Research Topics
Genomes and Genes | A J WarrenSummaryAffiliation: University of Cambridge Country: UK Publications
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Publications
Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndromeAndrew J Finch
Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom
Genes Dev 25:917-29. 2011..Our findings establish a direct role for SBDS and EFL1 in catalyzing the translational activation of ribosomes in all eukaryotes, and define SDS as a ribosomopathy caused by uncoupling GTP hydrolysis from eIF6 release...
Eukaryotic transcription factorsAlan J Warren
MRC Laboratory of Molecular Biology, Hills Road, CB22QH, Cambridge, UK
Curr Opin Struct Biol 12:107-14. 2002..Structures of sequence-specific transcription factors have revealed further versatility in the mode of interaction with DNA and several have provided new insights into the molecular basis of human disease...- Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFbetaA J Warren
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
EMBO J 19:3004-15. 2000.... - The mll-AF9 gene fusion in mice controls myeloproliferation and specifies acute myeloid leukaemogenesisC L Dobson
MRC Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Hills Road, Cambridge, CB2 2QH, UK
EMBO J 18:3564-74. 1999..Thus, the late onset of overt tumours suggests that secondary tumorigenic mutations are necessary for malignancy associated with MLL-AF9 gene fusion and that myeloproliferation provides the pool of cells in which such events can occur... - Null mutation of the Lmo4 gene or a combined null mutation of the Lmo1/Lmo3 genes causes perinatal lethality, and Lmo4 controls neural tube development in miceE Tse
MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom
Mol Cell Biol 24:2063-73. 2004..Our results complete the gene targeting of the LIM-only family in mice and suggest that all four members of this family are important in regulators of distinct developmental pathways... - The leukemia-associated AML1 (Runx1)--CBF beta complex functions as a DNA-induced molecular clampJ Bravo
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
Nat Struct Biol 8:371-8. 2001..The structure clearly explains the molecular basis for the loss of DNA binding function of the Runt domain--CBF beta complex as a consequence of the human disease-associated mutations in leukemogenesis and cleidocranial dysplasia... - An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenesJ Corral
Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom
Cell 85:853-61. 1996..This novel use of homologous recombination formally proves that chromosomal translocations contribute to malignancy and provides a general strategy to create fusion oncogenes for studying their role in tumorigenesis... - Tumorigenesis in mice with a fusion of the leukaemia oncogene Mll and the bacterial lacZ geneC L Dobson
MRC Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Hills Road, Cambridge CB2 2QH, UK
EMBO J 19:843-51. 2000..Thus, truncation and fusion of MLL can be sufficient for tumorigenesis, regardless of the fusion partner... - The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cellsV E Valge-Archer
Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom
Proc Natl Acad Sci U S A 91:8617-21. 1994..Further, since both proteins can be involved in leukemogenesis, these data provide a direct link between proteins activated by chromosomal translocations in T-cell acute leukemia... - The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid developmentA J Warren
Medical Research Council Laboratory of Molecular Biology, Cambridge, England
Cell 78:45-57. 1994..This shows a pivotal role for a LIM domain protein in lineage specification during mammalian development and suggests that RBTN2 and GATA-1 are critical at similar stages of erythroid differentiation... - The T cell leukemia LIM protein Lmo2 is necessary for adult mouse hematopoiesisY Yamada
Medical Research Council, Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
Proc Natl Acad Sci U S A 95:3890-5. 1998..Thus, Lmo2 is necessary for early stages of hematopoiesis, and the Lmo2 master gene encodes a protein that has a central and crucial role in the hematopoietic development... - The Hox11 gene is essential for cell survival during spleen developmentT N Dear
MRC Laboratory of Molecular Biology, Cambridge, UK
Development 121:2909-15. 1995..This function for hox11 suggests that enhanced cell survival may result from the t(10;14) which activates HOX11 in T cell leukaemias, further strengthening the association between oncogene-induced cell survival and tumorigenesis... - Mutagenesis of the Runt domain defines two energetic hot spots for heterodimerization with the core binding factor beta subunitLina Zhang
Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
J Biol Chem 278:33097-104. 2003..The importance of the hot spot residues for Runx1 function was demonstrated in in vivo transient transfection assays. These data refine the structural analyses and further our understanding of the Runx1-CBF beta interface... - Hematopoietic stem cell expansion and distinct myeloid developmental abnormalities in a murine model of the AML1-ETO translocationCristina G de Guzman
Department of Human Genetics, University of Alabama at Birmingham, 1824 6th Avenue South, Birmingham, AL 35294, USA
Mol Cell Biol 22:5506-17. 2002..This suggests that the principal contribution of AML1-ETO to acute myeloid leukemia is the inhibition of multiple developmental pathways... - Structural and mutational analysis of the SBDS protein family. Insight into the leukemia-associated Shwachman-Diamond SyndromeCamille Shammas
Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom
J Biol Chem 280:19221-9. 2005.... - The mechanism of repression of the myeloid-specific c-fms gene by Pax5 during B lineage restrictionHiromi Tagoh
Division of Experimental Haematology, LIMM, University of Leeds, St James s University Hospital, Leeds, UK
EMBO J 25:1070-80. 2006..Our results support a model by which Pax5 does not lead to major alterations in chromatin modification, but inhibits transcription by interfering with the action of myeloid transcription factors... - Solution structure of the nonmethyl-CpG-binding CXXC domain of the leukaemia-associated MLL histone methyltransferaseMark D Allen
Centre for Protein Engineering, Cambridge, UK
EMBO J 25:4503-12. 2006..In particular, we have shown that residues in an extended surface loop are in close contact with the DNA. These data provide a template for the design of specifically targeted therapeutics for poor prognosis MLL-associated leukaemias... - Energetic contribution of residues in the Runx1 Runt domain to DNA bindingZhe Li
Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
J Biol Chem 278:33088-96. 2003..We propose mechanisms by which mutations in the Runt domain found in hematopoietic and bone disorders affect its affinity for DNA... - Structural consequences of nucleophosmin mutations in acute myeloid leukemiaCharles G Grummitt
Medical Research Council Centre for Protein Engineering, Cambridge CB2 0QH, UK
J Biol Chem 283:23326-32. 2008....