Jason D Warren

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint The paradox of syndromic diversity in Alzheimer disease
    Jason D Warren
    Dementia Research Centre, Institute of Neurology, University College London, London, UK
    Nat Rev Neurol 8:451-64. 2012
  2. pmc Nonverbal sound processing in semantic dementia: a functional MRI study
    Johanna C Goll
    Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK
    Neuroimage 61:170-80. 2012
  3. pmc A hypnic hypothesis of Alzheimer's disease
    Camilla N Clark
    Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK
    Neurodegener Dis 12:165-76. 2013
  4. pmc Primary progressive aphasia with parkinsonism
    Karen M Doherty
    Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, UK
    Mov Disord 28:741-6. 2013
  5. pmc The brain basis of musicophilia: evidence from frontotemporal lobar degeneration
    Phillip D Fletcher
    Dementia Research Centre, UCL Institute of Neurology, University College London London, UK
    Front Psychol 4:347. 2013
  6. pmc Molecular nexopathies: a new paradigm of neurodegenerative disease
    Jason D Warren
    Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK Electronic address
    Trends Neurosci 36:561-9. 2013
  7. pmc Disintegrating brain networks: from syndromes to molecular nexopathies
    Jason D Warren
    Dementia Research Centre, Department of Neurodegenerative Disease, University College London Institute of Neurology, London WC1N 3BG, UK
    Neuron 73:1060-2. 2012
  8. pmc Parietal lobe deficits in frontotemporal lobar degeneration caused by a mutation in the progranulin gene
    Jonathan D Rohrer
    Dementia Research Centre, Institute of Neurology, University College London, London, England
    Arch Neurol 65:506-13. 2008
  9. pmc Progressive logopenic/phonological aphasia: erosion of the language network
    Jonathan D Rohrer
    Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London, UK
    Neuroimage 49:984-93. 2010
  10. doi request reprint The language profile of posterior cortical atrophy
    Sebastian J Crutch
    Dementia Research Centre, Box 16, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    J Neurol Neurosurg Psychiatry 84:460-6. 2013

Detail Information

Publications78

  1. ncbi request reprint The paradox of syndromic diversity in Alzheimer disease
    Jason D Warren
    Dementia Research Centre, Institute of Neurology, University College London, London, UK
    Nat Rev Neurol 8:451-64. 2012
    ..The clinical and neurobiological implications of this network paradigm in the quest for disease-modifying treatments are also explored...
  2. pmc Nonverbal sound processing in semantic dementia: a functional MRI study
    Johanna C Goll
    Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK
    Neuroimage 61:170-80. 2012
    ..The breakdown of these mechanisms constitutes a network-level functional signature of this neurodegenerative disease...
  3. pmc A hypnic hypothesis of Alzheimer's disease
    Camilla N Clark
    Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK
    Neurodegener Dis 12:165-76. 2013
    ..Understanding the pathophysiology of Alzheimer's disease (AD) is of fundamental importance for improved diagnosis, monitoring and ultimately, treatment...
  4. pmc Primary progressive aphasia with parkinsonism
    Karen M Doherty
    Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, UK
    Mov Disord 28:741-6. 2013
    ..He died after a disease duration of 12 years. The clinical syndrome is discussed by an expert, the pathology is described, and important clinical points from the case are highlighted...
  5. pmc The brain basis of musicophilia: evidence from frontotemporal lobar degeneration
    Phillip D Fletcher
    Dementia Research Centre, UCL Institute of Neurology, University College London London, UK
    Front Psychol 4:347. 2013
    ....
  6. pmc Molecular nexopathies: a new paradigm of neurodegenerative disease
    Jason D Warren
    Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK Electronic address
    Trends Neurosci 36:561-9. 2013
    ..g., toxic-gain-of-function versus loss-of-function) on gradients of network damage. The paradigm has implications for understanding and predicting neurodegenerative disease biology. ..
  7. pmc Disintegrating brain networks: from syndromes to molecular nexopathies
    Jason D Warren
    Dementia Research Centre, Department of Neurodegenerative Disease, University College London Institute of Neurology, London WC1N 3BG, UK
    Neuron 73:1060-2. 2012
    ..2012) use graph theory to suggest that neurodegenerative diseases spread diffusively via intrinsic brain networks. These studies provide a powerful model for understanding and predicting disease-specific profiles of neurodegeneration...
  8. pmc Parietal lobe deficits in frontotemporal lobar degeneration caused by a mutation in the progranulin gene
    Jonathan D Rohrer
    Dementia Research Centre, Institute of Neurology, University College London, London, England
    Arch Neurol 65:506-13. 2008
    ..To describe the clinical, neuropsychologic, and radiologic features of a family with a C31LfsX35 mutation in the progranulin gene CCDS11483.1)...
  9. pmc Progressive logopenic/phonological aphasia: erosion of the language network
    Jonathan D Rohrer
    Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London, UK
    Neuroimage 49:984-93. 2010
    ....
  10. doi request reprint The language profile of posterior cortical atrophy
    Sebastian J Crutch
    Dementia Research Centre, Box 16, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    J Neurol Neurosurg Psychiatry 84:460-6. 2013
    ..Characterising and quantifying the aphasia associated with PCA is important for clarifying diagnostic and selection criteria for clinical and research studies...
  11. pmc Accent processing in dementia
    Julia C Hailstone
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Neuropsychologia 50:2233-44. 2012
    ....
  12. pmc Distinct profiles of brain atrophy in frontotemporal lobar degeneration caused by progranulin and tau mutations
    Jonathan D Rohrer
    Dementia Research Centre, UCL Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    Neuroimage 53:1070-6. 2010
    ..The findings suggest that the effects of GRN and MAPT mutations are expressed in partly overlapping but distinct anatomical networks that link specific molecular dysfunction with clinical phenotype...
  13. pmc Receptive prosody in nonfluent primary progressive aphasias
    Jonathan D Rohrer
    Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, UK
    Cortex 48:308-16. 2012
    ..Prosody has been little studied in the primary progressive aphasias (PPAs), a group of neurodegenerative disorders presenting with progressive language impairment...
  14. pmc The structural neuroanatomy of music emotion recognition: evidence from frontotemporal lobar degeneration
    Rohani Omar
    Dementia Research Centre, Institute of Neurology, University College London, London, UK
    Neuroimage 56:1814-21. 2011
    ..Musical emotion recognition may probe the interface of these processes, delineating a profile of brain damage that is essential for the abstraction of complex social emotions...
  15. ncbi request reprint Genetic influences on atrophy patterns in familial Alzheimer's disease: a comparison of APP and PSEN1 mutations
    Rachael I Scahill
    Dementia Research Centre, Department of Neurodegeneration, UCL Institute of Neurology, London, UK
    J Alzheimers Dis 35:199-212. 2013
    ..We conclude that the mechanisms by which APP and PSEN1 mutations cause neuronal loss may differ which furthers our understanding of the neuropathology underlying AD and may inform future therapeutic strategies and trial designs...
  16. pmc Impairments of auditory scene analysis in Alzheimer's disease
    Johanna C Goll
    Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    Brain 135:190-200. 2012
    ..This work suggests a basis for understanding a class of clinical symptoms in Alzheimer's disease and for delineating cognitive mechanisms that mediate auditory scene analysis both in health and in neurodegenerative disease...
  17. ncbi request reprint Reduced cortical thickness in the posterior cingulate gyrus is characteristic of both typical and atypical Alzheimer's disease
    Manja Lehmann
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, UK
    J Alzheimers Dis 20:587-98. 2010
    ..Reduced cortical thickness in the posterior cingulate gyrus is characteristic of AD pathology in patients with typical and atypical clinical presentations of AD, and may assist a clinical distinction of AD pathology from FTLD pathology...
  18. pmc Auditory object cognition in dementia
    Johanna C Goll
    Dementia Research Centre, Institute of Neurology, University College London, 8 11 Queen Square, London WC1N 3BG, United Kingdom
    Neuropsychologia 49:2755-65. 2011
    ..The findings provide evidence for separable stages of auditory object analysis and separable profiles of impaired auditory object cognition in different dementia syndromes...
  19. pmc Voice processing in dementia: a neuropsychological and neuroanatomical analysis
    Julia C Hailstone
    Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Brain 134:2535-47. 2011
    ..The right anterior temporal lobe is likely to have a critical role in the recognition of voices and other modalities of person knowledge...
  20. pmc Homozygosity for the C9orf72 GGGGCC repeat expansion in frontotemporal dementia
    Pietro Fratta
    Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    Acta Neuropathol 126:401-9. 2013
    ..Our findings have implications for genetic counselling, highlighting the need to use genetic tests that distinguish C9orf72 homozygosity. ..
  21. pmc Non-verbal sound processing in the primary progressive aphasias
    Johanna C Goll
    Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Brain 133:272-85. 2010
    ....
  22. pmc Progressive associative phonagnosia: a neuropsychological analysis
    Julia C Hailstone
    Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, United Kingdom
    Neuropsychologia 48:1104-14. 2010
    ..The findings have implications for current cognitive models of voice recognition...
  23. pmc Mapping the progression of progranulin-associated frontotemporal lobar degeneration
    Jonathan D Rohrer
    Dementia Research Centre, Institute of Neurology, University College London, London, UK
    Nat Clin Pract Neurol 4:455-60. 2008
    ..The patient was initially asymptomatic but developed progressive behavioral and cognitive decline characterized by apathy, impaired emotion recognition, mixed aphasia and parietal lobe dysfunction...
  24. pmc Frontotemporal dementia with the C9ORF72 hexanucleotide repeat expansion: clinical, neuroanatomical and neuropathological features
    Colin J Mahoney
    Dementia Research Centre, Department of Neurodegenerative Diseases, UCL Institute of Neurology, London WC1N 3BG, UK
    Brain 135:736-50. 2012
    ....
  25. pmc Mentalising music in frontotemporal dementia
    Laura E Downey
    Dementia Research Centre, UCL Institute of Neurology, University College London, London, United Kingdom
    Cortex 49:1844-55. 2013
    ....
  26. pmc Agnosia for accents in primary progressive aphasia
    Phillip D Fletcher
    Dementia Research Centre, UCL Institute of Neurology, University College London, London, United Kingdom
    Neuropsychologia 51:1709-15. 2013
    ....
  27. pmc Large C9orf72 hexanucleotide repeat expansions are seen in multiple neurodegenerative syndromes and are more frequent than expected in the UK population
    Jon Beck
    Medical Research Council Prion Unit, Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London, UK
    Am J Hum Genet 92:345-53. 2013
    ..C9orf72-related disease might mimic several neurodegenerative disorders and, with potentially 90,000 carriers in the United Kingdom, is more common than previously realized...
  28. pmc Progranulin-associated primary progressive aphasia: a distinct phenotype?
    Jonathan D Rohrer
    Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, UK
    Neuropsychologia 48:288-97. 2010
    ....
  29. doi request reprint Rates of hemispheric and lobar atrophy in the language variants of frontotemporal lobar degeneration
    Jonathan D Rohrer
    Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London, UK
    J Alzheimers Dis 30:407-11. 2012
    ..These patterns provide information about disease evolution in the FTLD language variants that is of both clinical and neurobiological relevance...
  30. ncbi request reprint Voxel-based morphometry in tau-positive and tau-negative frontotemporal lobar degenerations
    Jennifer L Whitwell
    Dementia Research Centre, Institute of Neurology, London, UK
    Neurodegener Dis 1:225-30. 2004
    ..Correlations between regional patterns of tissue loss and specific proteinopathies have not been established...
  31. pmc White matter tract signatures of the progressive aphasias
    Colin J Mahoney
    Dementia Research Centre, UCL Institute of Neurology, London, UK
    Neurobiol Aging 34:1687-99. 2013
    ..These WM signatures of PPA syndromes illustrate the selective vulnerability of brain language networks in these diseases and might have some pathologic specificity...
  32. pmc Abnormal laughter-like vocalisations replacing speech in primary progressive aphasia
    Jonathan D Rohrer
    Dementia Research Centre, Department of Neurodegenerative Disease, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    J Neurol Sci 284:120-3. 2009
    ..Abnormal laughter-like vocalisations may be a hallmark of a subgroup in the PPA spectrum with impaired control and production of nonverbal vocal behaviour due to disruption of fronto-temporal networks mediating vocalisation...
  33. doi request reprint Defective emotion recognition in early HD is neuropsychologically and anatomically generic
    Susie M D Henley
    Dementia Research Centre, Institute of Neurology, University College London, UK
    Neuropsychologia 46:2152-60. 2008
    ..Even in early HD there is a wide-ranging impairment in recognition of negative emotions denoting 'threat'. Our findings implicate a generic fronto-subcortical network in the pathogenesis of these emotion recognition deficits...
  34. pmc The cognitive organization of music knowledge: a clinical analysis
    Rohani Omar
    Dementia Research Centre, Institute of Neurology, University College, and Department of Clinical Neuroscience, Hammersmith Hospital Campus, London, UK
    Brain 133:1200-13. 2010
    ..Within the domain of music knowledge, dissociable cognitive mechanisms process knowledge derived from physical sources and the knowledge of abstract musical entities...
  35. pmc Clinical and neuroanatomical signatures of tissue pathology in frontotemporal lobar degeneration
    Jonathan D Rohrer
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Brain 134:2565-81. 2011
    ....
  36. ncbi request reprint VBM signatures of abnormal eating behaviours in frontotemporal lobar degeneration
    Jennifer L Whitwell
    Dementia Research Centre, Institute of Neurology, 8 11 Queen Square, London WC1N 3BG, UK
    Neuroimage 35:207-13. 2007
    ..In accord with emerging evidence in humans and other species, our findings implicate distinct components of a multi-component brain network in the control of specific aspects of eating behaviour...
  37. pmc The diagnosis of young-onset dementia
    Martin N Rossor
    Dementia Research Centre, Department of Neurodegeneration, UCL Institute of Neurology, Queen Square, London, UK
    Lancet Neurol 9:793-806. 2010
    ..This understanding offers the potential for future treatments to be tailored to a specific diagnosis of both young-onset and late-onset dementia...
  38. doi request reprint Developmental phonagnosia: a selective deficit of vocal identity recognition
    Lucia Garrido
    Institute of Cognitive Neuroscience, University College London, UK
    Neuropsychologia 47:123-31. 2009
    ....
  39. pmc Early-onset Alzheimer disease clinical variants: multivariate analyses of cortical thickness
    Gerard R Ridgway
    Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK
    Neurology 79:80-4. 2012
    ....
  40. pmc Altered brain mechanisms of emotion processing in pre-manifest Huntington's disease
    Marianne J U Novak
    Wellcome Trust Centre for Neuroimaging, University College London Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Brain 135:1165-79. 2012
    ..Overall, these findings suggest that pathophysiological effects of Huntington's disease may precede the development of overt clinical symptoms and detectable cerebral atrophy...
  41. pmc Central auditory disorders: toward a neuropsychology of auditory objects
    Johanna C Goll
    Dementia Research Centre, Institute of Neurology, London, UK
    Curr Opin Neurol 23:617-27. 2010
    ..Here we review current evidence concerning the phenomenology, mechanisms and brain substrates of auditory agnosias and related disorders of auditory object processing...
  42. pmc Delusions in frontotemporal lobar degeneration
    Rohani Omar
    Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    J Neurol 256:600-7. 2009
    ..We conclude that delusions may be a clinical issue in FTLD, and this should be explored further in future work...
  43. doi request reprint Progressive supranuclear palsy syndrome presenting as progressive nonfluent aphasia: a neuropsychological and neuroimaging analysis
    Jonathan D Rohrer
    Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, University College London, London, United Kingdom
    Mov Disord 25:179-88. 2010
    ..In summary, although the PSP-PNFA syndrome overlaps with PNFA without PSP, certain neuropsychological and neuroanatomical differences may help predict the development of a PSP syndrome...
  44. pmc Structural neuroanatomy of tinnitus and hyperacusis in semantic dementia
    Colin J Mahoney
    Dementia Research Centre, Institute of Neurology, University College London, London, UK
    J Neurol Neurosurg Psychiatry 82:1274-8. 2011
    ..Tinnitus and hyperacusis are common symptoms of excessive auditory perception in the general population; however, their anatomical substrates and disease associations continue to be defined...
  45. pmc It's not what you play, it's how you play it: timbre affects perception of emotion in music
    Julia C Hailstone
    Dementia Research Centre, Institute of Neurology, University College London, London, UK
    Q J Exp Psychol (Hove) 62:2141-55. 2009
    ..Our findings show that timbre (instrument identity) independently affects the perception of emotions in music after controlling for other acoustic, cognitive, and performance factors...
  46. ncbi request reprint Magnetic resonance imaging signatures of tissue pathology in frontotemporal dementia
    Jennifer L Whitwell
    Dementia Research Centre, Institute of Neurology, University College London, England
    Arch Neurol 62:1402-8. 2005
    ..The pathologic substrates of frontotemporal dementia (FTD) are difficult to predict in vivo...
  47. doi request reprint Validation of next-generation sequencing technologies in genetic diagnosis of dementia
    John Beck
    MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK
    Neurobiol Aging 35:261-5. 2014
    ..The MRC Dementia Gene Panel and similar technologies are likely to be transformational in EOD diagnosis with a significant impact on the proportion of patients in whom a genetic cause is identified. ..
  48. pmc The MAPT p.A152T variant is a risk factor associated with tauopathies with atypical clinical and neuropathological features
    Eleanna Kara
    Reta Lila Weston Laboratories and Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, UK
    Neurobiol Aging 33:2231.e7-2231.e14. 2012
    ..We suggest that the A152T variant is a risk factor associated with the development of atypical neurodegenerative conditions with abnormal tau accumulation...
  49. doi request reprint Issues with threshold masking in voxel-based morphometry of atrophied brains
    Gerard R Ridgway
    Centre for Medical Image Computing CMIC, Department of Medical Physics and Bioengineering, University College London, WC1E 6BT, London, UK
    Neuroimage 44:99-111. 2009
    ..We investigate the issues related to mask construction, and recommend the use of alternative strategies which greatly decrease this danger of false negatives...
  50. pmc Syndromes of nonfluent primary progressive aphasia: a clinical and neurolinguistic analysis
    Jonathan D Rohrer
    Dementia Research Centre, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Neurology 75:603-10. 2010
    ..Despite recent work, the nosology of nonfluent primary progressive aphasia (PPA) remains unresolved...
  51. ncbi request reprint Presymptomatic generalized brain atrophy in frontotemporal dementia caused by CHMP2B mutation
    Jonathan D Rohrer
    Dementia Research Centre, Institute of Neurology, University College, London, UK
    Dement Geriatr Cogn Disord 27:182-6. 2009
    ..There are no detailed studies of brain imaging in CHMP2B mutation-associated FTD. This study aimed to investigate whether there were early or presymptomatic changes in this group of patients...
  52. doi request reprint A novel exon 2 I27V VCP variant is associated with dissimilar clinical syndromes
    Jonathan D Rohrer
    Dementia Research Centre, Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    J Neurol 258:1494-6. 2011
    ..Together these cases suggest a potential for the same VCP mutation to produce distinct patterns of brain damage, underlining the clinical heterogeneity of VCP-associated disease...
  53. pmc Intact reading in patients with profound early visual dysfunction
    Keir X X Yong
    Dementia Research Centre, Department of Neurodegeneration, UCL Institute of Neurology, University College London, UK Electronic address
    Cortex 49:2294-306. 2013
    ..The current data emphasise the need for much clearer evidence of causality when attempting to draw connections between specific aspects of visual processing and different types of acquired peripheral dyslexia. ..
  54. pmc Flavour identification in frontotemporal lobar degeneration
    Rohani Omar
    Dementia Research Centre, UCL Institute of Neurology, London WC1N 3BG, UK
    J Neurol Neurosurg Psychiatry 84:88-93. 2013
    ..Deficits of flavour processing may be clinically important in frontotemporal lobar degeneration (FTLD)...
  55. pmc Neuroanatomical profiles of personality change in frontotemporal lobar degeneration
    Colin J Mahoney
    Dementia Research Centre, Institute of Neurology, London, UK
    Br J Psychiatry 198:365-72. 2011
    ..Frontotemporal lobar degeneration (FTLD) frequently presents with complex behavioural changes, and therefore potentially provides a disease model in which to investigate brain substrates of personality...
  56. pmc Relatively preserved knowledge of music in semantic dementia
    Julia C Hailstone
    Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    J Neurol Neurosurg Psychiatry 80:808-9. 2009
    ..Our findings suggest that music is partly separable neuropsychologically and anatomically from other semantic domains, with implications for the clinical management of patients with brain disease...
  57. ncbi request reprint Music and the brain: disorders of musical listening
    Lauren Stewart
    Auditory Group, Newcastle University, Newcastle upon Tyne, London, UK
    Brain 129:2533-53. 2006
    ..Both the bases for normal musical listening and the clinical assessment of disorders now have a solid grounding in systems neuroscience...
  58. pmc A comparative clinical, pathological, biochemical and genetic study of fused in sarcoma proteinopathies
    Tammaryn Lashley
    Queen Square Brain Bank, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Brain 134:2548-64. 2011
    ..The co-existence of fused in sarcoma-positive inclusions in both motor neurons and extramotor cerebral structures is a characteristic finding in sporadic fused in sarcoma proteinopathies, indicating a multisystem disorder...
  59. pmc An information theoretic characterisation of auditory encoding
    Tobias Overath
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, United Kingdom
    PLoS Biol 5:e288. 2007
    ..The results establish PT as an efficient neural engine that demands less computational resource to encode redundant signals than those with high information content...
  60. pmc Word-finding difficulty: a clinical analysis of the progressive aphasias
    Jonathan D Rohrer
    Dementia Research Centre, Department of Neurodegenerative Disease, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Brain 131:8-38. 2008
    ....
  61. pmc Alzheimer's pathology in primary progressive aphasia
    Jonathan D Rohrer
    Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, Queen Square, London, UK
    Neurobiol Aging 33:744-52. 2012
    ..We propose that LPA may be a "unihemispheric" presentation of AD, and discuss this concept in relation to accumulating evidence concerning language dysfunction in AD...
  62. pmc Phenomenology and anatomy of abnormal behaviours in primary progressive aphasia
    Jonathan D Rohrer
    Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK
    J Neurol Sci 293:35-8. 2010
    ..Behavioural abnormalities may be clinically significant in PPA, and these abnormalities are underpinned by atrophy of overlapping frontotemporal networks centred on OFC...
  63. pmc Structural neuroanatomy of face processing in frontotemporal lobar degeneration
    Rohani Omar
    Dementia Research Centre, Institute of Neurology, University College London, 8 11 Queen Square, London WC1N 3BG, UK
    J Neurol Neurosurg Psychiatry 82:1341-3. 2011
    ..FTLD provides a perspective on the neuroanatomy of face processing that is complementary to focal lesion and normal functional imaging work...
  64. ncbi request reprint Computation of tactile object properties requires the integrity of praxic skills
    Sebastian J Crutch
    Dementia Research Centre, Department of Neurodegeneration, Institute of Neurology, University College, Box 16, National Hospital for Neurology and Neurosurgery, 8 11 Queen Square, London WC1N 3BG, UK
    Neuropsychologia 43:1792-800. 2005
    ..Macro-geometrical tactile analysis depends on intact programming of exploratory hand movements, while the role of such movements in micro-geometrical analysis is less clear...
  65. pmc The presenilin 1 P264L mutation presenting as non-fluent/agrammatic primary progressive aphasia
    Colin J Mahoney
    Dementia Research Centre, UCL Institute of Neurology, London, UK
    J Alzheimers Dis 36:239-43. 2013
    ..The case adds to accumulating evidence that particular mutations can promote specific brain network degeneration, with wider implications for understanding the sporadic forms of Alzheimer's disease and PPA...
  66. pmc A distinct clinical, neuropsychological and radiological phenotype is associated with progranulin gene mutations in a large UK series
    Jonathan Beck
    MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Brain 131:706-20. 2008
    ..Finally, we confirmed a modifying effect of APOE-E4 genotype on clinical phenotype with a later onset in the GRN carriers suggesting that this gene has distinct phenotypic effects in different neurodegenerative diseases...
  67. ncbi request reprint Brain biopsy in dementia: clinical indications and diagnostic approach
    Jonathan M Schott
    Dementia Research Centre, The National Hospital for Neurology and Neurosurgery, London WC1N 3BG, UK
    Acta Neuropathol 120:327-41. 2010
    ..We propose algorithms to aid the clinician in selecting appropriate patients for a biopsy and the neuropathologist in assessing a biopsy specimen...
  68. pmc Apraxia in progressive nonfluent aphasia
    Jonathan Daniel Rohrer
    Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    J Neurol 257:569-74. 2010
    ..Our findings show that apraxia of various kinds can be a clinical issue in PNFA and demonstrate that specific apraxias are clinically and anatomically dissociable within this population of patients...
  69. pmc Neologistic jargon aphasia and agraphia in primary progressive aphasia
    Jonathan D Rohrer
    Dementia Research Centre, Department of Neurodegenerative Disease, Institute of Neurology, University College London, UK
    J Neurol Sci 277:155-9. 2009
    ..Parietal lobe involvement is relatively unusual in PPA, perhaps accounting for the comparative rarity of jargon early in the course of these diseases...
  70. doi request reprint Phenotypic signatures of genetic frontotemporal dementia
    Jonathan D Rohrer
    Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, University College London, Queen Square, London, UK
    Curr Opin Neurol 24:542-9. 2011
    ..This review describes recent progress in identifying clinical and neuroanatomical phenotypes associated with autosomal-dominant FTD...
  71. pmc Semantic dementia: a specific network-opathy
    Phillip D Fletcher
    Dementia Research Centre, Institute of Neurology, University College London, 8 11 Queen Square, London, WC1N 3BG, UK
    J Mol Neurosci 45:629-36. 2011
    ..Here, we discuss outstanding nosological and neurobiological challenges posed by the syndrome and propose a pathophysiological model of SD based on sequential, regionally determined disintegration of a vulnerable neural network...
  72. pmc Flavour processing in semantic dementia
    Katherine E Piwnica-Worms
    Dementia Research Centre, Institute of Neurology, University College London, UK
    Cortex 46:761-8. 2010
    ..The findings suggest a potential mechanism for the development of food fads and other abnormal eating behaviours...
  73. pmc Odour identification in frontotemporal lobar degeneration
    Lorena Rami
    Dementia Research Centre, Institute of Neurology, London, WC1N 3BG, UK
    J Neurol 254:431-5. 2007
    ..Central deficits of odour identification may be more common in FTLD than previously recognised, and these deficits may assist in clinical characterisation...
  74. doi request reprint Emotion recognition in Huntington's disease: a systematic review
    Susie M D Henley
    Research Department of Clinical, Educational and Health Psychology, University College London, London WC1E 6BT, UK
    Neurosci Biobehav Rev 36:237-53. 2012
    ..Future work should focus on using more ecologically-valid tests, and testing inter-modality differences...
  75. doi request reprint Ten simple rules for reporting voxel-based morphometry studies
    Gerard R Ridgway
    Centre for Medical Image Computing, University College London, UK
    Neuroimage 40:1429-35. 2008
    ..This editorial suggests core principles that should be followed and information that should be included when reporting a VBM study in order to make it transparent, replicable and useful...
  76. ncbi request reprint Craving for music after treatment for partial epilepsy
    Jonathan D Rohrer
    Dementia Research Centre, Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, England
    Epilepsia 47:939-40. 2006