C Weissmann

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi A mouse to remember
    Charles Weissmann
    MRC Prion Unit, Department of Neurodegenerative Disease, Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom
    Cell 116:S111-3, 2 p following S113. 2004
  2. ncbi Approaches to therapy of prion diseases
    Charles Weissmann
    Department of Neurodegenerative Disease MRC Prion Unit, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Annu Rev Med 56:321-44. 2005
  3. ncbi Transmission of prions
    C Weissmann
    Medical Research Council Prion Unit, Department of Neurodegenerative Disease, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    J Infect Dis 186:S157-65. 2002
  4. ncbi Molecular biology of prions
    Charles Weissmann
    MRC Prion Unit, Department of Neurodegenerative Disease, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Acta Neurobiol Exp (Wars) 62:153-66. 2002
  5. ncbi Transmission of prions
    C Weissmann
    Medical Research Council Prion Unit, Department of Neurodegenerative Disease, Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom
    Proc Natl Acad Sci U S A 99:16378-83. 2002
  6. ncbi The state of the prion
    Charles Weissmann
    MRC Prion Unit, Department of Neurodegenerative Disease, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Nat Rev Microbiol 2:861-71. 2004
  7. ncbi PrP knock-out and PrP transgenic mice in prion research
    C Weissmann
    MRC Prion Unit, Department of Neurodegenerative Disease, Institute of Neurology, London, UK
    Br Med Bull 66:43-60. 2003
  8. ncbi Scrapie prion protein accumulation by scrapie-infected neuroblastoma cells abrogated by exposure to a prion protein antibody
    M Enari
    Medical Research Council Prion Unit, Neurogenetics, Imperial College School of Medicine at St. Mary's, London W2 1PG, United Kingdom
    Proc Natl Acad Sci U S A 98:9295-9. 2001
  9. ncbi Ethical issues in human prion diseases
    S J Tabrizi
    Department of Neurodegenerative Disease/MRC Prion Unit, Institute of Neurology, London, UK
    Br Med Bull 66:305-16. 2003
  10. ncbi Molecular genetics of transmissible spongiform encephalopathies: an introduction
    Charles Weissmann
    MRC Prion Unit, Department of Neurodegenerative Disease, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    J Toxicol Sci 27:69-77. 2002

Collaborators

  • E Flechsig
  • John Collinge
  • A J Raeber
  • A Aguzzi
  • L Stoltze
  • Daniela Rossi
  • Jürgen Götz
  • Mathias Heikenwalder
  • Sukhvir P Mahal
  • Graham S Jackson
  • Christian Julius
  • Jackie Linehan
  • Sebastian Brandner
  • Julie A Edgeworth
  • Julie Ann Edgeworth
  • Peter Christian Klohn
  • Cheryl A Demczyk
  • Emery W Smith
  • M Enari
  • Anthony R Clarke
  • Lucy Anderson
  • P C Klöhn
  • S J Tabrizi
  • Nathalie Gros
  • Jonathan D F Wadsworth
  • Susan Joiner
  • Jack Alden
  • Harald Seeger
  • Peter Klöhn
  • Gregor Hutter
  • Gino Miele
  • Peter-Christian Klohn
  • Veronika Kana
  • Jan Kranich
  • Ulrich Wagner
  • Christopher A Baker
  • Edward McKintosh
  • Kanella Prodromidou
  • Petra Hirsch
  • C L Elliott

Detail Information

Publications22

  1. ncbi A mouse to remember
    Charles Weissmann
    MRC Prion Unit, Department of Neurodegenerative Disease, Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom
    Cell 116:S111-3, 2 p following S113. 2004
  2. ncbi Approaches to therapy of prion diseases
    Charles Weissmann
    Department of Neurodegenerative Disease MRC Prion Unit, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Annu Rev Med 56:321-44. 2005
    ....
  3. ncbi Transmission of prions
    C Weissmann
    Medical Research Council Prion Unit, Department of Neurodegenerative Disease, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    J Infect Dis 186:S157-65. 2002
    ..This property, first observed in a clinical setting, is now being investigated in experimental settings, both in animals and in cell culture...
  4. ncbi Molecular biology of prions
    Charles Weissmann
    MRC Prion Unit, Department of Neurodegenerative Disease, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Acta Neurobiol Exp (Wars) 62:153-66. 2002
    ..This property, first observed in a clinical setting, is now being investigated in experimental settings, both in animals and in cell culture...
  5. ncbi Transmission of prions
    C Weissmann
    Medical Research Council Prion Unit, Department of Neurodegenerative Disease, Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom
    Proc Natl Acad Sci U S A 99:16378-83. 2002
    ..This property, first observed in a clinical setting, is now being investigated in experimental settings, both in animals and in cell culture...
  6. ncbi The state of the prion
    Charles Weissmann
    MRC Prion Unit, Department of Neurodegenerative Disease, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Nat Rev Microbiol 2:861-71. 2004
    ..The precise structure of the prion is not yet known, nor are the mechanisms of infection, conformational conversion and pathogenesis understood...
  7. ncbi PrP knock-out and PrP transgenic mice in prion research
    C Weissmann
    MRC Prion Unit, Department of Neurodegenerative Disease, Institute of Neurology, London, UK
    Br Med Bull 66:43-60. 2003
    ..In addition, the availability of PrP knock-out mice provided an approach to carry out reverse genetics on PrP, both in regard to prion disease and to its physiological role...
  8. ncbi Scrapie prion protein accumulation by scrapie-infected neuroblastoma cells abrogated by exposure to a prion protein antibody
    M Enari
    Medical Research Council Prion Unit, Neurogenetics, Imperial College School of Medicine at St. Mary's, London W2 1PG, United Kingdom
    Proc Natl Acad Sci U S A 98:9295-9. 2001
    ..These findings encourage the belief that passive immunization may provide a therapeutic approach to prion disease...
  9. ncbi Ethical issues in human prion diseases
    S J Tabrizi
    Department of Neurodegenerative Disease/MRC Prion Unit, Institute of Neurology, London, UK
    Br Med Bull 66:305-16. 2003
    ..In this chapter, we outline ethical questions posed by research, diagnostic procedures and therapy in the field of prion diseases...
  10. ncbi Molecular genetics of transmissible spongiform encephalopathies: an introduction
    Charles Weissmann
    MRC Prion Unit, Department of Neurodegenerative Disease, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    J Toxicol Sci 27:69-77. 2002
    ..How these murine models for human prion-related disease would contribute to the presently ongoing TSE research?..
  11. ncbi A quantitative, highly sensitive cell-based infectivity assay for mouse scrapie prions
    P C Klöhn
    Medical Research Council Prion Unit, Department of Neurodegenerative Disease, Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, United Kingdom
    Proc Natl Acad Sci U S A 100:11666-71. 2003
    ..SC assays performed in a more time-consuming end point titration format extend the sensitivity and show that infectivity titers measured in tissue culture and in the mouse are similar...
  12. ncbi Prions and the lymphoreticular system
    C Weissmann
    Medical Research Council Prion Unit, Imperial College School of Medicine at St Mary s, Norfolk Place, London W2 1PG, UK
    Philos Trans R Soc Lond B Biol Sci 356:177-84. 2001
    ....
  13. ncbi Transgene-driven expression of the Doppel protein in Purkinje cells causes Purkinje cell degeneration and motor impairment
    Lucy Anderson
    Medical Research Council Prion Unit and Department of Neurodegenerative Disease, and Division of Neuropathology, Institute of Neurology, University College, Queen Square, London WC1N 3BG, United Kingdom
    Proc Natl Acad Sci U S A 101:3644-9. 2004
    ..A similar situation was reported for the corresponding TgL7-DeltaPrP mice supporting the concept that Dpl and DeltaPrP cause cell death, possibly by interfering with a common signaling cascade essential for cell survival...
  14. ncbi An enzyme-detergent method for effective prion decontamination of surgical steel
    Graham S Jackson
    MRC Prion Unit, Department of Neurodegenerative Disease, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    J Gen Virol 86:869-78. 2005
    ..The prion-degrading reagents identified in this study are readily available, inexpensive, non-corrosive to instruments, non-hazardous to staff and compatible with current equipment and procedures used in hospital sterilization units...
  15. ncbi Highly sensitive, quantitative cell-based assay for prions adsorbed to solid surfaces
    Julie Ann Edgeworth
    Medical Research Council Prion Unit, Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom
    Proc Natl Acad Sci U S A 106:3479-83. 2009
    ..In addition, its specific application in assay of metal-bound prions allows evaluation of novel prion decontamination methods...
  16. ncbi Spontaneous generation of mammalian prions
    Julie A Edgeworth
    Medical Research Council Prion Unit, Department of Neurodegenerative Disease, University College London Institute of Neurology, London WC1N 3BG, United Kingdom
    Proc Natl Acad Sci U S A 107:14402-6. 2010
    ..Alternatively, if prions were naturally present in the brain at levels not detectable by conventional methods, metal surfaces might concentrate them to the extent that they become quantifiable by the scrapie cell assay...
  17. ncbi Birth of a prion: spontaneous generation revisited
    Charles Weissmann
    Scripps Florida, Jupiter 33480, USA
    Cell 122:165-8. 2005
    ..Recent work shows that the agent, the prion, can be replicated in a cell-free system, that it can be generated de novo, and that the strain-specific properties of prions are encoded by conformational variations of the underlying protein...
  18. ncbi Chronic lymphocytic inflammation specifies the organ tropism of prions
    Mathias Heikenwalder
    Institute of Neuropathology, University Hospital of Zurich, CH 8091 Zurich, Switzerland
    Science 307:1107-10. 2005
    ..By expanding the tissue distribution of prions, chronic inflammatory conditions may act as modifiers of natural and iatrogenic prion transmission...
  19. ncbi Transcriptional stability of cultured cells upon prion infection
    Christian Julius
    Institute of Neuropathology, University Hospital of Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    J Mol Biol 375:1222-33. 2008
    ..We conclude that, surprisingly, there are no universal transcriptional changes induced by prion infection of neural cells in vitro...
  20. ncbi Assaying prions in cell culture: the standard scrapie cell assay (SSCA) and the scrapie cell assay in end point format (SCEPA)
    Sukhvir P Mahal
    Department of Infectology, Scripps Florida, Jupiter, FL, USA
    Methods Mol Biol 459:49-68. 2008
    ..Assays performed in a more time-consuming end point titration format extend the sensitivity and show that infectivity titers measured in tissue culture and in the mouse are similar...
  21. ncbi Expression of truncated PrP targeted to Purkinje cells of PrP knockout mice causes Purkinje cell death and ataxia
    Eckhard Flechsig
    Institut fur Molekularbiologie, Universitat Zurich, CH 8057 Zurich, Switzerland
    EMBO J 22:3095-101. 2003
    ..Doppel and truncated PrP probably cause Purkinje cell degeneration by the same mechanism...
  22. ncbi Prion strain discrimination in cell culture: the cell panel assay
    Sukhvir P Mahal
    Department of Infectology, Scripps Florida, 5353 Parkside Drive, Jupiter, FL 33458, USA
    Proc Natl Acad Sci U S A 104:20908-13. 2007
    ....