S Watson

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. ncbi request reprint Post-dexamethasone arginine vasopressin levels in patients with severe mood disorders
    Stuart Watson
    Department of Psychiatry, Leazes Wing, Royal Victoria Infirmary, University of Newcastle upon Tyne, Newcastle NE1 4LP, UK
    J Psychiatr Res 40:353-9. 2006
  2. ncbi request reprint Cortisol/DHEA ratios in schizophrenia
    Keith S Reid
    J Psychiatr Res 40:183-4; author reply 185. 2006
  3. pmc Family history, early adversity and the hypothalamic-pituitary-adrenal (HPA) axis: Mediation of the vulnerability to mood disorders
    Stuart Watson
    Stanley Research Centre School of Neurology, Neurobiology and Psychiatry University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Neuropsychiatr Dis Treat 3:647-53. 2007
  4. pmc A feasibility study of expert patient and community mental health team led bipolar psychoeducation groups: implementing an evidence based practice
    Katharine Coulthard
    Wolfson Unit, Campus for Ageing and Vitality, Institute of Neuroscience, Newcastle University, Newcastle NE4 5PL, UK
    BMC Psychiatry 13:301. 2013
  5. doi request reprint Effect of aspirin on hypothalamic-pituitary-adrenal function and on neuropsychological performance in healthy adults: a pilot study
    Stuart Watson
    Institute of Neuroscience, Leazes Wing Psychiatry, Royal Victoria Infirmary, Newcastle University, Newcastle, UK
    Psychopharmacology (Berl) 205:151-5. 2009
  6. ncbi request reprint Lithium, arginine vasopressin and the dex/CRH test in mood disordered patients
    Stuart Watson
    The Stanley Research Centre, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, UK
    Psychoneuroendocrinology 32:464-9. 2007
  7. ncbi request reprint The dex/CRH test--is it better than the DST?
    Stuart Watson
    School of Neurology, Neurobiology and Psychiatry, The Stanley Research Centre, University of Newcastle upon Tyne, Leazes Wing Psychiatry, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    Psychoneuroendocrinology 31:889-94. 2006
  8. ncbi request reprint Association between childhood trauma and dissociation among patients with borderline personality disorder
    Stuart Watson
    School of Neurology, Neurobiology and Psychiatry, University of Newcastle, Royal Victoria Infirmary, Newcastle upon Tyne, England, UK
    Aust N Z J Psychiatry 40:478-81. 2006
  9. ncbi request reprint Bipolar disorders: new approaches to therapy
    S Watson
    University of Newcastle upon Tyne, Leazes Wing, RVI, Newcastle, NE1 4LP, UK
    Expert Opin Pharmacother 2:601-12. 2001
  10. ncbi request reprint Effects of adjunctive mifepristone (RU-486) administration on neurocognitive function and symptoms in schizophrenia
    Peter Gallagher
    Stanley Research Centre, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, United Kingdom
    Biol Psychiatry 57:155-61. 2005

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Post-dexamethasone arginine vasopressin levels in patients with severe mood disorders
    Stuart Watson
    Department of Psychiatry, Leazes Wing, Royal Victoria Infirmary, University of Newcastle upon Tyne, Newcastle NE1 4LP, UK
    J Psychiatr Res 40:353-9. 2006
    ....
  2. ncbi request reprint Cortisol/DHEA ratios in schizophrenia
    Keith S Reid
    J Psychiatr Res 40:183-4; author reply 185. 2006
  3. pmc Family history, early adversity and the hypothalamic-pituitary-adrenal (HPA) axis: Mediation of the vulnerability to mood disorders
    Stuart Watson
    Stanley Research Centre School of Neurology, Neurobiology and Psychiatry University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Neuropsychiatr Dis Treat 3:647-53. 2007
    ..These data suggest that early adverse life events and genetic susceptibility have dissociable effects on glucocorticoid receptor-mediated negative feedback of the HPA axis in adult patients with severe mood disorders...
  4. pmc A feasibility study of expert patient and community mental health team led bipolar psychoeducation groups: implementing an evidence based practice
    Katharine Coulthard
    Wolfson Unit, Campus for Ageing and Vitality, Institute of Neuroscience, Newcastle University, Newcastle NE4 5PL, UK
    BMC Psychiatry 13:301. 2013
    ..Organisational learning was used to identify and address systematically barriers and enablers, at organisational, health professional and patient levels, to its implementation into a routine service...
  5. doi request reprint Effect of aspirin on hypothalamic-pituitary-adrenal function and on neuropsychological performance in healthy adults: a pilot study
    Stuart Watson
    Institute of Neuroscience, Leazes Wing Psychiatry, Royal Victoria Infirmary, Newcastle University, Newcastle, UK
    Psychopharmacology (Berl) 205:151-5. 2009
    ..Aspirin has been shown to attenuate the adrenocorticotropic hormone (ACTH) and cortisol response to physiological challenge suggesting its potential to act as an augmenting agent in depression...
  6. ncbi request reprint Lithium, arginine vasopressin and the dex/CRH test in mood disordered patients
    Stuart Watson
    The Stanley Research Centre, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, UK
    Psychoneuroendocrinology 32:464-9. 2007
    ..These data demonstrate that patients taking lithium have elevated post-dexamethasone AVP levels compared to both healthy controls and patients not on lithium...
  7. ncbi request reprint The dex/CRH test--is it better than the DST?
    Stuart Watson
    School of Neurology, Neurobiology and Psychiatry, The Stanley Research Centre, University of Newcastle upon Tyne, Leazes Wing Psychiatry, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    Psychoneuroendocrinology 31:889-94. 2006
    ..9% and the specificity 71.4%. The sensitivity of 1500 h cortisol (the DST) was 66.6% and the specificity was 47.6%. This suggests that the two tests measure common pathology but that the dex/CRH test has better diagnostic utility...
  8. ncbi request reprint Association between childhood trauma and dissociation among patients with borderline personality disorder
    Stuart Watson
    School of Neurology, Neurobiology and Psychiatry, University of Newcastle, Royal Victoria Infirmary, Newcastle upon Tyne, England, UK
    Aust N Z J Psychiatry 40:478-81. 2006
    ..To examine the relationship between childhood trauma and dissociative experience in adulthood in patients with borderline personality disorder...
  9. ncbi request reprint Bipolar disorders: new approaches to therapy
    S Watson
    University of Newcastle upon Tyne, Leazes Wing, RVI, Newcastle, NE1 4LP, UK
    Expert Opin Pharmacother 2:601-12. 2001
    ..This paper will focus on one element of such a plan, the currently available somatic management strategies for bipolar disorder...
  10. ncbi request reprint Effects of adjunctive mifepristone (RU-486) administration on neurocognitive function and symptoms in schizophrenia
    Peter Gallagher
    Stanley Research Centre, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, United Kingdom
    Biol Psychiatry 57:155-61. 2005
    ..We hypothesized that antiglucocorticoid treatments, particularly glucocorticoid receptor (GR) antagonists, would improve neurocognitive functioning and clinical symptoms in this disorder...
  11. ncbi request reprint Persistent effects of mifepristone (RU-486) on cortisol levels in bipolar disorder and schizophrenia
    Peter Gallagher
    School of Neurology, Neurobiology and Psychiatry, Newcastle University, Leazes Wing, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    J Psychiatr Res 42:1037-41. 2008
    ..This may in part underlie the putative therapeutic effects of such drugs...
  12. ncbi request reprint Neurocognitive impairment in euthymic patients with bipolar affective disorder
    Jill M Thompson
    Stanley Research Centre, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Leazes Wing, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    Br J Psychiatry 186:32-40. 2005
    ..However, methodological issues such as the effect of residual mood symptoms and hypercortisolaemia may confound such studies...
  13. ncbi request reprint Hypothalamic-pituitary-adrenal axis function in patients with chronic depression
    S Watson
    Stanley Foundation Research Centre, School of Neurosciences and Psychiatry, University of Newcastle, Royal Victoria Infirmary, Newcastle upon Tyne
    Psychol Med 32:1021-8. 2002
    ..We also compared the sensitivity of the two tests and compared the results with previous studies in depression that have not specifically selected chronic patients...
  14. ncbi request reprint Hypothalamic-pituitary-adrenal axis function in patients with bipolar disorder
    Stuart Watson
    The Stanley Research Centre, University of Newcastle upon Tyne, The Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Br J Psychiatry 184:496-502. 2004
    ....
  15. ncbi request reprint Neuropsychological impairment in bipolar disorder: the relationship with glucocorticoid receptor function
    Stuart Watson
    The Stanley Research Centre, School of Neurology, Neurobiology, and Psychiatry, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Bipolar Disord 8:85-90. 2006
    ..This suggests a potential link between neuropsychological and hypothalamic-pituitary-adrenal axis function. We examined the hypothesis that neuropsychological impairment in bipolar disorder is associated with abnormal GR function...
  16. ncbi request reprint Impaired working memory monitoring in euthymic bipolar patients
    Jill M Thompson
    School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Bipolar Disord 9:478-89. 2007
    ..However, the component operations that contribute to this deficit remain unclear. The aim of the present study was to further profile the nature and specificity of WM impairment in euthymic BD...
  17. ncbi request reprint Effect of sub-chronic hydrocortisone on responses to amphetamine in normal male volunteers
    Andrea J Hearn
    Psychobiology Research Group, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Newcastle, UK
    Psychopharmacology (Berl) 171:458-64. 2004
    ..Enhancement of dopamine (DA) release by corticosteroids may be of aetiological importance in substance misuse...
  18. ncbi request reprint Changes in brain-derived neurotrophic factor following treatment with mifepristone in bipolar disorder and schizophrenia
    Paul Mackin
    School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Leazes Wing Psychiatry, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    Aust N Z J Psychiatry 41:321-6. 2007
    ..The aim of the present study was to investigate BDNF levels in patients with bipolar disorder and schizophrenia before and after treatment with the glucocorticoid receptor antagonist mifepristone...
  19. ncbi request reprint Temporal stability of the dex/CRH test in patients with rapid-cycling bipolar I disorder: a pilot study
    Stuart Watson
    Department of Psychiatry, Leazes Wing, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, U K
    Aust N Z J Psychiatry 39:244-8. 2005
    ..To examine the hypothesis that hypothalamic-pituitary-adrenal (HPA) axis function is a trait abnormality in bipolar disorder...
  20. ncbi request reprint Improvements in neurocognitive function and mood following adjunctive treatment with mifepristone (RU-486) in bipolar disorder
    Allan H Young
    Stanley Research Centre, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, UK
    Neuropsychopharmacology 29:1538-45. 2004
    ..These data require replication but provide preliminary evidence that glucocorticoid receptor antagonists may have useful cognitive-enhancing and possibly antidepressant properties in bipolar disorder...
  21. ncbi request reprint Neurocognitive functioning in bipolar depression: a component structure analysis
    P Gallagher
    Institute of Neuroscience Academic Psychiatry, Newcastle University, UK
    Psychol Med 44:961-74. 2014
    ..In this study we aimed to compare the neurocognitive profile of BD patients when depressed with healthy controls and explore the component structure of neurocognitive processes in these populations...
  22. ncbi request reprint Tiagabine in the treatment of acute affective episodes in bipolar disorder: efficacy and acceptability
    A H Young
    Royal Victoria Infirmary, Department of Psychiatry, Divison of Psychiatry, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Leazes Wing, Royal Victoria Infirmary, Newcastle upon Tyne, UK NW1 4LP
    Cochrane Database Syst Rev 3:CD004694. 2006
    ..There is a need to clarify the evidence available, in the form of randomised controlled trials, for its use in the treatment of acute affective episodes in bipolar disorder..
  23. ncbi request reprint Plasma cortisol-dehydroepiandrosterone (DHEA) ratios in schizophrenia and bipolar disorder
    Peter Gallagher
    School of Neurology, Neurobiology and Psychiatry, Newcastle University, UK
    Schizophr Res 90:258-65. 2007
    ..These data suggest that afternoon hypercortisolaemia is evident in symptomatic bipolar and schizophrenic patients compared to controls. However, an elevation in DHEA levels may represent a specific endocrine marker in schizophrenia...
  24. ncbi request reprint Bipolar disorder ignored by the Mental Health National Service framework but not forgotten by the British Association for Psychopharmacology
    R H McAllister-Williams
    Psychobiology Research Group, School of Neurology, Neurobiology and Psychiatry, University of Newcastle, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    J Psychopharmacol 17:7-10. 2003
    ..Local Implementation Teams would be well advised to take note of the recently published British Association for Psychopharmacology guidelines for the management of BD...
  25. ncbi request reprint Neurocognitive function in unaffected first-degree relatives of patients with bipolar disorder: a preliminary report
    I Nicol Ferrier
    School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, UK
    Bipolar Disord 6:319-22. 2004
    ..This study, therefore, examined neuropsychological function in healthy first-degree relatives of patients with BD...
  26. ncbi request reprint Pituitary volume and third ventricle width in euthymic patients with bipolar disorder
    David A Cousins
    Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, United Kingdom
    Psychoneuroendocrinology 35:1074-81. 2010
    ..Although current neuroimaging techniques inadequately resolve the structural components of the hypothalamus, evidence of derangement can be sought by examining the adjacent third ventricle and the functionally related pituitary...
  27. ncbi request reprint Facial expression perception: an objective outcome measure for treatment studies in mood disorders?
    Helen R Venn
    Stanley Research Centre, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, NE1 4LP, UK
    Int J Neuropsychopharmacol 9:229-45. 2006
    ..This review suggests that measurement of facial expression perception may prove to be a useful experimental tool for assessing efficacy of antidepressant treatments...
  28. ncbi request reprint Elevated prolactin responses to L-tryptophan infusion in medication-free depressed patients
    Richard J Porter
    Department of Psychological Medicine, Christchurch School of Medicine, New Zealand
    Psychopharmacology (Berl) 169:77-83. 2003
    ..Several previous neuroendocrine studies have demonstrated reduced 5-HT1A receptor function in major depressive disorder (MDD). However, hypercortisolaemia or previous drug treatment may have been significant confounds...
  29. ncbi request reprint The role of hypothalamic-pituitary-adrenal axis dysfunction in the attenuated growth hormone response in adolescents with familial loading for affective disorder
    Stuart Watson
    Arch Gen Psychiatry 59:186-7. 2002
  30. ncbi request reprint Corticosteroid-serotonin interactions in depression: a review of the human evidence
    Richard J Porter
    Department of Psychological Medicine, Christchurch School of Medicine, Christchurch, New Zealand
    Psychopharmacology (Berl) 173:1-17. 2004
    ..It has been suggested that corticosteroid-serotonin interactions are central to the pathophysiology of depression. These interactions have been investigated in healthy and depressed humans, primarily using neuroendocrine techniques...
  31. ncbi request reprint Markers of endothelial activation and atherothrombosis in women with history of preeclampsia or gestational hypertension
    Mark Vickers
    Department of Medicine and Therapeutics, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen AB25 2ZD, Scotland
    Thromb Haemost 90:1192-7. 2003
    ..Moderate alcohol consumption was also associated with lower levels of inflammatory markers...
  32. ncbi request reprint The role of endogenous cortisol in neuroendocrine studies
    Stuart Watson
    Neuropsychopharmacology 26:408-9. 2002
  33. ncbi request reprint Increased libido associated with quetiapine
    Anuradha Menon
    St George s Hospital, Morpeth, Northumberland, UK
    J Psychopharmacol 20:125-7. 2006
    ..We discuss the potential neuro-chemical mechanisms for this and argue that quetiapine's unique pharmacological profile may have contributed to the development of his symptoms...
  34. ncbi request reprint The effects of sub-chronic administration of hydrocortisone on hormonal and psychological responses to L-tryptophan in normal male volunteers
    Richard J Porter
    Department of Psychological Medicine, Christchurch School of Medicine, Christchurch, New Zealand
    Psychopharmacology (Berl) 163:68-75. 2002
    ..This response has been shown to be reduced following acute administration of hydrocortisone, and we hypothesised that sub-chronic administration of hydrocortisone would also blunt it...
  35. ncbi request reprint Phenytoin, an anti-bipolar anticonvulsant: a potential anti-glucocorticoid mechanism?
    Peter Gallagher
    Int J Neuropsychopharmacol 9:627-8. 2006