R A Weiss

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc The promiscuous CC chemokine receptor D6 is a functional coreceptor for primary isolates of human immunodeficiency virus type 1 (HIV-1) and HIV-2 on astrocytes
    Stuart J D Neil
    Wohl Virion Centre, Division of Infection and Immunity, University College London, UK
    J Virol 79:9618-24. 2005
  2. pmc Multistage carcinogenesis
    R A Weiss
    Br J Cancer 91:1981-2. 2004
  3. pmc Neutralizing antibodies to HIV-1 induced by immunization
    Laura E McCoy
    Wohl Virion Centre, Division of Infection and Immunity, University College London, London WC1E 6BT, England, UK
    J Exp Med 210:209-23. 2013
  4. pmc On the concept and elucidation of endogenous retroviruses
    Robin A Weiss
    Division of Infection and Immunity, Wohl Virion Centre, University College London, Cruciform Building, Gower Street, London WC1 6BT, UK
    Philos Trans R Soc Lond B Biol Sci 368:20120494. 2013
  5. pmc Potent and broad neutralization of HIV-1 by a llama antibody elicited by immunization
    Laura E McCoy
    Wohl Virion Centre, University College London, London WC1E 6BT, England, UK
    J Exp Med 209:1091-103. 2012
  6. pmc Thirty years on: HIV receptor gymnastics and the prevention of infection
    Robin A Weiss
    Wohl Virion Centre, Division of Infection and Immunity, University College London, Gower Street, London WC1E, UK
    BMC Biol 11:57. 2013
  7. doi request reprint On HIV diversity
    Thumbi Ndung'u
    HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa
    AIDS 26:1255-60. 2012
  8. pmc Extensive complement-dependent enhancement of HIV-1 by autologous non-neutralising antibodies at early stages of infection
    Suzanne Willey
    Division of Infection and Immunity, University College London, MRC UCL Centre for Medical Molecular Virology, 46 Cleveland Street, London W1T 4JF, UK
    Retrovirology 8:16. 2011
  9. ncbi request reprint Cross-species infections
    R A Weiss
    Department of Immunology and Molecular Pathology, Windeyer Institute of Medical Sciences, University College London, 46 Cleveland Street, London, W1T 4JF, UK
    Curr Top Microbiol Immunol 278:47-71. 2003
  10. ncbi request reprint Getting to know HIV
    R A Weiss
    Windeyer Institute of Medical Sciences, University College London, UK
    Trop Med Int Health 5:A10-5. 2000

Detail Information

Publications85

  1. pmc The promiscuous CC chemokine receptor D6 is a functional coreceptor for primary isolates of human immunodeficiency virus type 1 (HIV-1) and HIV-2 on astrocytes
    Stuart J D Neil
    Wohl Virion Centre, Division of Infection and Immunity, University College London, UK
    J Virol 79:9618-24. 2005
    ..D6 usage may account for some previous observations of alternative receptor tropism for primary human cells. Thus, D6 may be an important receptor for HIV pathogenesis in the brain and for the early dissemination of virus in the host...
  2. pmc Multistage carcinogenesis
    R A Weiss
    Br J Cancer 91:1981-2. 2004
  3. pmc Neutralizing antibodies to HIV-1 induced by immunization
    Laura E McCoy
    Wohl Virion Centre, Division of Infection and Immunity, University College London, London WC1E 6BT, England, UK
    J Exp Med 210:209-23. 2013
    ..A greater understanding of the successes and failures for inducing a neutralizing response upon immunization is required to accelerate the development of an effective HIV vaccine...
  4. pmc On the concept and elucidation of endogenous retroviruses
    Robin A Weiss
    Division of Infection and Immunity, Wohl Virion Centre, University College London, Cruciform Building, Gower Street, London WC1 6BT, UK
    Philos Trans R Soc Lond B Biol Sci 368:20120494. 2013
    ..The evolution of xenotropism and cross-species infection is discussed in the light of the dynamic relationship between exogenous and endogenous retroviruses. ..
  5. pmc Potent and broad neutralization of HIV-1 by a llama antibody elicited by immunization
    Laura E McCoy
    Wohl Virion Centre, University College London, London WC1E 6BT, England, UK
    J Exp Med 209:1091-103. 2012
    ..This study may represent a new benchmark for immunogens to be included in B cell-based vaccines and supports the development of VHH as anti-HIV-1 microbicides...
  6. pmc Thirty years on: HIV receptor gymnastics and the prevention of infection
    Robin A Weiss
    Wohl Virion Centre, Division of Infection and Immunity, University College London, Gower Street, London WC1E, UK
    BMC Biol 11:57. 2013
    ..Eliciting neutralizing antibodies to the sites of receptor interaction on HIV glycoproteins is a promising approach to HIV vaccine development...
  7. doi request reprint On HIV diversity
    Thumbi Ndung'u
    HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa
    AIDS 26:1255-60. 2012
    ..The great degree of HIV diversity presents challenges to maintaining sensitivity to antiretroviral therapy and to the development of preventive strategies such as microbicides and vaccines...
  8. pmc Extensive complement-dependent enhancement of HIV-1 by autologous non-neutralising antibodies at early stages of infection
    Suzanne Willey
    Division of Infection and Immunity, University College London, MRC UCL Centre for Medical Molecular Virology, 46 Cleveland Street, London W1T 4JF, UK
    Retrovirology 8:16. 2011
    ..Here we report that non-neutralising antibodies produced early in response to HIV-1 infection can enhance viral infectivity...
  9. ncbi request reprint Cross-species infections
    R A Weiss
    Department of Immunology and Molecular Pathology, Windeyer Institute of Medical Sciences, University College London, 46 Cleveland Street, London, W1T 4JF, UK
    Curr Top Microbiol Immunol 278:47-71. 2003
    ..Cross-species viral and other infections are reviewed historically with respect to the evolution of virulence and the concern about iatrogenic enhancement of cross-species transfer by medical procedures akin to xenotransplantation...
  10. ncbi request reprint Getting to know HIV
    R A Weiss
    Windeyer Institute of Medical Sciences, University College London, UK
    Trop Med Int Health 5:A10-5. 2000
    ..HIV comprises just 9 genes but represents one of humanity's most formidable foes...
  11. ncbi request reprint Viruses, cancer and AIDS
    R A Weiss
    Windeyer Institute of Medical Sciences, Royal Free and University College Medical School, 46 Cleveland Street, London, UK
    FEMS Immunol Med Microbiol 26:227-32. 1999
    ....
  12. ncbi request reprint Gulliver's travels in HIVland
    R A Weiss
    Wohl Virion Centre, Department of Immunology and Molecular Pathology, University College London, Windeyer Institute of Medical Sciences, UK
    Nature 410:963-7. 2001
    ..The existence of a growing proportion of HIV-infected, immunocompromised children and adults may significantly affect current immunization programmes and the evolution of opportunistic infections...
  13. doi request reprint On viruses, discovery, and recognition
    Robin A Weiss
    MRC UCL Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, London W1T4JF, UK
    Cell 135:983-6. 2008
    ..Identifying human papilloma virus (HPV) and human immunodeficiency virus (HIV) might now appear to have been simple, but the way forward was far from obvious at the time...
  14. pmc The Leeuwenhoek Lecture 2001. Animal origins of human infectious disease
    R A Weiss
    Wohl Virion Centre, Department of Immunology and Molecular Pathology, University College London, 46 Cleveland Street, London W1T 4JF, UK
    Philos Trans R Soc Lond B Biol Sci 356:957-77. 2001
    ....
  15. ncbi request reprint HIV and AIDS: looking ahead
    Robin A Weiss
    Department of Immunology and Molecular Pathology, University College London, 46 Cleveland Street, London, W1T 4JF UK
    Nat Med 9:887-91. 2003
  16. pmc A cautionary tale of virus and disease
    Robin A Weiss
    Division of Infection and Immunity, University College London, 46 Cleveland Street, London W1T 4JF, UK
    BMC Biol 8:124. 2010
    ..However, it remains highly controversial whether the detection of these viruses represents true infection or laboratory artifacts...
  17. ncbi request reprint Virulence and pathogenesis
    Robin A Weiss
    Department of Immunology and Molecular Pathology, University College London, 46 Cleveland Street, London W1T 4JF, UK
    Trends Microbiol 10:314-7. 2002
    ..Moreover, minor host differences can result in major changes in pathogen virulence. Although viral burden relates to disease severity, pathogenesis is not necessarily coupled with transmission dynamics...
  18. ncbi request reprint HIV receptors and cellular tropism
    Robin A Weiss
    Department of Immunology and Molecular Pathology, University College London, United Kingdom
    IUBMB Life 53:201-5. 2002
    ..Knowledge of the HIV receptors has led to practical developments such as inhibitory drugs, reasons for genetic resistance to infection, and should inform the judicious choice of candidate vaccines...
  19. pmc HIV and AIDS in relation to other pandemics. Among the viruses plaguing humans, HIV is a recent acquisition. Its outstanding success as an infection poses immense scientific challenges to human health and raises the question "What comes nest?"
    Robin A Weiss
    Department of Immunology and Molecular Pathology, University College London, UK
    EMBO Rep 4:S10-4. 2003
  20. pmc The discovery of endogenous retroviruses
    Robin A Weiss
    Division of Infection and Immunity, University College London, 46 Cleveland Street, London W1T 4JF, UK
    Retrovirology 3:67. 2006
    ..Here I recount some of the key observations in birds and mammals that led to the discovery of ERV, and comment on their evolution, cross-species dispersion, and what remains to be elucidated...
  21. ncbi request reprint Cancer, infection and immunity: a personal homage to Jan Svoboda
    R A Weiss
    Division of Infection and Immunity, University College London, United Kingdom
    Folia Biol (Praha) 50:78-86. 2004
    ....
  22. pmc What have we learnt from SARS?
    Robin A Weiss
    Division of Infection and Immunity, University College London, 46 Cleveland Street, London W1T 4JF, UK
    Philos Trans R Soc Lond B Biol Sci 359:1137-40. 2004
    ..These were the features that helped to make the outbreak containable. The next outbreak of another kind of transmissible disease may well be quite different...
  23. ncbi request reprint Lessons from naked apes and their infections
    Robin A Weiss
    Division of Infection and Immunity, University College London, London, UK
    J Med Primatol 36:172-9. 2007
    ..As humans have acquired infections horizontally from our closest living relatives, the chimpanzee and the gorilla, might we also have exchanged pathogens with other hominid species?..
  24. pmc Special anniversary review: twenty-five years of human immunodeficiency virus research: successes and challenges
    R A Weiss
    Division of Infection and Immunity, University College London, London, UK
    Clin Exp Immunol 152:201-10. 2008
    ..HIV prevention through behavioural change has been successful, and we do not yet have any safe and efficacious microbicides or vaccines...
  25. pmc Apes, lice and prehistory
    Robin A Weiss
    University College London, UK
    J Biol 8:20. 2009
    ..Such infidelity may account for the survival of certain types of human lice, and it is currently exemplified by viruses such as HIV...
  26. pmc 100 years of Rous sarcoma virus
    Robin A Weiss
    Division of Infection and Immunity, University College London, WC1E 6BT, England, UK
    J Exp Med 208:2351-5. 2011
    ..Rous spent his entire research career at The Rockefeller Institute, and he was the JEM's longest serving editor. Here, we comment briefly on the life of this remarkable scientist and on the importance of his discoveries...
  27. ncbi request reprint HIV-2 and SIV infection of nonprimate cell lines expressing human CD4: restrictions to replication at distinct stages
    A McKnight
    Chester Beatty Laboratories, Institute of Cancer Research, London, United Kingdom
    Virology 201:8-18. 1994
    ....
  28. ncbi request reprint Characterization of recombinant gp120 and gp160 from HIV-1: binding to monoclonal antibodies and soluble CD4
    J P Moore
    Chester Beatty Laboratories, Institute of Cancer Research, London, UK
    AIDS 4:307-15. 1990
    ....
  29. pmc Biological characterization of human immunodeficiency virus type 1 clones derived from different organs of an AIDS patient by long-range PCR
    M T Dittmar
    Virology Laboratory, Chester Beatty Laboratories, Institute of Cancer Research, London, United Kingdom
    J Virol 71:5140-7. 1997
    ....
  30. pmc Investigating antibody neutralization of lyssaviruses using lentiviral pseudotypes: a cross-species comparison
    Edward Wright
    MRC UCL Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, 46 Cleveland Street, London W1T 4JF, UK
    J Gen Virol 89:2204-13. 2008
    ....
  31. ncbi request reprint Dissociation of gp120 from HIV-1 virions induced by soluble CD4
    J P Moore
    Chester Beatty Laboratories, Institute of Cancer Research, London, United Kingdom
    Science 250:1139-42. 1990
    ..This may represent the initial stage in virus-cell and cell-cell fusion. Shedding of gp120 from virions induced by sCD4 may also contribute to the mechanism by which these soluble receptor molecules neutralize HIV-1...
  32. ncbi request reprint Role of the amino-terminal extracellular domain of CXCR-4 in human immunodeficiency virus type 1 entry
    L Picard
    Chester Beatly Laboratories, Institute of Cancer Research, London, United Kingdom
    Virology 231:105-11. 1997
    ..We conclude that distinct virus strains interact differently with the CXCR-4 coreceptor and that the N-terminal extracellular domain is not the sole functional domain important for HIV-1 entry...
  33. pmc Recombinant CD4-selected human immunodeficiency virus type 1 variants with reduced gp120 affinity for CD4 and increased cell fusion capacity
    J McKeating
    Chester Beatty Laboratories, Institute of Cancer Research, London, United Kingdom
    J Virol 65:4777-85. 1991
    ..The ready selection of rCD4-resistant variants has obvious relevance for rCD4-based therapeutic stratagems...
  34. pmc Human immunodeficiency virus type 2 infection and fusion of CD4-negative human cell lines: induction and enhancement by soluble CD4
    P R Clapham
    Chester Beatty Laboratories, Institute of Cancer Research, London, England
    J Virol 66:3531-7. 1992
    ..While some strains entered efficiently, others retained a dependency on an interaction with sCD4 to initiate changes in the virion envelope required for membrane fusion...
  35. ncbi request reprint Expression of HIV-1 envelope glycoproteins by Semliki Forest virus vectors
    N L Paul
    Chester Beatty Laboratories, Institute of Cancer Research, London, England
    AIDS Res Hum Retroviruses 9:963-70. 1993
    ..Furthermore, they exhibit functional activity as indicated by their ability to bind to soluble receptor and induce cell-to-cell fusion...
  36. ncbi request reprint Our retroviral heritage
    C Patience
    Chester Beatty Laboratories, Institute of Cancer Research, London, UK
    Trends Genet 13:116-20. 1997
    ..It is timely, however, to revisit the topic of human endogenous retroviruses-the subject of this article...
  37. ncbi request reprint Endogenous retroviruses: a potential problem for xenotransplantation?
    J P Stoye
    National Institute of Medical Research, London, United Kingdom
    Ann N Y Acad Sci 862:67-74. 1998
    ..Nature 389: 681-681, 1997). The implications of our results for assessing the potential risk of retroviral transfer during xenotransplantation are discussed...
  38. pmc Multiple extracellular domains of CCR-5 contribute to human immunodeficiency virus type 1 entry and fusion
    L Picard
    Chester Beatty Laboratories, Institute of Cancer Research, London, United Kingdom
    J Virol 71:5003-11. 1997
    ..Thus, different strains are likely to have different ways of interacting with the CCR-5 coreceptor...
  39. ncbi request reprint Soluble CD4 blocks the infectivity of diverse strains of HIV and SIV for T cells and monocytes but not for brain and muscle cells
    P R Clapham
    Chester Beatty Laboratories, Institute of Cancer Research, London, UK
    Nature 337:368-70. 1989
    ..Soluble CD4 prevents HIV infection of T-lymphocytic and myelomonocytic cell lines, but neither sCD4 nor anti-CD4 antibodies inhibit infection of glioma and rhabdomyosarcoma cell lines...
  40. ncbi request reprint No evidence of pig DNA or retroviral infection in patients with short-term extracorporeal connection to pig kidneys
    C Patience
    Section of Virology, Institute of Cancer Research, Chester Beatty Laboratories, London, UK
    Lancet 352:699-701. 1998
    ..However, a small number of patients have already been treated with or exposed to living porcine cells or tissue, and investigation of these patients may provide valuable information...
  41. ncbi request reprint Effect of mutations in the V3 loop of HIV-1 gp120 on infectivity and susceptibility to proteolytic cleavage
    T F Schulz
    Chester Beatty Laboratories, Institute of Cancer Research, London, UK
    AIDS Res Hum Retroviruses 9:159-66. 1993
    ..Therefore, one would have to postulate the involvement of several cellular proteinases, or proteases with multiple specificities, in V3-based viral tropism...
  42. ncbi request reprint Zoonosis in xenotransplantation
    C Patience
    Chester Beatty Laboratories, The Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK
    Curr Opin Immunol 10:539-42. 1998
    ..Our knowledge about micro-organisms in donor animals is limited and it is difficult to predict the consequence of such cross-species infection...
  43. pmc Packaging of endogenous retroviral sequences in retroviral vectors produced by murine and human packaging cells
    C Patience
    Chester Beatty Laboratories, Institute of Cancer Research, London, United Kingdom
    J Virol 72:2671-6. 1998
    ..Although both HERV-K and RTVL-H sequences were found in association with the particles, beta-Gal transcripts were not detected, indicating that HERV Gag proteins do not efficiently package MLV-based vectors...
  44. pmc Blocking the docking of HIV-1
    Aine McKnight
    Department of Immunology and Molecular Pathology, University College London, 46 Cleveland Street, London W1T 4JF, United Kingdom
    Proc Natl Acad Sci U S A 100:10581-2. 2003
  45. ncbi request reprint Endogenous D-type (HERV-K) related sequences are packaged into retroviral particles in the placenta and possess open reading frames for reverse transcriptase
    G R Simpson
    Chester Beatty Laboratories, Institute of Cancer Research, London, United Kingdom
    Virology 222:451-6. 1996
    ..These open reading frames could encode the reverse transcriptase enzyme activity found in the particles...
  46. ncbi request reprint Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cells
    C Boshoff
    Virology Laboratory, Royal Marsden Hospital, London, UK
    Nat Med 1:1274-8. 1995
    ..These findings show that KSHV/HHV-8 is present in the cell types thought to represent neoplastic cells in these lesions...
  47. ncbi request reprint Monoclonal antibodies to the C4 region of human immunodeficiency virus type 1 gp120: use in topological analysis of a CD4 binding site
    J A McKeating
    Chester Beatty Laboratory, Institute of Cancer Research, London, England
    AIDS Res Hum Retroviruses 8:451-9. 1992
    ..Our results indicate that the amino acids WQEVGKAMYA are exposed on the surface of recombinant gp120. Antibodies to these amino acids on recombinant gp120 compete for soluble CD4 binding in vitro, but only weakly neutralize HIV...
  48. pmc Sensitization of rhabdo-, lenti-, and spumaviruses to human serum by galactosyl(alpha1-3)galactosylation
    Y Takeuchi
    Chester Beatty Laboratories, Institute of Cancer Research, London, England
    J Virol 71:6174-8. 1997
    ..Virus vectors for human in vivo gene therapy based on the viruses mentioned above should be produced from alphaGal-negative cells...
  49. pmc Characterization of monoclonal antibodies raised against the latent nuclear antigen of human herpesvirus 8
    P Kellam
    Institute of Cancer Research, Chester Beatty Laboratories, London SW3 6JB, United Kingdom
    J Virol 73:5149-55. 1999
    ..In situ immunocytochemistry of KS lesions with these antibodies show that LNA is extensively expressed in KS spindle cells...
  50. pmc Epidemiology and pathogenesis of Kaposi's sarcoma-associated herpesvirus
    C Boshoff
    Department of Oncology and Molecular Pathology, The Wolfson Institute for Biomedical Research, Cruciform Building, University College London, Gower Street, London WC1 6BT, UK
    Philos Trans R Soc Lond B Biol Sci 356:517-34. 2001
    ..The histogenesis, clonality and pathology of the tumours are described, together with the epidemiology and possible modes of transmission of the virus...
  51. pmc Llama antibody fragments with cross-subtype human immunodeficiency virus type 1 (HIV-1)-neutralizing properties and high affinity for HIV-1 gp120
    Anna Forsman
    MRC UCL Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, 46 Cleveland Street, London W1T 4JF, United Kingdom
    J Virol 82:12069-81. 2008
    ..Antienvelope VHH might also prove useful in defining neutralizing and nonneutralizing epitopes on HIV-1 envelope proteins, with implications for HIV-1 vaccine design...
  52. doi request reprint Virus neutralising activity of African fruit bat (Eidolon helvum) sera against emerging lyssaviruses
    Edward Wright
    Division of Infection and Immunity, University College London, 46 Cleveland Street, London, W1T 4JF, UK
    Virology 408:183-9. 2010
    ..helvum remains high enough to persist in this species. This supports the hypothesis that LBV is endemic in Ghanaian E. helvum and we speculate that LBV may have co-evolved with African megachiroptera...
  53. pmc A robust lentiviral pseudotype neutralisation assay for in-field serosurveillance of rabies and lyssaviruses in Africa
    Edward Wright
    Division of Infection and Immunity, University College London, 46 Cleveland Street, London, United Kingdom
    Vaccine 27:7178-86. 2009
    ..These results suggest the proposed pseudotype assay is a suitable option for undertaking lyssavirus serosurveillance in areas most affected by these infections...
  54. doi request reprint A sensitive retroviral pseudotype assay for influenza H5N1-neutralizing antibodies
    Nigel J Temperton
    MRC UCL Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, 46 Cleveland Street, London, United Kingdom
    Influenza Other Respir Viruses 1:105-12. 2007
    ..We have used retroviral pseudotypes bearing influenza H5 hemagglutinin (HA) as safe, surrogate viruses for influenza neutralization assays which can be carried out at Biosafety Level 2...
  55. doi request reprint Novel subtype C human immunodeficiency virus type 1 envelopes cloned directly from plasma: coreceptor usage and neutralization phenotypes
    Willie W L Koh
    MRC UCL Centre for Medical Molecular Virology, University College London, London W1T 4JF, UK
    J Gen Virol 91:2374-80. 2010
    ..The subtype C chimeric viruses generated in this study will be useful for evaluating the breadth of neutralizing antibodies and other entry inhibitors...
  56. ncbi request reprint Social and environmental risk factors in the emergence of infectious diseases
    Robin A Weiss
    Wohl Virion Centre, Division of Infection and Immunity, University College London, W1T 4JF, UK
    Nat Med 10:S70-6. 2004
    ..A better understanding of the evolving social dynamics of emerging infectious diseases ought to help us to anticipate and hopefully ameliorate current and future risks...
  57. pmc Novel endogenous retrovirus in rabbits previously reported as human retrovirus 5
    David J Griffiths
    Wohl Virion Centre, Windeyer Institute of Medical Sciences, University College London, United Kingdom
    J Virol 76:7094-102. 2002
    ..In light of these findings we propose that the sequence previously designated HRV-5 should now be denoted RERV-H (for rabbit endogenous retrovirus H)...
  58. pmc Longitudinally profiling neutralizing antibody response to SARS coronavirus with pseudotypes
    Nigel J Temperton
    Wohl Virion Centre and Division of Infection and Immunity, University College London, 46 Cleveland St, London W1T 4JF, London, UK
    Emerg Infect Dis 11:411-6. 2005
    ..The pseudotype assay does not require handling live SARS virus; it is a useful tool to determine neutralizing titers during natural infection and the preclinical evaluation of candidate vaccines...
  59. pmc Distribution of human herpesvirus-8 latently infected cells in Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphoma
    N Dupin
    Departments of Oncology and Molecular Pathology, Royal Free and University College Medical School, UCL, London, United Kingdom W1P 6BT
    Proc Natl Acad Sci U S A 96:4546-51. 1999
    ..No staining for LNA-1 is seen in samples from multiple myeloma, prostate cancer, and angiosarcoma, supporting the absence of any etiological link between these diseases and HHV-8...
  60. pmc Multiple groups of novel retroviral genomes in pigs and related species
    C Patience
    Institute of Cancer Research, University College London, London, United Kingdom
    J Virol 75:2771-5. 2001
    ..Thus domestic swine and their phylogenetic relatives harbor multiple groups of hitherto undescribed PERV genomes...
  61. pmc Natural and iatrogenic factors in human immunodeficiency virus transmission
    R A Weiss
    Wohl Virion Centre, Department of Immunology and Molecular Pathology, Windeyer Institute of Medical Sciences, University College London, 46 Cleveland Street, London W1T 4JF, UK
    Philos Trans R Soc Lond B Biol Sci 356:947-53. 2001
    ..Exactly how, when and where the first human(s) became infected with the progenitor of HIV-1 group M, which gave rise to the pandemic strain, is likely, however, to remain a matter of conjecture...
  62. ncbi request reprint Aetiology of Kaposi's sarcoma: current understanding and implications for therapy
    C Boshoff
    Institute of Cancer Research, Chester Beatty Laboratories, London, UK
    Mol Med Today 3:488-94. 1997
    ..Today, Kaposi's sarcoma is one of the most frequent neoplasms in men under 50 years old in the USA, and in some African countries it is the most common tumour overall...
  63. pmc Mutation of amino acids within the gibbon ape leukemia virus (GALV) receptor differentially affects feline leukemia virus subgroup B, simian sarcoma-associated virus, and GALV infections
    C S Tailor
    Chester Beatty Laboratories, Institute of Cancer Research, London, England
    J Virol 67:6737-41. 1993
    ..Substitution of human GLVR1 amino acids in the critical region of rat GLVR1 identified three amino acids as responsible for resistance to FeLV-B infection; two of these affect SSAV infection, but none affects GALV infection...
  64. ncbi request reprint HIV-1 incorporates ABO histo-blood group antigens that sensitize virions to complement-mediated inactivation
    Stuart J D Neil
    Wohl Virion Centre, Division of Infection and Immunity, University College London, London, United Kingdom
    Blood 105:4693-9. 2005
    ..Thus, incorporation of ABO antigens by HIV-1 may affect transmission of virus between individuals of discordant blood groups by interaction with host natural antibody and complement...
  65. ncbi request reprint CD4-dependent and CD4-independent HIV-2: consequences for neutralization
    Elaine R Thomas
    The Wohl Virion Centre, Windeyer Institute of Medical Sciences, University College London, London W1T 4JF, UK
    AIDS 17:291-300. 2003
    ..HIV-2 is less pathogenic than HIV-1. In contrast to HIV-1, many isolates of HIV-2, including primary isolates, can infect cells independently of CD4...
  66. pmc Clonal origin and evolution of a transmissible cancer
    Claudio Murgia
    MRC UCL Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, 46 Cleveland Street, London W1T 4JF, UK
    Cell 126:477-87. 2006
    ..Our findings have implications for understanding genome instability in cancer, natural transplantation of allografts, and the capacity of a somatic cell to evolve into a transmissible parasite...
  67. pmc Generation of a family-specific phage library of llama single chain antibody fragments that neutralize HIV-1
    Willie W L Koh
    Division of Infection and Immunity, University College London, Medical Research Council University College London Centre for Medical Molecular Virology, London W1T 4JF, United Kingdom
    J Biol Chem 285:19116-24. 2010
    ....
  68. ncbi request reprint PCR-based cloning and immunocytological titration of infectious porcine endogenous retrovirus subgroup A and B
    Birke Bartosch
    Wohl Virion Centre, The Windeyer Institute of Medical Sciences, University College London, 46 Cleveland Street, London W1T 4JF, UK
    J Gen Virol 83:2231-40. 2002
    ..This detection method proved to be more sensitive than the current method of choice (transfer of MLV-lacZ vectors) for infectivity assessment of PERV. These findings should be considered for future characterization of PERV isolates...
  69. ncbi request reprint Robert Koch: the grandfather of cloning?
    Robin A Weiss
    Wohl Virion Centre, Division of Infection and Immunity, University College London, London W1T 4JF, United Kingdom
    Cell 123:539-42. 2005
    ..Yet perhaps one of his greatest contributions to biology is the least appreciated: his method for propagating individual colonies of bacteria on plates, a technique that came to be called cloning...
  70. ncbi request reprint Detection and quantitation of human immunodeficiency virus type-1 particles by confocal microscopy
    Bishnupriya Bhattacharya
    Department of Immunology and Molecular Pathology, Windeyer Institute of Medical Sciences, Medical School, Royal Free and University College London, 46 Cleveland Street, London W1T 4JF, UK
    J Virol Methods 120:13-21. 2004
    ..Confocal microscopy may prove to be a simple alternative to electron microscopy for virus identification and quantitation...
  71. doi request reprint Why is HIV a pathogen?
    Anna Forsman
    MRC UCL Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, 46 Cleveland Street, London W1T 4JF, UK
    Trends Microbiol 16:555-60. 2008
    ..Thus, lessons from pathogenic and nonpathogenic lentivirus infections provide insight into the complex syndrome called AIDS...
  72. ncbi request reprint Evidence for nonspecific adsorption of targeted retrovirus vector particles to cells
    M Pizzato
    Wohl Virion Centre, Windeyer Institute of Medical Sciences, University College London, UK
    Gene Ther 8:1088-96. 2001
    ..Significant implications arise from these observations on the interpretation of previous reports on 'targeted' vectors, and for the development of vectors for in vivo gene therapy protocols...
  73. pmc Detection of antibodies to human herpesvirus 8 in Italian children: evidence for horizontal transmission
    D Whitby
    Institute of Cancer Research, London, UK
    Br J Cancer 82:702-4. 2000
    ..In this study we examine HHV-8 infection in children from Italy, a country with an elevated prevalence of HHV-8 in adults and high socio-economic conditions...
  74. ncbi request reprint Infectogenomics: insights from the host genome into infectious diseases
    Paul Kellam
    MRC UCL Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, London W1T 4JF, UK
    Cell 124:695-7. 2006
    ..This "infectogenomics" approach should yield further insights into both diagnostic and therapeutic advances, as well as normal cellular function...
  75. ncbi request reprint Abundance of an endogenous retroviral envelope protein in placental trophoblasts suggests a biological function
    P J Venables
    Kennedy Institute of Rheumatology, London, United Kingdom
    Virology 211:589-92. 1995
    ..The similarity of a domain of ERV-3 env to putative immunosuppressive p15E sequences suggests that ERV-3 might form part of the placental immunosuppressive barrier between mother and foetus...
  76. ncbi request reprint Origins of HIV and the evolution of resistance to AIDS
    Jonathan L Heeney
    Department of Virology, Biomedical Primate Research Centre, Rijswijk 2280 GH, Netherlands
    Science 313:462-6. 2006
    ..Further understanding of host resistance factors and the mechanisms of disease in natural primate hosts may provide insight into unexplored therapeutic avenues for the prevention of AIDS...
  77. pmc T cell responses to whole SARS coronavirus in humans
    Chris Ka fai Li
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK
    J Immunol 181:5490-500. 2008
    ..Our study provides a roadmap for the immunogenicity of SARS-CoV and types of immune responses that may be responsible for the virus clearance, and should serve as a benchmark for SARS-CoV vaccine design and evaluation...
  78. ncbi request reprint A plea for justice for jailed medical workers
    Sunil K Ahuja
    Science 314:924-5. 2006
  79. pmc Duffy antigen receptor for chemokines mediates trans-infection of HIV-1 from red blood cells to target cells and affects HIV-AIDS susceptibility
    Weijing He
    Veterans Administration Research Center for AIDS and HIV 1 Infection, South Texas Veterans Health Care System, San Antonio, TX 78229, USA
    Cell Host Microbe 4:52-62. 2008
    ..Thus, DARC influences HIV/AIDS susceptibility by mediating trans-infection of HIV-1 and by affecting both chemokine-HIV interactions and chemokine-driven inflammation...
  80. pmc Human RNA "rumor" viruses: the search for novel human retroviruses in chronic disease
    Cécile Voisset
    CNRS UMR8161, Institut de Biologie de Lille et Institut Pasteur de Lille, Lille, France
    Microbiol Mol Biol Rev 72:157-96, table of contents. 2008
    ..In addition, some of the difficulties associated with obtaining formal proof of causation for common or ubiquitous agents such as HERVs are discussed...
  81. ncbi request reprint Circe, Cassandra, and the trojan pigs: xenotransplantation
    Robin A Weiss
    Professor of Viral Oncology University College London
    Proc Am Philos Soc 148:281-95. 2004
  82. pmc Identification of receptors for pig endogenous retrovirus
    Thomas A Ericsson
    Immerge BioTherapeutics, Inc, 300 Technology Square, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 100:6759-64. 2003
    ..The identification of the PERV-A receptors opens avenues of research necessary for a more complete assessment of the retroviral risks of pig to human xenotransplantation...
  83. pmc Celebrating novel cancer drugs
    Robin A Weiss
    Br J Cancer 89:425. 2003
  84. pmc The oncologists' and radiologists' PET
    Robin A Weiss
    Br J Cancer 89:223. 2003