D J Weatherall

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint Genetic variability in response to infection: malaria and after
    D J Weatherall
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Genes Immun 3:331-7. 2002
  2. pmc Inherited haemoglobin disorders: an increasing global health problem
    D J Weatherall
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, England
    Bull World Health Organ 79:704-12. 2001
  3. ncbi request reprint Hematologic disorders of children in developing countries
    D J Weatherall
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, United Kingdom
    Pediatr Clin North Am 49:1149-64. 2002
  4. ncbi request reprint The molecular basis for the thalassaemias in Sri Lanka
    Christopher A Fisher
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Br J Haematol 121:662-71. 2003
  5. ncbi request reprint Genomics and global health: time for a reappraisal
    David J Weatherall
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK
    Science 302:597-9. 2003
  6. pmc 2003 William Allan Award address. The Thalassemias: the role of molecular genetics in an evolving global health problem
    David Weatherall
    Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, United Kingdom
    Am J Hum Genet 74:385-92. 2004
  7. ncbi request reprint Thalassaemia: the long road from bedside to genome
    David J Weatherall
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    Nat Rev Genet 5:625-31. 2004
  8. pmc Interaction of malaria with a common form of severe thalassemia in an Asian population
    A O'DONNELL
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
    Proc Natl Acad Sci U S A 106:18716-21. 2009
  9. doi request reprint The population genetics and dynamics of the thalassemias
    D J Weatherall
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, UK
    Hematol Oncol Clin North Am 24:1021-31. 2010
  10. ncbi request reprint Alpha+ -thalassaemia and pregnancy in a malaria endemic region of Papua New Guinea
    A O'DONNELL
    Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK
    Br J Haematol 135:235-41. 2006

Collaborators

Detail Information

Publications51

  1. ncbi request reprint Genetic variability in response to infection: malaria and after
    D J Weatherall
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Genes Immun 3:331-7. 2002
    ....
  2. pmc Inherited haemoglobin disorders: an increasing global health problem
    D J Weatherall
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, England
    Bull World Health Organ 79:704-12. 2001
    ....
  3. ncbi request reprint Hematologic disorders of children in developing countries
    D J Weatherall
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, United Kingdom
    Pediatr Clin North Am 49:1149-64. 2002
    ..In short, the handling of hematologic disorders in developing or tropical countries is no longer confined to the physicians who work in these countries; these diseases are now part of the work of every hematologist...
  4. ncbi request reprint The molecular basis for the thalassaemias in Sri Lanka
    Christopher A Fisher
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Br J Haematol 121:662-71. 2003
    ..These findings have implications for the control of thalassaemia in high-frequency populations with complex ethnic histories...
  5. ncbi request reprint Genomics and global health: time for a reappraisal
    David J Weatherall
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK
    Science 302:597-9. 2003
    ....
  6. pmc 2003 William Allan Award address. The Thalassemias: the role of molecular genetics in an evolving global health problem
    David Weatherall
    Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, United Kingdom
    Am J Hum Genet 74:385-92. 2004
  7. ncbi request reprint Thalassaemia: the long road from bedside to genome
    David J Weatherall
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    Nat Rev Genet 5:625-31. 2004
  8. pmc Interaction of malaria with a common form of severe thalassemia in an Asian population
    A O'DONNELL
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
    Proc Natl Acad Sci U S A 106:18716-21. 2009
    ..Because P. vivax malaria is widespread in Asia, further studies of its interaction with HbE beta thalassemia and related diseases are required urgently as a part of ongoing thalassemia control programs...
  9. doi request reprint The population genetics and dynamics of the thalassemias
    D J Weatherall
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, UK
    Hematol Oncol Clin North Am 24:1021-31. 2010
    ....
  10. ncbi request reprint Alpha+ -thalassaemia and pregnancy in a malaria endemic region of Papua New Guinea
    A O'DONNELL
    Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK
    Br J Haematol 135:235-41. 2006
    ..Although median haemoglobin concentration was significantly lower in mothers homozygous for alpha+ -thalassaemia than those with a normal alpha-globin genotype, this did not result in an adverse outcome of pregnancy...
  11. ncbi request reprint The hemoglobin E syndromes
    D C Rees
    MRC Molecular Haematology Unit, The John Radcliffe, Headington, Oxford, United Kingdom
    Ann N Y Acad Sci 850:334-43. 1998
    ..The Oakland individuals, mostly from Southeast Asia, show similar variation in Hb, which again is largely unexplained...
  12. doi request reprint The alpha thalassaemias
    D R Higgs
    Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Headington, Oxford OX39DS, United Kingdom
    Cell Mol Life Sci 66:1154-62. 2009
    ....
  13. ncbi request reprint Phenotype-genotype relationships in monogenic disease: lessons from the thalassaemias
    D J Weatherall
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    Nat Rev Genet 2:245-55. 2001
    ..They also emphasize the value of an understanding of phenotype-genotype relationships in designing approaches to gene therapy...
  14. ncbi request reprint Dissecting the loci controlling fetal haemoglobin production on chromosomes 11p and 6q by the regressive approach
    J E Craig
    MRC Molecular Haematology Unit, John Radcliffe Hospital, Oxford, UK
    Nat Genet 12:58-64. 1996
    ....
  15. ncbi request reprint Muscle cell injury, haemolysis and dark urine in children with falciparum malaria in Papua New Guinea
    A O'DONNELL
    Weatherall Institute of Molecular Medicine, University of Oxford, The John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    Trans R Soc Trop Med Hyg 100:817-25. 2006
    ..In malaria, hyperlactataemia may result directly from breakdown of muscle protein as well as tissue hypoxia...
  16. ncbi request reprint Thalassemia in the next millennium. Keynote address
    D J Weatherall
    MRC Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital, United Kingdom
    Ann N Y Acad Sci 850:1-9. 1998
    ....
  17. pmc Localisation of human alpha globin to 16p13.3----pter
    V J Buckle
    Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford
    J Med Genet 25:847-9. 1988
    ..13----qter. DNA studies show that the patient has not inherited either maternal alpha globin allele. This accounts for the alpha thalassaemia trait in the child and places the human alpha globin complex in band 16p13.3----pter...
  18. ncbi request reprint Thalassaemia and malaria, revisited
    D J Weatherall
    Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, U K
    Ann Trop Med Parasitol 91:885-90. 1997
    ..vivax and P. falciparum malaria; such early immunization may provide some protection against the disease in later life...
  19. ncbi request reprint The global problem of genetic disease
    D J Weatherall
    Weatherall Institute of Molecular Medicine, University of Oxford, UK
    Ann Hum Biol 32:117-22. 2005
    ..There is a major case for the development of regional networks to apply such technology as has been developed for the control and prevention of the important haemoglobin disorders, particularly in Asian countries...
  20. doi request reprint Thalassemia as a global health problem: recent progress toward its control in the developing countries
    D J Weatherall
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, United Kingdom
    Ann N Y Acad Sci 1202:17-23. 2010
    ..Here, I will try to assess the current situation in these countries and examine some of the potential approaches for improving the current situation...
  21. pmc Multiple glucose 6-phosphate dehydrogenase-deficient variants correlate with malaria endemicity in the Vanuatu archipelago (southwestern Pacific)
    M Ganczakowski
    Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    Am J Hum Genet 56:294-301. 1995
    ..G6PD deficiency is of clinical importance in Vanuatu because it is a cause of neonatal jaundice and is responsible for numerous episodes of drug-induced acute hemolytic anemia...
  22. ncbi request reprint Plasmodium vivax: a cause of malnutrition in young children
    T N Williams
    Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    QJM 90:751-7. 1997
    ..falciparum was not. Wasting neither predisposed to nor protected against malaria of either species. Although P. vivax malaria is generally regarded as benign, it may produce considerable global mortality through malnutrition...
  23. ncbi request reprint Pharmacological treatment of monogenic disease
    D J Weatherall
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Pharmacogenomics J 3:264-6. 2003
  24. doi request reprint Genetic variation and susceptibility to infection: the red cell and malaria
    D J Weatherall
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, UK
    Br J Haematol 141:276-86. 2008
    ....
  25. pmc Age-related changes in adaptation to severe anemia in childhood in developing countries
    Angela O'Donnell
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX 3 9DS, United Kingdom
    Proc Natl Acad Sci U S A 104:9440-4. 2007
    ..These observations may have important implications both for the better understanding of the pathophysiology of profound anemia in early life and for its more logical and cost-effective management...
  26. ncbi request reprint The clinical and pathophysiological features of malarial anaemia
    D J Roberts
    Nuffield Department of Clinical Laboratory Sciences, University of Oxford and Blood Research Laboratory, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
    Curr Top Microbiol Immunol 295:137-67. 2005
    ....
  27. pmc Molecular basis for dominantly inherited inclusion body beta-thalassemia
    S L Thein
    Medical Research Council, John Radcliffe Hospital, Oxford, United Kingdom
    Proc Natl Acad Sci U S A 87:3924-8. 1990
    ....
  28. ncbi request reprint Molecular medicine; the road to the better integration of the medical sciences in the twenty-first century
    D J Weatherall
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    Notes Rec R Soc Lond 64:S5-15. 2010
    ....
  29. pmc alpha+-Thalassemia protects children against disease caused by other infections as well as malaria
    S J Allen
    Institute of Molecular Medicine, University of Oxford, The John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
    Proc Natl Acad Sci U S A 94:14736-41. 1997
    ..The mechanism of the remarkable protective effect of alpha+-thalassemia against severe childhood disease remains unclear but must encompass the clear interaction between this hemoglobinopathy and both malarial and nonmalarial infections...
  30. ncbi request reprint A review of the molecular genetics of the human alpha-globin gene cluster
    D R Higgs
    Nuffield Department of Clinical Medicine, John Radcliff Hospital, Oxford, England
    Blood 73:1081-104. 1989
  31. pmc Evidence linking familial thrombosis with a defective antithrombin III gene in two British kindreds
    S H Sacks
    Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford
    J Med Genet 25:20-4. 1988
    ..1 (theta = 0). These results are consistent with previously published data suggesting that mutation of the antithrombin III structural gene is the cause of inherited antithrombin III deficiency in some families...
  32. ncbi request reprint 2005 Runme Shaw Memorial Lecture: Training doctors for the 21st century--a global perspective
    D J Weatherall
    Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Headington, Oxford OX3 9DS, UK
    Ann Acad Med Singapore 34:666-5. 2005
  33. ncbi request reprint A highly conserved amino-acid sequence in thrombospondin, properdin and in proteins from sporozoites and blood stages of a human malaria parasite
    K J Robson
    MRC Molecular Haematology Unit, Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, UK
    Nature 335:79-82. 1988
    ..Unlike the CS protein, TRAP is expressed during the erythrocytic stage of the parasite life cycle...
  34. pmc Recent advances in understanding haemochromatosis: a transition state
    K J H Robson
    MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Headley Way, Oxford, OX3 9DS, UK
    J Med Genet 41:721-30. 2004
    ..Here we review these findings and discuss how understanding the different types of haemochromatosis and our increasing knowledge of iron metabolism may help to elucidate the host's response to infection...
  35. pmc Increased microerythrocyte count in homozygous alpha(+)-thalassaemia contributes to protection against severe malarial anaemia
    Freya J I Fowkes
    Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, Oxford, United Kingdom
    PLoS Med 5:e56. 2008
    ..We tested the hypothesis that the erythrocyte indices associated with alpha(+)-thalassaemia homozygosity provide a haematological benefit during acute malaria...
  36. ncbi request reprint Who killed Cockrobin? The limitations of pathobiography
    David J Weatherall
    Weatherall Institute of Molecular Medicine, Oxford OX3 9DS, UK
    Lancet 372:108-9. 2008
  37. doi request reprint Studies in haemoglobin E beta-thalassaemia
    Nancy F Olivieri
    Hemoglobinopathy Research Program, Toronto General Hospital, University of Toronto, Toronto, ON, Canada
    Br J Haematol 141:388-97. 2008
    ..Age-related changes in the pattern of adaptation to anaemia suggest that more cost-effective approaches to management should be explored...
  38. ncbi request reprint Keynote address: The challenge of thalassemia for the developing countries
    David J Weatherall
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK
    Ann N Y Acad Sci 1054:11-7. 2005
    ..Unless this is done, the large populations of patients with thalassemia in these countries will continue to be neglected...
  39. ncbi request reprint The centenary of Garrod's Croonian lectures
    David J Weatherall
    University of Oxford
    Clin Med 8:309-11. 2008
    ..Although their significance remained dormant for many years, and is still not fully appreciated, they are now recognised as the foundation of medical genetics...
  40. ncbi request reprint Science in the undergraduate curriculum during the 20th century
    David J Weatherall
    Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK
    Med Educ 40:195-201. 2006
    ..This issue is examined by a brief description of the changing methods of medical education over the last century...
  41. ncbi request reprint Single and combination drug therapy for fetal hemoglobin augmentation in hemoglobin E-beta 0-thalassemia: Considerations for treatment
    Sylvia T Singer
    Children s Hospital and Research Center at Oakland, 747 52nd St, Oakland, CA 94609, USA
    Ann N Y Acad Sci 1054:250-6. 2005
    ..After 5 years of follow-up, a subset of patients remained off transfusions. Hydroxyurea should be considered for a subset of Hb E-beta 0-thalassemia patients...
  42. ncbi request reprint Hemoglobin E-beta-thalassemia: Progress report from the International Study Group
    Anuja Premawardhena
    Department of Medicine, University of Kelaniya, Kelaniya, Sri Lanka
    Ann N Y Acad Sci 1054:33-9. 2005
    ..These preliminary observations, made over the last 7 years, provide directions for future research into this increasingly important disease...
  43. ncbi request reprint A novel molecular basis for beta thalassemia intermedia poses new questions about its pathophysiology
    Anuja Premawardhena
    Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka
    Blood 106:3251-5. 2005
    ....
  44. ncbi request reprint Globin gene expression in Hb Lepore-BAC transgenic mice
    Jackie Sloane-Stanley
    MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK
    Br J Haematol 135:735-7. 2006
    ..Low levels of human gamma chains were detectable as F cells in adult mice, but numbers did not increase after treatment with drugs that raise F cells in human subjects, even on a thalassaemic background...
  45. ncbi request reprint Academic freedom in clinical research
    David G Nathan
    Dana Farber Cancer Institute, Boston, MA 02115, USA
    N Engl J Med 347:1368-71. 2002
  46. ncbi request reprint UGT1A1 variation and gallstone formation in sickle cell disease
    Eden V Haverfield
    Institute of Biological Anthropology and the Weatherall Institute of Molecular Medicine, University of Oxford, United Kingdom
    Blood 105:968-72. 2005
    ..Although further studies of the pathogenesis of gallstones in SS disease are required, the (TA)(7)/(TA)(7) genotype may be a risk factor for symptomatic gallstones in older people with SS disease...
  47. ncbi request reprint Fetal haemoglobin augmentation in E/beta(0) thalassaemia: clinical and haematological outcome
    Sylvia T Singer
    Children s Hospital and Research Center at Oakland, CA 94609, USA
    Br J Haematol 131:378-88. 2005
    ..Continuous monitoring of toxicity and growth is required...
  48. pmc Negative epistasis between the malaria-protective effects of alpha+-thalassemia and the sickle cell trait
    Thomas N Williams
    Kenya Medical Research Institute Wellcome Trust Programme, Centre for Geographic Medicine Research, Coast, PO Box 230, Kilifi District Hospital, Kilifi, Kenya
    Nat Genet 37:1253-7. 2005
    ..Negative epistasis could explain the failure of alpha(+)-thalassemia to reach fixation in any population in sub-Saharan Africa...
  49. pmc An immune basis for malaria protection by the sickle cell trait
    Thomas N Williams
    Kenya Medical Research Institute, Wellcome Trust Programme, Centre for Geographic Medicine Research, Coast, Kilifi District Hospital, Kilifi, Kenya
    PLoS Med 2:e128. 2005
    ....
  50. pmc The effect of alpha+-thalassaemia on the incidence of malaria and other diseases in children living on the coast of Kenya
    Sammy Wambua
    Kenya Medical Research Institute Wellcome Trust Programme, Centre for Geographic Medicine Research Coast, Kilifi District Hospital, Kilifi, Kenya
    PLoS Med 3:e158. 2006
    ....
  51. ncbi request reprint The membrane characteristics of Plasmodium falciparum-infected and -uninfected heterozygous alpha(0)thalassaemic erythrocytes
    Thomas Neil Williams
    Molecular Parasitology Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Br J Haematol 118:663-70. 2002
    ..We hypothesize that altered red-cell membrane band 3 protein may be a target for enhanced antibody binding to alpha-thalassaemic IRBCs and could be involved in the mechanism of malaria protection...