Philippe Chessex

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. ncbi The mode of delivery of parenteral multivitamins influences nutrient handling in an animal model of total parenteral nutrition
    Philippe Chessex
    Division of Neonatology, Children s and Women s Health Centre of British Columbia, Vancouver, BC, Canada
    Clin Nutr 24:281-7. 2005
  2. ncbi In preterm neonates, is the risk of developing bronchopulmonary dysplasia influenced by the failure to protect total parenteral nutrition from exposure to ambient light?
    Philippe Chessex
    Division of Neonatology, Children s and Women s Health Centre of British Columbia, and University of British Columbia, Vancouver, British Columbia, Canada
    J Pediatr 151:213-4. 2007
  3. doi Early life events, sex, and arterial blood pressure in critically ill infants
    Philippe Chessex
    Division of Neonatology, Departments of Pediatrics, Children s and Women s Health Centre of BC and University of British Columbia, Vancouver, BC, Canada
    Pediatr Crit Care Med 11:75-81. 2010
  4. ncbi Variations in metabolic response to TPN are influenced more by sex than by light exposure
    Adele Harrison
    Division of Neonatology, Children s and Women s Hospitals, University of British Columbia, Vancouver, Canada
    J Pediatr Gastroenterol Nutr 45:577-81. 2007
  5. doi Inflammatory response in preterm infants is induced early in life by oxygen and modulated by total parenteral nutrition
    Pascal M Lavoie
    Division of Neonatology, Children s and Women s Health Centre of British Columbia, University of British Columbia, Vancouver, BC, Canada
    Pediatr Res 68:248-51. 2010
  6. ncbi Influence of shielding TPN from photooxidation on the number of early blood transfusions in ELBW premature neonates
    Amélie Stritzke
    Department of Pediatrics, Division of Neonatology, Children s and Women s Health Center of BC, Vancouver, BC, Canada
    J Pediatr Gastroenterol Nutr 55:398-402. 2012
  7. doi Impact of shielding parenteral nutrition from light on routine monitoring of blood glucose and triglyceride levels in preterm neonates
    Minesh Khashu
    Division of Neonatology, Children s and Women s Health Centre of British Columbia, 4480 Oak Street, Vancouver, BC, Canada
    Arch Dis Child Fetal Neonatal Ed 94:F111-5. 2009
  8. doi Determinants of oxidant stress in extremely low birth weight premature infants
    Philippe Chessex
    Division of Neonatology, Department of Pediatrics, Children s and Women s Health Centre of British Columbia, University of British Columbia, Vancouver, BC, Canada V6H 3V4
    Free Radic Biol Med 49:1380-6. 2010
  9. doi Shielding parenteral nutrition from light: does the available evidence support a randomized, controlled trial?
    Rebecca Sherlock
    Division of Neonatology, Children s and Women s Hospitals, 4480 Oak St, Vancouver, British Columbia, Canada V6H 3V4
    Pediatrics 123:1529-33. 2009
  10. ncbi Photoprotection of parenteral nutrition enhances advancement of minimal enteral nutrition in preterm infants
    Minesh Khashu
    Division of Neonatology, Children s and Women s Health Centre of British Columbia, University of British Columbia, 4480 Oak Street, Vancouver, BC, Canada
    Semin Perinatol 30:139-45. 2006

Collaborators

  • Jean Claude Lavoie
  • P M Lavoie
  • Jean Pierre Chanoine
  • Minesh Khashu
  • Adele Harrison
  • Thérèse Rouleau
  • Amélie Stritzke
  • Avash J Singh
  • Rebecca Sherlock
  • James Friel
  • Vikki Lalari
  • Joyce C Wong
  • Laurent Knafo
  • Juliet Farquhar
  • Sophie Laborie
  • Valérie Turcot
  • Kyle Lee
  • Vadim Bronshtein
  • James E Potts
  • Marianne Tofan
  • Jasvinder Aulakh
  • Andrew Gow
  • Albert R McDougal
  • Marjolan Pineault
  • Jane Gardiner
  • Michael Sargent
  • Alejandra Valenzuela
  • Mark Heiman
  • Richard Wach
  • Alfred C K Wong

Detail Information

Publications25

  1. ncbi The mode of delivery of parenteral multivitamins influences nutrient handling in an animal model of total parenteral nutrition
    Philippe Chessex
    Division of Neonatology, Children s and Women s Health Centre of British Columbia, Vancouver, BC, Canada
    Clin Nutr 24:281-7. 2005
    ..Adding multivitamins (MVP) to the lipid emulsion (MVP+LIP) rather than to the amino acid+dextrose moiety of TPN (AA+MVP) limits the effects of light exposure on lipid peroxidation and vitamin loss...
  2. ncbi In preterm neonates, is the risk of developing bronchopulmonary dysplasia influenced by the failure to protect total parenteral nutrition from exposure to ambient light?
    Philippe Chessex
    Division of Neonatology, Children s and Women s Health Centre of British Columbia, and University of British Columbia, Vancouver, British Columbia, Canada
    J Pediatr 151:213-4. 2007
    ..In preterm infants, photoprotection of TPN is associated with a 30% reduction in bronchopulmonary dysplasia in a post-hoc analysis. This analysis provides justification for a randomized controlled trial...
  3. doi Early life events, sex, and arterial blood pressure in critically ill infants
    Philippe Chessex
    Division of Neonatology, Departments of Pediatrics, Children s and Women s Health Centre of BC and University of British Columbia, Vancouver, BC, Canada
    Pediatr Crit Care Med 11:75-81. 2010
    ..Girls may be better protected against an oxidant load than boys. We questioned whether shielding total parenteral nutrition may have cardiovascular effects that are influenced by gender...
  4. ncbi Variations in metabolic response to TPN are influenced more by sex than by light exposure
    Adele Harrison
    Division of Neonatology, Children s and Women s Hospitals, University of British Columbia, Vancouver, Canada
    J Pediatr Gastroenterol Nutr 45:577-81. 2007
    ..We hypothesized that photo-protection improves the metabolic response to TPN...
  5. doi Inflammatory response in preterm infants is induced early in life by oxygen and modulated by total parenteral nutrition
    Pascal M Lavoie
    Division of Neonatology, Children s and Women s Health Centre of British Columbia, University of British Columbia, Vancouver, BC, Canada
    Pediatr Res 68:248-51. 2010
    ..The choice of a TPN admixture may have important consequences on the systemic inflammatory response triggered by an oxidant stress...
  6. ncbi Influence of shielding TPN from photooxidation on the number of early blood transfusions in ELBW premature neonates
    Amélie Stritzke
    Department of Pediatrics, Division of Neonatology, Children s and Women s Health Center of BC, Vancouver, BC, Canada
    J Pediatr Gastroenterol Nutr 55:398-402. 2012
    ..Shielding TPN from light limits oxidation. Our hypothesis was protecting TPN from light decreases haemolysis and therefore the need for early blood transfusions...
  7. doi Impact of shielding parenteral nutrition from light on routine monitoring of blood glucose and triglyceride levels in preterm neonates
    Minesh Khashu
    Division of Neonatology, Children s and Women s Health Centre of British Columbia, 4480 Oak Street, Vancouver, BC, Canada
    Arch Dis Child Fetal Neonatal Ed 94:F111-5. 2009
    ..Oxidative stress impairs glucose uptake and affects lipid metabolism. Hypothesis: products of photo-oxidation contaminating TPN affect lipid metabolism...
  8. doi Determinants of oxidant stress in extremely low birth weight premature infants
    Philippe Chessex
    Division of Neonatology, Department of Pediatrics, Children s and Women s Health Centre of British Columbia, University of British Columbia, Vancouver, BC, Canada V6H 3V4
    Free Radic Biol Med 49:1380-6. 2010
    ..The impact of these findings relates to a strong association between a more oxidized redox potential and later bronchopulmonary dysplasia, a clinical marker of oxidant stress...
  9. doi Shielding parenteral nutrition from light: does the available evidence support a randomized, controlled trial?
    Rebecca Sherlock
    Division of Neonatology, Children s and Women s Hospitals, 4480 Oak St, Vancouver, British Columbia, Canada V6H 3V4
    Pediatrics 123:1529-33. 2009
    ..Our hypothesis was that shielding total parenteral nutrition from ambient light is linked to clinical benefits...
  10. ncbi Photoprotection of parenteral nutrition enhances advancement of minimal enteral nutrition in preterm infants
    Minesh Khashu
    Division of Neonatology, Children s and Women s Health Centre of British Columbia, University of British Columbia, 4480 Oak Street, Vancouver, BC, Canada
    Semin Perinatol 30:139-45. 2006
    ..Since photo-protection of TPN decreases peroxide generation, we hypothesized that shielding TPN from light may improve the establishment of minimal enteral nutrition in preterm infants...
  11. doi Vitamin A is systemically bioavailable after intratracheal administration with surfactant in an animal model of newborn respiratory distress
    Avash J Singh
    Department of Pediatrics, Children s and Women s Health Center of British Columbia, University of British Columbia, Vancouver, British Columbia, Canada V6H 3V4
    Pediatr Res 67:619-23. 2010
    ..Intratracheal administration of surfactant+vitamin A did not alter the beneficial effects of surfactant on lung compliance and gas exchange. Intratracheal Vitamin A was associated with rapid hepatic uptake. Further studies are warranted...
  12. ncbi Doubling calcium and phosphate concentrations in neonatal parenteral nutrition solutions using monobasic potassium phosphate
    Joyce C Wong
    Department of Pharmacy, Children s and Women s Health Centre of BC, 4480 Oak Street, Vancouver, British Columbia V6H 3V4, Canada
    J Am Coll Nutr 25:70-7. 2006
    ..Premature infants require high intakes of Ca and P to mimic fetal accretion rates. With the current phosphate salt used, adequate amounts cannot be provided due to the precipitation of Ca and P in TPN solutions...
  13. ncbi Superfetation as a cause of growth discordance in a multiple pregnancy
    Adele Harrison
    Division of Neonatology, Department of Ophthalmology, Children s and Women s Health Centre of British Columbia, Vancouver, British Columbia, Canada
    J Pediatr 147:254-5. 2005
    ..A triplet pregnancy is described, in which the diagnosis of in utero growth restriction is questioned after postnatal suspicion of superfetation, by using neurosonography and ophthalmic examination to aid gestational age assessment...
  14. ncbi Iodine overload and severe hypothyroidism in a premature neonate
    Minesh Khashu
    Division of Neonatology, Department of Pediatrics, British Columbia Children s Hospital and University of British Columbia, Vancouver BC V6H 3V4, Canada
    J Pediatr Surg 40:E1-4. 2005
    ....
  15. ncbi Elevated umbilical cord ghrelin concentrations in small for gestational age neonates
    Juliet Farquhar
    Special Care Nursery, British Columbia s Children s Hospital, Vancouver, British Columbia, Canada V6H 3V4
    J Clin Endocrinol Metab 88:4324-7. 2003
    ..In conclusion, SGA neonates present with higher umbilical cord ghrelin plasma concentrations than AGA/LGA neonates. Ghrelin may play a physiological role in fetal adaptation to intrauterine malnutrition...
  16. ncbi Photoprotection prevents TPN-induced lung procollagen mRNA in newborn guinea pigs
    Jean Claude Lavoie
    Research Centre and Neonatal Service, Hopital Sainte Justine, Montreal, QC, Canada
    Free Radic Biol Med 33:512-20. 2002
    ..Peroxidation induces gene expression of procollagen. We hypothesized that photo exposure of the MVP solution might promote pulmonary fibrosis. The aim of the study was to assess the potential for MVP to increase procollagen mRNA...
  17. ncbi Postnatal gender-dependent maturation of cellular cysteine uptake
    Jean Claude Lavoie
    Research Centre and Neonatal Service, Hĵpital Ste Justine, Montreal, Que, Canada
    Free Radic Res 36:811-7. 2002
    ....
  18. ncbi Photooxidation of parenteral multivitamins induces hepatic steatosis in a neonatal guinea pig model of intravenous nutrition
    Philippe Chessex
    Perinatal Service and Research Center, Hopital Ste Justine, Montreal, Quebec, Canada
    Pediatr Res 52:958-63. 2002
    ..Photo-oxidation of multivitamins might be the common link between reports involving amino acids, lipids, and light exposure in the ethiology of hepatic complications of parenteral nutrition...
  19. ncbi Light-induced byproducts of vitamin C in multivitamin solutions
    Jean Claude Lavoie
    Research Centre and Pediatric Department, Sainte Justine Hospital, University of Montreal, Montreal, Quebec, Canada
    Clin Chem 50:135-40. 2004
    ....
  20. ncbi Interaction between ascorbate and light-exposed riboflavin induces lung remodeling
    Jean Claude Lavoie
    Research Centre, Sainte Justine Hospital, 3175 Cote Ste Catherine, Montreal, Quebec, Canada H3T 1C5
    J Pharmacol Exp Ther 311:634-9. 2004
    ..It is speculated that this interaction may play a role in the development of chronic lung disease of premature infants who receive TPN and have immature antioxidant defenses...
  21. doi Influence of lung oxidant and antioxidant status on alveolarization: role of light-exposed total parenteral nutrition
    Jean Claude Lavoie
    Department of Paediatrics, CHU Sainte Justine, University of Montreal, Montreal, QC, Canada H3T 1C5
    Free Radic Biol Med 45:572-7. 2008
    ..LP and LIP-MVP had a beneficial effect, with higher number of alveoli. Globally, results indicate that in this model, alveolarization and modifications in lung redox potential are two independent events induced by light exposed TPN...
  22. ncbi Effect of coadministration of parenteral multivitamins with lipid emulsion on lung remodeling in an animal model of total parenteral nutrition
    Jean Claude Lavoie
    Research Centre and Neonatal Service, Hopital Sainte Justine, University of Montreal, Montreal, Quebec, Canada
    Pediatr Pulmonol 40:53-6. 2005
    ..Specific roles of peroxides, components of MVP, and light exposure on lung remodeling need to be explored before LIP + MVP can be recommended as an alternative mode of parenteral vitamin delivery...
  23. ncbi Shielding parenteral multivitamins from light increases vitamin A and E concentration in lung of newborn guinea pigs
    Jean Claude Lavoie
    Department of Paediatrics, CHU Sainte Justine, University of Montreal, Montreal, Que, Canada H3T 1C5
    Clin Nutr 26:341-7. 2007
    ..This discrepancy suggests differences in handling of infused antioxidant vitamins between the two organs. Hypothesis: antioxidant capacity of lung depends on the MVP concentration and light protection of infused solutions...
  24. ncbi Association between hydrogen peroxide-dependent byproducts of ascorbic acid and increased hepatic acetyl-CoA carboxylase activity
    Laurent Knafo
    Research Centre and Paediatric Department, CHU Sainte Justine, University of Montreal, Montreal, Quebec, Canada
    Clin Chem 51:1462-71. 2005
    ..We hypothesized that H(2)O(2) initiates the peroxidation of ascorbic acid (AA), producing biologically active byproducts affecting hepatic lipid metabolism...
  25. ncbi Multivitamin solutions for enteral supplementation: a source of peroxides
    Sophie Laborie
    Department of Pediatrics, Research Center of Hospital Ste Justine, University of Montreal, 3175 Chemin Cote Sainte Catherine, Montreal, Quebec H3T 1C5, Canada
    Nutrition 18:470-3. 2002
    ..We investigated whether solutions of enteral vitamin supplementation are involved in the generation of peroxides and whether that contamination is biologically significant...