Alastair J M Watson

Summary

Affiliation: University of East Anglia
Country: UK

Publications

  1. doi request reprint TNF-α-induced intestinal epithelial cell shedding: implications for intestinal barrier function
    Alastair J M Watson
    Department of Medicine, Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, England
    Ann N Y Acad Sci 1258:1-8. 2012
  2. pmc Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease
    R Kiesslich
    Medical Department, Johannes Gutenberg University of Mainz, Mainz, Germany
    Gut 61:1146-53. 2012
  3. pmc The epithelial barrier is maintained by in vivo tight junction expansion during pathologic intestinal epithelial shedding
    Amanda M Marchiando
    Department of Pathology, The University of Chicago, Chicago, Illinois, USA
    Gastroenterology 140:1208-1218.e1-2. 2011
  4. doi request reprint Colon cancer: a civilization disorder
    Alastair J M Watson
    Norwich Medical School, University of East Anglia, Norwich, UK
    Dig Dis 29:222-8. 2011
  5. pmc Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo
    Amanda M Marchiando
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    J Cell Biol 189:111-26. 2010
  6. pmc Confocal laser endomicroscopy is a new imaging modality for recognition of intramucosal bacteria in inflammatory bowel disease in vivo
    Driffa Moussata
    Department of Gastroenterology, Lyon Sud Hospital, Claude Bernard University Pierre Benite, France
    Gut 60:26-33. 2011
  7. ncbi request reprint Progastrin stimulates murine colonic epithelial mitosis after DNA damage
    Penelope D Ottewell
    Department of Medicine, University of Liverpool, England
    Gastroenterology 124:1348-57. 2003

Collaborators

  • Le Shen
  • M Goetz
  • D M Pritchard
  • M F Neurath
  • Christopher R Weber
  • Amanda M Marchiando
  • R Kiesslich
  • Driffa Moussata
  • Jerrold R Turner
  • W Vallen Graham
  • Marshall H Montrose
  • Yanfang Guan
  • Penelope D Ottewell
  • D Moussata
  • C A Duckworth
  • L G Lim
  • A Gloeckner
  • P R Galle
  • Bernard Flourie
  • Barry Campbell
  • Annabel Gloeckner
  • Marcus Kerner
  • Karen L Edelblum
  • Peter R Galle
  • Arthur Hoffman
  • Ralf Kiesslich
  • Carrie A Duckworth
  • Stephan Biesterfeld
  • Jean Christophe Saurin
  • Brad T Schwarz
  • Jotham R Austin
  • David R Raleigh
  • Andrea Varro
  • Graham J Dockray
  • Timothy C Wang

Detail Information

Publications7

  1. doi request reprint TNF-α-induced intestinal epithelial cell shedding: implications for intestinal barrier function
    Alastair J M Watson
    Department of Medicine, Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, England
    Ann N Y Acad Sci 1258:1-8. 2012
    ..Here, we review the mechanisms governing maintenance of these barrier functions and the implications of inflammation-induced barrier dysfunction in IBD...
  2. pmc Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease
    R Kiesslich
    Medical Department, Johannes Gutenberg University of Mainz, Mainz, Germany
    Gut 61:1146-53. 2012
    ..The objectives of the study were (1) to determine whether cell shedding and barrier loss in humans can be detected by confocal endomicroscopy and (2) whether these parameters predict relapse of IBD...
  3. pmc The epithelial barrier is maintained by in vivo tight junction expansion during pathologic intestinal epithelial shedding
    Amanda M Marchiando
    Department of Pathology, The University of Chicago, Chicago, Illinois, USA
    Gastroenterology 140:1208-1218.e1-2. 2011
    ..We investigated the mechanism of tight junction remodeling and barrier maintenance as well as the roles of cytoskeletal regulatory molecules during TNF-induced shedding...
  4. doi request reprint Colon cancer: a civilization disorder
    Alastair J M Watson
    Norwich Medical School, University of East Anglia, Norwich, UK
    Dig Dis 29:222-8. 2011
    ..The mechanisms by which some environmental factors modify the mutation risk in these pathways have been described...
  5. pmc Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo
    Amanda M Marchiando
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    J Cell Biol 189:111-26. 2010
    ..These data demonstrate that MLCK activation triggers caveolin-1-dependent endocytosis of occludin to effect structural and functional tight junction regulation...
  6. pmc Confocal laser endomicroscopy is a new imaging modality for recognition of intramucosal bacteria in inflammatory bowel disease in vivo
    Driffa Moussata
    Department of Gastroenterology, Lyon Sud Hospital, Claude Bernard University Pierre Benite, France
    Gut 60:26-33. 2011
    ....
  7. ncbi request reprint Progastrin stimulates murine colonic epithelial mitosis after DNA damage
    Penelope D Ottewell
    Department of Medicine, University of Liverpool, England
    Gastroenterology 124:1348-57. 2003
    ..We have investigated whether alterations in the regulation of apoptosis or mitosis after DNA damage contribute to the effects of progastrin on murine colonic epithelium...