Lucy R Wedderburn

Summary

Affiliation: University College London
Country: UK

Publications

  1. doi request reprint Hsp60 in inflamed muscle tissue is the target of regulatory autoreactive T cells in patients with juvenile dermatomyositis
    Elisabeth F Elst
    University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 58:547-55. 2008
  2. pmc Autologous haematopoietic stem cell transplantation in juvenile idiopathic arthritis
    L R Wedderburn
    Rheumatology Unit, Institute of Child Health, UCL and Great Ormond Street Hospital NHS Trust, London, UK
    Arch Dis Child 88:201-5. 2003
  3. ncbi request reprint International consensus on a proposed score system for muscle biopsy evaluation in patients with juvenile dermatomyositis: a tool for potential use in clinical trials
    Lucy R Wedderburn
    University College London, London, UK
    Arthritis Rheum 57:1192-201. 2007
  4. ncbi request reprint Paediatric idiopathic inflammatory muscle disease
    Lucy R Wedderburn
    Rheumatology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Best Pract Res Clin Rheumatol 18:345-58. 2004
  5. pmc Juvenile dermatomyositis: new developments in pathogenesis, assessment and treatment
    Lucy R Wedderburn
    Rheumatology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Best Pract Res Clin Rheumatol 23:665-78. 2009
  6. ncbi request reprint HLA class II haplotype and autoantibody associations in children with juvenile dermatomyositis and juvenile dermatomyositis-scleroderma overlap
    L R Wedderburn
    Rheumatology Unit, Institute of Child Health, UCL, 30 Guilford Street, London WC1N 1EH, UK
    Rheumatology (Oxford) 46:1786-91. 2007
  7. ncbi request reprint Divergence in the degree of clonal expansions in inflammatory T cell subpopulations mirrors HLA-associated risk alleles in genetically and clinically distinct subtypes of childhood arthritis
    L R Wedderburn
    Rheumatology Unit, Institute of Child Health, University College London, 30 Guilford Street, London, UK
    Int Immunol 13:1541-50. 2001
  8. pmc The developing human immune system: T-cell receptor repertoire of children and young adults shows a wide discrepancy in the frequency of persistent oligoclonal T-cell expansions
    L R Wedderburn
    Department of Molecular Pathology, University College London, UK
    Immunology 102:301-9. 2001
  9. pmc Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment
    Kiran Nistala
    Rheumatology Unit, University College London Institute of Child Health, London WC1N 1EH, United Kingdom
    Proc Natl Acad Sci U S A 107:14751-6. 2010
  10. pmc Generation of novel pharmacogenomic candidates in response to methotrexate in juvenile idiopathic arthritis: correlation between gene expression and genotype
    Halima Moncrieffe
    Rheumatology Unit, UCL Institute of Child Health, London, UK
    Pharmacogenet Genomics 20:665-76. 2010

Collaborators

Detail Information

Publications41

  1. doi request reprint Hsp60 in inflamed muscle tissue is the target of regulatory autoreactive T cells in patients with juvenile dermatomyositis
    Elisabeth F Elst
    University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 58:547-55. 2008
    ..The purpose of this study was to determine whether Hsp60 could serve as an autoantigen in juvenile DM...
  2. pmc Autologous haematopoietic stem cell transplantation in juvenile idiopathic arthritis
    L R Wedderburn
    Rheumatology Unit, Institute of Child Health, UCL and Great Ormond Street Hospital NHS Trust, London, UK
    Arch Dis Child 88:201-5. 2003
  3. ncbi request reprint International consensus on a proposed score system for muscle biopsy evaluation in patients with juvenile dermatomyositis: a tool for potential use in clinical trials
    Lucy R Wedderburn
    University College London, London, UK
    Arthritis Rheum 57:1192-201. 2007
    ..To devise and test a system with which to evaluate abnormalities on muscle biopsy samples obtained from children diagnosed with juvenile dermatomyositis (DM)...
  4. ncbi request reprint Paediatric idiopathic inflammatory muscle disease
    Lucy R Wedderburn
    Rheumatology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Best Pract Res Clin Rheumatol 18:345-58. 2004
    ....
  5. pmc Juvenile dermatomyositis: new developments in pathogenesis, assessment and treatment
    Lucy R Wedderburn
    Rheumatology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Best Pract Res Clin Rheumatol 23:665-78. 2009
    ..Aggressive treatment approaches, including multiple initial therapies, as well as new drugs and biological therapies for refractory disease, offer promise of improved outcomes and less corticosteroid-related toxicity...
  6. ncbi request reprint HLA class II haplotype and autoantibody associations in children with juvenile dermatomyositis and juvenile dermatomyositis-scleroderma overlap
    L R Wedderburn
    Rheumatology Unit, Institute of Child Health, UCL, 30 Guilford Street, London WC1N 1EH, UK
    Rheumatology (Oxford) 46:1786-91. 2007
    ..To investigate a large cohort of children with juvenile dermatomyositis (JDM), and those with JDM-scleroderma (JDM-SSc) overlap, using detailed serological analysis, HLA class II genotyping and clinical characterization...
  7. ncbi request reprint Divergence in the degree of clonal expansions in inflammatory T cell subpopulations mirrors HLA-associated risk alleles in genetically and clinically distinct subtypes of childhood arthritis
    L R Wedderburn
    Rheumatology Unit, Institute of Child Health, University College London, 30 Guilford Street, London, UK
    Int Immunol 13:1541-50. 2001
    ..These data provide powerful data to support the concept that recognition of MHC-peptide complexes by T cells plays a role in the pathogenesis of juvenile arthritis...
  8. pmc The developing human immune system: T-cell receptor repertoire of children and young adults shows a wide discrepancy in the frequency of persistent oligoclonal T-cell expansions
    L R Wedderburn
    Department of Molecular Pathology, University College London, UK
    Immunology 102:301-9. 2001
    ..These studies suggest that many factors affect the overall regulation of clone size in response to chronic antigens during the development of the immune system...
  9. pmc Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment
    Kiran Nistala
    Rheumatology Unit, University College London Institute of Child Health, London WC1N 1EH, United Kingdom
    Proc Natl Acad Sci U S A 107:14751-6. 2010
    ..Therefore therapies targeting the induction of Th17 cells could also attenuate Th17/1 and Th1 effector populations within the inflamed joint...
  10. pmc Generation of novel pharmacogenomic candidates in response to methotrexate in juvenile idiopathic arthritis: correlation between gene expression and genotype
    Halima Moncrieffe
    Rheumatology Unit, UCL Institute of Child Health, London, UK
    Pharmacogenet Genomics 20:665-76. 2010
    ..The aims of this study were to use gene expression profiling to identify novel pathways/genes altered by MTX and then investigate these genes for genotype associations with response to MTX treatment...
  11. pmc Interleukin-17-producing T cells are enriched in the joints of children with arthritis, but have a reciprocal relationship to regulatory T cell numbers
    Kiran Nistala
    University College London, London, UK
    Arthritis Rheum 58:875-87. 2008
    ....
  12. pmc High expression of the ectonucleotidase CD39 on T cells from the inflamed site identifies two distinct populations, one regulatory and one memory T cell population
    Halima Moncrieffe
    Rheumatology Unit, University College London, London, United Kingdom
    J Immunol 185:134-43. 2010
    ..Our data suggest that in human CD4(+) T cells from the inflamed site, CD39 can be highly expressed on two populations, one regulatory and the other of a memory phenotype...
  13. pmc Association of the IL-10 gene family locus on chromosome 1 with juvenile idiopathic arthritis (JIA)
    Ebun Omoyinmi
    Department of Immunology and Molecular Pathology, University College London, London, United Kingdom
    PLoS ONE 7:e47673. 2012
    ....
  14. pmc Th1 and Th17 cell subpopulations are enriched in the peripheral blood of patients with systemic juvenile idiopathic arthritis
    Ebun Omoyinmi
    Department of Immunology and Molecular Pathology, University College London, 5 University Street, London WC1E 6JF, UK
    Rheumatology (Oxford) 51:1881-6. 2012
    ..The aim of this study was to examine the phenotype of circulating peripheral blood CD4(+) T-cell subpopulations in a cross-sectional study of sJIA patients during disease remission on medication and during acute flare of the disease...
  15. pmc Overexpression of MHC class I heavy chain protein in young skeletal muscle leads to severe myositis: implications for juvenile myositis
    Charles Kwok chong Li
    Rheumatology Unit, Institute of Child Health, University College London, 30 Guilford Street, London, UK
    Am J Pathol 175:1030-40. 2009
    ..This novel model has important implications for our understanding of muscle pathology in dermatomyositis of both adults and children...
  16. ncbi request reprint Quantification of normal range of inflammatory changes in morphologically normal pediatric muscle
    Hemlata Varsani
    Rheumatology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, United Kingdom
    Muscle Nerve 37:259-61. 2008
    ..Normal findings were defined for each feature. These data will facilitate quantitative analysis of inflammatory changes in pediatric muscle biopsy...
  17. pmc CD161 defines the subset of FoxP3+ T cells capable of producing proinflammatory cytokines
    Anne M Pesenacker
    Rheumatology Unit, UCL Institute of Child Health, University College London, London, United Kingdom
    Blood 121:2647-58. 2013
    ..Our data therefore demonstrate that CD161+FoxP3+ T cells are a novel Treg subset, found in health and disease, which display high proinflammatory potential but also exhibit hallmark Treg characteristics...
  18. pmc A national registry for juvenile dermatomyositis and other paediatric idiopathic inflammatory myopathies: 10 years' experience; the Juvenile Dermatomyositis National (UK and Ireland) Cohort Biomarker Study and Repository for Idiopathic Inflammatory Myopat
    Neil Martin
    Rheumatology Unit, UCL Institute of Child Health, Great Ormond Street Hospital, 30 Guilford Street, University College London, London WC1N 1EH, UK
    Rheumatology (Oxford) 50:137-45. 2011
    ..We have established a national registry and repository for childhood IIM, which aims to improve knowledge, facilitate research and clinical trials, and ultimately to improve outcomes for these patients...
  19. pmc Biologic predictors of extension of oligoarticular juvenile idiopathic arthritis as determined from synovial fluid cellular composition and gene expression
    Patricia J Hunter
    Rheumatology Unit, University College London Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Arthritis Rheum 62:896-907. 2010
    ....
  20. pmc Mothers' reports of the difficulties that their children experience in taking methotrexate for Juvenile Idiopathic Arthritis and how these impact on quality of life
    Kathleen Mulligan
    School of Health Sciences, City University London, Northampton Square, London, EC1V OHB, UK
    Pediatr Rheumatol Online J 11:23. 2013
    ..The aim of this study was to examine the prevalence and extent of these difficulties and their impact on quality of life...
  21. pmc Expression of the inflammatory chemokines CCL5, CCL3 and CXCL10 in juvenile idiopathic arthritis, and demonstration of CCL5 production by an atypical subset of CD8+ T cells
    Daniel S Pharoah
    Rheumatology Unit, Institute of Child Health, UCL, London, UK
    Arthritis Res Ther 8:R50. 2006
    ..We believe this to be the first in depth analysis of these mediators of inflammation in JIA...
  22. pmc Delineation of the innate and adaptive T-cell immune outcome in the human host in response to Campylobacter jejuni infection
    Lindsey A Edwards
    Infectious Diseases and Microbiology, Institute of Child Health, London, United Kingdom
    PLoS ONE 5:e15398. 2010
    ..jejuni using an ex-vivo human gut model of infection. Secondly, impact of bacterial-driven dendritic cell activation on T-cell mediated immunity was also sought...
  23. pmc Human dendritic cells infected with an adenoviral vector suppress proliferation of autologous and allogeneic T cells
    Katy R Newton
    Rheumatology Unit, Institute of Child Health, UCL, London, UK
    Immunology 125:469-79. 2008
    ..Together our data suggest that infection of DCs by adenoviral vectors leads to suppression of the resulting immune response...
  24. ncbi request reprint MHC Class I overexpression on muscles in early juvenile dermatomyositis
    Charles K C Li
    Rheumatology Unit, Institute of Child Health, University College London and Great Ormond Street Hospital, London, UK
    J Rheumatol 31:605-9. 2004
    ....
  25. doi request reprint Th17 and regulatory T cells: rebalancing pro- and anti-inflammatory forces in autoimmune arthritis
    Kiran Nistala
    Rheumatology Unit, Institute of Child Health, University College London, London, UK
    Rheumatology (Oxford) 48:602-6. 2009
    ..Anti-rheumatic biologic therapies may offer a means of restoring the Th17/Treg balance in favour of Tregs and thereby re-establishing immune tolerance...
  26. doi request reprint Duration of etanercept treatment and reasons for discontinuation in a cohort of juvenile idiopathic arthritis patients
    Taunton R Southwood
    Department of Paediatric Rheumatology, Institute of Child Health, 4th Floor Laboratories Block, Birmingham Children s Hospital NHS Foundation Trust, University of Birmingham, Whittall Street, Birmingham, B4 6NH, UK
    Rheumatology (Oxford) 50:189-95. 2011
    ..Here, we report the duration of etanercept use for the first 5 years of the register and reasons for discontinuation...
  27. ncbi request reprint Clonal expansions in acute EBV infection are detectable in the CD8 and not the CD4 subset and persist with a variable CD45 phenotype
    M K Maini
    Department of Sexually Transmitted Diseases and Immunology, University College London, London, United Kingdom
    J Immunol 165:5729-37. 2000
    ....
  28. ncbi request reprint Quantitative assessment of MRI T2 relaxation time of thigh muscles in juvenile dermatomyositis
    S M Maillard
    Juvenile Dermatomyositis Research Centre, Institute of Child Health, London, UK
    Rheumatology (Oxford) 43:603-8. 2004
    ..The aim of the study was to examine the validity and reliability of a quantifiable measure of inflammation using magnetic resonance imaging (MRI) in children with juvenile dermatomyositis (JDM)...
  29. ncbi request reprint Autologous stem cell transplantation for paediatric-onset polyarteritis nodosa: changes in autoimmune phenotype in the context of reduced diversity of the T- and B-cell repertoires, and evidence for reversion from the CD45RO(+) to RA(+) phenotype
    L R Wedderburn
    Paediatric Rheumatology Unit, Institute of Child Health and Department of Molecular Pathology, University College London, London, UK
    Rheumatology (Oxford) 40:1299-307. 2001
    ..Our data also show that 12 months after treatment these expanded T-cell clones were within the CD45RA(+) population, suggesting that reversion from the CD45RO(+) to the CD45RA(+) phenotype had occurred in vivo...
  30. doi request reprint A subgroup of juvenile idiopathic arthritis patients who respond well to methotrexate are identified by the serum biomarker MRP8/14 protein
    Halima Moncrieffe
    Rheumatology Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Rheumatology (Oxford) 52:1467-76. 2013
    ..The aim of this study was to define the prognostic value of baseline serum proteins and clinical variables in response to MTX to help inform the clinician at time of diagnosis whether the patient is likely to respond well to MTX...
  31. ncbi request reprint Failure to over express MHC-CLASS-1 on muscle biopsy in a case of amyopathic juvenile dermatomyositis
    L J McCann
    Rheumatology Unit, Royal Liverpool Children s Hospital, Liverpool, UK
    Clin Exp Rheumatol 25:96-8. 2007
    ..This supports the concept of amyopathic dermatomyositis as a subgroup of juvenile dermatomyositis (JDM) and suggests that immunohistological analysis may be a valuable in excluding a myositic element in such cases...
  32. pmc Limb girdle muscular dystrophy type 2B masquerading as inflammatory myopathy: case report
    Hannah Jethwa
    Dubowitz Neuromuscular Centre, 30 Guilford Street, London, WC1N 1EH, UK
    Pediatr Rheumatol Online J 11:19. 2013
    ..Furthermore, characteristic inflammatory-related morning pain should not rule out consideration of non-inflammatory causes...
  33. ncbi request reprint Quantitative assessments of the effects of a single exercise session on muscles in juvenile dermatomyositis
    Susan M Maillard
    Juvenile Dermatomyositis Research Centre, Institute of Child Health, University College of London, London, United Kingdom
    Arthritis Rheum 53:558-64. 2005
    ..To investigate the short-term effects of exercise on muscle inflammation in children with juvenile dermatomyositis (juvenile DM). Magnetic resonance imaging (MRI), muscle strength, and blood parameters were used as outcome measures...
  34. ncbi request reprint Paediatric idiopathic inflammatory muscle disease: recognition and management
    Clarissa A Pilkington
    Rheumatology Unit, Great Ormond Street Hospital for Children and Institute of Child Health, University College of London, London, UK
    Drugs 65:1355-65. 2005
    ..The efforts of these large collaborative groups should provide much needed networks for mulitcentre trials in the future...
  35. ncbi request reprint Analysis of the T-cell receptor repertoire of synovial T-cells
    Lucy R Wedderburn
    Rheumatology Unit, Institute of Child Health, UCL, London, UK
    Methods Mol Med 136:97-116. 2007
    ..Two alternative molecular methods to analyse TCR diversity, identify clonal expansions, and track specific T-cell populations over both time and location are also detailed...
  36. doi request reprint Do mothers and fathers hold similar views about their child's arthritis?
    Kathleen Mulligan
    University College London, London, UK
    Arthritis Rheum 61:1712-8. 2009
    ..The aim of this study was to examine the level of agreement between mothers' and fathers' ratings of their child's quality of life (QOL) and to identify possible predictors of disagreement...
  37. ncbi request reprint Synovial dendritic cells in juvenile idiopathic arthritis (JIA) express receptor activator of NF-kappaB (RANK)
    H Varsani
    Rheumatology Unit, Institute of Child Health, University College London, London, UK
    Rheumatology (Oxford) 42:583-90. 2003
    ....
  38. ncbi request reprint Intravenous cyclophosphamide pulse therapy in juvenile dermatomyositis. A review of efficacy and safety
    P Riley
    Juvenile Dermatomyositis Research Centre, Institute of Child Health, Great Ormond Street, London, UK
    Rheumatology (Oxford) 43:491-6. 2004
    ..To assess the efficacy and safety of intravenous cyclophosphamide (CYP) used in severe and refractory juvenile dermatomyositis (JDM)...
  39. ncbi request reprint Labeling antigen-specific CD4(+) T cells with class II MHC oligomers
    Thomas O Cameron
    Department of Chemistry, MIT, 77 Massachusetts Avenue, Cambridge 02139, USA
    J Immunol Methods 268:51-69. 2002
    ....
  40. pmc Blood and synovial fluid cytokine signatures in patients with juvenile idiopathic arthritis: a cross-sectional study
    Wilco de Jager
    Department of Pediatric Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Ann Rheum Dis 66:589-98. 2007
    ..Although onset and disease course differ, the subtypes of JIA share the occurrence of chronic inflammation of the joints, with infiltrations of immunocompetent cells that secrete inflammatory mediators...
  41. ncbi request reprint CD4+CD25bright regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis
    Ismé M de Kleer
    University Medical Center Utrecht, Wilhelmina Children s Hospital, Department of Pediatric Immunology and Immunology Advanced Center on Preclinical Immuno genomics Institute for Translational Medicine, Utrecht, The Netherlands
    J Immunol 172:6435-43. 2004
    ..These data suggest that CD4(+)CD25(bright) Treg cells play a role in determining the patient's fate toward either a favorable or unfavorable clinical course of disease...