Roy O Weller

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. ncbi Lymphocyte targeting of the central nervous system: a review of afferent and efferent CNS-immune pathways
    R O Weller
    Department of Pathology Neuropathology, Southampton University School of Medicine, Southampton General Hospital, UK
    Brain Pathol 6:275-88. 1996
  2. pmc Population studies of sporadic cerebral amyloid angiopathy and dementia: a systematic review
    Hannah A D Keage
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    BMC Neurol 9:3. 2009
  3. doi Microvasculature changes and cerebral amyloid angiopathy in Alzheimer's disease and their potential impact on therapy
    Roy O Weller
    Clinical Neurosciences, University of Southampton School of Medicine, LD74, South Laboratory and Pathology Block, Southampton General Hospital, Southampton SO166YD, UK
    Acta Neuropathol 118:87-102. 2009
  4. doi Lymphatic drainage of the brain and the pathophysiology of neurological disease
    Roy O Weller
    Clinical Neurosciences, Southampton General Hospital, University of Southampton School of Medicine, LD74, South Lab and Path Block, Southampton, SO16 6YD, UK
    Acta Neuropathol 117:1-14. 2009
  5. doi Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer's disease
    Roy O Weller
    Clinical Neurosciences, School of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK
    Brain Pathol 18:253-66. 2008
  6. ncbi Pathophysiology of dementias and implications for therapy
    O Weller Roy
    Clinical Neurosciences, Mailpoint 813, Southampton General Hospital, Southampton, SO16 6YD, UK
    Indian J Pathol Microbiol 48:289-99. 2005
  7. ncbi Microscopic morphology and histology of the human meninges
    R O Weller
    Clinical Neurosciences, Southampton University School of Medicine, Mail Point 813, Southampton General Hospital, Southampton SO16 6YD, UK
    Morphologie 89:22-34. 2005
  8. ncbi Cerebrovascular disease and the pathophysiology of Alzheimer's disease. Implications for therapy
    R O Weller
    Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK
    Panminerva Med 46:239-51. 2004
  9. ncbi Cerebral amyloid angiopathy: pathogenesis and effects on the ageing and Alzheimer brain
    Roy O Weller
    Division of Clinical Neurosciences, University of Southampton School of Medicine, Southampton, UK
    Neurol Res 25:611-6. 2003
  10. pmc Cerebral amyloid angiopathy: amyloid beta accumulates in putative interstitial fluid drainage pathways in Alzheimer's disease
    R O Weller
    Department of Neuropathology, University of Southampton Medical School, Southampton General Hospital, United Kingdom
    Am J Pathol 153:725-33. 1998

Collaborators

Detail Information

Publications31

  1. ncbi Lymphocyte targeting of the central nervous system: a review of afferent and efferent CNS-immune pathways
    R O Weller
    Department of Pathology Neuropathology, Southampton University School of Medicine, Southampton General Hospital, UK
    Brain Pathol 6:275-88. 1996
    ....
  2. pmc Population studies of sporadic cerebral amyloid angiopathy and dementia: a systematic review
    Hannah A D Keage
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    BMC Neurol 9:3. 2009
    ..We searched the literature for prospective population-based epidemiological clinicopathological studies, free of the biases of other sampling techniques, which were used as a comparison...
  3. doi Microvasculature changes and cerebral amyloid angiopathy in Alzheimer's disease and their potential impact on therapy
    Roy O Weller
    Clinical Neurosciences, University of Southampton School of Medicine, LD74, South Laboratory and Pathology Block, Southampton General Hospital, Southampton SO166YD, UK
    Acta Neuropathol 118:87-102. 2009
    ..Drainage of Abeta along perivascular pathways in ageing artery walls may need to be improved to maximise the potential for improvement of cognitive function with immunotherapy...
  4. doi Lymphatic drainage of the brain and the pathophysiology of neurological disease
    Roy O Weller
    Clinical Neurosciences, Southampton General Hospital, University of Southampton School of Medicine, LD74, South Lab and Path Block, Southampton, SO16 6YD, UK
    Acta Neuropathol 117:1-14. 2009
    ....
  5. doi Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer's disease
    Roy O Weller
    Clinical Neurosciences, School of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK
    Brain Pathol 18:253-66. 2008
    ..Therapeutic strategies that improve elimination of Abeta and other soluble metabolites from the brain may prevent cognitive decline in Alzheimer's disease...
  6. ncbi Pathophysiology of dementias and implications for therapy
    O Weller Roy
    Clinical Neurosciences, Mailpoint 813, Southampton General Hospital, Southampton, SO16 6YD, UK
    Indian J Pathol Microbiol 48:289-99. 2005
    ..Reducing cerebrovascular disease and facilitating elimination of Abeta along perivascular drainage routes may offer long-term preventative measuresfor both Vascular Dementia and for Alzheimer's disease...
  7. ncbi Microscopic morphology and histology of the human meninges
    R O Weller
    Clinical Neurosciences, Southampton University School of Medicine, Mail Point 813, Southampton General Hospital, Southampton SO16 6YD, UK
    Morphologie 89:22-34. 2005
    ..Despite the multiple anatomical arrangements and physiological functions, leptomeningeal cells retain many histological features that are similar from site to site...
  8. ncbi Cerebrovascular disease and the pathophysiology of Alzheimer's disease. Implications for therapy
    R O Weller
    Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK
    Panminerva Med 46:239-51. 2004
    ..Therapies for AD are reviewed, especially those involving immunotherapy for the removal of insoluble Abeta from the cerebral cortex and the facilitation of drainage of ISF and soluble Abeta from the brain...
  9. ncbi Cerebral amyloid angiopathy: pathogenesis and effects on the ageing and Alzheimer brain
    Roy O Weller
    Division of Clinical Neurosciences, University of Southampton School of Medicine, Southampton, UK
    Neurol Res 25:611-6. 2003
    ..If therapeutic agents, including anti-A beta antibodies, are to be used to eliminate A beta in the treatment of Alzheimer's disease, the effects of CAA on the treatment and the effects of the treatment on the CAA need to be considered...
  10. pmc Cerebral amyloid angiopathy: amyloid beta accumulates in putative interstitial fluid drainage pathways in Alzheimer's disease
    R O Weller
    Department of Neuropathology, University of Southampton Medical School, Southampton General Hospital, United Kingdom
    Am J Pathol 153:725-33. 1998
    ..These observations support the hypothesis that Abeta is deposited in periarterial interstitial fluid drainage pathways of the brain and contributes significantly to cerebral amyloid angiopathy in Alzheimer's disease...
  11. ncbi How well does the CSF inform upon pathology in the brain in Creutzfeldt-Jakob and Alzheimer's diseases?
    R O Weller
    Department of Microbiology and Pathology, University of Southampton School of Medicine, Southampton General Hospital, Southampton SO16 6YD, UK
    J Pathol 194:1-3. 2001
    ..In both diseases, facilitation of ISF drainage and elimination of PrP and Abeta peptides from the extracellular spaces of the brain may lead to practical therapeutic strategies for these devastating disorders...
  12. ncbi Cerebrovascular disease is a major factor in the failure of elimination of Abeta from the aging human brain: implications for therapy of Alzheimer's disease
    Roy O Weller
    Neuropathology, Division of Clinical Neurosciences, University of Southampton School of Medicine, Mail Point 813, Southampton SO16 6YD, United Kingdom
    Ann N Y Acad Sci 977:162-8. 2002
    ..Therapies to increase elimination of Abeta in AD need to consider the effects of CVD on the elimination of Abeta from the aging human brain...
  13. ncbi [Immunologic significance of lymphatic drainage of the brain]
    R O Weller
    Department of Pathology Neuropathology, Southampton General Hospital, UK
    Bull Acad Natl Med 181:661-7; discussion 667-71. 1997
    ..If similar mechanisms apply in man, study of cervical lymphocytes and their manipulation could open new therapeutic avenues for the treatment of multiple sclerosis...
  14. ncbi Cerebral amyloid angiopathy: accumulation of A beta in interstitial fluid drainage pathways in Alzheimer's disease
    R O Weller
    Department of Neuropathology, University of Southampton, UK
    Ann N Y Acad Sci 903:110-7. 2000
    ..Elucidation of factors that reduce elimination of A beta via perivascular drainage pathways may lead to their rectification and to new strategies for treatment of Alzheimer's disease...
  15. doi Regional differences in the morphological and functional effects of aging on cerebral basement membranes and perivascular drainage of amyloid-β from the mouse brain
    Cheryl A Hawkes
    Faculty of Medicine, South Lab and Pathology Block, Southampton General Hospital, University of Southampton, Southampton, SO16 6YD, UK
    Aging Cell 12:224-36. 2013
    ....
  16. ncbi Cerebral amyloid angiopathy plays a direct role in the pathogenesis of Alzheimer's disease. Pro-CAA position statement
    James A R Nicoll
    Clinical Neurosciences, University of Southampton, Southampton General Hospital, Mailpoint 813, Southampton, SO 16 6YD, UK
    Neurobiol Aging 25:589-97; discussion 603-4. 2004
    ..Increased concentration of soluble Abeta leads to the formation of insoluble Abeta plaques, other features of AD pathology, and dementia...
  17. pmc Disruption of arterial perivascular drainage of amyloid-β from the brains of mice expressing the human APOE ε4 allele
    Cheryl A Hawkes
    Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
    PLoS ONE 7:e41636. 2012
    ..This effect may be mediated, in part, by changes in age-related expression of basement membrane proteins in the cerebral vasculature...
  18. ncbi Immunotherapy for Alzheimer's disease and other dementias
    Delphine Boche
    Division of Clinical Neurosciences, University of Southampton, School of Medicine, Southampton General Hospital, Southampton, SO16 6YD, UK
    Curr Opin Neurol 18:720-5. 2005
    ..The aim of this article is to review the role of immunotherapy in the removal of proteins which accumulate abnormally in neurodegenerative disorders associated with dementia, in particular amyloid-beta accumulation in Alzheimer's disease...
  19. doi Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy
    Cheryl A Hawkes
    Division of Clinical Neurosciences, Southampton General Hospital, University of Southampton, South Lab and Pathology Block, LD66 Mailpoint 806, Tremona Road, Southampton, Hampshire, SO166YD, UK
    Acta Neuropathol 121:431-43. 2011
    ..These findings have implications for the success of therapeutic strategies for the treatment of AD that rely upon the health of the ageing cerebral vasculature...
  20. pmc Interaction of Neisseria meningitidis with human meningeal cells induces the secretion of a distinct group of chemotactic, proinflammatory, and growth-factor cytokines
    Myron Christodoulides
    Molecular Microbiology and Infection, Division of Infection, Inflammation and Repair, University of Southampton Medical School, Southampton General Hospital, United Kingdom
    Infect Immun 70:4035-44. 2002
    ....
  21. doi Consequence of Abeta immunization on the vasculature of human Alzheimer's disease brain
    D Boche
    Division of Clinical Neurosciences, University of Southampton, Southampton General Hospital, Southampton, UK
    Brain 131:3299-310. 2008
    ..The extent to which these vascular alterations following Abeta immunization in Alzheimer's disease are reflected in changes in cognitive function remains to be determined...
  22. ncbi Mechanisms to explain the reverse perivascular transport of solutes out of the brain
    D Schley
    Department of Medical Physics and Bioengineering, Southampton University Hospitals NHS Trust, Southampton General Hospital, Southampton, Hampshire SO16 6YD, UK
    J Theor Biol 238:962-74. 2006
    ..These factors may play a role in the pathogenesis of cerebral amyloid angiopathy and in the accumulation of Abeta in the brain in Alzheimer's disease...
  23. ncbi Capillary and arterial cerebral amyloid angiopathy in Alzheimer's disease: defining the perivascular route for the elimination of amyloid beta from the human brain
    S D Preston
    Neuropathology, Division of Clinical Neurosciences, University of Southampton School of Medicine, Southampton, UK
    Neuropathol Appl Neurobiol 29:106-17. 2003
    ..Such factors might affect therapies for AD that entail administration of anti-Abeta antibodies to eliminate Abeta from the human brain...
  24. ncbi Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report
    James A R Nicoll
    Division of Clinical Neurosciences, University of Southampton, Southampton, UK
    Nat Med 9:448-52. 2003
    ..The T-lymphocyte meningoencephalitis is likely to correspond to the side effect seen in some other patients who received AN-1792 (refs. 7-9)...
  25. ncbi A new role for astrocytes: beta-amyloid homeostasis and degradation
    James A R Nicoll
    Clinical Neurosciences, University of Southampton, Mailpoint 813, Southampton General Hospital, Southampton SO16 6YD, UK
    Trends Mol Med 9:281-2. 2003
  26. ncbi Different meningitis-causing bacteria induce distinct inflammatory responses on interaction with cells of the human meninges
    Mark I Fowler
    Molecular Microbiology and Infection, Division of Infection, Inflammation and Repair, University of Southampton Medical School, Southampton General Hospital, Southampton SO16 6YD, UK
    Cell Microbiol 6:555-67. 2004
    ....
  27. doi Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology
    R O Carare
    Clinical Neurosciences, University of Southampton, UK
    Neuropathol Appl Neurobiol 34:131-44. 2008
    ..This atypical pattern of drainage may contribute to partial immune privilege of the brain and play a role in neuroimmunological diseases such as multiple sclerosis...
  28. ncbi Cytokine-induced enhancement of autoimmune inflammation in the brain and spinal cord: implications for multiple sclerosis
    D Sun
    Pathology and Clinical Neurosciences Neuropathology, University of Southampton, Southampton, UK
    Neuropathol Appl Neurobiol 30:374-84. 2004
    ..Conclusion: local changes in the release of pro-inflammatory cytokines within the brain in EAE results in the widespread enhancement of autoimmune inflammation within the brain and cord, and exacerbation of clinical symptoms...
  29. pmc Cortical and leptomeningeal cerebrovascular amyloid and white matter pathology in Alzheimer's disease
    Alex E Roher
    The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, AZ 85351, USA
    Mol Med 9:112-22. 2003
    ..This failure of fluid drainage has implications for therapeutic strategies to treat Alzheimer's disease...
  30. ncbi The phagocytic capacity of neurones
    Samantha Bowen
    Neuroscience Centre and Pathology Group, Queen Mary s School of Medicine and Dentistry, Institute of Pathology, Royal London Hospital, London, UK
    Eur J Neurosci 25:2947-55. 2007
    ....
  31. ncbi Cerebral amyloid angiopathy: both viper and maggot in the brain
    Roy O Weller
    Ann Neurol 58:348-50. 2005