Research Topics
Genomes and GenesSpecies | S B WhartonSummaryAffiliation: University of Sheffield Country: UK Publications
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Detail Information
Publications
Population studies of sporadic cerebral amyloid angiopathy and dementia: a systematic reviewHannah A D Keage
Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
BMC Neurol 9:3. 2009..We searched the literature for prospective population-based epidemiological clinicopathological studies, free of the biases of other sampling techniques, which were used as a comparison...
Replicative Mcm2 protein as a novel proliferation marker in oligodendrogliomas and its relationship to Ki67 labelling index, histological grade and prognosisS B Wharton
Academic Unit of Pathology, University of Sheffield, Medical School, UK
Neuropathol Appl Neurobiol 27:305-13. 2001..Demonstration of Mcm2 expression is of value to demonstrate the proliferative fraction of tumours and is likely to be of prognostic value. Its study in a larger series is therefore warranted...
Population variation in glial fibrillary acidic protein levels in brain ageing: relationship to Alzheimer-type pathology and dementiaS B Wharton
Academic Unit of Pathology, University of Sheffield Medical School, Sheffield, UK
Dement Geriatr Cogn Disord 27:465-73. 2009..The cellular pathology of astrocytes in brain ageing and their role in modulating the brain's response to neurodegenerative pathology remain incompletely understood...- Subtypes of oligodendroglioma defined by 1p,19q deletions, differ in the proportion of apoptotic cells but not in replication-licensed non-proliferating cellsS B Wharton
Department of Histopathology, Sheffield Teaching Hospitals, and Academic Unit of Pathology, University of Sheffield, Medical School, UK
Acta Neuropathol 113:119-27. 2007..001). An increased susceptibility to apoptosis in oligodendrogliomas with 1p+/-19q deletion may be important in their improved clinical outcome compared to Del- tumours... - Expression of Ki67, PCNA and the chromosome replication licensing protein Mcm2 in glial cells of the ageing human hippocampus increases with the burden of Alzheimer-type pathologyStephen B Wharton
Academic Unit of Pathology, University of Sheffield, Medical School, UK
Neurosci Lett 383:33-8. 2005..A quantitative relationship to the burden of Alzheimer-type pathology suggests that cell-cycle re-entry in glial cells may be important in the pathogenesis of age-related neurodegeneration... - Gliosarcoma with areas of primitive neuroepithelial differentiation and extracranial metastasisS B Wharton
Academic Unit of Pathology, University of Sheffield Medical School, UK
Clin Neuropathol 20:212-8. 2001..We believe this to be a novel pattern of differentiation in a gliosarcoma which in this case was associated with an aggressive metastatic potential... - The cellular and molecular pathology of the motor system in hereditary spastic paraparesis due to mutation of the spastin geneStephen B Wharton
Academic Unit of Pathology, University of Sheffield, Sheffield, United Kingdom
J Neuropathol Exp Neurol 62:1166-77. 2003..All 3 cases also demonstrated evidence of tau pathology outside the motor system, suggesting that the neuropathology is not confined to the motor system in spastin-related HSP... - Mesial temporal astrocyte tau pathology in the MRC-CFAS ageing brain cohortG Lace
Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK
Dement Geriatr Cogn Disord 34:15-24. 2012..Glial tau pathology is seen in certain tauopathies and in ageing. We determined its frequency in ageing mesial temporal lobe and its relationship to other tau pathologies in the MRC-CFAS population-representative neuropathology cohort... - Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brainJ E Simpson
Academic Unit of Pathology, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, UK
Neurobiol Aging 31:578-90. 2010..Alzheimer-type pathology only partially explains the variation in gliosis and astrocyte functional markers, suggesting that other factors contribute to the population variance in astrocyte pathology... - DNA replication licensing and cell cycle kinetics of oligodendroglial tumoursS B Wharton
1Academic Unit of Pathology, University of Sheffield, UK
Br J Cancer 91:262-9. 2004..Origin licensing proteins thus provide powerful novel tools for assessment of tumour cell cycle kinetics in routinely processed surgical biopsy material... - Microglial activation in white matter lesions and nonlesional white matter of ageing brainsJ E Simpson
Academic Unit of Pathology, University of Sheffield Medical School, Sheffield, UK
Neuropathol Appl Neurobiol 33:670-83. 2007..We also show that microglia in control WM from lesional cases express significantly more MHC II than control WM from nonlesional ageing brain, suggesting that WML occur in a 'field-effect' of abnormal WM... - Hippocampal tau pathology is related to neuroanatomical connections: an ageing population-based studyG Lace
Academic Unit of Pathology, University of Sheffield, Medical School, Beech Hill Road, Sheffield S10 2RX, UK
Brain 132:1324-34. 2009..These stages were significantly associated with dementia, and may provide a clinically useful tool in the clinico-pathological assessment of dementia and mild cognitive impairment... - White matter lesions in an unselected cohort of the elderly: astrocytic, microglial and oligodendrocyte precursor cell responsesJ E Simpson
Academic Unit of Pathology, University of Sheffield Medical School, Sheffield S10 2RX, UK
Neuropathol Appl Neurobiol 33:410-9. 2007.... - Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brainJ E Simpson
Academic Unit of Pathology, University of Sheffield Medical School, Sheffield, UK
Neuropathol Appl Neurobiol 36:25-40. 2010..Most studies have focussed on the reduced capacity for DNA repair by neurones, and have not taken into account the effect of oxidative stress on astrocytes, and their contribution to pathology... - Corticospinal tract degeneration in the progressive muscular atrophy variant of ALSP G Ince
Neuropathology, Academic Unit of Pathology, Division of Genomic Medicine, Sheffield University, UK
Neurology 60:1252-8. 2003..Examining the unresolved relationship between the lower motor neuron disorder progressive muscular atrophy (PMA) and ALS is important in clinical practice because of emerging therapies... - Myopathy associated with gluten sensitivityMarios Hadjivassiliou
Department of Neurology, The Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
Muscle Nerve 35:443-50. 2007..Myopathy may be another manifestation of gluten sensitivity and is likely to have an immune-mediated pathogenesis. A gluten-free diet may be a useful therapeutic intervention... - Neuropathy associated with gluten sensitivityM Hadjivassiliou
Department of Neurology, The Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
J Neurol Neurosurg Psychiatry 77:1262-6. 2006.... - Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patientsPaul R Kasher
Academic Neurology Unit, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, UK
J Neurochem 110:34-44. 2009..These results strongly support a direct role for defective axonal transport in the pathogenesis of HSP because of spastin mutation... - Broad clinical phenotypes associated with TAR-DNA binding protein (TARDBP) mutations in amyotrophic lateral sclerosisJanine Kirby
Department of Neuroscience, Faculty of Medicine, Dentistry and Health, University of Sheffield, Medical School, Sheffield, UK
Neurogenetics 11:217-25. 2010..However, all cases had an absence of clinically overt cognitive dysfunction... - Phosphatase and tensin homologue/protein kinase B pathway linked to motor neuron survival in human superoxide dismutase 1-related amyotrophic lateral sclerosisJanine Kirby
Academic Neurology Unit, Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK
Brain 134:506-17. 2011..Therefore, these data indicate that proteins in the phosphatidylinositol-3 kinase pathway could represent a target for therapeutic manipulation in motor neuron degeneration... - A brief history of tau: the evolving view of the microtubule-associated protein tau in neurodegenerative diseasesG L Lace
Neuropathology Group, Academic Unit of Pathology, University of Sheffield Medical School, Sheffield, UK
Clin Neuropathol 26:43-58. 2007..By examining the evolution of research on tau, related to advances in technology and the emergence of new diseases, the future developments needed to resolve remaining issues in the tau-story may be discerned... - Expression of vascular endothelial growth factor and its receptors in the central nervous system in amyotrophic lateral sclerosisAlice Brockington
Academic Neurology Unit and the Academic Unit of Pathology, University of Sheffield, Medical School, Sheffield, U K
J Neuropathol Exp Neurol 65:26-36. 2006.... - Isolation of enriched glial populations from post-mortem human CNS material by immuno-laser capture microdissectionR Waller
Sheffield Institute for Translational Neuroscience, The University of Sheffield, 385a Glossop Road, Sheffield, UK
J Neurosci Methods 208:108-13. 2012.... - Sensory ganglionopathy due to gluten sensitivityM Hadjivassiliou
Department of Neurology, Royal Hallamshire Hospital, Sheffield, UK
Neurology 75:1003-8. 2010..The commonest type of neuropathy seen in the context of gluten sensitivity is sensorimotor axonal. We report 17 patients with sensory ganglionopathy associated with gluten sensitivity... - Comparative genomic hybridization and pathological findings in atypical teratoid/rhabdoid tumour of the central nervous systemS B Wharton
Academic Unit of Pathology, University of Sheffield, Medical School, Sheffield, UK
Neuropathol Appl Neurobiol 29:254-61. 2003.... - Hereditary spastic paraparesis: disrupted intracellular transport associated with spastin mutationChristopher J McDermott
Academic Neurology Unit, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, United Kingdom
Ann Neurol 54:748-59. 2003.... - Microarray RNA expression analysis of cerebral white matter lesions reveals changes in multiple functional pathwaysJulie E Simpson
Academic Units of Pathology, University of Sheffield, Sheffield, UK
Stroke 40:369-75. 2009..Ischemia contributes to their pathogenesis but other mechanisms may contribute. We used RNA microarray analysis with functional pathway grouping as an unbiased approach to investigate evidence for additional pathogenetic mechanisms... - Fatal spontaneous thrombosis of a cerebral arteriovenous malformation in a young patient with a rare heterozygous prothrombin gene mutation. Case reportMahmoud Taha
Department of Neurosurgery, Royal Hallamshire Hospital, Sheffield, United Kingdom
J Neurosurg 106:143-6. 2007..Acute neurological decline after spontaneous thrombosis of an intracranial AVM is rare, and an association with the prothrombin defect in this patient is likely... - White matter lesions in an unselected cohort of the elderly: molecular pathology suggests origin from chronic hypoperfusion injuryMalee S Fernando
Division of Genomic Medicine, University of Sheffield, United Kingdom
Stroke 37:1391-8. 2006..04). CONCLUSIONS: The data support a hypoxic environment within MRI WMLs. Persistent HIF expression may result from failure of normal adaptive mechanisms. WM ischemia appears to be a common feature of the aging brain... - Morphological changes and stress responses in neurons in cerebral cortex infiltrated by diffuse astrocytomaShom Goel
Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom
Neuropathology 23:262-70. 2003..The patterns of cellular pathology identified suggest possible mechanisms, by which neurons are damaged and eventually lost in peritumoral brain... - A robust assay for alternative lengthening of telomeres in tumors shows the significance of alternative lengthening of telomeres in sarcomas and astrocytomasJeremy D Henson
Children's Medical Research Institute, New South Wales, Australia
Clin Cancer Res 11:217-25. 2005..It showed that a substantial proportion of STS, osteosarcomas, and astrocytomas, but not papillary thyroid carcinomas use ALT. APB positivity correlated strongly with survival of patients with astrocytomas... - Progressive loss of motor neuron function in wasted mice: effects of a spontaneous null mutation in the gene for the eEF1 A2 translation factorHelen J Newbery
Medical Genetics, Molecular Medicine Center, University of Edinburgh, Western General Hospital, Edinburgh, UK
J Neuropathol Exp Neurol 64:295-303. 2005..The early initiation and rapid progression of motor unit degeneration in wst/wst mice suggest that they should be considered an important and accessible model of early-onset motor neuron degeneration in humans... - Production of monocyte chemoattractant protein-1 in amyotrophic lateral sclerosisPierLuigi Baron
Department of Neurological Sciences, Dino Ferrari Center, University of Milan Medical School, IRCCS Ospedale Maggiore Policlinico, Via S Sforza 35, 20122 Milan, Italy
Muscle Nerve 32:541-4. 2005..Our findings suggest a role for MCP-1 as an important molecular mediator of the injury response in ALS...