Alastair J M Watson

Summary

Affiliation: University of East Anglia
Country: UK

Publications

  1. pmc Confocal laser endomicroscopy is a new imaging modality for recognition of intramucosal bacteria in inflammatory bowel disease in vivo
    Driffa Moussata
    Department of Gastroenterology, Lyon Sud Hospital, Claude Bernard University Pierre Benite, France
    Gut 60:26-33. 2011
  2. pmc Cited1 deficiency suppresses intestinal tumorigenesis
    Valerie Meniel
    School of Biological Sciences, Cardiff University, Cardiff, Wales, UK
    PLoS Genet 9:e1003638. 2013
  3. doi request reprint TNF-α-induced intestinal epithelial cell shedding: implications for intestinal barrier function
    Alastair J M Watson
    Department of Medicine, Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, England
    Ann N Y Acad Sci 1258:1-8. 2012
  4. pmc Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease
    R Kiesslich
    Medical Department, Johannes Gutenberg University of Mainz, Mainz, Germany
    Gut 61:1146-53. 2012
  5. doi request reprint Colon cancer: a civilization disorder
    Alastair J M Watson
    Norwich Medical School, University of East Anglia, Norwich, UK
    Dig Dis 29:222-8. 2011
  6. pmc The epithelial barrier is maintained by in vivo tight junction expansion during pathologic intestinal epithelial shedding
    Amanda M Marchiando
    Department of Pathology, The University of Chicago, Chicago, Illinois, USA
    Gastroenterology 140:1208-1218.e1-2. 2011
  7. pmc Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo
    Amanda M Marchiando
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    J Cell Biol 189:111-26. 2010
  8. ncbi request reprint Identification of epithelial gaps in human small and large intestine by confocal endomicroscopy
    Ralf Kiesslich
    I Medical Clinic, University of Mainz, Mainz, Germany
    Gastroenterology 133:1769-78. 2007
  9. pmc A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide
    Jonathan M Williams
    Department of Gastroenterology, Institute of Translational Medicine, University of Liverpool, Liverpool, L69 3GE, UK
    Dis Model Mech 6:1388-99. 2013
  10. doi request reprint Hsp90 inhibitors sensitise human colon cancer cells to topoisomerase I poisons by depletion of key anti-apoptotic and cell cycle checkpoint proteins
    Anne V McNamara
    The University of Liverpool, Institute of Translational Medicine, Department of Gastroenterology, The Henry Wellcome Laboratory, Crown Street, Liverpool L69 3GE, UK
    Biochem Pharmacol 83:355-67. 2012

Collaborators

Detail Information

Publications11

  1. pmc Confocal laser endomicroscopy is a new imaging modality for recognition of intramucosal bacteria in inflammatory bowel disease in vivo
    Driffa Moussata
    Department of Gastroenterology, Lyon Sud Hospital, Claude Bernard University Pierre Benite, France
    Gut 60:26-33. 2011
    ....
  2. pmc Cited1 deficiency suppresses intestinal tumorigenesis
    Valerie Meniel
    School of Biological Sciences, Cardiff University, Cardiff, Wales, UK
    PLoS Genet 9:e1003638. 2013
    ....
  3. doi request reprint TNF-α-induced intestinal epithelial cell shedding: implications for intestinal barrier function
    Alastair J M Watson
    Department of Medicine, Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, England
    Ann N Y Acad Sci 1258:1-8. 2012
    ..Here, we review the mechanisms governing maintenance of these barrier functions and the implications of inflammation-induced barrier dysfunction in IBD...
  4. pmc Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease
    R Kiesslich
    Medical Department, Johannes Gutenberg University of Mainz, Mainz, Germany
    Gut 61:1146-53. 2012
    ..The objectives of the study were (1) to determine whether cell shedding and barrier loss in humans can be detected by confocal endomicroscopy and (2) whether these parameters predict relapse of IBD...
  5. doi request reprint Colon cancer: a civilization disorder
    Alastair J M Watson
    Norwich Medical School, University of East Anglia, Norwich, UK
    Dig Dis 29:222-8. 2011
    ..The mechanisms by which some environmental factors modify the mutation risk in these pathways have been described...
  6. pmc The epithelial barrier is maintained by in vivo tight junction expansion during pathologic intestinal epithelial shedding
    Amanda M Marchiando
    Department of Pathology, The University of Chicago, Chicago, Illinois, USA
    Gastroenterology 140:1208-1218.e1-2. 2011
    ..We investigated the mechanism of tight junction remodeling and barrier maintenance as well as the roles of cytoskeletal regulatory molecules during TNF-induced shedding...
  7. pmc Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo
    Amanda M Marchiando
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    J Cell Biol 189:111-26. 2010
    ..These data demonstrate that MLCK activation triggers caveolin-1-dependent endocytosis of occludin to effect structural and functional tight junction regulation...
  8. ncbi request reprint Identification of epithelial gaps in human small and large intestine by confocal endomicroscopy
    Ralf Kiesslich
    I Medical Clinic, University of Mainz, Mainz, Germany
    Gastroenterology 133:1769-78. 2007
    ..The goals of this study were to determine if confocal endomicroscopy could resolve the presence of human epithelial gaps and whether a proinflammatory cytokine could increase cell shedding...
  9. pmc A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide
    Jonathan M Williams
    Department of Gastroenterology, Institute of Translational Medicine, University of Liverpool, Liverpool, L69 3GE, UK
    Dis Model Mech 6:1388-99. 2013
    ..This model will enable investigation of the importance and regulation of pathological IEC apoptosis and cell shedding in various diseases. ..
  10. doi request reprint Hsp90 inhibitors sensitise human colon cancer cells to topoisomerase I poisons by depletion of key anti-apoptotic and cell cycle checkpoint proteins
    Anne V McNamara
    The University of Liverpool, Institute of Translational Medicine, Department of Gastroenterology, The Henry Wellcome Laboratory, Crown Street, Liverpool L69 3GE, UK
    Biochem Pharmacol 83:355-67. 2012
    ....
  11. ncbi request reprint Progastrin stimulates murine colonic epithelial mitosis after DNA damage
    Penelope D Ottewell
    Department of Medicine, University of Liverpool, England
    Gastroenterology 124:1348-57. 2003
    ..We have investigated whether alterations in the regulation of apoptosis or mitosis after DNA damage contribute to the effects of progastrin on murine colonic epithelium...