Christine J Watson

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc Conditional deletion of Stat3 in mammary epithelium impairs the acute phase response and modulates immune cell numbers during post-lactational regression
    Katherine Hughes
    Department of Pathology, University of Cambridge, UK
    J Pathol 227:106-17. 2012
  2. ncbi request reprint The Stat family of transcription factors have diverse roles in mammary gland development
    C J Watson
    University of Cambridge, Department of Pathology, Tennis Court Road, Cambridge CB2 1QP, United Kingdom
    Semin Cell Dev Biol 19:401-6. 2008
  3. pmc Involution: apoptosis and tissue remodelling that convert the mammary gland from milk factory to a quiescent organ
    Christine J Watson
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Breast Cancer Res 8:203. 2006
  4. pmc A prophylactic vaccine for breast cancer?
    Christine J Watson
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Breast Cancer Res 12:310. 2010
  5. ncbi request reprint Post-lactational mammary gland regression: molecular basis and implications for breast cancer
    Christine J Watson
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK
    Expert Rev Mol Med 8:1-15. 2006
  6. ncbi request reprint The search for breast cancer therapies--the value of genetically engineered mice
    Christine J Watson
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Transgenic Res 11:615. 2002
  7. ncbi request reprint Stat transcription factors in mammary gland development and tumorigenesis
    C J Watson
    Department of Pathology, University of Cambridge, United Kingdom
    J Mammary Gland Biol Neoplasia 6:115-27. 2001
  8. pmc PML depletion disrupts normal mammary gland development and skews the composition of the mammary luminal cell progenitor pool
    Wenjing Li
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, United Kingdom
    Proc Natl Acad Sci U S A 106:4725-30. 2009
  9. doi request reprint Stat3 controls lysosomal-mediated cell death in vivo
    Peter A Kreuzaler
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Nat Cell Biol 13:303-9. 2011
  10. doi request reprint A dual role for oncostatin M signaling in the differentiation and death of mammary epithelial cells in vivo
    Paul G Tiffen
    Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    Mol Endocrinol 22:2677-88. 2008

Collaborators

Detail Information

Publications39

  1. pmc Conditional deletion of Stat3 in mammary epithelium impairs the acute phase response and modulates immune cell numbers during post-lactational regression
    Katherine Hughes
    Department of Pathology, University of Cambridge, UK
    J Pathol 227:106-17. 2012
    ..These findings have relevance to the study of pregnancy-associated breast cancer and the role of Stat3 signalling in recruitment of alternatively activated tumour-associated macrophages in breast cancer...
  2. ncbi request reprint The Stat family of transcription factors have diverse roles in mammary gland development
    C J Watson
    University of Cambridge, Department of Pathology, Tennis Court Road, Cambridge CB2 1QP, United Kingdom
    Semin Cell Dev Biol 19:401-6. 2008
    ..Thus, the adult mammary gland is somewhat unusual in that it is a tissue where different Stats are sequentially activated to orchestrate the processes of functional differentiation, cell death and tissue remodelling...
  3. pmc Involution: apoptosis and tissue remodelling that convert the mammary gland from milk factory to a quiescent organ
    Christine J Watson
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Breast Cancer Res 8:203. 2006
    ..Considerable effort has been directed towards understanding the molecular mechanisms of the involution process and this has resulted in the identification of the principal signalling pathways involved...
  4. pmc A prophylactic vaccine for breast cancer?
    Christine J Watson
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Breast Cancer Res 12:310. 2010
    ..This also showed some efficacy as a therapeutic vaccine. Can we look forward to the elimination of breast cancer?..
  5. ncbi request reprint Post-lactational mammary gland regression: molecular basis and implications for breast cancer
    Christine J Watson
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK
    Expert Rev Mol Med 8:1-15. 2006
    ..In this review, I discuss the roles of the JAK-STAT, NF-kappaB and other signalling pathways in the regulation of apoptosis and tissue remodelling during involution...
  6. ncbi request reprint The search for breast cancer therapies--the value of genetically engineered mice
    Christine J Watson
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Transgenic Res 11:615. 2002
  7. ncbi request reprint Stat transcription factors in mammary gland development and tumorigenesis
    C J Watson
    Department of Pathology, University of Cambridge, United Kingdom
    J Mammary Gland Biol Neoplasia 6:115-27. 2001
    ..It is now important to understand the mechanism of constitutive Stat activity and to develop strategies which will abrogate aberrant Stat signaling in tumors in vivo...
  8. pmc PML depletion disrupts normal mammary gland development and skews the composition of the mammary luminal cell progenitor pool
    Wenjing Li
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, United Kingdom
    Proc Natl Acad Sci U S A 106:4725-30. 2009
    ..Overall, it is shown that PML is required for cell lineage determination in bi-potent luminal progenitor cells and that the precise regulation of PML expression is required for functional differentiation of alveolar cells...
  9. doi request reprint Stat3 controls lysosomal-mediated cell death in vivo
    Peter A Kreuzaler
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Nat Cell Biol 13:303-9. 2011
    ..We anticipate that these findings will be of major importance in the design of treatments for cancers such as breast, colon and liver, where cathepsins and Stat3 are commonly overexpressed and/or hyperactivated respectively...
  10. doi request reprint A dual role for oncostatin M signaling in the differentiation and death of mammary epithelial cells in vivo
    Paul G Tiffen
    Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    Mol Endocrinol 22:2677-88. 2008
    ....
  11. ncbi request reprint The genes induced by signal transducer and activators of transcription (STAT)3 and STAT5 in mammary epithelial cells define the roles of these STATs in mammary development
    Richard W E Clarkson
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, United Kingdom
    Mol Endocrinol 20:675-85. 2006
    ....
  12. ncbi request reprint Stat3-induced apoptosis requires a molecular switch in PI(3)K subunit composition
    Kathrine Abell
    Mammary Apoptosis and Development Group, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK
    Nat Cell Biol 7:392-8. 2005
    ..We propose a novel mechanism in which Stat3 regulates apoptosis by inducing expression of distinct PI(3)K regulatory subunits to downregulate PI(3)K-Akt-mediated survival signalling...
  13. pmc Gene expression profiling of mammary gland development reveals putative roles for death receptors and immune mediators in post-lactational regression
    Richard W E Clarkson
    Department of Pathology, University of Cambridge, Cambridge, UK
    Breast Cancer Res 6:R92-109. 2004
    ....
  14. pmc Stat3 is required to maintain the full differentiation potential of mammary stem cells and the proliferative potential of mammary luminal progenitors
    Anna D Staniszewska
    Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 7:e52608. 2012
    ..In addition, Stat3 is required for maximal proliferation of luminal progenitors...
  15. pmc The Stat6-regulated KRAB domain zinc finger protein Zfp157 regulates the balance of lineages in mammary glands and compensates for loss of Gata-3
    Carrie H Oliver
    Department of Pathology, University of Cambridge, Cambridge CB2 1QP, United Kingdom
    Genes Dev 26:1086-97. 2012
    ..These data suggest that the luminal alveolar compartment of the mammary gland is comprised of a number of distinct cell populations that, although interdependant, exhibit considerable cell fate plasticity...
  16. pmc Characterisation of microRNA expression in post-natal mouse mammary gland development
    Stefanie Avril-Sassen
    Breast Cancer Functional Genomics Laboratory, Cancer Research UK Cambridge Research Institute and Department of Oncology, University of Cambridge, Li Ka Shing Centre, Cambridge, UK
    BMC Genomics 10:548. 2009
    ..In parallel whole-genome mRNA expression data were obtained...
  17. ncbi request reprint The IL-4/IL-13/Stat6 signalling pathway promotes luminal mammary epithelial cell development
    Walid T Khaled
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Development 134:2739-50. 2007
    ....
  18. doi request reprint The role of cathepsins in involution and breast cancer
    Christine J Watson
    Department of Pathology, University of Cambridge, Cambridge, MA, USA
    J Mammary Gland Biol Neoplasia 14:171-9. 2009
    ..We discuss here the roles of cathepsins and their endogenous inhibitors in breast tumorigenesis and post-lactational involution...
  19. ncbi request reprint IKKbeta/2 induces TWEAK and apoptosis in mammary epithelial cells
    Fiona O Baxter
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Development 133:3485-94. 2006
    ..This unexpected function of the IKK2/NF-kappaB pathway as a regulator of TWEAK expression and inducer of apoptosis has significant consequences for future therapeutic approaches for cancer and inflammatory diseases...
  20. ncbi request reprint The KRAB domain zinc finger protein, Zfp157, is expressed in multiple tissues during mouse embryogenesis and in specific cells in adult mammary gland and skin
    Carrie H Oliver
    Department of Pathology, University of Cambridge, Cambridge, CB2 1QP, United Kingdom
    Genesis 51:179-86. 2013
    ..These data lay the foundation for further work on the function of Zfp157...
  21. ncbi request reprint Microarray analysis of the involution switch
    Richard W E Clarkson
    Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    J Mammary Gland Biol Neoplasia 8:309-19. 2003
    ..These results provide a novel insight into the involution process and demonstrate the value of microarray analysis in defining molecular events associated with critical developmental transitions in mammary gland...
  22. doi request reprint Cytokine signalling in mammary gland development
    Christine J Watson
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    J Reprod Immunol 88:124-9. 2011
    ..A recent surprising discovery was that the signalling pathways and cytokines that regulate lineage determination in T helper cells are also involved in mammary gland development during pregnancy...
  23. ncbi request reprint Epithelial-to-mesenchymal transition confers resistance to apoptosis in three murine mammary epithelial cell lines
    Ewan J D Robson
    Mammary Apoptosis and Development Group, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Differentiation 74:254-64. 2006
    ....
  24. doi request reprint Remodeling mechanisms of the mammary gland during involution
    Christine J Watson
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, UK
    Int J Dev Biol 55:757-62. 2011
    ....
  25. ncbi request reprint A dual, non-redundant, role for LIF as a regulator of development and STAT3-mediated cell death in mammary gland
    Ekaterini A Kritikou
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Development 130:3459-68. 2003
    ..Inhibition of LIF-mediated ERK1/2 phosphorylation potentiates the proapoptotic effects of STAT3. LIF therefore signals alternately through ERK1/2, then STAT3, to regulate mammary growth and apoptosis...
  26. ncbi request reprint A 3-D in vitro co-culture model of mammary gland involution
    Jonathan J Campbell
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Integr Biol (Camb) 6:618-26. 2014
    ..7. Thus, such 3D models are suitable platforms for studying cell-cell interactions and cell death mechanisms in relation to cancer. ..
  27. pmc Key signalling nodes in mammary gland development and cancer. Signalling downstream of PI3 kinase in mammary epithelium: a play in 3 Akts
    Julie A Wickenden
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, UK
    Breast Cancer Res 12:202. 2010
    ....
  28. doi request reprint Killing a cancer: what are the alternatives?
    Peter Kreuzaler
    University of Cambridge, Department of Pathology, Tennis Court Road, Cambridge CB2 1QP, UK
    Nat Rev Cancer 12:411-24. 2012
    ..In this Review, we discuss converging and diverging features of these pathways, as well as attempts to exploit this newly gained knowledge pharmacologically to provide therapeutics for cancer...
  29. ncbi request reprint PML: a tumor suppressor that regulates cell fate in mammary gland
    Wenjing Li
    University of Cambridge, Cambridge, UK
    Cell Cycle 8:2711-7. 2009
    ..These data begin to show the cell types and tissues that are most sensitive to PML dose and provide new perspectives for the regulation of mammary gland development and tumorigenesis...
  30. doi request reprint Mammary development in the embryo and adult: a journey of morphogenesis and commitment
    Christine J Watson
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Development 135:995-1003. 2008
    ..A surprising recent discovery has been that mammary epithelial cells commit to differentiated lineages using the same signalling pathways that regulate lineage determination in T helper cells...
  31. ncbi request reprint Enzymatic dissociation, flow cytometric analysis, and culture of normal mouse mammary tissue
    Michael Prater
    Cancer Research, UK Cambridge Research Institute, Cambridge, UK
    Methods Mol Biol 946:395-409. 2013
    ....
  32. ncbi request reprint The Jak/Stat pathway: a novel way to regulate PI3K activity
    Kathrine Abell
    Department of Pathology, University of Cambridge, Cambridge, UK
    Cell Cycle 4:897-900. 2005
    ..An important implication of our results is that the p55alpha and p50alpha small regulatory subunits are regulated independently of the larger p85alpha subunit, and have an essential role in Stat3-mediated apoptosis in mammary gland...
  33. pmc A multifunctional 3D co-culture system for studies of mammary tissue morphogenesis and stem cell biology
    Jonathan J Campbell
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, United Kingdom
    PLoS ONE 6:e25661. 2011
    ....
  34. pmc c-myc as a mediator of accelerated apoptosis and involution in mammary glands lacking Socs3
    Kate D Sutherland
    VBCRC Laboratory, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    EMBO J 25:5805-15. 2006
    ..Our data establish Socs3 as a critical attenuator of pro-apoptotic pathways that act in the developing mammary gland and provide evidence that c-myc regulates apoptosis during involution...
  35. pmc Mammary-specific deletion of parathyroid hormone-related protein preserves bone mass during lactation
    Joshua N VanHouten
    Section of Endocrinology and Metabolism, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8020, USA
    J Clin Invest 112:1429-36. 2003
    ..We conclude that during lactation mammary epithelial cells are a source of circulating PTHrP that promotes bone loss by increasing rates of bone resorption...
  36. pmc Caspase-dependent proteolytic cleavage of STAT3alpha in ES cells, in mammary glands undergoing forced involution and in breast cancer cell lines
    James R Matthews
    Department of Mammalian Genetics, Cardiff University, School of Biosciences, Museum Avenue, Cardiff CF10 3US, UK
    BMC Cancer 7:29. 2007
    ..After observing a proteolytic cleavage in STAT3alpha close to a potential apoptotic caspase protease cleavage site we investigated whether STAT3alpha might be a caspase substrate...