R H Waring

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. ncbi Xenobiotic sulphation and its variability during inflammation: a factor in adverse drug reactions?
    R H Waring
    Centre for Toxicology, School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK
    Curr Drug Metab 14:361-5. 2013
  2. ncbi Biomarkers of endocrine disruption: cluster analysis of effects of plasticisers on Phase 1 and Phase 2 metabolism of steroids
    R H Waring
    School of Biosciences, University of Birmingham, Birmingham, UK
    Int J Androl 35:415-23. 2012
  3. ncbi Phytoestrogens and xenoestrogens: the contribution of diet and environment to endocrine disruption
    R H Waring
    School of Biosciences, University of Birmingham, Birmingham, United Kingdom
    J Steroid Biochem Mol Biol 108:213-20. 2008
  4. ncbi Do dietary phytoestrogens influence susceptibility to hormone-dependent cancer by disrupting the metabolism of endogenous oestrogens?
    C J Kirk
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U K
    Biochem Soc Trans 29:209-16. 2001
  5. ncbi Phytoestrogens are potent inhibitors of estrogen sulfation: implications for breast cancer risk and treatment
    R M Harris
    School of Biosciences and Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Clin Endocrinol Metab 89:1779-87. 2004
  6. ncbi Cysteine dioxygenase: regional localisation of protein and mRNA in rat brain
    R B Parsons
    Department of Medicine, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham, United Kingdom
    J Neurosci Res 65:78-84. 2001
  7. ncbi Effects of culture with TNF-alpha, TGF-beta and insulin on sulphotransferase (SULT 1A1 and 1A3) activity in human colon and neuronal cell lines
    E Davies
    School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK
    Toxicol In Vitro 18:749-54. 2004
  8. ncbi Detection of endocrine disruptors - from simple assays to whole genome scanning
    E Sung
    School of Biosciences, University of Birmingham, Birmingham, UK
    Int J Androl 35:407-14. 2012
  9. ncbi Wide-ranging genomic effects of plasticisers and related compounds
    N Turan
    Department of Medicine, Division of Medical Sciences, The Medical School, University of Birmingham, UK
    Curr Drug Metab 9:285-303. 2008
  10. ncbi Hepatic localisation of rat cysteine dioxygenase
    R B Parsons
    School of Biochemistry, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, UK
    J Hepatol 29:595-602. 1998

Collaborators

Detail Information

Publications33

  1. ncbi Xenobiotic sulphation and its variability during inflammation: a factor in adverse drug reactions?
    R H Waring
    Centre for Toxicology, School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK
    Curr Drug Metab 14:361-5. 2013
    ..Being ill may, therefore, in itself make drug metabolism unpredictable...
  2. ncbi Biomarkers of endocrine disruption: cluster analysis of effects of plasticisers on Phase 1 and Phase 2 metabolism of steroids
    R H Waring
    School of Biosciences, University of Birmingham, Birmingham, UK
    Int J Androl 35:415-23. 2012
    ....
  3. ncbi Phytoestrogens and xenoestrogens: the contribution of diet and environment to endocrine disruption
    R H Waring
    School of Biosciences, University of Birmingham, Birmingham, United Kingdom
    J Steroid Biochem Mol Biol 108:213-20. 2008
    ..Endocrine disrupting effects in man may be multifactorial when components from both the diet and the environment act at the same point in steroid metabolism...
  4. ncbi Do dietary phytoestrogens influence susceptibility to hormone-dependent cancer by disrupting the metabolism of endogenous oestrogens?
    C J Kirk
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U K
    Biochem Soc Trans 29:209-16. 2001
    ..Hence the inhibition of sulphotransferases by dietary phytoestrogens may have complex effects upon human susceptibility to breast cancer...
  5. ncbi Phytoestrogens are potent inhibitors of estrogen sulfation: implications for breast cancer risk and treatment
    R M Harris
    School of Biosciences and Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Clin Endocrinol Metab 89:1779-87. 2004
    ..Hence, dietary flavonoids may be able to influence the bioavailability of endogenous estrogens, and disrupt endocrine balance, by increasing the ratio of active estrogens to inactive estrogen sulfates in human tissues...
  6. ncbi Cysteine dioxygenase: regional localisation of protein and mRNA in rat brain
    R B Parsons
    Department of Medicine, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham, United Kingdom
    J Neurosci Res 65:78-84. 2001
    ..CDO expression in the brain may have several possibilities functions, the most likely being the prevention of free radical production by the autoxidation of cysteine and dopamine...
  7. ncbi Effects of culture with TNF-alpha, TGF-beta and insulin on sulphotransferase (SULT 1A1 and 1A3) activity in human colon and neuronal cell lines
    E Davies
    School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK
    Toxicol In Vitro 18:749-54. 2004
    ....
  8. ncbi Detection of endocrine disruptors - from simple assays to whole genome scanning
    E Sung
    School of Biosciences, University of Birmingham, Birmingham, UK
    Int J Androl 35:407-14. 2012
    ..The significance of differential expressed genes was assessed based on gene ontology and pathways analyses using DAVID and GenMaPP programs. The results illustrated the very wide-ranging effects of these chemicals across the genome...
  9. ncbi Wide-ranging genomic effects of plasticisers and related compounds
    N Turan
    Department of Medicine, Division of Medical Sciences, The Medical School, University of Birmingham, UK
    Curr Drug Metab 9:285-303. 2008
    ..CONCLUSIONS: These plasticisers affected the steady-state mRNA levels of many human genes. Exposure to these compounds over many years has the potential to influence human health...
  10. ncbi Hepatic localisation of rat cysteine dioxygenase
    R B Parsons
    School of Biochemistry, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, UK
    J Hepatol 29:595-602. 1998
    ..CDO abnormality has been implicated in a number of neurological and non-neurological diseases, with CDO deficiency possibly leading to excitotoxic damage to the brain and impaired Phase II metabolism in the liver...
  11. ncbi Expression of cysteine dioxygenase (EC 1.13.11.20) and sulfite oxidase in the human lung: a potential role for sulfate production in the protection from airborne xenobiotica
    J Millard
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Mol Pathol 56:270-4. 2003
    ....
  12. ncbi Sulfotransferase inhibition: potential impact of diet and environmental chemicals on steroid metabolism and drug detoxification
    R M Harris
    School of Biosciences, University of Birmingham, Birmingham, UK
    Curr Drug Metab 9:269-75. 2008
    ....
  13. ncbi The effect of plasticisers on "sulphate supply" enzymes
    N Turan
    School of Biosciences, University of Birmingham, UK
    Mol Cell Endocrinol 244:15-9. 2005
    ..005-0.5 microM octylphenol, bis (2-ethylhexyl) phthalate and DIP treatment. Endocrine disrupting effects of some plasticisers may be a consequence of modulation of expression of enzymes supplying PAPS for hormone sulphation...
  14. ncbi The aetiology of idiopathic Parkinson's disease
    D B Ramsden
    Department of Medicine, Division of Medical Science, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2TH, UK
    Mol Pathol 54:369-80. 2001
    ....
  15. ncbi Renal localisation of rat cysteine dioxygenase
    R B Parsons
    Department of Medicine, Queen Elizabeth Hospital, University of Birmingham, Edgbaston, Birmingham, UK
    Nephron 88:340-6. 2001
    ..In order to address this, this report demonstrates the expression of CDO in the kidney...
  16. ncbi In vitro effect of the cysteine metabolites homocysteic acid, homocysteine and cysteic acid upon human neuronal cell lines
    R B Parsons
    School of Biochemistry, University of Birmingham, Edgbaston, UK
    Neurotoxicology 19:599-603. 1998
    ..HCYS is selectively toxic to medulloblastoma cells; this may explain why high HCYS levels result in neural tube defects in prenatal humans, where the same cell-type is involved...
  17. ncbi The effects of flavonoids on human phenolsulphotransferases: potential in drug metabolism and chemoprevention
    R A Ghazali
    School of Biochemistry, University of Birmingham, Edgbaston, United Kingdom
    Life Sci 65:1625-32. 1999
    ..These observations suggest the potential for clinically important pharmacological and toxicological interactions by flavonoids...
  18. ncbi Non-genomic effects of endocrine disrupters: inhibition of estrogen sulfotransferase by phenols and chlorinated phenols
    R M Harris
    School of Biosciences, The University of Birmingham, Edgbaston, UK
    Mol Cell Endocrinol 244:72-4. 2005
    ..Our results demonstrate a potential non-genomic mechanism of action for these compounds and suggest that, where viable alternatives exist, both phenols substituted in the 2-position and their metabolic precursors should be avoided...
  19. ncbi Degradation to sulphate of S-methyl-L-cysteine sulphoxide and S-carboxymethyl-L-cysteine sulphoxide in man
    R H Waring
    School of Biosciences, University of Birmingham, Birmingham, UK
    Drug Metabol Drug Interact 19:241-55. 2003
    ..Subtle differences were noted in the pattern of radioactive sulphate excretion following administration of the two cysteine-sulphoxide compounds, suggesting that their sulphur-containing moieties may enter different catabolic routes...
  20. ncbi Cysteine dioxygenase: modulation of expression in human cell lines by cytokines and control of sulphate production
    L J Wilkinson
    School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK
    Toxicol In Vitro 16:481-3. 2002
    ..Cytokine release may therefore modulate sulphate production and hence regulate formation of sulphated biocomponents...
  21. ncbi Sulfation of "estrogenic" alkylphenols and 17beta-estradiol by human platelet phenol sulfotransferases
    R M Harris
    School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Biol Chem 275:159-66. 2000
    ..We conclude that by acting either as substrates or inhibitors of SULT1A1/2, alkylphenols may influence the sulfation, and hence the excretion, of estrogens and other phenol sulfotransferase substrates in humans...
  22. ncbi Endocrine disrupters--a threat to women's health?
    R H Waring
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK
    Maturitas 68:111-5. 2011
    ..However, despite many years of effort, the effects on human health of long-term environmental exposure to EDs, whether singly or as mixtures, remain unknown...
  23. ncbi Cysteine dioxygenase: regional expression of activity in rat brain
    R B Parsons
    Department of Medicine, University of Birmingham, UK
    Neurosci Lett 248:101-4. 1998
    ..Protein expression appeared to correlate with activity expression when levels before and after induction were compared. This non-uniformity of expression may reflect different physiological functions of CDO in these areas...
  24. ncbi Measurement of exogenous carbohydrate oxidation: a comparison of [U-14C]glucose and [U-13C]glucose tracers
    L Moseley
    Human Performance Laboratory, School of Sport and Exercise Sciences, The Univ. of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    Am J Physiol Endocrinol Metab 289:E206-11. 2005
    ..C. Kalhan, S. M. Savin, and P. A. Adam. J Lab Clin Med89: 285-294, 1977). Therefore, the explanation for the discrepancy in calculated CHO(EXO) remains to be fully understood...
  25. ncbi Endocrine disrupters: a human risk?
    R H Waring
    School of Biosciences, University of Birmingham, UK
    Mol Cell Endocrinol 244:2-9. 2005
    ..This may be of long-term concern since traces of EDs such as plasticisers, brominated fire retardants, sunscreen agents and cosmetic ingredients are widely distributed in the environment and in human biofluids...
  26. ncbi Determination of glutathione S-transferase mu and theta polymorphisms in neurological disease
    M C Stroombergen
    Department of Biochemistry, University of Birmingham, UK
    Hum Exp Toxicol 18:141-5. 1999
    ..Furthermore, subjects with a deletion of the GSTT1 gene were more susceptible to AD...
  27. ncbi Reactive oxygen species and oxidative DNA damage mediate the cytotoxicity of tungsten-nickel-cobalt alloys in vitro
    R M Harris
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Toxicol Appl Pharmacol 250:19-28. 2011
    ..By combining these in vitro data we offer a mechanistic explanation of the effect of this alloy in vivo and show that in vitro tests are a viable alternative for assessing new alloys in the future...
  28. ncbi Development of an in vitro model for cysteine dioxygenase expression in the brain
    S Qusti
    School of Biosciences, University of Birmingham, Edgbaston, UK
    Cell Biol Toxicol 16:243-55. 2000
    ..The characterization of an in vitro model for CDO expression provides a useful tool for the investigation of this important enzyme, which may have an etiological role in the pathogenesis of Parkinson's disease...
  29. ncbi Diethylstilboestrol--a long-term legacy
    R M Harris
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Maturitas 72:108-12. 2012
    ..It has been suggested that, like other endocrine disrupters, DES may have acted as an obesogen in the human population...
  30. ncbi Environmental impacts on enzymes involved in drug and steroid metabolism
    R H Waring
    Curr Drug Metab 9:267-8. 2008
  31. ncbi The effect of cysteine analogues on the excretion of urinary sulphate in the rat following cysteine administration
    E S Roopnarinsingh
    Section of Biological Chemistry, Division of Biomedical Sciences, Faculty of Medicine, Imperial College London, UK
    Drug Metabol Drug Interact 20:1-10. 2004
    ..It is not known where, within the complex sequence of events surrounding the degradation of cysteine to sulphate, that D-penicillamine or S-carboxymethyl-L-cysteine may interact...
  32. ncbi A direct correlation between nicotinamide N-methyltransferase activity and protein levels in human liver cytosol
    M L Smith
    Department of Biochemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Biochim Biophys Acta 1442:238-44. 1998
    ..Thus phenotypic differences in the general population are due to differences in steady-state mRNA levels and not because of a polymorphism in the coding region of the NNMT gene...
  33. ncbi Carboxanilide persistence in wildlife: excretion and retention in a rat model
    S C Mitchell
    Section of Biological Chemistry, Division of Biomedical Sciences, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, United Kingdom
    Bull Environ Contam Toxicol 72:686-91. 2004