Affiliation: University College London
- Long-term starvation and ageing induce AGE-1/PI 3-kinase-dependent translocation of DAF-16/FOXO to the cytoplasmDavid Weinkove
Department of Biology, University College London, London WC1E 6BT, UK
BMC Biol 4:1. 2006..To address this question we used C. elegans first stage larvae (L1s), which when starved enter a developmentally-arrested diapause stage until food is encountered...
- Overexpression of PPK-1, the Caenorhabditis elegans Type I PIP kinase, inhibits growth cone collapse in the developing nervous system and causes axonal degeneration in adultsDavid Weinkove
Division of Cellular Biochemistry, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
Dev Biol 313:384-97. 2008....
- Metformin retards aging in C. elegans by altering microbial folate and methionine metabolismFilipe Cabreiro
Institute of Healthy Ageing, and G E E, University College London, London WC1E 6BT, UK
Cell 153:228-39. 2013..Thus, metformin-induced alteration of microbial metabolism could contribute to therapeutic efficacy-and also to its side effects, which include folate deficiency and gastrointestinal upset...
- Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegansTimothy M Bass
Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK
Mech Ageing Dev 128:546-52. 2007..1 mutant animals. We postulate that the effect of resveratrol upon lifespan in C. elegans could reflect induction of phase 2 drug detoxification or activation of AMP kinase...
- A casein kinase 1 and PAR proteins regulate asymmetry of a PIP(2) synthesis enzyme for asymmetric spindle positioningCostanza Panbianco
The Gurdon Institute and Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB21QN, UK
Dev Cell 15:198-208. 2008..Furthermore, loss of CSNK-1 leads to increased levels of PIP(2). We propose that asymmetric generation of PIP(2) by PPK-1 directs the posterior enrichment of GPR-1/2 and LIN-5, leading to posterior spindle displacement...
- The G-protein gamma subunit gpc-1 of the nematode C.elegans is involved in taste adaptationGert Jansen
MGC Department of Cell Biology and Genetics and Centre for Biomedical Genetics, Erasmus University Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
EMBO J 21:986-94. 2002..Our finding that G proteins, OSM-9 and ADP-1 are involved in taste adaptation offer the first molecular insight into this process...