L J Whalley

Summary

Affiliation: University of Aberdeen
Country: UK

Publications

  1. pmc Human intelligence and polymorphisms in the DNA methyltransferase genes involved in epigenetic marking
    Paul Haggarty
    Nutrition and Epigenetics Group, Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, United Kingdom
    PLoS ONE 5:e11329. 2010
  2. doi request reprint Homocysteine, antioxidant micronutrients and late onset dementia
    Lawrence J Whalley
    Institute of Applied Health Sciences, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen, Scotland, AB25 2ZH, UK
    Eur J Nutr 53:277-85. 2014
  3. doi request reprint Genetic and environmental factors in late onset dementia: possible role for early parental death
    Lawrence J Whalley
    Institute of Applied Health Sciences, University of Aberdeen, UK
    Int J Geriatr Psychiatry 28:75-81. 2013
  4. doi request reprint Anticholinergic drugs in late life: adverse effects on cognition but not on progress to dementia
    Lawrence J Whalley
    The Institute of Applied Health Sciences, Foresterhill, University of Aberdeen, Aberdeen, Scotland, UK
    J Alzheimers Dis 30:253-61. 2012
  5. doi request reprint Spatial distribution and secular trends in the epidemiology of Alzheimer's disease
    Lawrence J Whalley
    Institute of Applied Health Sciences, School of Medicine and Dentistry, University of Aberdeen, Polwarth Building, Aberdeen AB25 2ZH, UK
    Neuroimaging Clin N Am 22:1-10, vii. 2012
  6. pmc All-cause mortality in the Aberdeen 1921 birth cohort: effects of socio-demographic, physical and cognitive factors
    John M Starr
    Geriatric Medicine Unit, University of Edinburgh, Edinburgh, UK
    BMC Public Health 8:307. 2008
  7. pmc Paraoxonase gene polymorphisms and haplotype analysis in a stroke population
    Alireza Pasdar
    Department of Medicine and Therapeutics, University of Aberdeen, UK
    BMC Med Genet 7:28. 2006
  8. pmc The effect of ABCA1 gene polymorphisms on ischaemic stroke risk and relationship with lipid profile
    Alireza Pasdar
    Department of Medicine and Therapeutics, University of Aberdeen, UK
    BMC Med Genet 8:30. 2007
  9. pmc The Lothian Birth Cohort 1936: a study to examine influences on cognitive ageing from age 11 to age 70 and beyond
    Ian J Deary
    Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
    BMC Geriatr 7:28. 2007
  10. pmc A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition
    Sarah E Harris
    Department of Psychology, University of Edinburgh, Edinburgh, UK
    BMC Genet 8:43. 2007

Detail Information

Publications77

  1. pmc Human intelligence and polymorphisms in the DNA methyltransferase genes involved in epigenetic marking
    Paul Haggarty
    Nutrition and Epigenetics Group, Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, United Kingdom
    PLoS ONE 5:e11329. 2010
    ..We believe that the role of epigenetics in the normal variation in human intelligence merits further study and that this novel finding should be tested in other cohorts...
  2. doi request reprint Homocysteine, antioxidant micronutrients and late onset dementia
    Lawrence J Whalley
    Institute of Applied Health Sciences, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen, Scotland, AB25 2ZH, UK
    Eur J Nutr 53:277-85. 2014
    ..To distinguish between contributions to dementia made by homocysteine, folate, B12 and antioxidant micronutrients...
  3. doi request reprint Genetic and environmental factors in late onset dementia: possible role for early parental death
    Lawrence J Whalley
    Institute of Applied Health Sciences, University of Aberdeen, UK
    Int J Geriatr Psychiatry 28:75-81. 2013
    ....
  4. doi request reprint Anticholinergic drugs in late life: adverse effects on cognition but not on progress to dementia
    Lawrence J Whalley
    The Institute of Applied Health Sciences, Foresterhill, University of Aberdeen, Aberdeen, Scotland, UK
    J Alzheimers Dis 30:253-61. 2012
    ..We concluded that anticholinergic drug use in this narrow age range sample was linked to cognitive impairment but not to subsequent dementia...
  5. doi request reprint Spatial distribution and secular trends in the epidemiology of Alzheimer's disease
    Lawrence J Whalley
    Institute of Applied Health Sciences, School of Medicine and Dentistry, University of Aberdeen, Polwarth Building, Aberdeen AB25 2ZH, UK
    Neuroimaging Clin N Am 22:1-10, vii. 2012
    ..A life-course approach to dementia pathophysiology may help to elucidate the nature and timing of interventions that might delay dementia onset...
  6. pmc All-cause mortality in the Aberdeen 1921 birth cohort: effects of socio-demographic, physical and cognitive factors
    John M Starr
    Geriatric Medicine Unit, University of Edinburgh, Edinburgh, UK
    BMC Public Health 8:307. 2008
    ..Childhood intelligence predicts mortality throughout most of the life span. However, it is unknown whether its effect persists into advanced old age...
  7. pmc Paraoxonase gene polymorphisms and haplotype analysis in a stroke population
    Alireza Pasdar
    Department of Medicine and Therapeutics, University of Aberdeen, UK
    BMC Med Genet 7:28. 2006
    ..Alteration of enzyme activity due to polymorphisms in the PON genes may influence the development of atheroma and thus affect stroke risk. Three PON genes (PON1, PON2 and PON3) have been identifiedand mapped to chromosome 7...
  8. pmc The effect of ABCA1 gene polymorphisms on ischaemic stroke risk and relationship with lipid profile
    Alireza Pasdar
    Department of Medicine and Therapeutics, University of Aberdeen, UK
    BMC Med Genet 8:30. 2007
    ..It also examined the relationship of these polymorphisms with serum lipid profiles in cases and controls...
  9. pmc The Lothian Birth Cohort 1936: a study to examine influences on cognitive ageing from age 11 to age 70 and beyond
    Ian J Deary
    Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
    BMC Geriatr 7:28. 2007
    ..A limitation of many studies is the lack of a sufficiently long period between cognitive assessments to examine determinants. Here, the aim is to examine influences on cognitive ageing between childhood and old age...
  10. pmc A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition
    Sarah E Harris
    Department of Psychology, University of Edinburgh, Edinburgh, UK
    BMC Genet 8:43. 2007
    ..Non-pathological cognitive ageing is a distressing condition affecting an increasing number of people in our 'ageing society'. Oxidative stress is hypothesised to have a major role in cellular ageing, including brain ageing...
  11. ncbi request reprint Age at natural menopause and cognition
    Lawrence J Whalley
    Department of Mental Health, Aberdeen University, Royal Cornhill Hospital, Cornhill Road, Aberdeen AB25 2ZH, UK
    Maturitas 49:148-56. 2004
    ..To examine associations between age at natural menopause, childhood IQ and cognition at age 65 years. To determine if lower age at menopause partly mediates the effect of childhood IQ on cognition at age 65 years...
  12. ncbi request reprint Cognitive reserve and the neurobiology of cognitive aging
    Lawrence J Whalley
    Clinical Research Centre, School of Medicine, University of Aberdeen, Royal Cornhill Hospital, Cornhill Road, Aberdeen AB25 2ZH, UK
    Ageing Res Rev 3:369-82. 2004
    ..The cognitive reserve hypothesis conforms with reported associations between early and mid life lifestyle choices, early education, lifelong dietary habit, leisure pursuits and the retention of late life mental ability...
  13. ncbi request reprint Childhood IQ, smoking, and cognitive change from age 11 to 64 years
    Lawrence J Whalley
    Department of Mental Health, University of Aberdeen, Aberdeen, Scotland, UK
    Addict Behav 30:77-88. 2005
    ..In this sample, smoking makes a small (<1% variance) independent negative contribution to cognitive aging...
  14. ncbi request reprint Cognitive aging, childhood intelligence, and the use of food supplements: possible involvement of n-3 fatty acids
    Lawrence J Whalley
    University of Aberdeen, Department of Mental Health, Royal Cornhill Hospital, Aberdeen, United Kingdom
    Am J Clin Nutr 80:1650-7. 2004
    ..Food supplement use is widely promoted, but little is known about the cognitive effects of food supplements...
  15. ncbi request reprint Commentary: childhood education and disparities in adult health--the need for improved theories and better data
    Lawrence J Whalley
    Department of Mental Health, Institute of Applied Health Sciences, University of Aberdeen, Forresterhill, Aberdeen, AB25 2ZH, UK
    Int J Epidemiol 35:466-7. 2006
  16. ncbi request reprint n-3 Fatty acid erythrocyte membrane content, APOE varepsilon4, and cognitive variation: an observational follow-up study in late adulthood
    Lawrence J Whalley
    Department of Environmental and Occupational Medicine, University of Aberdeen, Aberdeen, United Kingdom
    Am J Clin Nutr 87:449-54. 2008
    ..This inconsistency may arise because the relation is present only in the absence of the apolipoprotein E epsilon4 (APOE epsilon4) allele...
  17. ncbi request reprint Childhood mental ability and dementia
    L J Whalley
    Aberdeen University, Department of Mental Health, Scotland
    Neurology 55:1455-9. 2000
    ..To examine links between childhood mental ability and dementia using data from a 1932 survey of the mental ability of the 1921 Scottish birth cohort...
  18. ncbi request reprint A life-course approach to the aetiology of late-onset dementias
    Lawrence J Whalley
    Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK
    Lancet Neurol 5:87-96. 2006
    ..Biological mechanisms that explain how fetal development might influence the risk of adult disease may be relevant to many age-related diseases including the dementias and, possibly, to the biology of ageing...
  19. ncbi request reprint Dietary supplement use in old age: associations with childhood IQ, current cognition and health
    L J Whalley
    University of Aberdeen, Clinical Research Centre, Royal Cornhill Hospital, Aberdeen, UK
    Int J Geriatr Psychiatry 18:769-76. 2003
    ..Dietary supplement (DS) use is actively promoted among old people but there is little evidence in favour of DS use or information about the demographic, health and cognitive characteristics of DS users...
  20. doi request reprint How the 1932 and 1947 mental surveys of Aberdeen schoolchildren provide a framework to explore the childhood origins of late onset disease and disability
    Lawrence J Whalley
    Institute of Applied Health Sciences, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom
    Maturitas 69:365-72. 2011
    ..To describe the discovery and development of the Aberdeen 1921 and 1936 birth cohort studies...
  21. ncbi request reprint Plasma vitamin C, cholesterol and homocysteine are associated with grey matter volume determined by MRI in non-demented old people
    L J Whalley
    Clinical Research Centre, Department of Mental Health, University of Aberdeen, Royal Cornhill Hospital, UK
    Neurosci Lett 341:173-6. 2003
    ..These data are consistent with the putative benefits of dietary vitamin C and folate intake and the role of cholesterol in age related neurodegeneration...
  22. pmc Brain white matter lesions detected by magnetic resonance [correction of resosnance] imaging are associated with balance and gait speed
    J M Starr
    Geriatric Medicine Unit, University of Edinburgh, Royal Victoria Hospital, Craigleith Road, Edinburgh EH4 2DN, Scotland, UK
    J Neurol Neurosurg Psychiatry 74:94-8. 2003
    ..To investigate the relations between premorbid and current mental ability, mood, and white matter signal abnormalities detected by T2 weighted brain magnetic resonance imaging (MRI) and impairment of balance and mobility in older adults...
  23. ncbi request reprint Smoking and cognitive change from age 11 to 66 years: a confirmatory investigation
    John M Starr
    Department of Geriatric Medicine, University of Edinburgh, Scotland, UK
    Addict Behav 32:63-8. 2007
    ..These data confirm the adverse effect of smoking on information processing speed, and provide new evidence for a similar adverse effect on memory for people in their mid-sixties...
  24. ncbi request reprint Neuropsychologic correlates of brain white matter lesions depicted on MR images: 1921 Aberdeen Birth Cohort
    S A Leaper
    Department of Mental Health, University of Aberdeen, Clinical Research Center, Royal Cornhill Hospital, Cornhill Rd, Aberdeen AB25 2ZJ, Scotland
    Radiology 221:51-5. 2001
    ..This indicates that MR imaging-depicted white matter lesions are of clinical importance...
  25. pmc Longitudinal cohort study of childhood IQ and survival up to age 76
    L J Whalley
    Department of Mental Health, University of Aberdeen, Clinical Research Centre, Cornhill Hospital, Aberdeen AB24 2ZD
    BMJ 322:819. 2001
    ..Controlling for this factor did not alter the association between mental ability and mortality. CONCLUSION: Childhood mental ability is a significant factor among the variables that predict age at death...
  26. doi request reprint Antioxidant and B vitamin intake in relation to cognitive function in later life in the Lothian Birth Cohort 1936
    G McNeill
    Public Health Nutrition Research Group, Population Health Section, Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK
    Eur J Clin Nutr 65:619-26. 2011
    ..The possibility that those with higher cognitive ability during earlier adult life consume more nutrient-rich diets in later life could provide an alternative explanation for the associations seen in observational studies...
  27. doi request reprint Predictors and correlates of edentulism in the healthy old people in Edinburgh (HOPE) study
    John M Starr
    Geriatric Medicine Unit, University of Edinburgh, Scotland, UK
    Gerodontology 25:199-204. 2008
    ..To determine the extent to which correlates of edentulism are explained by an association between tooth loss and cognitive ability...
  28. ncbi request reprint Early-onset Alzheimer's disease in Scotland: environmental and familial factors
    L J Whalley
    Department of Mental Health, Medical School, University of Aberdeen, Aberdeen AB25 2ZD, UK
    Br J Psychiatry Suppl 40:s53-9. 2001
    ..Future studies will require very large (> or = 600) sample sizes, molecular genetic analysis, and environmental data that span neurodevelopment and the period between disease onset and appearance of clinical symptoms...
  29. ncbi request reprint Quality of Life in healthy old age: relationships with childhood IQ, minor psychological symptoms and optimism
    Gillian H Bain
    The Medical School, University of Aberdeen, Aberdeen, UK
    Soc Psychiatry Psychiatr Epidemiol 38:632-6. 2003
    ....
  30. ncbi request reprint Homocysteine, B vitamin status, and cognitive function in the elderly
    Susan J Duthie
    Rowett Research Institute, Aberdeen, United Kingdom
    Am J Clin Nutr 75:908-13. 2002
    ..Old age is associated with reduced cognitive performance. Nutritional factors may contribute to this association...
  31. ncbi request reprint Quality of life and its correlates in octogenarians. Use of the SEIQoL-DW in Wave 5 of the Aberdeen Birth Cohort 1921 Study (ABC1921)
    David Gwyn Seymour
    Department of Medicine and Therapeutics, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen, AB25 2ZD, UK
    Qual Life Res 17:11-20. 2008
    ..The direct-weighted Schedule for the Evaluation of Individual Quality of Life, Direct Weighting (SEIQoL-DW) is an individualised measure of QoL that has been little used in very elderly people...
  32. ncbi request reprint Brain white matter hyperintensities: relative importance of vascular risk factors in nondemented elderly people
    Alison D Murray
    Department of Radiology, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland
    Radiology 237:251-7. 2005
    ....
  33. ncbi request reprint Generality and specificity in cognitive aging: a volumetric brain analysis
    Roger T Staff
    Department of Bio medical Physics, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZD, UK
    Neuroimage 30:1433-40. 2006
    ..To investigate whether, in old age, brain volume differences are associated with age-related change in general mental ability and/or specific cognitive abilities...
  34. ncbi request reprint What provides cerebral reserve?
    Roger T Staff
    Department of Bio Medical Physics and Bioengineering, University of Aberdeen and Aberdeen Royal Infirmary, Foresterhill, UK
    Brain 127:1191-9. 2004
    ..We conclude that the intellectual challenges experienced during life, such as education and occupation, accumulate reserve and allow cognitive function to be maintained in old age...
  35. ncbi request reprint Solvent exposure and cognitive ability at age 67: a follow-up study of the 1947 Scottish Mental Survey
    Finlay D Dick
    Environmental and Occupational Medicine, Population Health Section, Division of Applied Health Sciences, University of Aberdeen Medical School, Aberdeen, UK
    Occup Environ Med 67:401-7. 2010
    ..This study sought to examine the association between organic solvent exposure and cognitive function in later life...
  36. doi request reprint Genetic determinants of ageing processes and diseases in later life
    Clare V Bostock
    Department of Medicine for the Elderly, Woodend Hospital, Aberdeen, United Kingdom
    Maturitas 62:225-9. 2009
    ..To investigate the role of genetic factors in diseases of later life...
  37. ncbi request reprint Childhood mental ability and blood pressure at midlife: linking the Scottish Mental Survey 1932 and the Midspan studies
    John M Starr
    Royal Victoria Hospital, Craigleith Road, Edinburgh EH4 2DN, Scotland, UK
    J Hypertens 22:893-7. 2004
    ..To establish the relationship between childhood mental ability and adult hypertension...
  38. pmc Genome-wide association studies establish that human intelligence is highly heritable and polygenic
    G Davies
    Department of Psychology, University of Edinburgh, Edinburgh, Scotland, UK
    Mol Psychiatry 16:996-1005. 2011
    ....
  39. doi request reprint Is retaining the youthful functional anatomy underlying speed of information processing a signature of successful cognitive ageing? An event-related fMRI study of inspection time performance
    Gordon D Waiter
    Department of Radiology, College of Life Sciences and Medicine, University of Aberdeen, UK
    Neuroimage 41:581-95. 2008
    ..The relative preservation of complex reasoning skills in old age may be associated with the preservation of the neural networks that underpin fundamental information processing in youth...
  40. doi request reprint Associations between childhood intelligence (IQ), adult morbidity and mortality
    Alixe H M Kilgour
    University of Edinburgh Centre for Cognitive Ageing and Cognitive Epidemiology, Geriatric Medicine Unit, Edinburgh, Scotland, UK
    Maturitas 65:98-105. 2010
    ..When statistical models that include childhood adversity are tested, these attenuate and sometimes remove the contribution of IQ to morbidity and premature death...
  41. doi request reprint Association of KIBRA and memory
    Timothy C Bates
    Department of Psychology, University of Edinburgh, 7 George Square, EH89JZ, Scotland, UK
    Neurosci Lett 458:140-3. 2009
    ....
  42. doi request reprint Brain volume and survival from age 78 to 85: the contribution of Alzheimer-type magnetic resonance imaging findings
    Roger T Staff
    Department of Nuclear Medicine, Aberdeen Royal Infirmary, Aberdeen, United Kingdom
    J Am Geriatr Soc 58:688-95. 2010
    ..To test the prediction of survival using magnetic resonance imaging (MRI)-derived global and regional brain volumes in subjects aged 78 to 79 without dementia...
  43. doi request reprint Caffeine, cognition, and socioeconomic status
    Janet Kyle
    School of Medicine and Dentistry, Division of Applied Health Sciences, Foresterhill, University of Aberdeen, Aberdeen, UK
    J Alzheimers Dis 20:S151-9. 2010
    ..The results are discussed in terms of the withdrawal effects of caffeine during cognitive testing and strong links between SES and cognitive performance. No evidence in support of cognitive enhancing effects of caffeine was found...
  44. ncbi request reprint Diet and dementia
    Lawrence J Whalley
    Department of Mental Health, School of Medicine, University of Aberdeen, UK
    J Br Menopause Soc 10:113-7. 2004
    ..More compelling is the association between increased plasma homocysteine concentration and later increased risk of dementia. This association is possibly caused by an inadequate intake of vitamin B(12)/folate...
  45. ncbi request reprint Association between telomere length and heart disease in a narrow age cohort of older people
    John M Starr
    Geriatric Medicine Unit, University of Edinburgh, The Royal Victoria Hospital, Craigleith Road, Edinburgh, Scotland, UK
    Exp Gerontol 42:571-3. 2007
    ..Telomere shortening in peripheral blood leukocytes is a promising index of ischemic heart disease risk in older people and deserves further investigation as a potential mechanism...
  46. ncbi request reprint Enhanced hippocampal long-term potentiation in rats after chronic exposure to homocysteine
    Louisa A Christie
    School of Medical Sciences, College of Life Sciences and Medicine, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Neurosci Lett 373:119-24. 2005
    ..These changes may reflect the suggested (excito-)toxicity of HCY and its putative contribution to neurodegenerative disease...
  47. ncbi request reprint The association between telomere length, physical health, cognitive ageing, and mortality in non-demented older people
    Sarah E Harris
    Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, UK
    Neurosci Lett 406:260-4. 2006
    ..17, p=0.022) adjustment for mental ability at age 11. This might be a type 1 error. Otherwise, we find that telomere length in old age does not have a significant association with age-related physical and cognitive decline or mortality...
  48. ncbi request reprint Nicastrin gene polymorphisms, cognitive ability level and cognitive ageing
    Ian J Deary
    Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH89JZ, UK
    Neurosci Lett 373:110-4. 2005
    ..The possibility that this result might be a selection effect was not supported by the samples being in Hardy-Weinberg equilibrium with respect to the distribution of NCSTN genotypes...
  49. ncbi request reprint Re: "Relation of education and occupation-based socioeconomic status to incident Alzheimer's disease"
    G David Batty
    Am J Epidemiol 160:404-5; author reply 405-6. 2004
  50. ncbi request reprint Apolipoprotein e gene variability and cognitive functions at age 79: a follow-up of the Scottish mental survey of 1932
    Ian J Deary
    Department of Psychology, University of Edinburgh, Edinburgh, Scotland
    Psychol Aging 19:367-71. 2004
    ..Neither nonverbal reasoning nor verbal fluency were affected. In this sample, APOE genotype contributed to verbal memory in old age...
  51. ncbi request reprint KLOTHO genotype and cognitive ability in childhood and old age in the same individuals
    Ian J Deary
    Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
    Neurosci Lett 378:22-7. 2005
    ..Variation in the KLOTHO gene is a possible contributor to life-long reasoning differences in humans and/or to the ageing of non-verbal reasoning, especially in women...
  52. ncbi request reprint Searching for genetic influences on normal cognitive ageing
    Ian J Deary
    Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK
    Trends Cogn Sci 8:178-84. 2004
    ..However, current progress in genetic knowledge, technology and informatics will contribute to progress in this important area...
  53. ncbi request reprint The impact of childhood intelligence on later life: following up the Scottish mental surveys of 1932 and 1947
    Ian J Deary
    Department of Psychology, University of Edinburgh, Edinburgh, Scotland
    J Pers Soc Psychol 86:130-47. 2004
    ....
  54. ncbi request reprint Childhood IQ, social class, deprivation, and their relationships with mortality and morbidity risk in later life: prospective observational study linking the Scottish Mental Survey 1932 and the Midspan studies
    Carole L Hart
    Public Health and Health Policy, Division of Community Based Sciences, University of Glasgow, Glasgow, Scotland
    Psychosom Med 65:877-83. 2003
    ..To investigate how childhood mental ability (IQ) is related to mortality and morbidity risk, when socioeconomic factors are also considered...
  55. ncbi request reprint Lack of association between polymorphisms in angiotensin-converting-enzyme and methylenetetrahydrofolate reductase genes and normal cognitive ageing in humans
    Peter M Visscher
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh, UK
    Neurosci Lett 347:175-8. 2003
    ..02), which could indicate that this gene is under selection. Polymorphisms at the two studied genes are unlikely to be risk factors for normal cognitive ageing...
  56. ncbi request reprint Cerebral white matter abnormalities and lifetime cognitive change: a 67-year follow-up of the Scottish Mental Survey of 1932
    Ian J Deary
    Department of Psychology, University of Edinburgh, Scotland
    Psychol Aging 18:140-8. 2003
    ..Some of this effect might be due to hypertension. This contribution is independent of mental function in early life and is associated with general cognitive ability...
  57. ncbi request reprint Brain ageing and dementia: what makes the difference?
    Lawrence J Whalley
    Br J Psychiatry 181:369-71. 2002
  58. ncbi request reprint Cognitive change and the APOE epsilon 4 allele
    Ian J Deary
    Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
    Nature 418:932. 2002
    ..This effect of the APOE epsilon 4 allele on normal cognitive ageing may be mediated by a mechanism that is at least partly independent of its predisposing effect towards Alzheimer's disease...
  59. ncbi request reprint Differential cognitive outcomes in the Hypertensive Old People in Edinburgh study
    John M Starr
    Geriatric Medicine Unit, Edinburgh University, United Kingdom
    J Neurol Sci 229:103-7. 2005
    ..Future trials of the effects of antihypertensive therapy on cognition should focus more on outcomes other than memory. Early differential effects of therapeutic agents may not be maintained...
  60. ncbi request reprint The functional COMT polymorphism, Val 158 Met, is associated with logical memory and the personality trait intellect/imagination in a cohort of healthy 79 year olds
    Sarah E Harris
    Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
    Neurosci Lett 385:1-6. 2005
    ..Therefore, COMT genotype may contribute to differences in normal cognitive aging and to differences in some of the major personality traits in old age...
  61. doi request reprint PPARG Pro12Ala genotype and risk of cognitive decline in elders? Maybe with diabetes
    Wendy Johnson
    Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK
    Neurosci Lett 434:50-5. 2008
    ..The data did suggest that risk of cognitive decline is greater when Pro12Ala carriers contract diabetes...
  62. ncbi request reprint No association of CETP genotype with cognitive function or age-related cognitive change
    Wendy Johnson
    Department of Psychology, University of Edinburgh, Edinburgh, UK
    Neurosci Lett 420:189-92. 2007
    ..There were, however, no significant associations of CETP genotype with either childhood IQ or current cognitive function in old age, or with lifetime change in cognitive function...
  63. ncbi request reprint COMT genotype and cognitive ability: a longitudinal aging study
    John M Starr
    Department of Geriatric Medicine, Royal Victoria Hospital, Craigleith Road, Edinburgh EH4 2DN, UK
    Neurosci Lett 421:57-61. 2007
    ..9 (95% C.I. 34.3-35.5), and Met/Met 34.9 (95% C.I. 34.1-35.8). This study adds to the evidence that the Val/Val polymorphism has a detrimental effect on cognition, extending upwards the age range in which such an effect has been detected...
  64. ncbi request reprint Childhood IQ and social factors on smoking behaviour, lung function and smoking-related outcomes in adulthood: linking the Scottish Mental Survey 1932 and the Midspan studies
    Michelle D Taylor
    Department of Psychology, University of Edinburgh, UK
    Br J Health Psychol 10:399-410. 2005
    ..To investigate the associations of childhood IQ and adult social factors, and smoking behaviour, lung function (forced expiratory volume in one second; FEV(1)), and smoking-related outcomes in adulthood...
  65. ncbi request reprint Predictors of tooth loss in the 1921 Lothian Birth Cohort
    John M Starr
    Geriatric Medicine Unit, University of Edinburgh, Royal Victoria Hospital, Edinburgh, EH4 2DN, UK
    Age Ageing 37:111-4. 2008
  66. ncbi request reprint Blood pressure and cognition in the Aberdeen 1936 birth cohort
    John M Starr
    University of Edinburgh, Edinburgh, UK
    Gerontology 53:432-7. 2007
    ..Longitudinal studies in which mental ability earlier in life is known are needed to clarify the relationship...
  67. ncbi request reprint Polymorphisms in the gene encoding 11B-hydroxysteroid dehydrogenase type 1 (HSD11B1) and lifetime cognitive change
    Ian J Deary
    Department of Psychology, University of Edinburgh, 7 George Square, UK
    Neurosci Lett 393:74-7. 2006
    ..91) and rs846910-A/G (p=.90) between the groups. We conclude that these variants in HSD11B1 are not significant contributors to the range of cognitive ageing examined here...
  68. ncbi request reprint Large, consistent estimates of the heritability of cognitive ability in two entire populations of 11-year-old twins from Scottish mental surveys of 1932 and 1947
    Beben Benyamin
    School of Biological Sciences, University of Edinburgh, King s Buildings, West Mains Road, Edinburgh, EH9 3JT, UK
    Behav Genet 35:525-34. 2005
    ..More generally for studies in genetics, the methodological innovation developed here implies that large (national) data collections can provide sufficient information on twin pairs to estimate genetic parameters, even without zygosity...
  69. ncbi request reprint Physical fitness and lifetime cognitive change
    Ian J Deary
    Department of Psychology, School of Philosophy, Psychology and Language Sciences, University of Edinburgh, Edinburgh, UK
    Neurology 67:1195-200. 2006
    ..To test the hypothesis that physical fitness is associated with more successful cognitive aging...
  70. ncbi request reprint The association between retinal vascular network geometry and cognitive ability in an elderly population
    Niall Patton
    Princess Alexandra Eye Pavilion, Edinburgh, United Kingdom
    Invest Ophthalmol Vis Sci 48:1995-2000. 2007
    ..To test the hypothesis that parameters of retinal vascular network geometry are significantly associated with cognition...
  71. pmc Genetic enhancement of cognition in a kindred with cone-rod dystrophy due to RIMS1 mutation
    Sanjay M Sisodiya
    Department of Clinical and Experimental Epilepsy, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    J Med Genet 44:373-80. 2007
    ..RIMS1 encodes a synapse active-zone protein with important roles in the maintenance of normal synaptic function: mice lacking this protein have greatly reduced learning ability and memory function...
  72. ncbi request reprint The ongoing adaptive evolution of ASPM and Microcephalin is not explained by increased intelligence
    Nitzan Mekel-Bobrov
    Department of Human Genetics, Howard Hughes Medical Institute, University of Chicago, Chicago, IL 60637, USA
    Hum Mol Genet 16:600-8. 2007
    ....
  73. pmc Aspirin and cognitive function
    Lawrence J Whalley
    BMJ 334:961-2. 2007
  74. ncbi request reprint Life long changes in cognitive ability are associated with prescribed medications in old age
    John M Starr
    Geriatric Medicine Unit, University of Edinburgh, Edinburgh, UK
    Int J Geriatr Psychiatry 19:327-32. 2004
    ..To determine the association between prescribed medication and life long changes in cognitive ability...
  75. ncbi request reprint The cognitive cost of being a twin: two whole-population surveys
    Ian J Deary
    Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom
    Twin Res Hum Genet 8:376-83. 2005
    ..The same mental ability difference of about 5 IQ points was found, and was not accounted for by father's occupation, overcrowding in the childhood home, childhood height, school attendance or the number of people in the family...
  76. doi request reprint GSTz1 genotype and cognitive ability
    John M Starr
    Psychiatr Genet 18:211-2. 2008
  77. ncbi request reprint Genetic influences on oxidative stress and their association with normal cognitive ageing
    Swati J Kachiwala
    Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
    Neurosci Lett 386:116-20. 2005
    ..An interaction between PRNP and klotho (KL) genotypes was also identified (p=0.015), highlighting the importance of analysing gene interactions when investigating associations with quantitative traits...