J A Wedzicha

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Exacerbation of chronic obstructive pulmonary disease: pan-airway and systemic inflammatory indices
    John R Hurst
    Academic Unit of Respiratory Medicine, St Bartholomew s and The Royal London School of Medicine, Dominion House, London EC1A 7BE, UK
    Proc Am Thorac Soc 3:481-2. 2006
  2. ncbi request reprint The biology of a chronic obstructive pulmonary disease exacerbation
    John R Hurst
    Academic Unit of Respiratory Medicine, Royal Free and University College Medical School, Royal Free Hospital, London, NW3 2PF, UK
    Clin Chest Med 28:525-36, v. 2007
  3. ncbi request reprint COPD exacerbations: defining their cause and prevention
    Jadwiga A Wedzicha
    Academic Unit of Respiratory Medicine, Royal Free and University College Medical School University College London, UK
    Lancet 370:786-96. 2007
  4. pmc MMP-9, TIMP-1 and inflammatory cells in sputum from COPD patients during exacerbation
    P F Mercer
    School of Biological Sciences, University of Southampton, Southampton, UK
    Respir Res 6:151. 2005
  5. pmc Withdrawal of inhaled corticosteroids in people with COPD in primary care: a randomised controlled trial
    Aklak B Choudhury
    Centre for Health Sciences, Queen Mary s School of Medicine and Dentistry, Barts and The London, 2 Newark Street, London, E1 2AT, UK
    Respir Res 8:93. 2007
  6. pmc Domiciliary pulse-oximetry at exacerbation of chronic obstructive pulmonary disease: prospective pilot study
    John R Hurst
    Academic Unit of Respiratory Medicine, Royal Free Campus, UCL Medical School, London, UK
    BMC Pulm Med 10:52. 2010
  7. pmc Management and prevention of chronic obstructive pulmonary disease exacerbations: a state of the art review
    John R Hurst
    Academic Unit of Respiratory Medicine, Royal Free Campus, UCL Medical School, London, UK
    BMC Med 7:40. 2009
  8. ncbi request reprint Structural and functional co-conspirators in chronic obstructive pulmonary disease exacerbations
    Jadwiga A Wedzicha
    Academic Unit of Respiratory Medicine, Royal Free and University College Medical School, University College London, Rowland Hill Street, Hampstead, London NW3 2PF, UK
    Proc Am Thorac Soc 4:602-5. 2007
  9. ncbi request reprint The prevention of chronic obstructive pulmonary disease exacerbations by salmeterol/fluticasone propionate or tiotropium bromide
    Jadwiga A Wedzicha
    Academic Unit of Respiratory Medicine, Royal Free and University College Medical School, University College London, London, UK
    Am J Respir Crit Care Med 177:19-26. 2008
  10. ncbi request reprint Impact of chronic obstructive pulmonary disease exacerbations on patients and payers
    Jadwiga A Wedzicha
    Academic Unit of Respiratory Medicine, University College, London, UK
    Proc Am Thorac Soc 3:218-21. 2006

Detail Information

Publications67

  1. ncbi request reprint Exacerbation of chronic obstructive pulmonary disease: pan-airway and systemic inflammatory indices
    John R Hurst
    Academic Unit of Respiratory Medicine, St Bartholomew s and The Royal London School of Medicine, Dominion House, London EC1A 7BE, UK
    Proc Am Thorac Soc 3:481-2. 2006
  2. ncbi request reprint The biology of a chronic obstructive pulmonary disease exacerbation
    John R Hurst
    Academic Unit of Respiratory Medicine, Royal Free and University College Medical School, Royal Free Hospital, London, NW3 2PF, UK
    Clin Chest Med 28:525-36, v. 2007
    ....
  3. ncbi request reprint COPD exacerbations: defining their cause and prevention
    Jadwiga A Wedzicha
    Academic Unit of Respiratory Medicine, Royal Free and University College Medical School University College London, UK
    Lancet 370:786-96. 2007
    ....
  4. pmc MMP-9, TIMP-1 and inflammatory cells in sputum from COPD patients during exacerbation
    P F Mercer
    School of Biological Sciences, University of Southampton, Southampton, UK
    Respir Res 6:151. 2005
    ..This study has prospectively examined changes in sputum levels of inflammatory cells, MMP-9 and TIMP-1 during exacerbations comparing with paired samples taken prior to exacerbation...
  5. pmc Withdrawal of inhaled corticosteroids in people with COPD in primary care: a randomised controlled trial
    Aklak B Choudhury
    Centre for Health Sciences, Queen Mary s School of Medicine and Dentistry, Barts and The London, 2 Newark Street, London, E1 2AT, UK
    Respir Res 8:93. 2007
    ..Most COPD patients are managed in primary care and receive ICS long-term and irrespective of severity. The effect of withdrawing ICS from COPD patients in primary care is unknown...
  6. pmc Domiciliary pulse-oximetry at exacerbation of chronic obstructive pulmonary disease: prospective pilot study
    John R Hurst
    Academic Unit of Respiratory Medicine, Royal Free Campus, UCL Medical School, London, UK
    BMC Pulm Med 10:52. 2010
    ..We assessed the ability of domiciliary pulse oximetry to achieve this...
  7. pmc Management and prevention of chronic obstructive pulmonary disease exacerbations: a state of the art review
    John R Hurst
    Academic Unit of Respiratory Medicine, Royal Free Campus, UCL Medical School, London, UK
    BMC Med 7:40. 2009
    ..Ultimately, exacerbations are heterogeneous events in a heterogeneous disease, and an individualised approach is paramount...
  8. ncbi request reprint Structural and functional co-conspirators in chronic obstructive pulmonary disease exacerbations
    Jadwiga A Wedzicha
    Academic Unit of Respiratory Medicine, Royal Free and University College Medical School, University College London, Rowland Hill Street, Hampstead, London NW3 2PF, UK
    Proc Am Thorac Soc 4:602-5. 2007
    ..Underlying structural changes such as radiologic changes of bronchiectasis that can be found in COPD can also modulate exacerbation severity and contribute to morbidity associated with exacerbations...
  9. ncbi request reprint The prevention of chronic obstructive pulmonary disease exacerbations by salmeterol/fluticasone propionate or tiotropium bromide
    Jadwiga A Wedzicha
    Academic Unit of Respiratory Medicine, Royal Free and University College Medical School, University College London, London, UK
    Am J Respir Crit Care Med 177:19-26. 2008
    ..Exacerbations are key drivers of morbidity and mortality in chronic obstructive pulmonary disease (COPD)...
  10. ncbi request reprint Impact of chronic obstructive pulmonary disease exacerbations on patients and payers
    Jadwiga A Wedzicha
    Academic Unit of Respiratory Medicine, University College, London, UK
    Proc Am Thorac Soc 3:218-21. 2006
    ..Although pharmacologic therapies may improve clinical outcomes, these benefits must be optimized by prompt diagnosis and delivery. This will require improved understanding of this complex disease by physicians and patients alike...
  11. pmc Serum IP-10 as a biomarker of human rhinovirus infection at exacerbation of COPD
    Jennifer K Quint
    Academic Unit of Respiratory Medicine, University College London, Rowland Hill St, London NW3 2PF, England
    Chest 137:812-22. 2010
    ....
  12. pmc Journal impact factors for 2004: another rise for Thorax
    J A Wedzicha
    Thorax Editorial Office, BMA House, Tavistock Square, London WC1H 9JR, UK
    Thorax 60:712. 2005
  13. ncbi request reprint Inflammatory changes, recovery and recurrence at COPD exacerbation
    W R Perera
    Academic Unit of Respiratory Medicine, Royal Free and University College Medical School, Rowland Hill Street, Hampstead, London, NW3 2PF, UK
    Eur Respir J 29:527-34. 2007
    ..A high serum C-reactive protein concentration 14 days after an index exacerbation may be used as a predictor of recurrent exacerbations within 50 days...
  14. ncbi request reprint Effect of tiotropium on sputum and serum inflammatory markers and exacerbations in COPD
    D J Powrie
    Academic Unit of Respiratory Medicine, Royal Free and University College Medical School, Rowland Hill Street, London, UK
    Eur Respir J 30:472-8. 2007
    ..3 versus 34.5 days). Tiotropium reduces exacerbation frequency in chronic obstructive pulmonary disease, but this effect does not appear to be due to a reduction in airway or systemic inflammation...
  15. ncbi request reprint Effects of exacerbations and seasonality on exhaled nitric oxide in COPD
    A Bhowmik
    Academic Unit of Respiratory Medicine, St Bartholomew s and Royal London School of Medicine and Dentistry, London, UK
    Eur Respir J 26:1009-15. 2005
    ..The levels were lower in more severe chronic obstructive pulmonary disease. Exhaled nitric oxide levels were raised at the onset of exacerbation, particularly in the presence of a cold...
  16. pmc COPD exacerbations .1: Epidemiology
    G C Donaldson
    Academic Unit of Respiratory Medicine, University College London, UK
    Thorax 61:164-8. 2006
    ..The importance of distinguishing between recurrent and relapsed exacerbations is discussed...
  17. ncbi request reprint Acute exacerbations of chronic obstructive pulmonary disease are accompanied by elevations of plasma fibrinogen and serum IL-6 levels
    J A Wedzicha
    Department of Academic Respiratory Medicine, St Bartholomew s and Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, London, UK
    Thromb Haemost 84:210-5. 2000
    ....
  18. ncbi request reprint Randomised controlled trial of nasal ventilation in acute ventilatory failure due to chronic obstructive airways disease
    J Bott
    King s College School of Medicine and Dentistry, London, UK
    Lancet 341:1555-7. 1993
    ..33, CI = 0.10-1.11, p = 0.106). In patients with acute ventilatory failure due to COAD who received NIPPV there was a significant rise in pH, a reduction in PaCO2 and breathlessness, and reduced mortality...
  19. ncbi request reprint Managing acute on chronic respiratory failure: a guide to non-invasive ventilation
    J J P Goldring
    Royal Free and University College Medical School, London NW3 2PF
    Br J Hosp Med (Lond) 69:444-9. 2008
    ..It is associated with high mortality rates and so practising the best evidence-based management is vital...
  20. ncbi request reprint Longitudinal changes in the nature, severity and frequency of COPD exacerbations
    G C Donaldson
    Academic Unit of Respiratory Medicine, St Bartholomew s and Royal London School of Medicine and Dentistry, London, UK
    Eur Respir J 22:931-6. 2003
    ..1% x yr(-1) from an initial value of 17%. The results of this study suggest that over time, individual patients have more symptoms during exacerbations, with an increased chance of sputum purulence and longer recovery times...
  21. doi request reprint Predictive accuracy of patient-reported exacerbation frequency in COPD
    J K Quint
    Academic Unit of Respiratory Medicine, University College London, Rowland Hill Street, London, NW3 2PF, UK
    Eur Respir J 37:501-7. 2011
    ..Accuracy is increased when comparing the same 1-yr period. Patient recall is sufficiently robust for stratification into frequent and infrequent exacerbator groups for subsequent years...
  22. ncbi request reprint Respiratory viruses, symptoms, and inflammatory markers in acute exacerbations and stable chronic obstructive pulmonary disease
    T Seemungal
    Academic Department of Respiratory Medicine and Virology, St. Bartholomew's and Royal London School of Medicine and Dentistry, London, UK
    Am J Respir Crit Care Med 164:1618-23. 2001
    ..Prevention and early treatment of viral infections may lead to a decreased exacerbation frequency and morbidity associated with COPD...
  23. ncbi request reprint Epidemiological relationships between the common cold and exacerbation frequency in COPD
    J R Hurst
    Academic Unit of Respiratory Medicine, Royal Free and University College Medical School, Hampstead, London, NW3 2QG, UK
    Eur Respir J 26:846-52. 2005
    ..Exacerbation frequency in chronic obstructive pulmonary disease is associated with an increased frequency of acquiring the common cold, rather than an increased propensity to exacerbation once a cold has been acquired...
  24. ncbi request reprint Effect of interactions between lower airway bacterial and rhinoviral infection in exacerbations of COPD
    Tom M A Wilkinson
    Academic Unit of Respiratory Medicine, St Bartholomew s and The Royal London School of Medicine, St Bartholomew s Hospital, London, UK
    Chest 129:317-24. 2006
    ....
  25. ncbi request reprint Airway and systemic inflammation and decline in lung function in patients with COPD
    Gavin C Donaldson
    Academic Unit of Respiratory Medicine, St Bartholomew s and Royal London Hospital School of Medicine and Dentistry, London, UK
    Chest 128:1995-2004. 2005
    ..Patients with COPD experience lower airway and systemic inflammation, and an accelerated decline in FEV1. There is no evidence on whether this inflammation changes over time, or if it is associated with a faster decline in FEV1...
  26. ncbi request reprint Airway epithelial inflammatory responses and clinical parameters in COPD
    I S Patel
    Academic Unit of Respiratory Medicine, St Bartholomew s and The Royal London Hospital School of Medicine and Dentistry, London, UK
    Eur Respir J 22:94-9. 2003
    ....
  27. ncbi request reprint Respiratory syncytial virus, airway inflammation, and FEV1 decline in patients with chronic obstructive pulmonary disease
    Tom M A Wilkinson
    Academic Unit of Respiratory Medicine, University College London, Royal Free and University College Medical School, Hampstead Campus, Rowland Hill Street, London, NW3 2PF, UK
    Am J Respir Crit Care Med 173:871-6. 2006
    ..We therefore studied the consequences of RSV persistence in adults with COPD and its effect on airway inflammation and lung function decline...
  28. pmc Strategies for improving outcomes of COPD exacerbations
    Tom Wilkinson
    Academic Unit of Respiratory Medicine, University College London, Royal Free and University College Medical School, London UK
    Int J Chron Obstruct Pulmon Dis 1:335-42. 2006
    ..This review will consider the current management of COPD exacerbations and how new clinical strategies may improve outcome of these important clinical events...
  29. ncbi request reprint Patterns of home mechanical ventilation use in Europe: results from the Eurovent survey
    S J Lloyd-Owen
    Academic Unit of Respiratory Medicine, Dominion House, St Bartholomew s Hospital, West Smithfield, London EC1A 7BE, UK
    Eur Respir J 25:1025-31. 2005
    ..In conclusion, wide variations exist in the patterns of home mechanical ventilation provision throughout Europe. Further work is needed to monitor its use and ensure equality of provision and access...
  30. ncbi request reprint The potential value of biomarkers in diagnosis and staging of COPD and exacerbations
    Anant R C Patel
    Academic Unit of Respiratory Medicine, University College London Medical School, London, United Kingdom
    Semin Respir Crit Care Med 31:267-75. 2010
    ..There is substantial ongoing investigation of many biomarkers that we are hopeful will advance the field for the benefit of our patients...
  31. ncbi request reprint Use and utility of a 24-hour Telephone Support Service for 'high risk' patients with COPD
    John R Hurst
    Academic Unit of Respiratory Medicine, Royal Free Campus, UCL Medical School, London, UK
    Prim Care Respir J 19:260-5. 2010
    ..Hospitalisations are important events in COPD, and exacerbation prevention strategies are not completely effective. Experience with our research cohort suggested that availability of 24-hour telephone advice may reduce hospital admission...
  32. ncbi request reprint Susceptibility to exacerbation in chronic obstructive pulmonary disease
    John R Hurst
    Academic Unit of Respiratory Medicine, Royal Free Campus, UCL Medical School, London, United Kingdom
    N Engl J Med 363:1128-38. 2010
    ..In a large observational cohort, we tested the hypothesis that there is a frequent-exacerbation phenotype of COPD that is independent of disease severity...
  33. pmc Chronic obstructive pulmonary disease: the clinical management of an acute exacerbation
    J R Hurst
    Academic Unit of Respiratory Medicine, Dominion House, St Bartholomew s Hospital, London EC1A 7BE, UK
    Postgrad Med J 80:497-505. 2004
    ..In this review we aim to bring the non-specialist reader up to date with current management principles and the evidence underlying such interventions...
  34. ncbi request reprint Relationship between depression and exacerbations in COPD
    J K Quint
    Academic Unit of Respiratory Medicine, University College London, Hampstead Campus, Rowland Hill Street, London NW3 2PF, UK
    Eur Respir J 32:53-60. 2008
    ..The finding that frequent exacerbators are more depressed than infrequent exacerbators is relevant, as exacerbation frequency is an important outcome measure in chronic obstructive pulmonary disease...
  35. ncbi request reprint Nasal symptoms, airway obstruction and disease severity in chronic obstructive pulmonary disease
    John R Hurst
    Academic Unit of Respiratory Medicine, Royal Free and University College Medical School, Royal Free Hospital, Hampstead, London, UK
    Clin Physiol Funct Imaging 26:251-6. 2006
    ..We also sought to investigate relationships between nasal symptoms and nasal patency in COPD...
  36. ncbi request reprint Early therapy improves outcomes of exacerbations of chronic obstructive pulmonary disease
    Tom M A Wilkinson
    Academic Unit of Respiratory Medicine, St Bartholomew s Hospital, London, UK
    Am J Respir Crit Care Med 169:1298-303. 2004
    ..21, p = 0.04). Patient recognition of exacerbation symptoms and prompt treatment improves exacerbation recovery, reduces risks of hospitalization, and is associated with a better health-related quality of life...
  37. ncbi request reprint Temporal clustering of exacerbations in chronic obstructive pulmonary disease
    John R Hurst
    Academic Unit of Respiratory Medicine, Royal Free and University College Medical School, London, United Kingdom
    Am J Respir Crit Care Med 179:369-74. 2009
    ..We hypothesized that exacerbations may cluster together in time, a finding that would have important implications for targeting preventative interventions and the analysis of clinical trial data...
  38. ncbi request reprint Use of plasma biomarkers at exacerbation of chronic obstructive pulmonary disease
    John R Hurst
    Academic Unit of Respiratory Medicine, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    Am J Respir Crit Care Med 174:867-74. 2006
    ..This study explores the use of measuring plasma biomarkers at exacerbation of chronic obstructive pulmonary disease (COPD), providing insight into the underlying pathogenesis of these important events...
  39. ncbi request reprint Increased risk of myocardial infarction and stroke following exacerbation of COPD
    Gavin C Donaldson
    Academic Unit of Respiratory Medicine, Royal Free and University College Medical School, University College London, Rowland Hill Street, London, NW3 2PF, England
    Chest 137:1091-7. 2010
    ..The course of COPD is punctuated by exacerbations, which further increase systemic inflammation, but the risk of vascular events in the postexacerbation period has never been defined...
  40. ncbi request reprint Systemic and upper and lower airway inflammation at exacerbation of chronic obstructive pulmonary disease
    John R Hurst
    F R C P, Academic Unit of Respiratory Medicine, Royal Free and University College Medical School, Royal Free Hospital London NW3 2PF UK
    Am J Respir Crit Care Med 173:71-8. 2006
    ..Although exacerbations of COPD are associated with increased pulmonary and systemic inflammation, determinants of the systemic response remain obscure, and nor is it known whether there is nasal involvement...
  41. ncbi request reprint Relationships among bacteria, upper airway, lower airway, and systemic inflammation in COPD
    John R Hurst
    Academic Unit of Respiratory Medicine, Dominion House, St Bartholomew s Hospital, London, EC1A 7BE, UK
    Chest 127:1219-26. 2005
    ....
  42. ncbi request reprint Exacerbations: etiology and pathophysiologic mechanisms
    Jadwiga A Wedzicha
    Academic Unit of Respiratory Medicine, St Bartholomew s Hospital and Royal London School of Medicine and Dentistry, Dominion House, West Smithfield, London EC1A 7BE, UK
    Chest 121:136S-141S. 2002
    ..The reduction of COPD exacerbations will have an important impact on the considerable morbidity and mortality associated with COPD...
  43. ncbi request reprint Bronchiectasis, exacerbation indices, and inflammation in chronic obstructive pulmonary disease
    Irem S Patel
    Academic Unit of Respiratory Medicine, Dominion House, St Bartholomew s Hospital, West Smithfield, London EC1A 7BE, UK
    Am J Respir Crit Care Med 170:400-7. 2004
    ..Evidence of moderate lower lobe bronchiectasis on HRCT is common in COPD and is associated with more severe COPD exacerbations, lower airway bacterial colonization, and increased sputum inflammatory markers...
  44. ncbi request reprint Short burst oxygen therapy is helpful?
    J A Wedzicha
    Academic Respiratory Medicine, St Bartholomew s and Royal London School of Medicine and Dentistry, St Bartholomew s Hospital, West Smithfield, London, UK
    Chron Respir Dis 1:101-3. 2004
  45. pmc What is (and what is not) a COPD exacerbation: thoughts from the new GOLD guidelines
    J R Hurst
    Academic Unit of Respiratory Medicine, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    Thorax 62:198-9. 2007
  46. ncbi request reprint Defective macrophage phagocytosis of bacteria in COPD
    A E Taylor
    Airways Disease Section, National Heart and Lung Institute, Dovehouse Street, London, UK
    Eur Respir J 35:1039-47. 2010
    ..COPD macrophage innate responses are suppressed and may lead to bacterial colonisation and increased exacerbation frequency...
  47. pmc Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease
    G C Donaldson
    Academic Unit of Respiratory Medicine, St Bartholomew s and Royal London School of Medicine and Dentistry, UK
    Thorax 57:847-52. 2002
    ..The aim of this study was to investigate whether these are related...
  48. ncbi request reprint Outcome of long-term noninvasive positive-pressure ventilation
    Jadwiga A Wedzicha
    Academic Unit of Respiratory Medicine, St Bartholomew s and the Royal London Medical School, St Bartholomew s Hospital, Dominion House, London EC1A 7BE, UK
    Respir Care Clin N Am 8:559-73. 2002
    ..If the initial experience with NPPV in COPD is confirmed in larger trials, then this important therapy will be available to an even larger group of patients worldwide...
  49. ncbi request reprint Relationship between chronic nasal and respiratory symptoms in patients with COPD
    Nicola J Roberts
    Academic Unit of Respiratory Medicine, St Bartholomew s Hospital and the Royal London School of Medicine, London EC1A 7BE, UK
    Respir Med 97:909-14. 2003
    ..Associations between nasal and respiratory symptoms were found suggesting that there is a relationship between the upper and lower airway in COPD...
  50. ncbi request reprint Exacerbations and time spent outdoors in chronic obstructive pulmonary disease
    Gavin C Donaldson
    Academic Unit of Respiratory Medicine, Dominion House, St Bartholomew s Hospital, London EC1A 7BE, UK
    Am J Respir Crit Care Med 171:446-52. 2005
    ..In conclusion, time spent outside the home declines over time and acutely at exacerbation. Patients with frequent exacerbations are more likely to become housebound and need targeting in rehabilitation programs...
  51. ncbi request reprint Noninvasive ventilation in chronic obstructive pulmonary disease, bronchiectasis and cystic fibrosis
    J A Wedzicha
    St Bartholomew s Hospital, London, UK
    Eur Respir J 20:777-84. 2002
    ....
  52. doi request reprint Respiratory syncytial virus persistence in chronic obstructive pulmonary disease
    Markus B Sikkel
    Department of Respiratory Medicine, National Heart and Lung Institute, Wright Fleming Institute of Infection and Immunity and MRC, Asthma UK Centre in Allergic Mechanisms of Asthma, Imperial College London, London, UK
    Pediatr Infect Dis J 27:S63-70. 2008
    ..Persistence of RSV in COPD may have direct relevance to the pathogenesis of childhood diseases such as postbronchiolitic wheeze and asthma...
  53. ncbi request reprint Determinants and impact of fatigue in patients with chronic obstructive pulmonary disease
    Ramin Baghai-Ravary
    Academic Unit of Respiratory Medicine, University College London, Hampstead Campus, Rowland Hill Street, London NW3 2PF, United Kingdom
    Respir Med 103:216-23. 2009
    ..We have shown that exacerbations are associated with reduced activity and health status. However, the relationship between fatigue and exacerbation is unknown...
  54. ncbi request reprint Role of viruses in exacerbations of chronic obstructive pulmonary disease
    Jadwiga A Wedzicha
    Academic Unit of Respiratory Medicine, St Bartholomew s and Royal London School of Medicine and Dentistry, Dominion House, St Bartholomew s Hospital, West Smithfield, London EC1A 7BE, UK
    Proc Am Thorac Soc 1:115-20. 2004
    ..Strategies to prevent viral infection will have a significant effect on the morbidity of COPD and will improve quality of life...
  55. ncbi request reprint Upper airway symptoms and quality of life in chronic obstructive pulmonary disease (COPD)
    John R Hurst
    Academic Unit of Respiratory Medicine, St Bartholomew s and Royal London Medical School, St Bartholomew s Hospital, Dominion House, London EC1A 7BE, UK
    Respir Med 98:767-70. 2004
    ..To assess the impact on quality of life from upper airway symptoms in chronic obstructive pulmonary disease (COPD)...
  56. ncbi request reprint An evaluation of the reliability and sensitivity of the London Chest Activity of Daily Living Scale (LCADL)
    R Garrod
    School of Physiotherapy, St George s Hospital, London, UK
    Respir Med 96:725-30. 2002
    ..91 (from -9.23 to -2.60) after rehabilitation. These data support the use of the LCADL as an outcome measure in COPD which is valid, reliable and responsive to change...
  57. ncbi request reprint Investigating new standards for prophylaxis in reduction of exacerbations--the INSPIRE study methodology
    Terence Seemungal
    Department of Clinical Medical Sciences, The University of the West Indies, Mt Hope, Trinidad and Tobago
    COPD 4:177-83. 2007
    ..If the innovative methodology of utilizing 2 definitions of exacerbation proves successful, it will set the benchmark for future studies in chronic obstructive pulmonary disease...
  58. ncbi request reprint Exacerbations of chronic obstructive pulmonary disease
    Jadwiga A Wedzicha
    Academic Unit of Respiratory Medicine, St Bartholomew s and Royal London School of Medicine and Dentistry, Dominion House, St Bartholomew s Hospital, London EC1A 7BE, United Kingdom
    Respir Care 48:1204-13; discussion 1213-5. 2003
    ..Antibiotics have some efficacy in treating exacerbations. Exacerbation frequency increases with progressive airflow obstruction; so patients with chronic respiratory failure are particularly susceptible to exacerbation...
  59. pmc ABC of chronic obstructive pulmonary disease. Acute exacerbations
    Graeme P Currie
    Respiratory Unit, Aberdeen Royal Infirmary, Aberdeen
    BMJ 333:87-9. 2006
  60. pmc Hospital at home for patients with acute exacerbations of chronic obstructive pulmonary disease: systematic review of evidence
    Felix S F Ram
    National Collaborating Centre for Women and Children s Health, London NW1 4RG
    BMJ 329:315. 2004
    ..To evaluate the efficacy of hospital at home schemes compared with inpatient care in patients with acute exacerbations of chronic obstructive pulmonary disease (COPD)...
  61. ncbi request reprint Viral infections in obstructive airway diseases
    Terence A R Seemungal
    Academic Unit of Respiatory Medicine, St Bartholomew s and the Royal London School of Medicine and Dentistry, UK
    Curr Opin Pulm Med 9:111-6. 2003
    ..Viruses may cause chronic infection in both diseases. This paper reviews some studies on the effects of respiratory viruses on asthma and COPD published in 2002 and discusses their relevance to current thinking in pulmonary medicine...
  62. ncbi request reprint Heliox in chronic obstructive pulmonary disease: lightening the airflow
    Jadwiga A Wedzicha
    Am J Respir Crit Care Med 173:825-6. 2006
  63. pmc Non-invasive positive pressure ventilation to treat respiratory failure resulting from exacerbations of chronic obstructive pulmonary disease: Cochrane systematic review and meta-analysis
    Josephine V Lightowler
    Department of Respiratory Medicine, St James s University Hospital, Leeds LS9 7TF
    BMJ 326:185. 2003
    ..To determine the effectiveness of non-invasive positive pressure ventilation (NPPV) in the management of respiratory failure secondary to acute exacerbation of chronic obstructive pulmonary disease...
  64. ncbi request reprint Prednisone for chronic obstructive pulmonary disease
    John R Hurst
    N Engl J Med 349:1288-90; author reply 1288-90. 2003
  65. ncbi request reprint Airway bacterial load and FEV1 decline in patients with chronic obstructive pulmonary disease
    Tom M A Wilkinson
    Academic Unit of Respiratory Medicine, St Bartholomew s and Royal London School of Medicine, St Bartholomew s Hospital, United Kingdom
    Am J Respir Crit Care Med 167:1090-5. 2003
    ..03). Rising airway bacterial load and species changes are associated with greater airway inflammation and accelerated decline in FEV1. Bacterial colonization in COPD is an important factor in disease progression...
  66. ncbi request reprint Mechanism of statin-associated mortality reduction in COPD
    John R Hurst
    Chest 132:1409; author reply 1409-10. 2007
  67. pmc Effectiveness of innovations in nurse led chronic disease management for patients with chronic obstructive pulmonary disease: systematic review of evidence
    Stephanie J C Taylor
    Centre for Health Sciences, Barts and The London, Queen Mary s School of Medicine and Dentistry, London E1 2AT
    BMJ 331:485. 2005
    ..To determine the effectiveness of innovations in management of chronic disease involving nurses for patients with chronic obstructive pulmonary disease (COPD)...