William Stephen Waring

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi Systemic uric acid administration increases serum antioxidant capacity in healthy volunteers
    W S Waring
    Clinical Pharmacology Unit and Research Centre, Department of Medical Sciences, The University of Edinburgh, Edinburgh, UK
    J Cardiovasc Pharmacol 38:365-71. 2001
  2. doi Lower incidence of anaphylactoid reactions to N-acetylcysteine in patients with high acetaminophen concentrations after overdose
    W Stephen Waring
    Scottish Poisons Information Bureau, The Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
    Clin Toxicol (Phila) 46:496-500. 2008
  3. ncbi Pattern of lithium exposure predicts poisoning severity: evaluation of referrals to a regional poisons unit
    W S Waring
    Scottish Poisons Information Bureau, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh EH16 4SA, UK
    QJM 100:271-6. 2007
  4. ncbi Delayed cardiotoxicity in chronic lithium poisoning: discrepancy between serum lithium concentrations and clinical status
    William Stephen Waring
    Scottish Poisons Information Bureau, Royal Infirmary of Edinburgh, Edinburgh, Scotland, UK
    Basic Clin Pharmacol Toxicol 100:353-5. 2007
  5. pmc Predictive factors for generalized seizures after deliberate citalopram overdose
    W Stephen Waring
    Scottish Poisons Information Bureau, Royal Infirmary of Edinburgh, Edinburgh, UK
    Br J Clin Pharmacol 66:861-5. 2008
  6. pmc Glycolysis inhibitors negatively bias blood glucose measurements: potential impact on the reported prevalence of diabetes mellitus
    W S Waring
    Clinical Pharmacology Unit, Roche Products, Welwyn Garden City, UK
    J Clin Pathol 60:820-3. 2007
  7. ncbi Acute myocarditis after massive phenelzine overdose
    W Stephen Waring
    Scottish Poisons Information Bureau, The Royal Infirmary of Edinburgh, Edinburgh, Scotland, UK
    Eur J Clin Pharmacol 63:1007-9. 2007
  8. ncbi Lowering serum urate does not improve endothelial function in patients with type 2 diabetes
    W S Waring
    Clinical Pharmacology Unit, University of Edinburgh, Edinburgh, UK
    Diabetologia 50:2572-9. 2007
  9. ncbi Coma blisters
    W S Waring
    Scottish Poisons Information Bureau, Royal Infirmary of Edinburgh, Edinburgh, Scotland, UK
    Clin Toxicol (Phila) 45:808-9. 2007
  10. ncbi Acute acetaminophen overdose is associated with dose-dependent hypokalaemia: a prospective study of 331 patients
    W Stephen Waring
    Scottish Poisons Information Bureau, Royal Infirmary of Edinburgh, Edinburgh, Scotland, UK
    Basic Clin Pharmacol Toxicol 102:325-8. 2008

Collaborators

Detail Information

Publications40

  1. ncbi Systemic uric acid administration increases serum antioxidant capacity in healthy volunteers
    W S Waring
    Clinical Pharmacology Unit and Research Centre, Department of Medical Sciences, The University of Edinburgh, Edinburgh, UK
    J Cardiovasc Pharmacol 38:365-71. 2001
    ..The effect of uric acid was substantially greater than that of vitamin C...
  2. doi Lower incidence of anaphylactoid reactions to N-acetylcysteine in patients with high acetaminophen concentrations after overdose
    W Stephen Waring
    Scottish Poisons Information Bureau, The Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
    Clin Toxicol (Phila) 46:496-500. 2008
    ..The present study examined the relationship between serum acetaminophen concentrations and risk of anaphylactoid reactions...
  3. ncbi Pattern of lithium exposure predicts poisoning severity: evaluation of referrals to a regional poisons unit
    W S Waring
    Scottish Poisons Information Bureau, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh EH16 4SA, UK
    QJM 100:271-6. 2007
    ..Lithium toxicity may result in severe clinical features. There is on-going uncertainty about the significance of serum lithium concentrations in patients with lithium toxicity...
  4. ncbi Delayed cardiotoxicity in chronic lithium poisoning: discrepancy between serum lithium concentrations and clinical status
    William Stephen Waring
    Scottish Poisons Information Bureau, Royal Infirmary of Edinburgh, Edinburgh, Scotland, UK
    Basic Clin Pharmacol Toxicol 100:353-5. 2007
    ....
  5. pmc Predictive factors for generalized seizures after deliberate citalopram overdose
    W Stephen Waring
    Scottish Poisons Information Bureau, Royal Infirmary of Edinburgh, Edinburgh, UK
    Br J Clin Pharmacol 66:861-5. 2008
    ..The present study sought to establish risk factors for seizures in this high-risk patient group, including stated dose ingested, co-ingested drugs or ethanol, and electrolyte disturbances...
  6. pmc Glycolysis inhibitors negatively bias blood glucose measurements: potential impact on the reported prevalence of diabetes mellitus
    W S Waring
    Clinical Pharmacology Unit, Roche Products, Welwyn Garden City, UK
    J Clin Pathol 60:820-3. 2007
    ..One of these involves addition of glycolysis inhibitors, such as sodium fluoride-potassium oxalate (NaF-KOx) to sample collection tubes, whereas the other requires immediate refrigeration and sample separation...
  7. ncbi Acute myocarditis after massive phenelzine overdose
    W Stephen Waring
    Scottish Poisons Information Bureau, The Royal Infirmary of Edinburgh, Edinburgh, Scotland, UK
    Eur J Clin Pharmacol 63:1007-9. 2007
    ..The clinical features of MAOI overdose are poorly characterised. This paper describes a novel cardiac complication of phenelzine toxicity in a previously healthy young adult with no history of cardiovascular disease...
  8. ncbi Lowering serum urate does not improve endothelial function in patients with type 2 diabetes
    W S Waring
    Clinical Pharmacology Unit, University of Edinburgh, Edinburgh, UK
    Diabetologia 50:2572-9. 2007
    ..We hypothesised that lowering of uric acid concentrations might allow restoration of endothelial function in this high-risk group...
  9. ncbi Coma blisters
    W S Waring
    Scottish Poisons Information Bureau, Royal Infirmary of Edinburgh, Edinburgh, Scotland, UK
    Clin Toxicol (Phila) 45:808-9. 2007
  10. ncbi Acute acetaminophen overdose is associated with dose-dependent hypokalaemia: a prospective study of 331 patients
    W Stephen Waring
    Scottish Poisons Information Bureau, Royal Infirmary of Edinburgh, Edinburgh, Scotland, UK
    Basic Clin Pharmacol Toxicol 102:325-8. 2008
    ..Acetaminophen appears to cause concentration-dependent hypokalaemia after overdose, and the pharmacological basis requires further consideration...
  11. doi Does the patient history predict hepatotoxicity after acute paracetamol overdose?
    W S Waring
    Scottish Poisons Information Bureau, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, EH16 4TJ, UK
    QJM 101:121-5. 2008
    ..However, the validity of this approach has received comparatively little attention...
  12. doi Acute ethanol coingestion confers a lower risk of hepatotoxicity after deliberate acetaminophen overdose
    W Stephen Waring
    Scottish Poisons Information Bureau, Royal Infirmary of Edinburgh, Edinburgh, Scotland
    Acad Emerg Med 15:54-8. 2008
    ..This study prospectively examined the effect of acute ethanol coingestion on risk of hepatotoxicity among patients admitted to hospital for N-acetylcysteine (NAC) therapy after deliberate acetaminophen overdose...
  13. doi Serum urea concentration and the risk of hepatotoxicity after paracetamol overdose
    W S Waring
    Scottish Poisons Information Bureau, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, EH16 4TJ
    QJM 101:359-63. 2008
    ..Therefore, we hypothesized that low serum urea concentration might itself be predictive of hepatotoxicity in patients that present to hospital after paracetamol overdose...
  14. pmc Constrictive pericarditis is an easily overlooked cause of right heart failure: a case report
    Aleksandra M Malkowska
    Scottish Poisons Information Bureau, Royal Infirmary of Edinburgh, Edinburgh, UK
    Cases J 1:27. 2008
    ..The case reminds us to consider the possibility of constrictive pericarditis in patients with unexplained chronic right heart failure, so that prompt investigation and treatment can be instigated...
  15. doi Impaired heart rate variability and altered cardiac sympathovagal balance after antidepressant overdose
    W S Waring
    Scottish Poisons Information Bureau, Royal Infirmary of Edinburgh, 51 Little France Crescent, EH164SA, Edinburgh, UK
    Eur J Clin Pharmacol 64:1037-41. 2008
    ..This study was designed to examine the feasibility of non-invasive heart rate variability recording in patients that present to hospital after deliberate antidepressant ingestion...
  16. ncbi Management of lithium toxicity
    W Stephen Waring
    Scottish Poisons Information Bureau, Royal Infirmary of Edinburgh, Edinburgh, UK
    Toxicol Rev 25:221-30. 2006
    ..Further research is required to establish the potential benefits of assisted elimination on clinical outcome in patients with lithium poisoning...
  17. ncbi Serum acetaminophen concentrations after acute overdose are not altered by opioid co-ingestion
    W Stephen Waring
    Scottish Poisons Information Bureau, Royal Infirmary of Edinburgh, Scotland, UK
    J Toxicol Sci 33:549-53. 2008
    ..Therefore, early serum acetaminophen concentrations can be used to determine the extent of drug exposure, irrespective of whether an opioid has been co-ingested...
  18. ncbi Cardiovascular effects of acute oxygen administration in healthy adults
    W Stephen Waring
    Clinical Pharmacology Unit and Research Centre, The University of Edinburgh, Western General Hospital, Porterfield Road, Edinburgh EH4 2LH, Scotland
    J Cardiovasc Pharmacol 42:245-50. 2003
    ..05). There were no effects on vascular responses in the isolated forearm bed. These findings indicate that oxygen administration causes acute effects on cardiovascular function, which might be important in the context of acute illness...
  19. ncbi The role of pharmacotherapy in assisting smoking cessation
    W Stephen Waring
    Clinical Pharmacology Unit, The University of Edinburgh, Western General Hospital, Crewe Road, EH4 2XU Edinburgh, Scotland, UK
    Eur J Clin Pharmacol 59:351-6. 2003
    ..These are discussed in further detail, with reference to evidence supporting their use in clinical practice...
  20. ncbi Acute caffeine intake influences central more than peripheral blood pressure in young adults
    W Stephen Waring
    Clinical Pharmacology Unit and Research Centre, The University of Edinburgh, Western General Hospital, Scotland, United Kingdom
    Am J Hypertens 16:919-24. 2003
    ..The aim of this study was to characterize the acute effects of caffeine on peripheral and central blood pressure (BP) in healthy individuals, using validated noninvasive techniques...
  21. ncbi Uric acid: an important antioxidant in acute ischaemic stroke
    W S Waring
    Clinical Pharmacology Unit and Research Centre, The University of Edinburgh, Western General Hospital, Edinburgh, UK
    QJM 95:691-3. 2002
  22. ncbi Comparison of spectrophotometric and enhanced chemiluminescent assays of serum antioxidant capacity
    W Stephen Waring
    Clinical Pharmacology Unit, The University of Edinburgh, Western General Hospital, Porterfield Road, Edinburgh, EH4 2XU, Scotland, UK
    Clin Chim Acta 338:67-71. 2003
    ..A number of assays are now available, and we wished to compare an enhanced chemiluminescence (ECL) method to a spectrophotometric method, the total antioxidant status (TAS) assay...
  23. pmc Hyperuricaemia does not impair cardiovascular function in healthy adults
    W S Waring
    Centre for Cardiovascular Science, The University of Edinburgh, Edinburgh, UK
    Heart 90:155-9. 2004
    ..To investigate the possibility that uric acid (UA) can impair endothelial function, an important surrogate for atherosclerosis...
  24. ncbi Autonomic cardiovascular responses are impaired in women with irritable bowel syndrome
    W Stephen Waring
    Clinical Pharmacology Unit and Research Centre, University of Edinburgh
    J Clin Gastroenterol 38:658-63. 2004
    ..This study characterizes cardiovascular autonomic function in women with irritable bowel syndrome (IBS), using standardized techniques...
  25. ncbi Emergency presentation of an elderly female patient with profound hypoglycaemia
    W S Waring
    Clinical Pharmacology Unit, The University of Edinburgh, Western General Hospital
    Scott Med J 49:105-7. 2004
    ..Furthermore, it serves to illustrate the sequence of events that may be created when foul play is suspected, and the factors related to patient confidentiality that require consideration by the responsible physician...
  26. ncbi Lithium carbonate as a potential pharmacological vehicle: intravenous kinetics of single-dose administration in healthy subjects
    W Stephen Waring
    Clinical Pharmacology Unit and Research Centre, The University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Eur J Clin Pharmacol 58:431-4. 2002
    ..We wished to determine the pharmacokinetics of a single systemic administration of 500 mg lithium carbonate (13.5 mmol free Li(+)) in healthy subjects...
  27. pmc Effects of salbutamol and glyceryl trinitrate on large arterial stiffness are similar between patients with hypertension and adults with normal blood pressure
    W Stephen Waring
    Clinical Pharmacology Unit, The University of Edinburgh, Queens Medical Research Institute, Edinburgh, UK
    Br J Clin Pharmacol 62:621-6. 2006
    ..Endothelial function is characteristically impaired in patients with hypertension. Endothelial function was assessed in men and women with hypertension using a recently described, non-invasive method...
  28. ncbi Uric acid restores endothelial function in patients with type 1 diabetes and regular smokers
    W Stephen Waring
    Clinical Pharmacology Unit, University of Edinburgh, The Queen s Medical Research Institute, 3rd Floor East, Room E3 22, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    Diabetes 55:3127-32. 2006
    ....
  29. ncbi Uric acid reduces exercise-induced oxidative stress in healthy adults
    W S Waring
    Clinical Pharmacology Unit and Research Centre, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, Scotland, UK
    Clin Sci (Lond) 105:425-30. 2003
    ..These findings indicate that the antioxidant properties of UA are of biological importance in vivo...
  30. doi Risk factors and mechanisms of anaphylactoid reactions to acetylcysteine in acetaminophen overdose
    Nasrin Pakravan
    National Poisons Information Service Edinburgh, University ofEdinburgh, Edinburgh, UK
    Clin Toxicol (Phila) 46:697-702. 2008
    ..Adverse effects to N-acetylcysteine (NAC) are well recognized, but their etiology and incidence are unclear...
  31. ncbi Effects of short-term isocapnic hyperoxia and hypoxia on cardiovascular function
    Alastair J Thomson
    Dept of Anaesthesia, Critical Care and Pain Medicine, Royal Infirmary, Edinburgh EH16 4SA, UK
    J Appl Physiol 101:809-16. 2006
    ..We conclude that both hyperoxia and hypoxia, when present during isocapnia, cause similar changes in cardiovascular function to those described with poikilocapnic conditions...
  32. ncbi Lack of significant toxicity after mirtazapine overdose: a five-year review of cases admitted to a regional toxicology unit
    W Stephen Waring
    Scottish Poisons Information Bureau, Royal Infirmary of Edinburgh, Edinburgh, Scotland, United Kingdom
    Clin Toxicol (Phila) 45:45-50. 2007
    ..The prevalence of mirtazapine prescribing has steadily risen; however, comparatively little information is available regarding the clinical features associated with mirtazapine overdose...
  33. ncbi Haemodynamic responses to salbutamol and isometric exercise are altered in young adults with mild asthma
    W Stephen Waring
    Clinical Pharmacology Unit and Research Centre, The University of Edinburgh, Edinburgh, UK
    Eur J Clin Pharmacol 61:9-14. 2005
    ..This study aimed to characterise the effects of acute salbutamol administration on systemic haemodynamics in adults with mild asthma who were receiving intermittent beta(2) agonist treatment...
  34. pmc Proteinuria is unrelated to the extent of acute acetaminophen overdose: a prospective clinical study
    Suzanne Benhalim
    Scottish Poisons Information Bureau, Royal Infirmary of Edinburgh, UK
    J Med Toxicol 4:232-7. 2008
    ..The present study examined whether proteinuria might correspond with the extent of acute acetaminophen exposure as a possible early marker of renal effects...
  35. ncbi Endogenous urate production augments plasma antioxidant capacity in healthy lowland subjects exposed to high altitude
    J Kenneth Baillie
    Apex Altitude Physiology Expeditions, c o College of Medicine and Veterinary Medicine, University of Edinburgh, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, UK
    Chest 131:1473-8. 2007
    ..Production of urate, a potent soluble antioxidant, is increased in hypoxic conditions. We aimed to determine whether urate is an important antioxidant defense in healthy subjects exposed to hypoxia...
  36. ncbi Acute myopathy in a patient with oesophageal stricture
    Lucia Possamai
    The Royal Infirmary of Edinburgh, Edinburgh, UK
    Age Ageing 36:698-9. 2007
    ..Muscle injury may be caused by any one of a number of factors, including trauma, drugs, hyperthermia and metabolic derangement. Symptoms and signs are often non-specific, and myopathy may be easily overlooked...
  37. ncbi Toxins that affect the cardiovascular system
    H K Ruben Thanacoody
    National Poisons Information Service Edinburgh Unit, Royal Infirmary of Edinburgh, Edinburgh
    Clin Med 8:92-5. 2008
  38. doi QT Prolongation and delayed atrioventricular conduction caused by acute ingestion of trazodone
    Jennifer A Service
    Scottish Poisons Information Bureau, Royal Infirmary of Edinburgh, Edinburgh, Scotland, United Kingdom
    Clin Toxicol (Phila) 46:71-3. 2008
    ..This case reminds us to consider the possibility of cardiotoxic effects after trazodone overdose, even in young patients with no established cardiovascular disease...
  39. doi Self-poisoning in older adults: patterns of drug ingestion and clinical outcomes
    Martin W Doak
    The Scottish Poisons Information Bureau, Royal Infirmary of Edinburgh, Scotland, UK
    Age Ageing 38:407-11. 2009
    ..This study sought to determine the agents ingested by older adults presenting to hospital after drug overdose, and to compare clinical outcomes to younger patients...
  40. ncbi Images in cardiovascular medicine. Tricyclic cardiotoxicity treated with sodium bicarbonate
    Candice Y Y Chan
    Scottish Poisons Information Bureau, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, Scotland, EH16 4SA
    Circulation 115:e63-4. 2007