H C Whalley

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc The influence of polygenic risk for bipolar disorder on neural activation assessed using fMRI
    H C Whalley
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
    Transl Psychiatry 2:e130. 2012
  2. doi request reprint Review of functional magnetic resonance imaging studies comparing bipolar disorder and schizophrenia
    Heather C Whalley
    Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, UK
    Bipolar Disord 14:411-31. 2012
  3. pmc Prospective multi-centre Voxel Based Morphometry study employing scanner specific segmentations: procedure development using CaliBrain structural MRI data
    T William J Moorhead
    The Division of Psychiatry, Centre for Clinical Brain Sciences, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, UK
    BMC Med Imaging 9:8. 2009
  4. pmc Grey matter changes can improve the prediction of schizophrenia in subjects at high risk
    Dominic E Job
    Division of Psychiatry, School of Molecular and Clinical Medicine, The University of Edinburgh, The Royal Edinburgh Hospital, Morningside Park, Edinburgh, Scotland, EH10 5HF, UK
    BMC Med 4:29. 2006
  5. doi request reprint Functional imaging of emotional memory in bipolar disorder and schizophrenia
    Heather C Whalley
    Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, Scotland, UK
    Bipolar Disord 11:840-56. 2009
  6. ncbi request reprint Functional disconnectivity in subjects at high genetic risk of schizophrenia
    Heather C Whalley
    Division of Psychiatry, School of Informatics, University of Edinburgh, Edinburgh, Scotland
    Brain 128:2097-108. 2005
  7. ncbi request reprint Neural correlates of enhanced genetic risk for schizophrenia
    Heather C Whalley
    Division of Psychiatry, University of Edinburgh, Edinburgh, Scotland
    Neuroscientist 11:238-49. 2005
  8. pmc Correlations between fMRI activation and individual psychotic symptoms in un-medicated subjects at high genetic risk of schizophrenia
    Heather C Whalley
    Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, Scotland, UK
    BMC Psychiatry 7:61. 2007
  9. doi request reprint Hypofrontality in subjects at high genetic risk of schizophrenia with depressive symptoms
    H C Whalley
    Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, Scotland, UK
    J Affect Disord 109:99-106. 2008
  10. doi request reprint fMRI changes over time and reproducibility in unmedicated subjects at high genetic risk of schizophrenia
    H C Whalley
    Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, UK
    Psychol Med 39:1189-99. 2009

Collaborators

Detail Information

Publications46

  1. pmc The influence of polygenic risk for bipolar disorder on neural activation assessed using fMRI
    H C Whalley
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
    Transl Psychiatry 2:e130. 2012
    ..The findings suggest that this novel polygenic approach to examine brain-imaging data may be a useful means of identifying genetically mediated traits mechanistically linked to the aetiology of BD...
  2. doi request reprint Review of functional magnetic resonance imaging studies comparing bipolar disorder and schizophrenia
    Heather C Whalley
    Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, UK
    Bipolar Disord 14:411-31. 2012
    ..Here, we examine the functional magnetic resonance imaging (fMRI) literature to determine the evidence for diagnosis-specific patterns of brain activation in the two patient groups...
  3. pmc Prospective multi-centre Voxel Based Morphometry study employing scanner specific segmentations: procedure development using CaliBrain structural MRI data
    T William J Moorhead
    The Division of Psychiatry, Centre for Clinical Brain Sciences, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, UK
    BMC Med Imaging 9:8. 2009
    ..The CaliBrain project was designed to provide for an assessment of scanner differences at three centres in Scotland, and to assess the practicality of pooling scans from multiple-centres...
  4. pmc Grey matter changes can improve the prediction of schizophrenia in subjects at high risk
    Dominic E Job
    Division of Psychiatry, School of Molecular and Clinical Medicine, The University of Edinburgh, The Royal Edinburgh Hospital, Morningside Park, Edinburgh, Scotland, EH10 5HF, UK
    BMC Med 4:29. 2006
    ....
  5. doi request reprint Functional imaging of emotional memory in bipolar disorder and schizophrenia
    Heather C Whalley
    Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, Scotland, UK
    Bipolar Disord 11:840-56. 2009
    ..We also investigate associations between activation levels and symptom severity across the disorders...
  6. ncbi request reprint Functional disconnectivity in subjects at high genetic risk of schizophrenia
    Heather C Whalley
    Division of Psychiatry, School of Informatics, University of Edinburgh, Edinburgh, Scotland
    Brain 128:2097-108. 2005
    ..These connectivity abnormalities may underlie the diverse deficits seen in the established condition and the more subtle deficits seen in close relatives of those with the disorder...
  7. ncbi request reprint Neural correlates of enhanced genetic risk for schizophrenia
    Heather C Whalley
    Division of Psychiatry, University of Edinburgh, Edinburgh, Scotland
    Neuroscientist 11:238-49. 2005
    ..In this article, studies on such individuals are discussed. It is concluded that deficits are apparent in relatives that are similar to but less marked than those seen in patients with schizophrenia...
  8. pmc Correlations between fMRI activation and individual psychotic symptoms in un-medicated subjects at high genetic risk of schizophrenia
    Heather C Whalley
    Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, Scotland, UK
    BMC Psychiatry 7:61. 2007
    ....
  9. doi request reprint Hypofrontality in subjects at high genetic risk of schizophrenia with depressive symptoms
    H C Whalley
    Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, Scotland, UK
    J Affect Disord 109:99-106. 2008
    ..The current study sought to investigate the neural correlates of depression in these subjects. We hypothesised abnormal activation of dorsolateral prefrontal regions in those at high risk with depression...
  10. doi request reprint fMRI changes over time and reproducibility in unmedicated subjects at high genetic risk of schizophrenia
    H C Whalley
    Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, UK
    Psychol Med 39:1189-99. 2009
    ..e. state effects)...
  11. doi request reprint Genetic variation in CNTNAP2 alters brain function during linguistic processing in healthy individuals
    Heather C Whalley
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
    Am J Med Genet B Neuropsychiatr Genet 156:941-8. 2011
    ....
  12. ncbi request reprint Connecting the brain and new drug targets for schizophrenia
    H C Whalley
    Division of Psychiatry, University of Edinburgh, Edinburgh, Scotland, UK
    Curr Pharm Des 15:2615-31. 2009
    ..We conclude that substantial work needs to be done on standardising connectivity analyses across laboratories and that disconnectivity studies should be an integral part of drug discovery programmes...
  13. doi request reprint Effects of the BDNF val66met polymorphism on prefrontal brain function in a population at high genetic risk of schizophrenia
    Heather C Whalley
    Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh, UK
    Am J Med Genet B Neuropsychiatr Genet 153:1474-82. 2010
    ..BDNF may therefore be one of the heritable factors involved in the development of abnormal prefrontal function in schizophrenia. © 2010 Wiley-Liss, Inc...
  14. ncbi request reprint fMRI correlates of state and trait effects in subjects at genetically enhanced risk of schizophrenia
    H C Whalley
    Division of Psychiatry, University of Edinburgh, Edinburgh EH10 5HF, UK
    Brain 127:478-90. 2004
    ....
  15. doi request reprint A common neural system mediating two different forms of social judgement
    J Hall
    Division of Psychiatry, University of Edinburgh, Edinburgh EH10 5HF, UK
    Psychol Med 40:1183-92. 2010
    ..We have investigated healthy control participants to see whether there is a common neural system activated during such social decisions, on the basis that deficits in this system may contribute to the impairments seen in these disorders...
  16. doi request reprint Hippocampal function in schizophrenia and bipolar disorder
    J Hall
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
    Psychol Med 40:761-70. 2010
    ..However, no previous studies have compared hippocampal activation in schizophrenia and bipolar disorder directly...
  17. ncbi request reprint Relationship of catechol-O-methyltransferase variants to brain structure and function in a population at high risk of psychosis
    Andrew M McIntosh
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, United Kingdom
    Biol Psychiatry 61:1127-34. 2007
    ....
  18. ncbi request reprint Methodological issues in volumetric magnetic resonance imaging of the brain in the Edinburgh High Risk Project
    H C Whalley
    Department of Psychiatry, Royal Edinburgh Hospital, UK
    Psychiatry Res 91:31-44. 1999
    ....
  19. ncbi request reprint Brain structure, genetic liability, and psychotic symptoms in subjects at high risk of developing schizophrenia
    S M Lawrie
    Edinburgh University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh, Scotland, United Kingdom
    Biol Psychiatry 49:811-23. 2001
    ..Particular risk factors for schizophrenia may interact at discrete time points of neurodevelopment with different effects on specific brain regions and may represent relatively distinct disease processes...
  20. ncbi request reprint Functional imaging as a predictor of schizophrenia
    Heather C Whalley
    Division of Psychiatry, University of Edinburgh, Edinburgh, Scotland, UK
    Biol Psychiatry 60:454-62. 2006
    ..Prospective studies of young individuals at high risk of schizophrenia allow the investigation of whether neural abnormalities predate development of illness and, if present, have the potential to identify those who may become ill...
  21. pmc Structural MRI of the brain in presumed carriers of genes for schizophrenia, their affected and unaffected siblings
    R M Steel
    University of Edinburgh, Department of Psychiatry, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, UK
    J Neurol Neurosurg Psychiatry 72:455-8. 2002
    ..Schizophrenia is a highly heritable disorder associated with structural brain abnormalities. The aim of this study was to establish if the gene(s) for schizophrenia are associated with specific abnormalities of brain structure...
  22. ncbi request reprint Reduced frontotemporal functional connectivity in schizophrenia associated with auditory hallucinations
    Stephen M Lawrie
    University Department of Psychiatry, Royal Edinburgh Hospital, Morningside Park, Edinburgh, Scotland, UK
    Biol Psychiatry 51:1008-11. 2002
    ..We used functional magnetic resonance imaging (fMRI) to investigate the frontotemporal disconnection hypothesis of schizophrenia...
  23. doi request reprint Functional magnetic resonance imaging of BDNF val66met polymorphism in unmedicated subjects at high genetic risk of schizophrenia performing a verbal memory task
    Benjamin J Baig
    Division of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh, United Kingdom
    Psychiatry Res 183:195-201. 2010
    ....
  24. doi request reprint Deficits in facial, body movement and vocal emotional processing in autism spectrum disorders
    R C M Philip
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
    Psychol Med 40:1919-29. 2010
    ..To date, however, no studies have examined emotion processing in autism across a broad range of social signals...
  25. ncbi request reprint A visual joke fMRI investigation into Theory of Mind and enhanced risk of schizophrenia
    Dominic Marjoram
    University of Edinburgh, Division of Psychiatry, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, UK
    Neuroimage 31:1850-8. 2006
    ..This study is the first time relatives of individuals with schizophrenia have been imaged using a ToM paradigm, and the results provide evidence of both a state and state-mediated trait effect...
  26. doi request reprint Effects of the BDNF Val66Met polymorphism on neural responses to facial emotion
    Prerona Mukherjee
    Division of Psychiatry, University of Edinburg, Edinburg, United Kingdom
    Psychiatry Res 191:182-8. 2011
    ..Together, these effects show significant differences in the neural substrate for fear processing with genetic variation in BDNF...
  27. doi request reprint The effects of DISC1 risk variants on brain activation in controls, patients with bipolar disorder and patients with schizophrenia
    Goultchira Chakirova
    The University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, Scotland, UK
    Psychiatry Res 192:20-8. 2011
    ..These findings may provide a better understanding of the neural effects of DISC1 variants and on the pathophysiology of schizophrenia and bipolar disorder...
  28. ncbi request reprint Neuropsychology, genetic liability, and psychotic symptoms in those at high risk of schizophrenia
    Majella Byrne
    University Department of Psychiatry, University of Edinburgh, Scotland
    J Abnorm Psychol 112:38-48. 2003
    ..These results suggest that what is inherited is not the disorder itself but a state of vulnerability manifested by neuropsychological impairment, occurring in many more individuals than are predicted to develop the disorder...
  29. ncbi request reprint Structural and functional abnormalities of the amygdala in schizophrenia
    Stephen M Lawrie
    Edinburgh University, Department of Psychiatry, Kennedy Tower, Royal Edinburgh Hospital, Edinburgh, Scotland, UK
    Ann N Y Acad Sci 985:445-60. 2003
    ....
  30. doi request reprint Midbrain activation during Pavlovian conditioning and delusional symptoms in schizophrenia
    Liana Romaniuk
    University of Edinburgh, Royal Edinburgh Hospital, Scotland
    Arch Gen Psychiatry 67:1246-54. 2010
    ..Recent theories have suggested that the inappropriate activation of limbic motivational systems in response to neutral stimuli may underlie the development of delusions in schizophrenia...
  31. ncbi request reprint Voxel-based morphometry of grey matter densities in subjects at high risk of schizophrenia
    Dominic E Job
    Department of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, Scotland, UK
    Schizophr Res 64:1-13. 2003
    ..control subjects. In contrast, first episode schizophrenia subjects had less GM than high-risk subjects in several frontal and temporal regions. These results are compatible with the findings of our previous volumetric ROI analysis...
  32. ncbi request reprint Temporal lobe volume changes in people at high risk of schizophrenia with psychotic symptoms
    Stephen M Lawrie
    University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh, UK
    Br J Psychiatry 181:138-43. 2002
    ..Magnetic resonance imaging (MRI) has demonstrated abnormalities of brain structure, particularly of the temporal lobes, in schizophrenia. These are thought to be neurodevelopmental in origin, but when they become evident is unknown...
  33. ncbi request reprint Genetic liability to schizophrenia or bipolar disorder and its relationship to brain structure
    Andrew M McIntosh
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh EH 10 5HF, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 141:76-83. 2006
    ..Genes for bipolar illness might have subtle effects on brain structure, which may need particularly large samples to detect...
  34. ncbi request reprint A neuregulin 1 variant associated with abnormal cortical function and psychotic symptoms
    Jeremy Hall
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Morningside Park, Edinburgh, EH10 5HF, UK
    Nat Neurosci 9:1477-8. 2006
    ..We show that this variant is associated with (i) decreased activation of frontal and temporal lobe regions, (ii) increased development of psychotic symptoms and (iii) decreased premorbid IQ...
  35. ncbi request reprint Empirical comparison of maximal voxel and non-isotropic adjusted cluster extent results in a voxel-based morphometry study of comorbid learning disability with schizophrenia
    T William J Moorhead
    Division of Psychiatry, Image Analysis Laboratory, University of Edinburgh, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, Scotland UK
    Neuroimage 28:544-52. 2005
    ....
  36. ncbi request reprint The neurobiological underpinnings of risk and conversion in relatives of patients with schizophrenia
    Heather C Whalley
    Division of Psychiatry, University of Edinburgh, Scotland, UK
    Int Rev Psychiatry 19:383-97. 2007
    ..The literature on predictors of conversion in people at genetic high risk is much smaller, but suggests a combination of baseline trait severity and further change in key measures...
  37. ncbi request reprint Grey matter changes over time in high risk subjects developing schizophrenia
    Dominic E Job
    Division of Psychiatry, University of Edinburgh, The Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, Scotland, UK
    Neuroimage 25:1023-30. 2005
    ..These particular reductions may therefore be able to predict the later onset of schizophrenia...
  38. ncbi request reprint Voxel-based morphometry of comorbid schizophrenia and learning disability: analyses in normalized and native spaces using parametric and nonparametric statistical methods
    T William J Moorhead
    Image Analysis Laboratory, Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh EH10 5HF, Scotland, UK
    Neuroimage 22:188-202. 2004
    ..VBM has the facility to compare grey matter distributions in this structurally diverse cohort...
  39. doi request reprint Prefrontal function and activation in bipolar disorder and schizophrenia
    Andrew M McIntosh
    Division of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Edinburgh, UK
    Am J Psychiatry 165:378-84. 2008
    ..The authors sought to determine whether there are differences in language-associated prefrontal activation that discriminate bipolar disorder and schizophrenia...
  40. doi request reprint Overactivation of fear systems to neutral faces in schizophrenia
    Jeremy Hall
    Division of Psychiatry, University of Edinburgh, United Kingdom
    Biol Psychiatry 64:70-3. 2008
    ..We investigated whether the apparent decrease in amygdala activation in schizophrenia could actually derive from increased amygdala activation to the neutral comparator stimuli...
  41. doi request reprint Genetic variation in the DAOA (G72) gene modulates hippocampal function in subjects at high risk of schizophrenia
    Jeremy Hall
    Division of Psychiatry, University of Edinburgh, United Kingdom
    Biol Psychiatry 64:428-33. 2008
    ..Preliminary evidence in healthy control subjects has implicated genetic variation in the DAOA gene in the modulation of hippocampal complex and prefrontal cortex activation...
  42. ncbi request reprint Structural gray matter differences between first-episode schizophrenics and normal controls using voxel-based morphometry
    Dominic E Job
    Department of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, Scotland, United Kingdom
    Neuroimage 17:880-9. 2002
    ..These results are compatible with and extend the relevant findings of the previous volumetric ROI analysis, when allowing for the differences between the methods and interpretation of their results...
  43. ncbi request reprint Event-related fMRI of word classification and successful word recognition in subjects at genetically enhanced risk of schizophrenia
    Marie Claire Whyte
    Division of Psychiatry, University of Edinburgh, UK
    Psychol Med 36:1427-39. 2006
    ..These deficits are also reflected in the small number of similar investigations in unaffected biological relatives. However, it is unclear the extent to which dysfunction is genetically mediated or a feature of the established illness...
  44. ncbi request reprint Accuracy and reproducibility of simple cross-sectional linear and area measurements of brain structures and their comparison with volume measurements
    H C Whalley
    Department of Psychiatry, University of Edinburgh, Edinburgh, UK
    Neuroradiology 43:263-71. 2001
    ..In circumstances where a large volume of work precludes detailed volume measurement, simple methods are reliable and can be used instead...
  45. ncbi request reprint Parcellating the temporal lobes from magnetic resonance images using generic software in subjects at high risk of developing schizophrenia
    Shona L Yates
    Division of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, UK
    Psychiatry Res 147:197-212. 2006
    ..It is, however, a laborious process, and it remains uncertain whether it is more sensitive to early disease processes in pre-schizophrenia than are other image-analysis techniques...
  46. doi request reprint Functional Magnetic Resonance Imaging (fMRI) reproducibility and variance components across visits and scanning sites with a finger tapping task
    Viktoria Eleni Gountouna
    Division of Psychiatry, The University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
    Neuroimage 49:552-60. 2010
    ....