Adam J Watkins

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. pmc The influence of mouse Ped gene expression on postnatal development
    Adam Watkins
    School of Biological Sciences, Developmental and Cell Biology Group, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    J Physiol 571:211-20. 2006
  2. pmc Mouse embryo culture induces changes in postnatal phenotype including raised systolic blood pressure
    Adam J Watkins
    School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Proc Natl Acad Sci U S A 104:5449-54. 2007
  3. doi Maternal low-protein diet during mouse pre-implantation development induces vascular dysfunction and altered renin-angiotensin-system homeostasis in the offspring
    Adam J Watkins
    School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton, UK
    Br J Nutr 103:1762-70. 2010
  4. pmc Low protein diet fed exclusively during mouse oocyte maturation leads to behavioural and cardiovascular abnormalities in offspring
    Adam J Watkins
    School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    J Physiol 586:2231-44. 2008
  5. pmc Metabolic induction and early responses of mouse blastocyst developmental programming following maternal low protein diet affecting life-long health
    Judith J Eckert
    Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
    PLoS ONE 7:e52791. 2012
  6. pmc Maternal periconceptional and gestational low protein diet affects mouse offspring growth, cardiovascular and adipose phenotype at 1 year of age
    Adam J Watkins
    School of Biological Sciences, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
    PLoS ONE 6:e28745. 2011
  7. ncbi The embryo and its future
    Tom P Fleming
    School of Biological Sciences, University of Southampton, Southampton SO16 7PX, United Kingdom
    Biol Reprod 71:1046-54. 2004
  8. ncbi Adaptive responses by mouse early embryos to maternal diet protect fetal growth but predispose to adult onset disease
    Adam J Watkins
    School of Biological Sciences, University of Southampton, Southampton SO16 7PX, United Kingdom
    Biol Reprod 78:299-306. 2008
  9. pmc Blastocyst environment and its influence on offspring cardiovascular health: the heart of the matter
    Adam J Watkins
    School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton, UK
    J Anat 215:52-9. 2009
  10. doi The preimplantation embryo: handle with care
    Adam J Watkins
    School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton, United Kingdom
    Semin Reprod Med 26:175-85. 2008

Detail Information

Publications12

  1. pmc The influence of mouse Ped gene expression on postnatal development
    Adam Watkins
    School of Biological Sciences, Developmental and Cell Biology Group, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    J Physiol 571:211-20. 2006
    ..K1 females having a higher ratio for lungs than B6. K2 females (P = 0.014). These data provide evidence of an association between the rate of preimplantation embryo development, postnatal growth and later cardiovascular function...
  2. pmc Mouse embryo culture induces changes in postnatal phenotype including raised systolic blood pressure
    Adam J Watkins
    School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Proc Natl Acad Sci U S A 104:5449-54. 2007
    ..These animal data indicate that postnatal physiological criteria important in cardiovascular and metabolic health may be more sensitive to routine ART procedures than growth...
  3. doi Maternal low-protein diet during mouse pre-implantation development induces vascular dysfunction and altered renin-angiotensin-system homeostasis in the offspring
    Adam J Watkins
    School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton, UK
    Br J Nutr 103:1762-70. 2010
    ....
  4. pmc Low protein diet fed exclusively during mouse oocyte maturation leads to behavioural and cardiovascular abnormalities in offspring
    Adam J Watkins
    School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    J Physiol 586:2231-44. 2008
    ..Similar and distinct postnatal outcomes were observed here compared with maternal LPD treatment during post-fertilization preimplantation development which may reflect the relative contribution of the paternal genome...
  5. pmc Metabolic induction and early responses of mouse blastocyst developmental programming following maternal low protein diet affecting life-long health
    Judith J Eckert
    Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
    PLoS ONE 7:e52791. 2012
    ..Moreover, this induction step associates with changes in extra-embryonic trophectoderm behaviour occurring as early compensatory responses leading to later nutrient recovery...
  6. pmc Maternal periconceptional and gestational low protein diet affects mouse offspring growth, cardiovascular and adipose phenotype at 1 year of age
    Adam J Watkins
    School of Biological Sciences, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
    PLoS ONE 6:e28745. 2011
    ..These adverse outcomes further exemplify the criticality of dietary behaviour around the time of conception on long-term offspring health...
  7. ncbi The embryo and its future
    Tom P Fleming
    School of Biological Sciences, University of Southampton, Southampton SO16 7PX, United Kingdom
    Biol Reprod 71:1046-54. 2004
    ..We conclude that a complex of different mechanisms may operate to associate early embryo environment with future health...
  8. ncbi Adaptive responses by mouse early embryos to maternal diet protect fetal growth but predispose to adult onset disease
    Adam J Watkins
    School of Biological Sciences, University of Southampton, Southampton SO16 7PX, United Kingdom
    Biol Reprod 78:299-306. 2008
    ..However, activation of such responses may also lead to adult excess growth and cardiovascular and behavioral diseases...
  9. pmc Blastocyst environment and its influence on offspring cardiovascular health: the heart of the matter
    Adam J Watkins
    School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton, UK
    J Anat 215:52-9. 2009
    ..Here, we review the relationship between preimplantation embryo environment and postnatal cardiovascular disease risk, and consider biochemical, molecular, genetic and physiological pathways implicated in this association...
  10. doi The preimplantation embryo: handle with care
    Adam J Watkins
    School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton, United Kingdom
    Semin Reprod Med 26:175-85. 2008
    ..We consider how fetal and postnatal phenotype may become susceptible to the plasticity of the preimplantation embryo and the risks for adult health and physiology...
  11. doi Appetite regulatory mechanisms and food intake in mice are sensitive to mismatch in diets between pregnancy and postnatal periods
    Dyan Sellayah
    Institute of Developmental Sciences, Developmental Origins of Health and Disease Division, University of Southampton School of Medicine, Southampton General Hospital, Southampton, UK
    Brain Res 1237:146-52. 2008
    ....
  12. doi Adaptive responses of the embryo to maternal diet and consequences for post-implantation development
    Tom P Fleming
    School of Biological Sciences, University of Southampton, Mailpoint 840, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Reprod Fertil Dev 24:35-44. 2011
    ..This review assesses the field of PC nutrition in vivo on short- and long-term developmental consequences in rodent and ruminant models and considers the implications for human health...