol Appl Neurobiol 27:305-13. 2001
    ..Demonstration of Mcm2 expression is of value to demonstrate the proliferative fraction of tumours and is likely to be of prognostic value. Its study in a larger series is therefore warranted...
  3. ncbi request reprint Expression of Ki67, PCNA and the chromosome replication licensing protein Mcm2 in glial cells of the ageing human hippocampus increases with the burden of Alzheimer-type pathology
    Stephen B Wharton
    Academic Unit of Pathology, University of Sheffield, Medical School, UK
    Neurosci Lett 383:33-8. 2005
    ..A quantitative relationship to the burden of Alzheimer-type pathology suggests that cell-cycle re-entry in glial cells may be important in the pathogenesis of age-related neurodegeneration...
  4. doi request reprint Population variation in glial fibrillary acidic protein levels in brain ageing: relationship to Alzheimer-type pathology and dementia
    S B Wharton
    Academic Unit of Pathology, University of Sheffield Medical School, Sheffield, UK
    Dement Geriatr Cogn Disord 27:465-73. 2009
    ..The cellular pathology of astrocytes in brain ageing and their role in modulating the brain's response to neurodegenerative pathology remain incompletely understood...
  5. pmc Subtypes of oligodendroglioma defined by 1p,19q deletions, differ in the proportion of apoptotic cells but not in replication-licensed non-proliferating cells
    S B Wharton
    Department of Histopathology, Sheffield Teaching Hospitals, and Academic Unit of Pathology, University of Sheffield, Medical School, UK
    Acta Neuropathol 113:119-27. 2007
    ..001). An increased susceptibility to apoptosis in oligodendrogliomas with 1p+/-19q deletion may be important in their improved clinical outcome compared to Del- tumours...
  6. ncbi request reprint The cellular and molecular pathology of the motor system in hereditary spastic paraparesis due to mutation of the spastin gene
    Stephen B Wharton
    Academic Unit of Pathology, University of Sheffield, Sheffield, United Kingdom
    J Neuropathol Exp Neurol 62:1166-77. 2003
    ..All 3 cases also demonstrated evidence of tau pathology outside the motor system, suggesting that the neuropathology is not confined to the motor system in spastin-related HSP...
  7. ncbi request reprint Gliosarcoma with areas of primitive neuroepithelial differentiation and extracranial metastasis
    S B Wharton
    Academic Unit of Pathology, University of Sheffield Medical School, UK
    Clin Neuropathol 20:212-8. 2001
    ..We believe this to be a novel pattern of differentiation in a gliosarcoma which in this case was associated with an aggressive metastatic potential...
  8. doi request reprint Mesial temporal astrocyte tau pathology in the MRC-CFAS ageing brain cohort
    G Lace
    Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK
    Dement Geriatr Cogn Disord 34:15-24. 2012
    ..Glial tau pathology is seen in certain tauopathies and in ageing. We determined its frequency in ageing mesial temporal lobe and its relationship to other tau pathologies in the MRC-CFAS population-representative neuropathology cohort...
  9. doi request reprint Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain
    J E Simpson
    Academic Unit of Pathology, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, UK
    Neurobiol Aging 31:578-90. 2010
    ..Alzheimer-type pathology only partially explains the variation in gliosis and astrocyte functional markers, suggesting that other factors contribute to the population variance in astrocyte pathology...
  10. pmc DNA replication licensing and cell cycle kinetics of oligodendroglial tumours
    S B Wharton
    1Academic Unit of Pathology, University of Sheffield, UK
    Br J Cancer 91:262-9. 2004
    ..Origin licensing proteins thus provide powerful novel tools for assessment of tumour cell cycle kinetics in routinely processed surgical biopsy material...
  11. ncbi request reprint Microglial activation in white matter lesions and nonlesional white matter of ageing brains
    J E Simpson
    Academic Unit of Pathology, University of Sheffield Medical School, Sheffield, UK
    Neuropathol Appl Neurobiol 33:670-83. 2007
    ..We also show that microglia in control WM from lesional cases express significantly more MHC II than control WM from nonlesional ageing brain, suggesting that WML occur in a 'field-effect' of abnormal WM...
  12. ncbi request reprint White matter lesions in an unselected cohort of the elderly: astrocytic, microglial and oligodendrocyte precursor cell responses
    J E Simpson
    Academic Unit of Pathology, University of Sheffield Medical School, Sheffield S10 2RX, UK
    Neuropathol Appl Neurobiol 33:410-9. 2007
    ....
  13. doi request reprint Hippocampal tau pathology is related to neuroanatomical connections: an ageing population-based study
    G Lace
    Academic Unit of Pathology, University of Sheffield, Medical School, Beech Hill Road, Sheffield S10 2RX, UK
    Brain 132:1324-34. 2009
    ..These stages were significantly associated with dementia, and may provide a clinically useful tool in the clinico-pathological assessment of dementia and mild cognitive impairment...
  14. doi request reprint Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain
    J E Simpson
    Academic Unit of Pathology, University of Sheffield Medical School, Sheffield, UK
    Neuropathol Appl Neurobiol 36:25-40. 2010
    ..Most studies have focussed on the reduced capacity for DNA repair by neurones, and have not taken into account the effect of oxidative stress on astrocytes, and their contribution to pathology...
  15. doi request reprint Calcium dysregulation in relation to Alzheimer-type pathology in the ageing brain
    C Garwood
    Sheffield Institute for Translational Neuroscience, Department of Neuroscience, University of Sheffield, Sheffield, UK
    Neuropathol Appl Neurobiol 39:788-99. 2013
    ..In this study we sought to determine the expression of calpain-10 and calcium/calmodulin-dependent kinase alpha (CamKIIα) in relation to Alzheimer-type pathology in a population-based study...
  16. doi request reprint Isolation of enriched glial populations from post-mortem human CNS material by immuno-laser capture microdissection
    R Waller
    Sheffield Institute for Translational Neuroscience, The University of Sheffield, 385a Glossop Road, Sheffield, UK
    J Neurosci Methods 208:108-13. 2012
    ....
  17. ncbi request reprint Corticospinal tract degeneration in the progressive muscular atrophy variant of ALS
    P G Ince
    Neuropathology, Academic Unit of Pathology, Division of Genomic Medicine, Sheffield University, UK
    Neurology 60:1252-8. 2003
    ..Examining the unresolved relationship between the lower motor neuron disorder progressive muscular atrophy (PMA) and ALS is important in clinical practice because of emerging therapies...
  18. doi request reprint Brain haemosiderin in older people: pathological evidence for an ischaemic origin of magnetic resonance imaging (MRI) microbleeds
    B M Janaway
    Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK
    Neuropathol Appl Neurobiol 40:258-69. 2014
    ..Light microscopy of ageing brain frequently reveals foci of haemosiderin from single crystalloids to larger, predominantly perivascular, aggregates. The pathological and radiological relationship between these findings is not resolved...
  19. ncbi request reprint Myopathy associated with gluten sensitivity
    Marios Hadjivassiliou
    Department of Neurology, The Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
    Muscle Nerve 35:443-50. 2007
    ..Myopathy may be another manifestation of gluten sensitivity and is likely to have an immune-mediated pathogenesis. A gluten-free diet may be a useful therapeutic intervention...
  20. pmc Neuropathy associated with gluten sensitivity
    M Hadjivassiliou
    Department of Neurology, The Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
    J Neurol Neurosurg Psychiatry 77:1262-6. 2006
    ....
  21. doi request reprint Broad clinical phenotypes associated with TAR-DNA binding protein (TARDBP) mutations in amyotrophic lateral sclerosis
    Janine Kirby
    Department of Neuroscience, Faculty of Medicine, Dentistry and Health, University of Sheffield, Medical School, Sheffield, UK
    Neurogenetics 11:217-25. 2010
    ..However, all cases had an absence of clinically overt cognitive dysfunction...
  22. ncbi request reprint Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients
    Paul R Kasher
    Academic Neurology Unit, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, UK
    J Neurochem 110:34-44. 2009
    ..These results strongly support a direct role for defective axonal transport in the pathogenesis of HSP because of spastin mutation...
  23. pmc Phosphatase and tensin homologue/protein kinase B pathway linked to motor neuron survival in human superoxide dismutase 1-related amyotrophic lateral sclerosis
    Janine Kirby
    Academic Neurology Unit, Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK
    Brain 134:506-17. 2011
    ..Therefore, these data indicate that proteins in the phosphatidylinositol-3 kinase pathway could represent a target for therapeutic manipulation in motor neuron degeneration...
  24. ncbi request reprint A brief history of tau: the evolving view of the microtubule-associated protein tau in neurodegenerative diseases
    G L Lace
    Neuropathology Group, Academic Unit of Pathology, University of Sheffield Medical School, Sheffield, UK
    Clin Neuropathol 26:43-58. 2007
    ..By examining the evolution of research on tau, related to advances in technology and the emergence of new diseases, the future developments needed to resolve remaining issues in the tau-story may be discerned...
  25. ncbi request reprint Expression of vascular endothelial growth factor and its receptors in the central nervous system in amyotrophic lateral sclerosis
    Alice Brockington
    Academic Neurology Unit and the Academic Unit of Pathology, University of Sheffield, Medical School, Sheffield, U K
    J Neuropathol Exp Neurol 65:26-36. 2006
    ....
  26. doi request reprint Sensory ganglionopathy due to gluten sensitivity
    M Hadjivassiliou
    Department of Neurology, Royal Hallamshire Hospital, Sheffield, UK
    Neurology 75:1003-8. 2010
    ..The commonest type of neuropathy seen in the context of gluten sensitivity is sensorimotor axonal. We report 17 patients with sensory ganglionopathy associated with gluten sensitivity...
  27. ncbi request reprint Comparative genomic hybridization and pathological findings in atypical teratoid/rhabdoid tumour of the central nervous system
    S B Wharton
    Academic Unit of Pathology, University of Sheffield, Medical School, Sheffield, UK
    Neuropathol Appl Neurobiol 29:254-61. 2003
    ....
  28. ncbi request reprint Hereditary spastic paraparesis: disrupted intracellular transport associated with spastin mutation
    Christopher J McDermott
    Academic Neurology Unit, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, United Kingdom
    Ann Neurol 54:748-59. 2003
    ....
  29. doi request reprint Microarray RNA expression analysis of cerebral white matter lesions reveals changes in multiple functional pathways
    Julie E Simpson
    Academic Units of Pathology, University of Sheffield, Sheffield, UK
    Stroke 40:369-75. 2009
    ..Ischemia contributes to their pathogenesis but other mechanisms may contribute. We used RNA microarray analysis with functional pathway grouping as an unbiased approach to investigate evidence for additional pathogenetic mechanisms...
  30. ncbi request reprint Fatal spontaneous thrombosis of a cerebral arteriovenous malformation in a young patient with a rare heterozygous prothrombin gene mutation. Case report
    Mahmoud Taha
    Department of Neurosurgery, Royal Hallamshire Hospital, Sheffield, United Kingdom
    J Neurosurg 106:143-6. 2007
    ..Acute neurological decline after spontaneous thrombosis of an intracranial AVM is rare, and an association with the prothrombin defect in this patient is likely...
  31. ncbi request reprint White matter lesions in an unselected cohort of the elderly: molecular pathology suggests origin from chronic hypoperfusion injury
    Malee S Fernando
    Division of Genomic Medicine, University of Sheffield, United Kingdom
    Stroke 37:1391-8. 2006
    ..Direct evidence of ischemia associated with incidental WM lesions (WMLs) has been lacking, and their pathogenesis is unresolved...
  32. ncbi request reprint Progressive loss of motor neuron function in wasted mice: effects of a spontaneous null mutation in the gene for the eEF1 A2 translation factor
    Helen J Newbery
    Medical Genetics, Molecular Medicine Center, University of Edinburgh, Western General Hospital, Edinburgh, UK
    J Neuropathol Exp Neurol 64:295-303. 2005
    ..The early initiation and rapid progression of motor unit degeneration in wst/wst mice suggest that they should be considered an important and accessible model of early-onset motor neuron degeneration in humans...
  33. ncbi request reprint Morphological changes and stress responses in neurons in cerebral cortex infiltrated by diffuse astrocytoma
    Shom Goel
    Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom
    Neuropathology 23:262-70. 2003
    ..The patterns of cellular pathology identified suggest possible mechanisms, by which neurons are damaged and eventually lost in peritumoral brain...
  34. ncbi request reprint Production of monocyte chemoattractant protein-1 in amyotrophic lateral sclerosis
    PierLuigi Baron
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan Medical School, IRCCS Ospedale Maggiore Policlinico, Via S Sforza 35, 20122 Milan, Italy
    Muscle Nerve 32:541-4. 2005
    ..Our findings suggest a role for MCP-1 as an important molecular mediator of the injury response in ALS...
  35. ncbi request reprint A robust assay for alternative lengthening of telomeres in tumors shows the significance of alternative lengthening of telomeres in sarcomas and astrocytomas
    Jeremy D Henson
    Children s Medical Research Institute, New South Wales, Australia
    Clin Cancer Res 11:217-25. 2005
    ..We aimed to establish and validate an ALT assay suitable for archived paraffin-embedded tumors and to use it to examine the prevalence and clinical significance of ALT in various types of tumors that are often telomerase negative...